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Colorectal cancer carcinogenesis:From bench to bedside

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 654-663页

作者： pedro Currais Isadora Rosa Isabel Claro Department of Gastroenterology Instituto Portugues de Oncologia de Lisboa Francisco GentilLisboa 1099-023Portugal

Colorectal cancer(CRC)remains one of the main causes of cancer death in developed ***,it is potentially preventable,by removing the precursor lesions-adenomas or serrated *** studies proved that this intervention reduces CRC mortality and that the first colonoscopy’s results can guide surveillance *** recently,it became clear that several carcinogenesis pathways may lead to sporadic *** is a heterogeneous disease,characterized by multiple molecular *** main pathways have been implicated in the development of CRC:Chromosomal instability,microsatellite instability,and the“serrated”pathways,with overlapping features between *** and other molecular and genetic based CRC classifications are known to have clinical implications,spanning from familial risk assessment to therapy *** authors review basic science data and provide insight on current implications for the management of patients with CRC.

关键词： Colorectal cancer Carcinogenesis pathways Microsatellite instability APC KRAS BRAF

Valorization of Aloe barbadensis Miller. (Aloe vera) Processing Waste

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Journal of Renewable Materials 2023年第3期11卷 1031-1061页

作者： Jeltzlin Semerel Nigel John Wim Dehaen pedro Fardim SISSTEM Program Faculty of Arts and ScienceUniversity of ArubaOranjestadAruba Department of Chemistry KU LeuvenLeuvenBelgium Department of Chemical Engineering KU LeuvenLeuvenBelgium

Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo,soap,and ***,the demand for these gel-based products has led to a surplus production of Aloe vera processing *** Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per *** the Aloe vera waste is being disposed to the landfill or used as fertilizer.A sustainable management system for the Aloe vera processing waste should be considered,due to the negative societal and environmental impacts of the currents waste disposal ***,this review focuses on various approaches that can be used to valorize Aloe vera waste into value-added products,such as animal and aquaculture feeds,biosorbents,biofuel and natural *** have reported Aloe vera waste for environmental applications biosorbents used for wastewater treatment of various *** studies have also reported on the valorization of Aloe vera waste for production of biofuels such as bioethanol,mixed alcohol fuels,biogas and *** vera waste could also be valorized through isolation and synthesis of natural polymers for application in wound dressing,tissue engineering and drug delivery *** vera waste valorization was also reviewed through extraction of value-added bioactive compounds such as aloe-emodin,aloin and *** value-added bioactive compounds have various applications in the cosmetics(non-steroidal anti-inflammatory,tyrosinase inhibitors)and pharmaceutical(anticancer agent and COVID 19 inhibitors)industry.

关键词： Aloe vera waste processing biomass conversion anthraquinone aloe-emodin aloin aloeresin

Urbanization drives adaptive evolution in a Neotropical bird

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Current Zoology 2023年第5期69卷 607-619页

作者： Rilquer Mascarenhas pedro Milet Meirelles Henrique Batalha-Filho National Institute of Science and Technology in Interdisciplinary and Transdisciplinary Studies in Ecology and Evolution(INCT IN-TREE) Instituto de BiologiaUniversidade Federal da Bahia40170-115 SalvadorBahiaBrazil

Urbanization has dramatic impacts on natural habitats and such changes may potentially drive local adaptation of urban *** change has been specifically shown to facilitate the fast adaptation of birds to changing environments,but few studies have investigated the genetic mechanisms of this *** investigations could provide insights into questions about both evolutionary theory and management of urban *** this study,we investigated whether local adaptation has occurred in urban populations of a Neotropical bird species,Coereba flaveola,specifically addressing whether observed behavioral adaptations are correlated to genetic signatures of natural *** answer this question,we sampled 24 individuals in urban and rural environments,and searched for selected loci through a genome-scan approach based on RADseq genomic data,generated and assembled using a reference genome for the *** recovered 46 loci as putative selection outliers,and 30 of them were identified as associated with biological processes possibly related to urban adaptation,such as the regulation of energetic metabolism,regulation of genetic expression,and changes in the immunological ***,genes involved in the development of the nervous system showed signatures of selection,suggesting a link between behavioral and genetic *** findings,in conjunction with similar results in previous studies,support the idea that cities provide a similar selective pressure on urban populations and that behavioral plasticity may be enhanced through genetic changes in urban populations.

