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PED Flex with Shield Technology:a feasible alternative for fusiform MCA aneurysms

Stroke & Vascular Neurology 2018年第3期3卷 185-188页

作者： Guilherme J.Agnoletto pedro aguilar-salinas Roberta Santos Eric Sauvageau Ricardo A.Hanel Lyerly Neurosurgery Baptist Neurological InstituteJacksonvilleFLUSA

BACKGROUND The advent of flow diverters(FDs)has changed the scope of endovascular treatment options for intracranial aneurysms(IAs).FDs can effectively treat complex aneurysms in which both microsurgical and conventional endovascular options are less than ideal.12 The Pipeline Flex Embolization Device(PED;Medtronic,Irvine,California,USA)has been available in the USA for several years demon-strating positive *** recently,the PED Flex with enhanced delivery features has been introduced,and although decreased,thromboembolic complications are still a potential risk.3 In light of this,a new surface modification was applied to the PED Flex known as Shield Technology consisting of a phosphorylcholine layer covalently bound to its metal braids potentially reducing its thrombogenicity.4 Herein,we report our initial experience using the PED Flex with Shield Technology in the treatment of an unruptured fusiform aneurysm located in the middle cerebral artery(MCA)using dual-an-tiplatelet therapy.

关键词： Flex PED MCA treatment

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Coronary angiography findings in cardiac arrest patients with non-diagnostic post-resuscitation electrocardiogram:A comparison of shockable and non-shockable initial rhythms

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World Journal of Cardiology 2017年第8期9卷 702-709页

作者： pedro Martínez-Losas Pablo salinas Carlos Ferrera María Teresa Nogales-Romo Francisco Noriega María Del Trigo Iván Javier Núnez-Gil Luis Nombela-Franco Nieves Gonzalo Pilar Jiménez-Quevedo Javier Escaned Antonio Fernández-Ortiz Carlos Macaya Ana Viana-Tejedor Interventional Cardiology and Coronary Care Unit Cardiovascular InstituteHospital Universitario Clínico San Carlos28040 MadridSpain

AIM To investigate the impact of coronary artery disease in a cohort of patients resuscitated from cardiac arrest with non-diagnostic *** From March 2004 to February 2016, 203 consecutive patients resuscitated from in or out-of-hospital sudden cardiac arrest and non-diagnostic post-resuscitation electrocardiogram(defined as ST segment elevation or pre-sumably new left bundle branch block) whounderwent invasive coronary angiogram during hospitalization were included. For purpose of analysis and comparison, patients were classified in two groups: Initial shockable rhythm(ventricular tachycardia or ventricular fibrillation; n = 148, 72.9%) and initial non-shockable rhythm(n = 55, 27.1%). Baseline characteristics, coronary angiogram findings including Syntax Score and long-term survival rates were compared. RESULTS Sudden cardiac arrest was witnessed in 95.2% of cases, 66.7% were out-of-hospital patients and 72.4% were male. There were no significant differences in baseline characteristics between groups except for higher mean age(68.1 years vs 61 years, P = 0.001) in the nonshockable rhythm group. Overall 5-year mortality of the resuscitated patients was 37.4%. Patients with non-shockable rhythms had higher mortality(60% vs 29.1%, P < 0.001) and a worst neurological status at hospital discharge based on cerebral performance category score(CPC 1-2: 32.7% vs 53.4%, P = 0.02). Although there were no significant differences in global burden of coronary artery disease defined by Syntax Score(mean Syntax Score: 10.2 vs 10.3, P = 0.96) there was a trend towards a higher incidence of acute coronary lesions in patients with shockable rhythm(29.7% vs 16.4%, P = 0.054). There was also a higher need for ad-hoc percutaneous coronary intervention in this group(21.9% vs 9.1%, P = 0.03). CONCLUSION Initial shockable group of patients had a trend towards higher incidence of acute coronary lesions and higher need of ad-hoc percutaneous intervention vs nonshockable

关键词： Sudden cardiac arrest Electrocardiogram Invasive coronary angiography Percutaneous coronary intervention Syntax score Coronary artery disease

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Antiprotozoal Activity of a <i>Thymus vulgaris</i>Methanol Extract and Its Fractions

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Health 2017年第7期9卷 1081-1094页

作者： Jesús Norberto Garza-González Javier Vargas-Villarreal Ma Julia Verde-Star Catalina Rivas-Morales Azucena Oranday-Cárdenas Magda E. Hernandez-García Laura De La Garza-salinas Francisco González-Salazar Department of Chemistry Phytochemistry and Analytical Chemistry Lab Faculty of Biological Sciences University Autonomous of Nuevo Leon San Nicolas de los Garza Mexico Department of Basic Sciences Division of Health Sciences University of Monterrey San Pedro Garza Garcia Mexico Laboratory of Biochemistry and Cell Physiology Division of Cellular and Molecular Biology Center for Biomedical Research of the Northeast Mexican Social Security Institute Monterrey Mexico Mexican Social Security Institute Nuevo Leon Delegation Monterrey Mexico

Introduction: Thymus vulgaris is used in traditional medicine to treat gastrointestinal diseases because of its antifungal, antibacterial, and antispasmodic activity. Objective: To verify whether Thymus vulgaris also has antiprotozoal activity against Trichomonas vaginalis, Giardia lamblia and Entamoeba histolytica trophozoites. Materials and methods: Conventional cultures of parasites were measured on the third day during the logarithmic growth phase. The antiprotozoal activity of the methanol extract and its fractions were evaluated comparing growth in cultures with and without extracts. Next, the extract was fractionated by polarity-based partitioning. Then, the purity of each fraction was determined by thin layer chromatography (TLC). The percentage of growth inhibition was calculated with respect to untreated controls. The 50% inhibitory concentration (IC50) of each extract was calculated by PROBIT analysis. Results: We found that a methanol extract of the aerial parts of Thymus vulgaris, at 300 μg/mL, inhibited the in vitro growth of G. lamblia and T. vaginalis, while E. histolytica growth was poorly inhibited. The methanol extract was further separated into mixtures of ursolic, oleanolic, and betulinic acids. The IC50 values of ursolic acid against G. lamblia and T. vaginalis were 8.12 μg/mL and 5.51 μg/mL, respectively. Conclusions: The methanol extract fraction containing ursolic acid obtained from Thymus vulgaris has antiprotozoal activity against G. lamblia and T. vaginalis trophozoites.

关键词： Thymus vulgaris Trichomonas vaginalis Giardia lamblia Entamoeba histolytica Antiprotozoal Agents

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