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Current and future therapeutic strategies for the treatment of retinal neurodegenerative diseases

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Neural Regeneration Research 2022年第1期17卷 103-104页

作者： Victoria Maneu pedro Lax Nicolás Cuenca Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain

the complex and mostly multiple and unknown aetiology of neurodegenerative diseases always give way to an intricate scenario of dying tissue that involves multiple cell mediators and cell *** neurodegenerative diseases of the central nervous system(CNS)share common mechanisms,regardless their origin:oxidative stress,neuroinflammation and cell ***,retinal degenerative diseases,with or without a genetic cause,as retinitis pigmentosa(RP),glaucoma,agerelated macular degeneration(amD)or diabetic retinopathy(DR)do not differ in their basic mechanisms of cell death neither one to another,nor from those observed in other CNS diseases as Parkinson’s or Alzheimer’s(Cuenca et al.,2014).Indeed,the therapeutic findings should be able to be more or less easily extrapolated between these conditions,as far as they are directed to common dartboards.

关键词： diseases degenerative therapeutic

Exploring spatial relationships between stream channel features,water depths and flow velocities during flash floods using HEC-GeoRAS and Geographic Information Systems

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Journal of Geographical Sciences 2022年第4期32卷 757-782页

作者： Miguel LEAL Eusébio REIS pedro Pinto SANtOS Centre of Geographical Studies and Associated Laboratory tERRA Institute of Geography and Spatial PlanningUniversidade de Lisboa1600-276 LisbonPortugal Forest Research Centre and Associated Laboratory tERRA School of AgricultureUniversidade de LisboaTapada da Ajuda1349-017 LisbonPortugal

Water depths and flow velocities decisively influence the damage caused by flash *** Information System(GIS)is a powerful and useful tool,allowing the spatial analysis of results obtained by hydraulic modelling,namely from the HEC-RAS/HEC-GeoRAS *** GIS spatial analysis performed in this study seeks to explain and quantify the spatial relationships between the stream channel features and flow components during flash flood *** these relationships are generically known,there are few studies exploring this subject in different geographic contexts.A 1D hydraulic model was applied in a small watershed in Portugal,providing good results in the definition of floodable areas,water depths and longitudinal *** direct relationship was found between water depths and velocities in the floodable areas;however,negative strong correlations were found between the two flow components along the stream *** slope,channel and flood width,and roughness prove to be highly relevant on the longitudinal variations of water depths and velocities and on the location of maximum *** peak discharges and return periods(R;)can change the relationships between water depths and velocities at the same *** can be improved with more accurate elevation data for stream channels and floodplains.

关键词： flash floods water depth flow velocity geographic information systems(GIS) spatial analysis

Small dams/reservoirs site location analysis in a semi-arid region of Mozambique

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International Soil and Water Conservation Research 2021年第3期9卷 381-393页

作者： Antònio dos Anjos Luís pedro Cabral Department of GIS and Regional Planning Universidade Catdlica de MozambiqueBeiraSofalaMozambique NOVA Information Management School(NOVA IMS) Universidade Nova de Lisboa1070-312LisboaPortugal

the water crisis is one of the biggest human problems in developing countries,especially in semi-arid regions where it can form an obstacle to irrigation and cultivation,cattle raising and people's *** construction of small dams/reservoirs are a possible solution to remediate this *** infrastructures must be located in suitable areas to be *** study aimed to find the most suitable locations for small dams/reservoirs in the tete province region,Mozambique,which has a pronounced water deficit A Geographical Information System(GIS)based approach was used to implement a multicriteria evaluation(MCE)analysis through an Analytic Hierarchical Process(AHP),which included local experts’*** main categories of suitability were identified:"Not suitable”(15%of total area),"Modestly suitable"(78%),and“Suitable"(7%).We found that 35 of the 38(92%)abandoned small dams/reservoirs were in areas classified as“Modestly suitable”confirming the robustness of our *** also found that most of the dams/reservoirs currently operating(78%)and planned(73%)are in modestly suitable *** finding suggests that the decision to construct dams/reservoirs may not have considered the most critical suitability factors identified in this *** data and/or additional criteria are required for the full understanding of finding out why so many dams/reservoirs failed before building new ones to address the population’s water needs in the region.

