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Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： pedro Moreira Roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Brain scarring in infants:immunological insights from a neonatal hypoxic-ischemic encephalopathy model

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Neural Regeneration Research 2025年第10期20卷 2909-2910页

作者： pedro Moreno Pimentel-Coelho Carlos Chagas Filho Biophysics Institute Federal University of Rio de JaneiroRio de JaneiroBrazil

Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in *** brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regenerative treatments at different stages of *** the first hours after the neonatal insult are the most critical period for neuroprotection,the existence of secondary and tertiary mechanisms of brain injury offers the possibility of preventing delayed neurodegeneration in the subsequent days,weeks,or months(Levison et al.,2022).

关键词： neonatal protective hypoxic

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城市环境设计 2016年第5期 70-77页

作者：威尼·马斯雅各布·凡·里斯娜塔莉·德·弗里斯 Ignacio Borrego Stefan Witteman Guillermo Reynes pedro garcía martinez Gabriela Bojalil Antonio Lloveras Nieves Mestre Marjolijn Guldemond Fabien Mazenc Dagmar Niecke Renzo Leeghwater Florian Jenewein Rob't Hart

欧洲边界的开放直接导致了西班牙房地产的繁荣。土地价格大幅上升,随之迎来了住宅建筑的大规模生产。在马德里,这一情形被围绕在老城周边的巨型新建住宅区所进一步推动。这一系列新城主要以围绕内部庭院的形式建造,形成街区,而且几乎都... 详细信息

欧洲边界的开放直接导致了西班牙房地产的繁荣。土地价格大幅上升,随之迎来了住宅建筑的大规模生产。在马德里,这一情形被围绕在老城周边的巨型新建住宅区所进一步推动。这一系列新城主要以围绕内部庭院的形式建造,形成街区,而且几乎都是开窗较小的内向型建筑。这种形态与西班牙传统的热情奔放的文化相冲突。圣齐纳若是坐落在马德里东北边的一个新城,四周环绕着高速公路,并可以观赏到瓜达拉玛山脉的美景。

关键词：住宅洛德街区平面图图(数学)

On the Restricted Arc-connectivity of s-geodetic Digraphs

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Acta Mathematica Sinica,English Series 2010年第10期26卷 1865-1876页

作者： Camino BALBUENA pedro garcíA-VZQUEZ Departament de Matemàtica Aplicada Ⅲ Universitat Politècnica de Catalunya Departamento de Matemática Aplicada I Universidad de Sevilla E.T.S. de Arquitectura

For a strongly connected digraph D the minimum ,cardinality of an arc-cut over all arc-cuts restricted arc-connectivity λ′（D） is defined as the S satisfying that D - S has a non-trivial strong component D1 such that D - V（D1） contains an arc. Let S be a subset of vertices of D. We denote by w＋（S） the set of arcs uv with u ∈ S and v S, and by w-（S） the set of arcs uv with u S and v ∈ S. A digraph D = （V, A） is said to be λ′-optimal if λ′（D） =ξ′（D）, where ξ′（D） is the minimum arc-degree of D defined as ξ（D） = min {ξ′（xy）： xy ∈ A}, and ξ′（xy） = min（｜ω＋（{x,y}）｜, ｜w-（{x,y}）｜, ｜w＋（x） ∪ w- （y）｜, ｜w- （x） ∪ω＋（y）｜}. In this paper a sufficient condition for a s-geodetic strongly connected digraph D to be λ′-optimal is given in terms of its diameter. Furthermore we see that the h-iterated line digraph Lh（D） of a s-geodetic digraph is λ′-optimal for certain iteration h.

关键词： Restricted arc-connectivity arc-cut diameter s-geodetic digraph line digraph

A Script-Based Prototyping Framework to Boost Agile-UX Developments

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Journal of Computer Science & Technology 2016年第6期31卷 1246-1261页

作者： pedro Luis Mateo Navarro Gregorio martinez Perez Diego Sevilla Ruiz Catedra Sociedad Anonima de Electrdnica Submarina ( SAES) Laboratories University of Murcia Murcia 30100 Spain

Prototypes are described as a successful mechanism to incorporate user-experience design （UX） into Agile de- velopments, but their integration into such developments is not exempt from difficulties. Prototypes and final applications are often developed using different tools, which hinders the collaboration between designers and developers and also compli- cates reuse. Moreover, integrating stakeholders such as clients and users into the Agile process of designing, evaluating, and refining a prototype is not straightforward mainly because of its iterative nature. In an attempt to tackle these problems, this work presents the design and implementation of a new framework in which scripting languages are used to code prototyped behaviors. Prototyping is then treated as a separate aspect that coexists and runs together with final functionality. Using this framework communication is enhanced because designers and developers work in parallel on the same software artifact. Prototypes are fully reused and iteratively added with final functionality while prototyped behaviors are removed. They can be also modified on the fly to implement participatory design techniques.

