检索结果-南通市图书馆

Macular atrophy after combined intravitreal triamcinolone and photodynamic therapy to treat choroidal neovascularization

引用

International Journal of Ophthalmology(English edition) 2010年第2期3卷 161-163页

作者： Jose M Ruiz-Moreno Javier A Montero pedro amat Francisco Lugo Department of Ophthalmology Albacete Medical SchoolUniversity of Castilla La ManchaSpain Alicante Institute of Ophthalmology Vitreo-Retinal Unit.Spain Pio del Rio Hortega University Hospital Ophthalmology UnitValladolidSpain

AIMTo report the appearance of choriocapillaris atrophy after combined high dose intravitreal triamcinolone acetonide (TA) and photodynamic therapy (PDT) to treat choroidal neovascularization (CNV) associated with age... 详细信息

关键词： age related macular degeneration choriocapillaris atrophy intravitreous triamcinolone photodynamic therapy retinal pigment epithelium atrophy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

玻璃体腔内注射曲安奈德联合光动力疗法治疗脉络膜新生血管所致的黄斑萎缩(英文)

引用

国际眼科杂志 2010年第7期10卷 1241-1244页

作者： Jose M Ruiz-Moreno Javier A Montero pedro amat-Peral Francisco L Lugo 西班牙Castilla La Mancha大学阿利坎特医学院眼科西班牙阿利坎特眼科研究所视网膜科西班牙Valladolid Pio del RioHortega大学附属医院眼科组

目的:报道经玻璃体腔内注射高剂量曲安奈德(triamcinolone acetonide,TA)联合光动力学疗法(photodynamic therapy,PDT)治疗老年性黄斑变性( age related macular degeneration, AMD)的脉络膜新生血管(choroidal neovascularization,CNV)后发生的脉络膜毛细血管萎缩。方法:我们采用非随机回顾性干涉治疗病例。在阿利坎特学院眼科,连续观察51眼(实验组)玻璃体腔内的注射(19.4±2.1)mg/0.1mL TA联合PDT治疗AMD的全部中心凹下型CNV患者,经过2a的随访,检查黄斑部脉络膜毛细血管和视网膜色素上皮细胞(RPE)萎缩情况。同时,采用单独PDT治疗的连续30眼患者作为对照组,其年龄,性别和AMD的CNV类型及大小与实验组相匹配。结果:随访24mo后,在治疗区域21/47眼(45%,实验组)和7/30眼(23%,对照组)发展成黄斑部RPE和脉络膜毛细血管萎缩(P=0.04,卡方检验)。实验组平均最大萎缩区域的直径为(5044±1666)μm,而对照组为(4345±1550)μm。在实验组中,RPE萎缩患者的平均最佳矫正视力为(0.87±0.33),而非RPE萎缩患者的平均最佳矫正视力为(0.66±0.26) (P=0.11,秩和U检验)。结论:玻璃体腔内注射大剂量TA联合PDT治疗可能会增加RPE和脉络膜毛细血管萎缩的风险。

关键词：老年性黄斑变性脉络膜毛细血管萎缩玻璃体腔内注射曲安奈德光动力学疗法视网膜色素上皮细胞萎缩

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

玻璃体腔内注射Bevacizumab联合白内障手术治疗湿性年龄相关性黄斑变性(英文)

引用

国际眼科杂志 2010年第7期10卷 1245-1247页

作者： José M Ruiz-Moreno Javier A Montero pedro amat-Pera Francisco L Lugo 两班牙Castilla La Mancha大学阿利坎特医学院眼科西班牙阿利坎特眼科研究所视网膜科两班牙Valladolid Pio del Rio Hortega大学附属医院眼科组

目的:探讨玻璃体腔内注射bevacizumab (Avastin)联合白内障手术预防脉络膜新生血管(choroidal neovascularization,CNV)的再次激活及年龄相关性黄斑变性(age-relatedmacular degeneration, AMD)。方法:对12例接受湿性年龄相关变性治疗的白内障患者给予透明角膜切口白内障超声乳化和人工晶状体植入手术,最后予以玻璃体腔内注射1.25mg bevacizumab (0.05mL)。主要评价指标:视力恢复、脉络膜新生血管的再次激活,及相干光断层成相术(OCT)对渗漏液体的评估。结果:患者最佳矫正视力(best-corrected visual acuity, BCVA)术后显著提高(脉络膜新生血管闭合后P<0.01,白内障发生后P=0.049,t检验)。白内障术后平均随访时间为11.8mo(标准差6.1,范围3 ～22mo),随访期内患者未出现脉络膜新生血管的再次激活及新的脉络膜新生血管病变。结论:在给予脉络膜新生血管及年龄相关性黄斑变性治疗的患者,白内障手术联合玻璃体腔内注射bevacizumab可预防脉络膜新生血管的再次激活。

