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Natural History and Treatment of Brown’s Syndrome: Long-Term Experience

Open Journal of Ophthalmology 2018年第4期8卷 232-240页

作者： pedro filipe rodrigues Raquel Seldon Gabriela Varandas Maria Lourdes Vieira Instituto de Oftalmologia Dr. Gama Pinto Lisbon Portugal

Purpose: Brown’s Syndrome (BS) is a restrictive strabismus characterized by a limitation of elevation in adduction. Several etiologies have been described, usually involving the superior oblique muscle. Spontaneous improvement has been reported in several studies, so surgery is reserved for a minority of cases. Our purpose is to review the characteristics, natural history and treatment of this pathology and present the experience of the Instituto de Oftalmologia Dr. Gama Pinto (IOGP). Methods: A consecutive retrospective series of BS patients seen at the Strabismus Department of IOGP between 1983 and 2014 was reviewed. All patients with complete clinical data were included in this study. The epidemiologic characteristics, clinical features, treatment, and clinical progression were reviewed. Results: Thirty-nine cases were selected, with a mean age at first diagnosis of 6.5 years. Of the thirty-nine cases, 6 were iatrogenic and the remainder idiopathic. Thirty-six cases were followed for a mean period of 6.1 years. Surgical intervention for BS was performed in 11 patients, using different approaches. Of these, 9 cases were considered successful. The remaining 25 cases were kept under observation without surgery, of which 17 showed spontaneous improvement and the other 7 remained unchanged. Conclusions: The surgical success rate was 82%, which demonstrates the good efficacy of the surgery despite the complexity and variety of pathophysiological mechanisms of the syndrome. In the patients kept under observation there was spontaneous improvement in 68%, confirming that a conservative approach seems to be adequate in most cases.

关键词： Brown’s Syndrome Extraocular Muscles Strabismus Superior Oblique Muscle Surgery

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Liquid crystal immunosensors for the selective detection of Escherichia coli with a fast analysis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： SANDRO C.OLIVEIRA MARIA S.SOARES BÁRBARA V.GONÇALVES ANDREIA C.M.rodrigues AMADEU M.V.M.SOARES RITA G.SOBRAL NUNO F.SANTOS JAN NEDOMA pedro L.ALMEIDA CARLOS MARQUES CICECO-Aveiro Institute of Materials Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate Laboratory i4HB-Institute for Health and Bioeconomy School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CESAM-Centre for Environmental and Marine Studies and Department of Biology University of Aveiro3810-193 AveiroPortugal Department of Telecommunications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CENIMAT School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Department of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consumption of contaminated food may cause serious illnesses,and traditional methods to detect Escherichia coli are still associated with long waiting times and high costs given the necessity to transport samples to specialized *** is a need to develop new technologies that allow cheap,fast,and direct monitoring at the site of ***,in this work,we developed optical immunosensors for the selective detection of ***,based on liquid crystal technology,whose molecules can align in different manners depending on the boundary conditions (such as substrates) as well as the environment that they *** glass substrate was functionalized with *** antibody using cysteamine as an intermediate,and a vertical alignment was imposed on the liquid crystal molecules by using DMOAP during *** presence of bacteria disrupts the alignment of the liquid crystal molecules,changing the intensity of light emerging between cross polarizers,measured using a polarized optical microscope and a *** was possible to detect *** in suspensions in the concentration range from 2.8 cells/mL to 2.8×10^(9) cells∕*** was also evaluated,and the sensors were used to analyze contaminated water samples.A prototype was developed to allow faster,in-situ,and easier analysis avoiding bulky instruments.

关键词： crystal alignment analysis

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Percutaneous decannulation of extracorporeal membrane oxygenation using MANTA device:A real-world single-center experience

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World Journal of Cardiology 2024年第10期16卷 574-579页

作者： Ioannis Milioglou Alice Qian pedro Rafael Vieira de Oliveira Salerno Gabriel Tensol rodrigues Pereira Luis Augusto Palma Dallan Kelsey E Gray Michael Morrison Yasir Abu-Omar Mohammad Eldiasty Cristian Baeza Department of Cardiology University Hospitals Cleveland Medical CenterClevelandOH 44106United States Department of Surgery University Hospitals Cleveland Medical Center and Case Western Reserve University School of MedicineClevelandOH 44106United States