关键词： Water scarcity Multi-criteria evaluation Geographic information systems Remote sensing Mozambique

Magmatic Evolution of Garnet-Bearing highly Fractionated Granitic Rocks from Macao,Southeast China:Implications for Granite-Related Mineralization Processes

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Journal of Earth Science 2021年第6期32卷 1454-1471页

作者： pedro Quelhas João Mata Ágata Alveirinho Dias Institute of Science and Environment University of Saint JosephRua de Londres106MacaoChina Instituto Dom Luiz Faculdade de CiênciasUniversidade de Lisboa1749-016LisboaPortugal

the widespread W-(Mo)-Sn-Nb-ta polymetallic mineralization in Southeast(SE)China is genetically associated with Mesozoic highly fractionated granitic *** rocks have enigmatic mineralogical and geochemical features,making its petrogenesis an intensely debated *** better understand the underlying magma evolution processes,petrography,garnet chemistry and whole-rock major and trace element data are reported for Jurassic highly fractionated granitic rocks and associated microgranite and aplitepegmatite dikes from Macao and compared with coeval similar granitic rocks from nearby areas in SE *** the fact that the most evolved rocks in Macao are garnet-bearing aplite-pegmatite dikes,the existence of coeval two-mica and garnet-bearing biotite and muscovite granites displaying more evolved compositions(e.g.,lower Zr/Hf ratios)indicates that the differentiation sequence reached higher degrees of fractionation at a regional *** crystal fractionation played an important role,late-stage fluid/melt interactions,involving F-rich fluids,imparted specific geochemical characteristics to Macao and SE China highly fractionated granitic rocks such as the non-CHARAC(CHArge-and-RAdius-Controlled)behavior of trace elements,leading,for example,to non-chondritic Zr/Hf ratios,Rare Earth Elements(REE)tetrad effects and Nb-ta enrichment and *** process contributed to the late-stage crystallization of accessory phases only found in these highly evolved *** the latter,two populations of garnet were identified in MGI(Macao GroupⅠ)highly fractionated granitic rocks:small grossular-poor euhedral grains and large grossular-rich skeletal garnet grains with quartz *** first group was mainly formed through precipitation from highly evolved Mn-rich slightly peraluminous melts under low-pressure and relatively low temperature(~700℃)*** of upper crust metasedimentary materials may have contributed as a source of Mn and

关键词： highly fractionated granites aplite Macao(South China) Jurassic late-stage fluid/melt interactions garnet non-CHARAC REE tetrad effect

A Comparison of Semi-Lagrangian and Lagrange-Galerkin hp-FEM Methods in Convection-Diffusion Problems

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Communications in Computational Physics 2011年第4期9卷 1020-1039页

作者： pedro Galan del Sastre Rodolfo Bermejo Departamento de Matematica Aplicada al Urbanismo a la Edificacion y al Medio AmbienteE.T.S.A.M.Universidad Politecnica de MadridAvda.Juan de Herrera 428040 MadridSpain Departamento de Matematica Aplicada E.T.S.I.I.Universidad Politecnica de MadridC/Jose Gutierrez Abascal 228006 MadridSpain

We perform a comparison in terms of accuracy and CPU time between second order BDF semi-Lagrangian and Lagrange-Galerkin schemes in combination with high order finite element *** numerical results show that for polynomials of degree 2 semi-Lagrangian schemes are faster than Lagrange-Galerkin schemes for the same number of degrees of freedom,however,for the same level of accuracy both methods are about the same in terms of CPU *** polynomials of degree larger than 2,Lagrange-Galerkin schemes behave better than semi-Lagrangian schemes in terms of both accuracy and CPU time;specially,for polynomials of degree 8 or ***,we have performed tests on the parallelization of these schemes and the speedup obtained is quasi-optimal even with more than 100 processors.