关键词：年龄相关性黄斑变性 bevacizmnab 白内障手术脉络膜新生血管

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Study on Modeling and Optimization of Memory Systems

引用

Journal of Computer Science & Technology 2021年第1期36卷 71-89页

作者： Jason Liu pedro Espina Xian-He Sun School of Computing and Information Sciences Florida International UniversityMiamiFL 33199U.S.A Department of Computer Science Illinois Institute of TechnologyChicagoIL 60616U.S.A

Accesses Per Cycle(APC),Concurrent Average Memory Access Time(C-amat),and Layered Performance Matching(LPM)are three memory performance models that consider both data locality and memory assess *** APC model measures the throughput of a memory architecture and therefore reflects the quality of service(QoS)of a memory *** C-amat model provides a recursive expression for the memory access delay and therefore can be used for identifying the potential bottlenecks in a memory *** LPM method transforms a global memory system optimization into localized optimizations at each memory layer by matching the data access demands of the applications with the underlying memory system *** three models have been proposed separately through prior *** paper reexamines the three models under one coherent mathematical *** specifically,we present a new memorycentric view of data *** divide the memory cycles at each memory layer into four distinct categories and use them to recursively define the memory access latency and concurrency along the memory *** new perspective offers new insights with a clear formulation of the memory performance considering both locality and ***,the performance model can be easily understood and applied in engineering *** such,the memory-centric approach helps establish a unified mathematical foundation for model-driven performance analysis and optimization of contemporary and future memory systems.

关键词： performance modeling performance optimization memory architecture memory hierarchy concurrent average memory access time

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma:A retrospective study

引用

Oncology Research 2023年第2期31卷 207-220页

作者： GUSTAVO MARTÍN VILLOLDO MARÍA TERESA POMBO MARIANA ARIS JOAQUÍN CHEMI PABLO MANDÓ SUPRIYA NAGARAJU JUAN CAMEAN ADRIÁN BURIONI DEBORAH EGEA MORA amat JOSÉLEÓN MELLADO JOSÉMORDOH ALBERTO VILLARONGA MARÍA MARCELA BARRIO Urology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Immunohistochemistry Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Centro de Investigaciones Oncológicas Fundación Cáncer FUCACiudad Autónoma de Buenos Aires1426Argentina Urology Department MD Anderson Cancer CenterHoustonTX77030USA Pathology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina

Intravesical Bacillus Calmette Guerin(BCG)is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer(NMIBC).However,the response rate is~60%,and 50%of non-responders will progress to muscle-invasive *** induces massive local infiltration of inflammatory cells(Th1)and ultimately cytotoxic tumor *** searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte(TIL)polarization in the tumor microenvironment(TME)in pre-treatment ***-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG(n=32)were evaluated retrospectively by *** polarization was assessed by quantifying the T-Bet+(Th1)and GATA-3+(Th2)lymphocyte ratio(G/T),and the density and degranulation of EPX+*** addition,PD-1/PD-L1 staining was *** results correlated with BCG *** most non-responders,Th1/Th2 markers were compared in pre-and post-BCG *** was 65.6%in the study *** responders had a higher G/T ratio and a greater number of degranulated EPX+*** combined into a Th2-score showed a significant association with higher scores in responders(p=0.027).A Th2-score cut-off value>48.1 allowed discrimination of responders with 91%sensitivity but lower ***-free survival was significantly associated with the Th2-score(p=0.007).In post-BCG biopsies from recurring patients,TILs increased Th2-polarization,probably reflecting BCG failure to induce a pro-inflammatory status and,thus,a lack of ***-L1/PD-1 expression was not associated with the response to *** results support the hypothesis that a preexisting Th2-polarized TME predicts a better response to BCG,assuming a reversion to Th1 polarization and antitumor activity.

关键词： Non-muscle invasive bladder cancer BCG predictive biomarkers Lymphocyte polarization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：