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Murine model to study brain,behavior and immunity during hepatic encephalopathy

World Journal of Hepatology 2014年第4期6卷 243-250页

作者： Lindisley ferreira Gomides pedro Elias marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo henrique Souza Resende Patricia alves Maia Guidine Giselle Foureaux Fabíola mara Ribeiro Fabiana Paiva martins marco Antonio Peliky Fontes Anderson José ferreira Remo Castro Russo Mauro martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes Laboratório de Imunobiofotonica Department of MorphologyICBUFMGBelo Horizonte 31270-901Brazil School of Medicine UFMGBelo Horizonte 31270-901Brazil Department of Physiology ICBUFMGBelo Horizonte 31270-901Brazil Department of Morphology UFMGBelo Horizonte 31270-901Brazil Department of Biochemistry and Immunology UFMGBelo Horizonte 31270-901Brazil

AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the ***:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(alT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital *** was evaluated using prolonged prothrombin and partial thromboplastin *** parameters were measured through tail *** levels were quantified in serum and brain ***(EEG) and psychomotor activity score were performed to show brain *** edema was evaluated using magnetic resonance ***:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum alT levels and a high degree of liver *** intense hepatic neutrophil accumulation occurred in response to TAA-induced liver *** led to mice mortality and weight loss,which was associated with severe ***,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance *** agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in *** this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction ***:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment.

关键词： Hepatic encephalopathy Liver injury Thioacetamide Neurological dysfunction Neuropsychomotor abnormalities Intracranial hypertension Cerebral herniation

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Main Microbial Genres and Its Profile of Resistance and Sensitivity to Antimicrobials Used in the Treatment of Oncological Patients with Febril Neutropenia

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Journal of Biosciences and Medicines 2018年第1期6卷 34-50页

作者： Hélvecio Cardoso Póvoa Richard Raphael Borges Tavares Vieira Elias Sobreira Sathler Isabela Nardoni Bernardes Rafael Batista ferreira Mário henrique Couto Lima Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Lamara Laguardia Valente Rocha Daniel almeida da Costa Federal Fluminense University Niterói Brazil The Medical School at the Center of Higher Education of Valenç a Valen&ccedil a Brazil The Medical School at the Health Sciences Institute of the University Center of Caratinga Caratinga Brazil

Objective: To determine the main microbial genotypes and their antimicrobial resistance and susceptibility profile commonly used in the treatment of oncologic patients with febrile neutropenia, carried out through the review of the clinical histories of the patients’ medical records at the Hospital do Cancer de Muriaé-Fundacao Cristiano Varella. Methods: Quantitative research, determined the susceptibility profile of microorganisms in patients with febrile neutropenia from April 2007 to April 2008 by reviewing clinical histories of patients’ medical records at the referred hospital. Results: Of the total of 8 patients evaluated with Gram-negative microorganisms, 50% of the patients were female and 50% were male. Of the 18 patients evaluated with Gram-positive microorganisms 66% were female and 34% male. Gram-positive bacteria are prevalent and cause around 60% of documented bacteremias, although Gram-negative bacteria are more common in febrile neutropenic patientes. Conclusion: Exaggerated use of antimicrobials in hospitalized patients leads to the suppression of drug-sensitive microorganisms from the intestinal flora and promotes the persistence and growth of resistant bacteria. The antibiotic should be used in a curative manner with other therapeutic measures with the determined bacterial infection.