BACKGROUND The MANTA vascular closure device(VCD)represents a novel approach to achieving hemostasis after large-bore femoral access *** clinical studies have evaluated the efficacy of the MANTA device across a range of patient populations undergoing different ***,there is still a paucity of data available concerning the use of MANTA devices in aiding the decannulation of venoarterial extracorporeal membrane oxygenation(VAECMO).AIM To present our single-center experience of utilizing the MANTA VCD in patients undergoing this *** This single-center study included all patients undergoing percutaneous decannulation of femoral VA-ECMO using the MANTA plug-based VCD between January 2021 and October 2023 at University Hospitals Cleveland Medical *** criteria were adult patients who required prolonged(>24 hours)hemodynamic support with *** included all-cause mortality,hemostasis,bleeding,limb ischemia,and site *** This is a retrospective cohort study of 19 patients with a mean age of 56.8 *** of them were males with a mean body mass index of *** most common extracorporeal membrane oxygenation indication was acute coronary syndrome complicated by cardiogenic shock at 36.8%.The mean length of intensive care unit stay for these patients was 18.8±8.42 *** out of 19 patients survived to *** MANTA device was successfully deployed in 19 patients,with 10 procedures conducted at the bedside and 9 in an operating room *** hemostasis was achieved within 5 minutes of MANTA deployment in 17 out of 19 *** 2 patients manual compression after Manta deployment was required to achieve adequate ***,acute lower extremity ischemia was noted in two patients,necessitating endovascular *** infections were reported at the site of MANTA *** Overall,based on our experience and that of other centers,the MANTA VCD

关键词： Extracorporeal membrane oxygenation MANTA Decannulation Hemostasis Ischemia

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What can a heavy U(1)B-L Z'boson do to the muon(g-2)u anomaly and to a new Higgs boson mass?

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Chinese Physics C 2021年第1期45卷 32-46页

作者： Antonio P.Morais Roman Pasechnik J.pedro rodrigues Departamenlo de Fisica da Universidade de Aveiro and CIDMA Campus de Santiago 3810-183 AveiroPortugal Department of Astronomy and Theoretical Physics Lund UniversitySE 223-62 LundSweden Nuclear Physics Institute ASCR 25068 RezCzech Republic Departamento de Fisica CFMUniversidade Federal de Santa CatarinaC.P.476CEP 88.040-900FlorianopolisSCBrazil

The minimal U(1)B_L extension of the Standard Model(B-L-SM)offers an explanation for neutrino mass generatio n via a seesaw mechanism;it also offers two new physics states,namely an extra Higgs bos on and a new Z'gauge *** emerge nee of a second Higgs particle as well as a new Z'gauge boson,both lin ked to the breaking of a local U(1)B_L symmetry,makes the B-L-SM rather constrained by direct searches in Large Hadron Collider(LHC)*** investigate the phenomenological status of the B-L-SM by confr on ting the new physics predictions with the LHC and electroweak precision *** into account the current bounds from direct LHC searches,we demonstrate that the prediction for the muon(g-2)u anomaly in the B-L-SM yields at most a contribution of approximately 8.9×10^-12,which represents a tension of 3.28 standard deviations,with the current 1σuncertainty,by means of a Z'boson if its mass is in the range of 6.3 to 6.5 TeV,within the reach of future LHC *** means that the B-L-SM,with heavy yet allowed Z‘bos on mass range,in practice,does not resolve the tension between the observed anomaly in the muon(g-2)u and the theoretical prediction in the Standard *** a heavy Z'boson also implies that the minimal value for the new Higgs mass is of the order of 400 GeV.

关键词： beyond Standard Model Higgs physics gauge extensions of the Standard Model Z'boson

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Fine-scale habitat differentiation shapes the composition, structure and aboveground biomass but not species richness of a tropical Atlantic forest

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Journal of Forestry Research 2020年第5期31卷 1599-1611页

作者： Alice Cristina rodrigues pedro Manuel Villa Arshad Ali Walnir Ferreira-Junior Andreza Viana Neri Laboratorio de Ecologia e Evoluc¸ao de Plantas–LEEP Departamento de Biologia VegetalUniversidade Federal de Vic¸osaVic¸osaMinas Gerais CEP 36570-900Brazil Fundacion para la Conservacion de la Biodiversidad Merida 7101MeridaVenezuela College of Forestry Nanjing Forestry UniversityNanjing 210037JiangsuPeople’s Republic of China Setor de Biologia e Meio Ambiente Instituto Federal do Sul de Minas Gerais-IFSULDEMINAS-Campus MachadoHighway Machado-Paraguac¸ukm 3MachadoMG CEP 37750000Brazil

Evaluating the influences of fine-scale habitat heterogeneity on the composition,diversity,structure and functioning of forests is critical to understand how tropical forests will respond to climate change and devise forest management strategies that will enhance biodiversity conservation and aboveground biomass ***,we hypothesized that topographic and soil factors determine fine-scale habitat differentiation,which in turn shape community composition,species richness,structure and aboveground biomass at the local scale in tropical *** test this hypothesis,we selected two areas(each 100×100 m)with contrasting fine-scale topographic conditions where all trees,palms and lianas with a diameter at breast height ≥ 10 cm were tagged and identified to *** each selected area,100 subplots of 10×10 m were *** mainly found that higher topographic variability caused higher habitat differentiation with changes in species composition and community structure,but did not change species *** habitat-scale analyses indicated that,in the less heterogeneous area,the distribution of species was more uniform along a fine-scale topographical gradient with no variation in convexity,which induced changes in structure and aboveground biomass,but not in species *** nonsignificant relationship between species richness and aboveground biomass may be attributable to species redundancy or functional *** study suggests that environmental filtering is a fundamental process for shaping community assembly and forest functioning along a local topographical gradient in tropical forests.