关键词： behavioral adaptation phenotypic plasticity selection selective sweep South America

Proportional-integral-derivative control of nonlinear half-car electro-hydraulic suspension systems

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浙江大学学报（英文版）A辑：应用物理与工程 2013年第6期14卷 401-416页

作者： John E. D. EKORU Jimoh O. pedro School of Mechanical Aeronautical and Industrial Engineering University of the Witwatersrand Private Bag 03 WITS 2050 Johannesburg South Africa

This paper presents the development of a proportional-integral-derivative (PID)-based control method for application to active vehicle suspension systems (AVSS). This method uses an inner PID hydraulic actuator force control loop, in combination with an outer PID suspension travel control loop, to control a nonlinear half-car AVSS. Robustness to model uncertainty in the form of variation in suspension damping is tested, comparing performance of the AVSS with a passive vehicle suspension system (PVSS), with similar model parameters. Spectral analysis of suspension system model output data, obtained by performing a road input disturbance frequency sweep, provides frequency response plots for both nonlinear vehicle suspension systems and time domain vehicle responses to a sinusoidal road input disturbance on a smooth road. The results show the greater robustness of the AVSS over the PVSS to parametric uncertainty in the frequency and time domains.

关键词： Force control Proportional-integral-derivative (PID) control Nonlinear half-car Active vehicle suspension system (AVSS) Hydraulic actuator dynamics Model uncertainty

A Script-Based Prototyping Framework to Boost Agile-UX Developments

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Journal of Computer Science & Technology 2016年第6期31卷 1246-1261页

作者： pedro Luis Mateo Navarro Gregorio Martinez Perez Diego Sevilla Ruiz Catedra Sociedad Anonima de Electrdnica Submarina ( SAES) Laboratories University of Murcia Murcia 30100 Spain

Prototypes are described as a successful mechanism to incorporate user-experience design （UX） into Agile de- velopments, but their integration into such developments is not exempt from difficulties. Prototypes and final applications are often developed using different tools, which hinders the collaboration between designers and developers and also compli- cates reuse. Moreover, integrating stakeholders such as clients and users into the Agile process of designing, evaluating, and refining a prototype is not straightforward mainly because of its iterative nature. In an attempt to tackle these problems, this work presents the design and implementation of a new framework in which scripting languages are used to code prototyped behaviors. Prototyping is then treated as a separate aspect that coexists and runs together with final functionality. Using this framework communication is enhanced because designers and developers work in parallel on the same software artifact. Prototypes are fully reused and iteratively added with final functionality while prototyped behaviors are removed. They can be also modified on the fly to implement participatory design techniques.

关键词： prototype Agile development aspect-oriented development scripting language participatory design

Anomalous behaviour detection using one-class support vector machine and remote sensing images: a case study of algal bloom occurrence in inland waters

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International Journal of Digital Earth 2021年第7期14卷 921-942页

作者： pedro Henrique Moraes Ananias Rogério Galante Negri Graduate Program in Natural Disasters UNESP/CEMADENSão Josédos CamposSão PauloBrazil Sciences Technology Institute São Paulo State University(UNESP)São Josédos CamposSão PauloBrazil

Algal blooms are a frequent subject in scientific discussions and are the focus of many recent studies,mainly due to their adverse effect on *** the lack of ground truth data and the need to develop tools for their detection and monitoring,this research proposes a novel method to automate *** derived from multi-temporal image series processing,spectral indices and classification with Oneclass Support Vector Machine(OC-SVM)are used in this *** from multi-spectral sensors on Landsat-8 and MODIS were acquired through the Google Earth Engine API(GEE API).In order to evaluate our method,two bloom detection case studies(Lake Erie(USA)and Lake Taihu(China))were *** were made with methods based on spectral index ***,to demonstrate the performance of the OC-SVM classifier compared to other machine learning methods,the proposal was adapted to be used with a Random Forest(RF)classifier,having its results added to the *** situ measurements show that the proposed method delivers highly accurate results compared to spectral index thresholding ***,a drawback of the proposal refers to its higher computational *** application of the new method to a real-world bloom case is demonstrated.

关键词： Remote sensing spectral indices unsupervised classification anomalies algal bloom detection

Towards the Recovery of By-Product Metals from Mine Wastes:An X-Ray Absorption Spectroscopy Study on the Binding State of Rhenium in Debris from a Centennial Iberian Pyrite Belt Mine

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Journal of Minerals and Materials Characterization and Engineering 2014年第2期2卷 135-143页

作者： Maria-Ondina figueiredo Teresa Pereira da Silva Joao pedro Veiga Daniel de Oliveira Maria Joao Batista CENIMAT/I3N Faculty of Sciences and TechnologyNew University of LisbonCampus da CaparicaLisbonPortugal Unit of Mineral Resources and Geophysics National Laboratory for Energy and GeologyAmadoraPortugal