关键词： Febrile Neutropenia Antimicrobial Resistance Oncologic Patients

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Sensitivity of a Rapid Mix Test with Combined Synthetic Antigens Derived from Mycobacterium Leprae PGL-1 for Diagnosis and Surveillance of Leprosy

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Open Journal of Immunology 2020年第1期10卷 1-9页

作者： maria do Perpétuo Socorro Amador Silvestre Maxwell Furtado de Lima Antonio G.P.Pereira aline Rodrigues Bernardo Rafaela Lopes Diniz pedro Paulo ferreira Ribeiro Edimílson Domingos da Silva Luana Nepomuceno Gondim Costa Lima Instituto Evandro Chagas Rodovia BR-316km 07AnanindeuaParáBrasil Programa de Desenvolvimento Tecnologico de reativos para diagnostico GPRED-Bio Manguinhos-FioCruzRio de JaneiroBrasil

Introduction: In the Americas, Brazil contributes 91.63% of the total cases and the state of Pará still has high endemia for leprosy. Objective: To analyze the performance of a rapid test for the diagnosis and epidemiological surveillance of leprosy in endemic areas. Methods: The sample consisted of 70 MB multibacillary leprosy (MB) patients, 63 paucibacillary (PB) patients, and 80 intradomiciliary consanguineous contacts (ICSCO) of patients. A rapid test with a 15-minute reading was applied using two prototypes: prototype 1, double test with trisaccharide antigen (NT-P-BSA) at 1a. line (83.2 ng/test) and disaccharide antigen (ND-O-BSA) at 2a. (83.2 ng/test), both with a flow of 0.08 μL/mm with a 10 μC membrane, anti-IgM conjugate with a flow of 0.040 μL/mm and a Tris-Triton and prototype 2 runner buffer with MIX antigen (trisaccharide + disaccharide) in the same concentrations and conditions of prototype 1. Results: The comparison of the MIX test positivity rate and the disaccharide or trisaccharide doublet test across all samples was statistically significant, demonstrating that the MIX test had higher seropositivity rates compared to the ND-O-BSA or NT-P-BSA. It was demonstrated that the MIX test showed a good performance, with 25.39% of the PB patients negative for the disaccharide and trisaccharide duplet test, but positive for MIX. Conclusions: These data suggest the potential for further optimizing the performance by adding other synthetic antigens to the MIX antigens.

关键词： Leprosy Diagnosis Rapid Test

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Are There Schizophrenia Genetic markers and Mutations? A Systematic Review and Meta-Analyses

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Health 2017年第5期9卷 811-838页

作者： maria Auxiliadora Brasil Sampaio Cardoso Tárcia Januário do Nascimento Gabriel Pereira Bernardo Lorena Pereira Bernardo maria Mirelle ferreira Leite Barbosa pedro Januário Nascimento Neto Danilo ferreira de Sousa Antonio Gilvan Teixeira Júnior marcos Antonio Pereira de Lima marcial Moreno Moreira David de Sousa Gregório Lídia Coelho do Nascimento Santos Modesto Leite Rolim Neto Postgraduate Program in Health Science FMABC Santo André Brazil Faculty of Medicine Estacio (FMJ) Juazeiro do Norte Brazil Federal University of Cariri (UFCA) Faculty of Medicine Barbalha Brazil Science without Borders fellow at University of Liverpool Liverpool UK

Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were “Genetic markers”, “Mutation”, and “Schizophrenia”. Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene.

关键词： Schizophrenia Genetic markers Mutations Systematic Review

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Erratum to:Conformal and continuous deposition of bifunctional cobalt phosphide layers on p-silicon nanowire arrays for improved solar hydrogen evolution

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Nano Research 2020年第6期13卷 1787-1787页

作者： Sitaramanjaneya Mouli Thalluri Jerome Borme Kang Yu Junyuan Xu Isilda Amorim Joao Gaspar Liang Qiao Paulo ferreira pedro alpuim Lifeng Liu International Iberian Nanotechnology Laboratory(INL) Av.Mestre.Jose VeigaBraga4715-330Portugal Materials Science and Engineering Program University of Texas at AustinAustinTX78712USA Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical SciencesFudan UniversityShanghai200433China Mechanical Engineering Department and IDMEC Instituto Superior TécnicoUniversity of LisbonAv.Rovisco PaisLisboa1049-001Portugal Center of Physics University of MinhoBraga4710-057Portugal