关键词： Community–habitat associations Convexity Rarefaction Topographic variability

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Modelling the role of ground-true riparian vegetation for providing regulating services in a Mediterranean watershed

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International Soil and Water Conservation Research 2023年第1期11卷 159-168页

作者： Bruno A.Aparício João pedro Nunes Léonard Bernard-Jannin Luis filipe Dias Andre Fonseca Teresa Ferreira cE3c-Centre for Ecology Evolution and Environmental Changes&CHANGE-Global Change and Sustainability InstituteFaculty of SciencesUniversity of LisbonLisbonPortugal Forest Research Centre&Laboratory TERRA School of AgricultureUniversity of LisbonLisbonPortugal Soil Physics and Land Management Group Wageningen University and ResearchWageningenNetherlands Longline Environment Ltd LondonUK

Intensive agricultural and industrial activities are often considered major sources of water ***,riparian vegetation(RV)is increasingly being promoted as a solution to balance the potentially adverse effects that agriculture may have on water ***,existing RV is often overlook in recent modelling efforts,failing to capture the current amount of ecosystem services ***,we used the Soil and Water Assessment Tool ecohydrological model to simulate the influence of ground-true RV on i)nutrient(nitrate and total phosphorus)and sediment exports from agricultural areas and ii)its effect for in-stream *** results are further compared against a set of hypothetical scenarios of different RV widths and different *** results point to a great rele-vance of existing RV in controlling in-stream concentration of sediments and nutrients where pressure from agriculture is highest,preventing them to surpass limits set in the EU Water Framework *** the other hand,in areas with industry discharges,the role of RV is limited and model results suggest that restoring RV would have limited *** illustrate how existing RV may already provide strong but not acknowledged water quality regulation services,how these services can differ substantially between nearby streams,and that effective strategies to improve water quality using RV must acknowledge existing patterns of vegetation,land use and contamination sources.

关键词： Agricultural pollution Riparian vegetation Ecosystem services Hydrological services Mediterranean region

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Ileal intussusception due to a parasite egg: A case report

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World Journal of Gastroenterology 2014年第36期20卷 13191-13194页

作者： José pedro Pinto Agostinho Cordeiro Ana Margarida Ferreira Conceio Antunes Patrícia Botelho Ana Joo rodrigues pedro Leo Department of General Surgery Hospital of Braga 2242 Apartado Portugal Servi?o de Anatomia Patológica Hospital de Braga 2242 Apartado Portugal Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho Braga 2242 Apartado Portugal ICVS/3B’s-PT Government Associate Laboratory Braga/Guimar?es 2242 Apartado Portugal

Ileal intussusception is the invagination of the small intestine within itself and accounts for 1% of cases of acute obstruction. However, physicians do not initially consider intussusception as a possible diagnosis of obstruction due to its rarity in adults. Herein, we report the case of a 22-year-old male who was admitted to the Emergency Department with continuous abdominal pain. Ultrasonography and computed tomography revealed an ileal intussusception. The patient underwent surgical removal of the segment of the small bowel. Unexpectedly, pathology revealed that the invagination occurred due to a parasite egg, with features suggestive of Schistosoma species. Schistosomiasis, although considered a parasitic disease in tropical countries, is not absent from Europe and though it is highly improbable, it may be responsible for cases of intussusception in adults.

关键词： Ileal intussusception Parasite egg Bowel obstruction Schistosoma Abdominal pain

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Dexamethasone intravitreal implant(Ozurdex) in diabetic macular edema: real-world data versus clinical trials outcomes

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1571-1580页

作者： pedro Neves Mário Ornelas Inês Matias João rodrigues Margarida Santos Marco DutraMedeiros David Martins Department of Ophthalmology Centro Hospitalar de SetúbalSetúbal 2910-549Portugal Department of Ophthalmology Hospital BeatrizÂngeloLoures 2674-514Portugal Department of Ophthalmology Hospital da Luz SetúbalSetúbal 2900-722Portugal Department of Ophthalmology Centro Hospitalar Lisboa CentralFaculdade de Ciências MédicasNOVA University of LisbonLisbon 1990-237Portugal