关键词： Navier-Stokes equations convection-diffusion equations semi-Lagrangian LagrangeGalerkin second order backward difference formula hp-finite element method

Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： Joana Menino pedro Camacho AndréCoelho Escola Superior de tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&tRC-Health&technology Research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama Pinto Lisbon 1150-255Portugal

AIM:to determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:this retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:this study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence

Colorectal cancer carcinogenesis:From bench to bedside

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 654-663页

作者： pedro Currais Isadora Rosa Isabel Claro Department of Gastroenterology Instituto Portugues de Oncologia de Lisboa Francisco GentilLisboa 1099-023Portugal

Colorectal cancer(CRC)remains one of the main causes of cancer death in developed ***,it is potentially preventable,by removing the precursor lesions-adenomas or serrated *** studies proved that this intervention reduces CRC mortality and that the first colonoscopy’s results can guide surveillance *** recently,it became clear that several carcinogenesis pathways may lead to sporadic *** is a heterogeneous disease,characterized by multiple molecular *** main pathways have been implicated in the development of CRC:Chromosomal instability,microsatellite instability,and the“serrated”pathways,with overlapping features between *** and other molecular and genetic based CRC classifications are known to have clinical implications,spanning from familial risk assessment to therapy *** authors review basic science data and provide insight on current implications for the management of patients with CRC.

关键词： Colorectal cancer Carcinogenesis pathways Microsatellite instability APC KRAS BRAF

Valorization of Aloe barbadensis Miller. (Aloe vera) Processing Waste

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Journal of Renewable Materials 2023年第3期11卷 1031-1061页

作者： Jeltzlin Semerel Nigel John Wim Dehaen pedro Fardim SISStEM Program Faculty of Arts and ScienceUniversity of ArubaOranjestadAruba Department of Chemistry KU LeuvenLeuvenBelgium Department of Chemical Engineering KU LeuvenLeuvenBelgium

Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo,soap,and ***,the demand for these gel-based products has led to a surplus production of Aloe vera processing *** Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per *** the Aloe vera waste is being disposed to the landfill or used as fertilizer.A sustainable management system for the Aloe vera processing waste should be considered,due to the negative societal and environmental impacts of the currents waste disposal ***,this review focuses on various approaches that can be used to valorize Aloe vera waste into value-added products,such as animal and aquaculture feeds,biosorbents,biofuel and natural *** have reported Aloe vera waste for environmental applications biosorbents used for wastewater treatment of various *** studies have also reported on the valorization of Aloe vera waste for production of biofuels such as bioethanol,mixed alcohol fuels,biogas and *** vera waste could also be valorized through isolation and synthesis of natural polymers for application in wound dressing,tissue engineering and drug delivery *** vera waste valorization was also reviewed through extraction of value-added bioactive compounds such as aloe-emodin,aloin and *** value-added bioactive compounds have various applications in the cosmetics(non-steroidal anti-inflammatory,tyrosinase inhibitors)and pharmaceutical(anticancer agent and COVID 19 inhibitors)industry.

关键词： Aloe vera waste processing biomass conversion anthraquinone aloe-emodin aloin aloeresin

Proportional-integral-derivative control of nonlinear half-car electro-hydraulic suspension systems

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浙江大学学报（英文版）A辑：应用物理与工程 2013年第6期14卷 401-416页

作者： John E. D. EKORU Jimoh O. pedro School of Mechanical Aeronautical and Industrial Engineering University of the Witwatersrand Private Bag 03 WITS 2050 Johannesburg South Africa

this paper presents the development of a proportional-integral-derivative (PID)-based control method for application to active vehicle suspension systems (AVSS). this method uses an inner PID hydraulic actuator force control loop, in combination with an outer PID suspension travel control loop, to control a nonlinear half-car AVSS. Robustness to model uncertainty in the form of variation in suspension damping is tested, comparing performance of the AVSS with a passive vehicle suspension system (PVSS), with similar model param.ters. Spectral analysis of suspension system model output data, obtained by performing a road input disturbance frequency sweep, provides frequency response plots for both nonlinear vehicle suspension systems and time domain vehicle responses to a sinusoidal road input disturbance on a smooth road. the results show the greater robustness of the AVSS over the PVSS to param.tric uncertainty in the frequency and time domains.

关键词： Force control Proportional-integral-derivative (PID) control Nonlinear half-car Active vehicle suspension system (AVSS) Hydraulic actuator dynamics Model uncertainty