The name of the first author was unfortunately misspelled

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Physical and Chemical Matrix Effects in Soil Carbon Quantification Using Laser-Induced Breakdown Spectroscopy

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American Journal of Analytical Chemistry 2014年第11期5卷 722-729页

作者： aline Segnini alfredo Augusto Pereira Xavier pedro Luís Otaviani-Junior Edilene Cristina ferreira alex marcel Watanabe marco Aurélio Speranca Gustavo Nicolodelli Paulino Ribeiro Villas-Boas Patrícia Perondi Anchao Oliveira Débora marcondes Bastos Pereira Milori Brazilian Agricultural Research Corporation(Embrapa)Instrumentation Sao CarlosBrazil Institute of Chemistry of Sao Carlos University of Sao Paulo(IQSC-USP)Sao CarlosBrazil Analytical Chemistry Department Sao Paulo State University(UNESP)AraraquaraBrazil Southeast Cattle Center EmbrapaSao CarlosBrazil

Advanced field methods of carbon (C) analysis should now be capable of providing repetitive, sequential measurements for the evaluation of spatial and temporal variation at a scale that was previously unfeasible. Some spectroscopy techniques, such as laser-induced breakdown spectroscopy (LIBS), have portable features that may potentially lead to clean and rapid alternative approaches for this purpose. The goal of this study was to quantify the C content of soils with different textures and with high iron and aluminum concentrations using LIBS. LIBS emission spectra from soil pellets were captured, and the C content was estimated (emission line of C (I) at 193.03 nm) after spectral offset and aluminum spectral interference correction. This technique is highly portable and could be ideal for providing the soil C content in a heterogeneous experiment. Dry combustion was used as a reference method, and for calibration a conventional linear model was evaluated based on soil textural classes. The correlation between reference and LIBS values showed r = 0.86 for medium-textured soils and r = 0.93 for fine-textured soils. The data showed that better correlation and lower error (14%) values were found for the fine-textured LIBS model. The limit of detection (LOD) was found to be 0.32% for medium-textured soils and 0.13% for fine-textured soils. The results indicated that LIBS quantification can be affected by the texture and chemical composition of soil. Signal treatment was shown to be very important for mitigation of these interferences and to improve quantification.

关键词： Soil C Content Spectral Correction Soil Textural Classes Field-Based Method Atomic Emission

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Postural Balance in the Elderly with Mild Cognitive Impairment: Relationship to Accidental Falls

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Open Journal of Therapy and Rehabilitation 2016年第2期4卷 67-75页

作者： Josélia Braz dos Santos ferreira Selma Petra Chaves Sá Rosimere ferreira Santana Ana maria Domingos Juliana Peres da Costa Pereira Luciana Krauss Rezende The Antô niopedro Hospital/UFF/Niterói The Miguel Pedro Municipal Hospital of Geriatrics and Gerontology (SMS) Rio de Janeiro Brazil The Aurora Afonso Costa Nursing School Fluminense Federal University (UFF) Niterói Brazil The AnaNeri Nursing School Federal University of Rio de Janeiro/UFRJ Rio de Janeiro Brazil The Estacio de Sa University The Redentor College Rio de Janeiro Brazil The Aurora Afonso Costa Nursing School (UFF) Niterói Brazil

This study analyzed postural balance in the elderly with mild cognitive impairment and its relationship to accidental falls. A quantitative and quasi-experimental method was used in a sample of 43 elderlies between 64 and 88 years old, mostly females. Data collection was performed in two Basic Health Units in the city of Rio de Janeiro in 2014. The instruments used were the Mini-Mental State Examination (MMSE), Tinetti scale, Motor Scale for the Elderly (EMTI) scale, and Elderly Falls Diary. The data were analyzed with the SAS statistical software version 9.3.1. The scales were applied before and after the psychomotor interventions. A significant difference was observed between the evaluating moments. Balance improvements were observed in all age groups, suggesting that all elderlies, regardless of age, showed satisfactory responses to the implemented psychomotor activities. The elderlies who fell more frequently were those between 60 and 69 years old. It is noteworthy that the age group with the lowest incidence of falls was that of elderlies between 70 and 79 years old. It was concluded that psychomotor activities are beneficial, regardless of age, proving their effectiveness when continued stimuli with cognitive and psychomotor activities are carried out.