Rhenium is a very scarce element, occurring in the Earth's crust mainly carried by molybdenite (MoS2). Due to a very low availability comparative to actual industrial demand, rhenium is nowadays one of the most expensive mineral commodities and an increased interest is focused on ex- ploring residues resulting from a long-term mining, particularly of sulphide ore deposits. It is therefore noteworthy to assign the presence of rhenium (in a concentration up to 3 ppm) in the waste materials from the old sulphur factory at the abandoned mine of Sao Domingos (Iberian Pyrite Belt, Southeast Portugal), exploited since the Roman occupation of Iberia. Aiming at a potential sustainable recovery of rhenium as a by-product, X-ray near-edge absorption spectroscopy (XANES) was applied to clarify the Re-binding and mode of occurrence by comparing Re L3-edge XANES spectra obtained from mine waste samples (previously fully characterized by X-ray laboratory techniques) with similar spectra collected from Re-rich molybdenites (Mo1-xRexS2) and from Re-O model compounds configuring various valences and coordination environments of rhenium ions. Obtained results are commented, ruling out a possible Re-S binding and rather conforming with the binding of rhenium to oxygen in the analysed mine waste materials.

关键词： Mine Waste Materials By-Products Iberian Pyrite Belt Rhenium XANES Re L_(3)-Edge

Clinical and Demographic Profile of Women with Uterine Fibroids Living in Puerto Rico

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1347-1362页

作者： Edwin Y. Soto-Velázquez Alexander J. Jaramillo-Cañas Shania N. Aponte-Paris Gabriela V. Martínez-Marrero Irazu S. Guinan Gabrielle A. Rivera-Maldonado Alexandra Novas pedro L. Cruz-Rosa Idhaliz Flores-Caldera Maricarmen Colón-Diaz Department of Physiology and Pathology San Juan Bautista School of Medicine Caguas Puerto Rico United States Ponce Research Institute Ponce Health Sciences University Ponce Puerto Rico United States

Introduction: Uterine leiomyomas, or fibroids, are prevalent benign tumors affecting up to 70% of reproductive-age women in the United States, significantly impacting productivity and quality of life. Despite their commonality, the epidemiology and clinical patterns of leiomyomas in Puerto Rico remain inadequately researched. Methods: This study conducted a secondary data analysis using clinical, menstrual cycle characteristics, and demographic data from self-administered questionnaires of women undergoing diagnostic laparoscopy for endometriosis in Puerto Rico. Chi-square tests and t-tests analyzed categorical and continuous variables, respectively (p Results: Among 1,610 endometriosis cases, 312 included uterine fibroids. Prevalence estimates were 10.3% (40 years). Primiparous women averaged 22.14 years, with 40.71% having 2 - 3 pregnancies and 26.28% experiencing miscarriages. Symptoms included infertility (29.5%), dyspareunia (40.7%), severe pain (50%), and dysmenorrhea (75.6%). Comorbidities included ovarian cysts (52.2%) and abnormal uterine bleeding (37.8%). Conclusions: Advanced age, parity, and comorbidities like diabetes and hypertension were prevalent in our cohort. Understanding the epidemiological profile of women living in Puerto Rico with uterine fibroids is crucial for improving diagnostic awareness and enhancing patient care.

关键词： Uterine Fibroids Puerto Rico Epidemiology Dysmenorrhea Abnormal Uterine Bleeding

Nutritional supplements use in high-performance athletes is related with lower nutritional inadequacy from food

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Journal of Sport and Health Science 2016年第3期5卷 368-374页

作者： Mónica Sousa Maria J.Fernandes pedro Carvalho José Soares pedro Moreira Vitor Hugo Teixeira Centre of Research Education Innovation and Intervention in Sport Faculty of Sport University of Porto Faculty of Nutrition and Food Sciences University of Porto Research Centre on Physical Activity Health and Leisure Faculty of Sport University of Porto

Background: The use of nutritional supplements(NS) among athletes is widespread. However, little is known about the relationship between nutritional adequacy and NS usage. The aims of this study were to evaluate the NS usage and to compare the nutritional intake from food and prevalence of micronutrient inadequacy(PMI) between NS users and ***: Portuguese athletes from 13 sports completed an NS usage questionnaire and a semi-quantitative food-frequency questionnaire assessing information over the previous 12 months. The estimated average requirement cut-point method was used to calculate PMI. General linear models were used to compare nutritional intake and NS usage. Chi-squared tests and logistic regression were performed to study, respectively,relationships and associations between PMI and NS ***: From the 244 athletes(66% males, 13–37 years), 64% reported NS usage. After adjustment, NS users showed a higher intake from food(p < 0.05), for at least 1 gender, for energy, and for 7 of the 17 studied nutrients. The highest PMI were seen for vitamins D and E, calcium, folate,and magnesium. After adjustment, NS users, irrespective of gender, reported lower PMI for calcium(OR = 0.28, 95%CI: 0.12–0.65), and female users for magnesium(OR = 0.06, 95%CI: 0.00–0.98).Conclusion: Athletes using NS reported a higher nutritional intake from food, and a lower PMI for several nutrients. Perhaps, those who were taking NS were probably the ones who would least benefit from it.

关键词： Carbohydrates Minerals Proteins Sport Vitamins