AIM: To investigate the safety and efficacy of intravitreal dexamethasone implants(Ozurdex?/DEX) in patients with diabetic macular edema(DME) either na?ve or nonna?ve to anti-VEGF therapies who switched to DEX implant independent of response to anti-vascular endothelial growth factors(anti-VEGFs).METHODS: This was an audit retrospective review of medical records of patients with DME who switched to the DEX intravitreal implant. Patients were divided into 2 groups: patients na?ve to antiangiogenic therapy and patients who were previously treated with anti-VEGFs. Data regarding demographics, changes in mean best-corrected visual acuity(BCVA), central macular thickness(CMT), and intraocular pressure(IOP) was collected over 6 mo. The demographic data mean changes in BCVA, CMT, and IOP were compared. Six-month follow-up data of 47 patients(57 eyes), who either switched to DEX implant irrespective of response to previous treatments or were treatment na?ve before receiving DEX implant, was ***: Improvement in mean BCVA was observed from 1-4 mo after injection with a decreased effect at month 6 as expected, with better outcomes in na?ve compared to non-na?ve patients. A statistically relevant decrease in mean CMT was observed during the follow-up period. An increase in mean IOP was observed in the first 2 mo after DEX therapy. The mean number of injections of the overall population during the 6 mo was 1.3. A subgroup analysis showed no relevant difference between phakic versus pseudophakic patients relative to measured outcomes. There was no cataract progression during the follow-up period and no adverse events ***: This real-life setting study shows that intravitreal DEX implant is effective and safe. The timings of greater therapeutic impact are concordant with previous studies and suggest that earlier treatment with corticosteroids may have an additional benefit in na?ve patients.

关键词： anti-VEGF therapy diabetic macular edema dexamethasone intravitreal implant na?ve eyes steroids

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Formation of DNA Strand Breaks in Peripheral Lymphocytes of Rats After Exposure to Natural Sunlight

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Biomedical and Environmental Sciences 2012年第2期25卷 245-249页

作者： Dorival Mendes rodrigues-JUNIOR Ana Amélia de CARVALHO MELO Benedito Borges da SILVA pedro Vitor LOPES-COSTA Department of Biology Federal University of Piaui-TeresinaPiauiBrazil Department of Gynecology Federal University of Piaui-TeresinaPiauiBrazil

Objective This paper aims to evaluate the genotoxicity in peripheral blood lymphocytes of rats after exposure to sunlight at different time points of day in a tropical region of Brazil（5oS,42oW）.Materials and Methods Thirty Wistar-Hannover rats,three months old,were randomly divided into three groups of 10 animals each：Group I [control,without exposure to ultraviolet（UV） radiation],Group II（exposed to sunlight during 08：00 *** 10：00 a.m.）,and Group III（exposed to sunlight during 10：00 *** 12：00 a.m.）.After a week of exposure,peripheral blood samples were taken from the tail of these animals to prepare smears on two slides per *** 24 h after exposure to sunlight in Group III,a new collection was obtained to observe the repair *** alkaline comet assay was used in this study to evaluate the genotoxic activity of sunlight（P0.05）.Results There was no statistical difference between Group I and II（P=0.672）.On the other hand,the exposure to sunlight in Group III showed genotoxic action in comparison to the other groups（P0.0001）.Also,there was no significant repair in Group III R（P=0.407）.Conclusion This study has shown a genotoxic potential of sunlight（UVA-B） in lymphocytes of mammals from 10：00 *** 12：00 a.m.,due to a higher intensity of UV in this tropical region.

关键词： Comet assay DNA damage Rats Sunlight Ultraviolet radiation

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Liquid biopsies in myeloid malignancies

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Cancer Drug Resistance 2019年第4期2卷 1044-1061页

作者： Bilal Abdulmawjood Catarina Roma-rodrigues Alexandra R.Fernandes pedro V.Baptista UCIBIO Department of Life SciencesFaculdade de Ciências e TecnologiaUniversidade NOVA de LisboaCampus CaparicaCaparica 2829-516Portugal

Hematologic malignancies are the most common type of cancer affecting children and young adults,and encompass diseases,such as leukemia,lymphoma,and myeloma,all of which impact blood associated tissues such as the bone marrow,lymphatic system,and blood *** diagnostics of these malignancies relies heavily on the use of bone marrow samples,which is painful,debilitating,and not free from risks for leukemia *** biopsies are based on minimally invasive assessment of markers in the blood(and other fluids)and have the potential to improve the efficacy of diagnostic/therapeutic strategies in leukemia patients,providing a useful tool for the real time molecular profiling of *** most promising noninvasive biomarkers are circulating tumor cells,circulating tumor DNA,microRNAs,and ***,we discuss the role of assessing these circulating biomarkers for the understanding of tumor progression and metastasis,tumor progression dynamics through treatment and for follow-up.

关键词： Liquid biopsy circulating tumor cells circulating tumor DNA exosomes microRNAs leukemia

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