关键词： Postural Balance Accidental Falls Elderlies Mild Cognitive Impairment

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The Application of Scales in the Diagnosis of Perceived Needs in the Elderly with Mild Cognitive Impairment

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Open Journal of Nursing 2016年第8期6卷 573-581页

作者： Josélia Braz dos Santos ferreira Selma Petra Chaves Sa Luciana Krauss Rezende Rosana Moreira de Sant’Anna Ana maria Domingos Rosimere ferreira Santana University Hospital Antônio pedro Universidade Federal Fluminense (UFF) Niterói Brazil Afonso Aurora Costa Nursing School Universidade Federal Fluminense (UFF) Niterói Brazil Ana Neri School of Nursing Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil

The study evaluated the use of the Mini-Mental State Examination scale (MMSE), Tinettiscale, and Motor Scale for the Elderly (EMTI) toassist in the diagnosis of potential needs observed in elderlies with Mild Cognitive Impairment. This was aquasi-experimental research, conducted in a Basic Health Unit in thecityof Rio de Janeiro in 2014. The sample population consisted of 22 elderlies aged 64 to 88 years and 86.36% females. The SAS statistical software (version 9.3.1) and Kruskal-Wallis test were used at a 95% confidence interval and a significance level of 0.05 and demonstrated significant differences in the evaluations performed before and after the intervention. The detected diagnoses were: impaired memory, the risk of falls, and willingness to improved relationships, among others. The evaluations showed MMSE results that were suggestive of cognitive impairment in 22.73% of the elderlies;the Tinetti scale showed a high risk of falls in 31.82% of theelderlies;and EMTI with 88.36 points, which was equivalent to the normal low classification. The intervention took place through ten weekly activity sessions after the initial evaluations. In the second evaluation, the Tinetti showed 59.09% of the elderlies with a moderate risk of falls and the EMTI as the normal average classification with 90.32 points. It was concluded that the scales offered diagnostic possibilities, which allowed for the implementation of necessary interventions according to the detected problems.

关键词： Nursing Diagnosis Mild Cognitive Impairment Sensory-Motor Performance Postural Balance Elderlies

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Relationship of Density of Specific Prostate Antigen (DPSA) with Prostate Histopathology: A Comparative Study of Patients Addressed in a School Hospital

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Journal of Biosciences and Medicines 2017年第3期5卷 105-111页

作者： marcos Benedito Figueiredo Brandã o maria Benedita Figueiredo Brandã o Elias Sobreira Sathler Richard Raphael Borges Tavares Vieira Carolina Cadinelli Vieira pedro Kozlowsky de alencar marcus Vinicius de Mello Pinto Lamara Laguardia Valente Rocha Lina Claudia Pereira Lopes Daniel almeida da Costa Carlos henrique Diniz Branco Luiz Gioseffi Jannuzzi School Hospital of the Dom Andre Arcoverde Foundation Valen&ccedil a Brazil Universidade Está cio de Sá Rio de Janeiro Brazil The Medical School at the Center of Higher Education of Valenç a Valen&ccedil a Brazil The Cellurare Institute Center of Laser Treatment and Cell Therapy Petr&oacute polis Brazil The Medical School at the Health Sciences Institute of the University Center of Caratinga Caratinga Brazil