关键词： prototype Agile development aspect-oriented development scripting language participatory design

The Origin of Patterning Systems in Bilateria——Insights from the Hox and ParaHox Genes in Acoelomorpha

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Genomics, Proteomics & Bioinformatics 2011年第3期9卷 65-76页

作者： Eduardo Moreno Jon Permanyer pedro martinez Department of Genetics University of Barcelona 08028-Barcelona Spain Catalan Institute for Research and Advanced Studies (ICREA) 08010-Barcelona Spain

Hox and ParaHox genes constitute two families of developmental regulators that pattern the Anterior-Posterior body axis in all bilaterians. The members of these two groups of genes are usually arranged in genomic clusters and work in a coordinated fashion, both in space and in time. While the mechanistic aspects of their action are relatively well known, it is still unclear how these systems evolved. For instance, we still need a proper model of how the Hox and ParaHox clusters were assembled over time. This problem is due to the shortage of information on gene complements for many taxa （mainly basal metazoans） and the lack of a consensus phylogenetic model of animal relationships to which we can relate our new findings. Recently, several studies have shown that the Acoelomorpha most probably represent the first offshoot of the Bilateria. This finding has prompted us, and others, to study the Hox and ParaHox complements in these animals, as well as their activity during development. In this review, we analyze how the current knowledge of Hox and ParaHox genes in the Acoelomorpha is shaping our view of bilaterian evolution.

关键词： Hox-ParaHox Acoelomorpha Bilateria cluster transposon Hox code

OPTIMAL DESIGN OF HOUSING ATTICS WITH INTEGRATED SOLAR COLLECTORS

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Journal of Green Building 2017年第4期12卷 3-20页

作者： Rodrigo garcía Alvarado pedro G.Campos Paulina Wegertseder Departmento Diseño y Teoría de la Arquitectura Universidad del Bío-BíoAv.Collao 1202Concepción 4051381Chile Departmento de Sistemas de Información Universidad del Bío-BíoAv.Collao 1202Concepción 4051381Chile Diseño y Teoría de la Arquitectura Universidad del Bío-BíoAv.Collao 1202Concepción 4051381Chile

In order to reduce the increasing energy consumption for the domestic demands of existing single-family housing and take advantage of frequent building enlargements,this paper presents a methodology and supporting software tool for determining the optimal design configuration of an attic with integrated solar *** analysis procedure is based on parametric modeling,energy simulation and the use of evolutionary algorithms for finding optimal *** has been implemented as a Web-platform for public use that provides users with a proposal of an attic shape with maximum solar energy collection,maximum living space and minimum construc-tion envelope for each house according its size and *** attic integrates PV,thermal and hybrid solar panels on one side of the *** paper describes the methodology and software design,asssment of the Web-platform usage and case-studies to verify its *** a matter of minutes,the Web-platform enables users to select a specific attic design for each house that has integrated solar collectors that can produce energy to cover almost 100%of domestic energy *** attics designed provide a nearly 30%increase in living space through the extension of one to four rooms,and the construction cost of the envelope is similar to that of a standard housing extension.

关键词： web platform for attic design integrated solar collectors attic spaces energy consumption of single family housing parametric modeling energy simulation optimal designs

Applied RCM^2 Algorithms Based on Statistical Methods

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International Journal of Automation and computing 2007年第2期4卷 109-116页

作者： Fausto pedro garcía Márquez Diego J. Pedregal ETSI Industriales Universidad de Castilla-La ManchaCampus Universitario s/n 13071 Ciudad RealSpain

The main purpose of this paper is to implement a system capable of detecting faults in railway point mechanisms. This is achieved by developing an algorithm that takes advantage of three empirical criteria simultaneously capable of detecting faults from records of measurements of force against time. The system is dynamic in several respects： the base reference data is computed using all the curves free from faults as they are encountered in the experimental data; the algorithm that uses the three criteria simultaneously may be applied in on-line situations as each new data point becomes available; and recursive algorithms are applied to filter noise from the raw data in an automatic way. Encouraging results are found in practice when the system is applied to a number of experiments carried out by an industrial sponsor.

关键词： Maintenance railways state space models system reliability monitoring elements.

Review of sub-synchronous interaction in wind integrated power systems: classification, challenges, and mitigation techniques

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Protection and Control of Modern Power Systems 2023年第2期8卷 13-38页

作者： Neevatika Verma Narendra Kumar Saket Gupta Hasmat Malik Fausto pedro garcía Márquez Department of Electrical Engineering Delhi Technological UniversityDelhi 110042India Department of Electrical Power Engineering Faculty of Electrical EngineeringUniversiti Teknologi Malaysia(UTM)81310 JohorMalaysia Ingenium Research Group DepartmentUniversidad Castilla-La Mancha13071 Ciudad RealSpain Department of Electrical Engineering Graphic Era Deemed to be UniversityDehradun 248002India Instrumentation and Control Engineering Department Bharati Vidyapeeth’s College of EngineeringNew Delhi 110056India

Emerging sub-synchronous interactions(SSI)in wind-integrated power systems have added intense attention after numerous incidents in the US and China due to the involvement of series compensated transmission lines and power electronics *** phenomenon occurs when two power system elements exchange energy below the synchro-nous *** phenomenon related to wind power plants is one of the most significant challenges to main-taining stability,while SSI phenomenon in practical wind farms,which has been observed recently,has not yet been described on the source of conventional SSI *** paper first explains the traditional development of SSI and its classification as given by the IEEE,and then it proposes a classification of SSI according to the current research status,reviews several mitigation techniques and challenges,and discusses analysis techniques for *** paper also describes the effect of the active damping controllers,control scheme parameters,degree of series compensation,and various techniques used in wind power plants(WPPs).In particular,a supplementary damping controller with converter controllers in Doubly Fed Induction Generator based WPPs is briefly *** paper provides a real-istic viewpoint and a potential outlook for the readers to properly deal with SSI and its mitigation techniques,which can help power engineers for the planning,economical operation,and future expansion of sustainable development.

关键词： Damping controller Doubly fed induction generator(DFIG) Series compensations Sub-synchronous interactions(SSI) Sub-synchronous resonance(SSR)