Background: The prostate is the site of problems that have great clinical relevance. Beside this, the alterations in their volume can be divided into benign or malignant pathologies, but of multifactorial cause and there is no examination that alone is reliable for the diagnosis. Despite the evolution of the various methods of diagnostic imaging in the evaluation of pelvic diseases, the diagnosis of prostate cancer still requires histological confirmation obtained by transrectal ultrasound guided biopsy, a procedure that is generally safe and well tolerated by the patients. The most common histological type found in prostate biopsies is adenocarcinoma. Methodology: The objective of this study was to study the values of density of the prostate-specific antigen (DPSA) compared to histopathological results of prostate biopsy, patients attended at the Urology Outpatient Clinic of the Luiz Gioseffi Jannuzzi School Hospital from 1999 to 2007, using Exploratory, retrospective and documentary descriptive study. The sample was divided into groups of patients with adenocarcinoma and patients without adenocarcinoma, who presented only benign prostatic hyperplasia. Results: Of the 251 patients undergoing prostate biopsy, 124 were diagnosed with adenocarcinoma and 127 without adenocarcinoma. It was observed in this study that the DPSA was higher in adenocarcinoma than in the cases of patients with prostatic hyperplasia alone, and could therefore be used as an auxiliary tool in both diagnosis and follow-up of patients with adenocarcinoma. Conclusion: In this study, it can be observed that DPSA was higher in patients presenting with adenocarcinoma than in patients presenting only Benign Prostatic Hyperplasia (BPH), reinforcing its promising role to assist in the diagnosis and follow-up of patients with adenocarcinoma.

关键词： Prostate Cancer Adenocarcinoma Benign Prostatic Hyperplasia Prostate Biopsy

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Antidepressant Drugs Modulate Differentially Anti-inflammatory Lithium＇s Property： An in Vitro and in Vivo Study

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 287-304页

作者： Femanda Barbisan pedro Antonio Schmidt do Prado-Lima Veronica Farina Azzolin Maiquidieli Dal Berto Claudia Giuliano Bica Cibele ferreira Teixeira Dianni Capeleto Ivo Emilio da Cruz Jung Euler Esteves Ribeiro marta maria Medeiros Frescura Duarte Ivana Beatrice Manica da Cruz Graduate Program in Pharmacology Federal University of Santa Maria Santa Maria-RS 97105900 Brazil Brain Institute Catholic University of Rio Grande do Sul Porto Alegre-RS 91410000 Brazil Graduate Program in Pathology Federal University of Health Sciences of Porto Alegre Porto Alegre-RS 90050170 Brazil Open University of the Third Age State University of Amazonas Manaus-AM 69029040 Brazil Lutheran University of Brazil Santa Maria-RS 97030080 Brazil

Li （lithium）, a mood stabilizer has anti-inflammatory effect. However, in clinical practice, Li can be administered together with other antidepressants drugs, such as FLX （fluoxetine）, IMI （imipramine）, NOR （nortriptyline） and ESC （escitalopram）. As interaction between Li and these antidepressant drugs on inflammatory modulation has not been investigated yet, we performed an in vitro protocol using a non-human macrophage cell line. Oxidative and inflammatory markers, as well as cell cycle analysis and cytokine gene expressions were compared among treatments. An IR （inflammatory ratio） was calculated based on the following oxidative-inflammatory variables： nitric oxide, superoxide anion, reactive oxygen molecules, cytokines IL-113, IL-6, TNF-ct and IL-10. The in vitro calculated IR data were validated through an in vivo analysis of 154 human subjects with similar IR. Li and control cells presented similar IR values. FLX, NOR and IMI increased slightly IR values indicating some proinflammatory effect, whereas ESC decreased IR values indicating some anti-inflammatory effect. However, cells exposed to Li ＋ ESC triggered a proinflammatory response on macrophages. Thus, IR comparison results suggest that the Li anti-inflammatory effect is not universal and could be influenced by both basal macrophage-inflammatory state and interaction of other psychiatric drugs. These results could be useful to understand some inconsistencies observed in human studies involving Li and other psychiatric drugs.

关键词： Mood disorders inflammation selective serotonin reuptake inhibitors bipolar disorder lithium.

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