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A Comparison of Semi-Lagrangian and Lagrange-Galerkin hp-FEM Methods in Convection-Diffusion Problems

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Communications in Computational Physics 2011年第4期9卷 1020-1039页

作者： pedro Galan del Sastre Rodolfo Bermejo Departamento de Matematica Aplicada al Urbanismo a la Edificacion y al Medio AmbienteE.T.S.A.M.Universidad Politecnica de MadridAvda.Juan de Herrera 428040 MadridSpain Departamento de Matematica Aplicada E.T.S.I.I.Universidad Politecnica de MadridC/Jose Gutierrez Abascal 228006 MadridSpain

We perform a comparison in terms of accuracy and CPU time between second order BDF semi-Lagrangian and Lagrange-Galerkin schemes in combination with high order finite element *** numerical results show that for polynomials of degree 2 semi-Lagrangian schemes are faster than Lagrange-Galerkin schemes for the same number of degrees of freedom,however,for the same level of accuracy both methods are about the same in terms of CPU *** polynomials of degree larger than 2,Lagrange-Galerkin schemes behave better than semi-Lagrangian schemes in terms of both accuracy and CPU time;specially,for polynomials of degree 8 or ***,we have performed tests on the parallelization of these schemes and the speedup obtained is quasi-optimal even with more than 100 processors.

关键词： Navier-Stokes equations convection-diffusion equations semi-Lagrangian LagrangeGalerkin second order backward difference formula hp-finite element method

Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： Joana Menino pedro Camacho AndréCoelho Escola Superior de Tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TRC-Health&Technology Research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama Pinto Lisbon 1150-255Portugal

AIM:To determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:This retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:This study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence

Unveiling Plant mTERF Functions

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Molecular Plant 2012年第2期5卷 294-296页

作者： pedro Robles Jose Luis Micol Victor Quesada Instituto de Bioingenieria Universidad Miguel Hernandez Campus de Elche 03202 Elche Spain

Chloroplasts and mitochondria genomes contain a few dozen genes required for gene expression, photosynthesis, and the electron transport chain. However, proteomic and bioinformatic studies suggest that approximately 2000 and 2600 proteins are located in plant mitochondria and chloroplasts, respectively; most of them are encoded by nuclear genes, synthesized in the cytoplasm, and targeted to organelles. Despite the simplicity of organelle genomes, their transcriptional regulation is complex and can only be partially explained by currently known transcriptional machinery components, suggesting that additional unidentified regulatory factors exist （Liere et al., 2011）.

关键词： Unveiling Plant

Colorectal cancer carcinogenesis:From bench to bedside

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 654-663页

作者： pedro Currais Isadora Rosa Isabel Claro Department of Gastroenterology Instituto Portugues de Oncologia de Lisboa Francisco GentilLisboa 1099-023Portugal

Colorectal cancer(CRC)remains one of the main causes of cancer death in developed ***,it is potentially preventable,by removing the precursor lesions-adenomas or serrated *** studies proved that this intervention reduces CRC mortality and that the first colonoscopy’s results can guide surveillance *** recently,it became clear that several carcinogenesis pathways may lead to sporadic *** is a heterogeneous disease,characterized by multiple molecular *** main pathways have been implicated in the development of CRC:Chromosomal instability,microsatellite instability,and the“serrated”pathways,with overlapping features between *** and other molecular and genetic based CRC classifications are known to have clinical implications,spanning from familial risk assessment to therapy *** authors review basic science data and provide insight on current implications for the management of patients with CRC.

关键词： Colorectal cancer Carcinogenesis pathways Microsatellite instability APC KRAS BRAF

Valorization of Aloe barbadensis Miller. (Aloe vera) Processing Waste

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Journal of Renewable Materials 2023年第3期11卷 1031-1061页

作者： Jeltzlin Semerel Nigel John Wim Dehaen pedro Fardim SISSTEM Program Faculty of Arts and ScienceUniversity of ArubaOranjestadAruba Department of Chemistry KU LeuvenLeuvenBelgium Department of Chemical Engineering KU LeuvenLeuvenBelgium

Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo,soap,and ***,the demand for these gel-based products has led to a surplus production of Aloe vera processing *** Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per *** the Aloe vera waste is being disposed to the landfill or used as fertilizer.A sustainable management system for the Aloe vera processing waste should be considered,due to the negative societal and environmental impacts of the currents waste disposal ***,this review focuses on various approaches that can be used to valorize Aloe vera waste into value-added products,such as animal and aquaculture feeds,biosorbents,biofuel and natural *** have reported Aloe vera waste for environmental applications biosorbents used for wastewater treatment of various *** studies have also reported on the valorization of Aloe vera waste for production of biofuels such as bioethanol,mixed alcohol fuels,biogas and *** vera waste could also be valorized through isolation and synthesis of natural polymers for application in wound dressing,tissue engineering and drug delivery *** vera waste valorization was also reviewed through extraction of value-added bioactive compounds such as aloe-emodin,aloin and *** value-added bioactive compounds have various applications in the cosmetics(non-steroidal anti-inflammatory,tyrosinase inhibitors)and pharmaceutical(anticancer agent and COVID 19 inhibitors)industry.

关键词： Aloe vera waste processing biomass conversion anthraquinone aloe-emodin aloin aloeresin

Urbanization drives adaptive evolution in a Neotropical bird

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Current Zoology 2023年第5期69卷 607-619页

作者： Rilquer Mascarenhas pedro Milet Meirelles Henrique Batalha-Filho National Institute of Science and Technology in Interdisciplinary and Transdisciplinary Studies in Ecology and Evolution(INCT IN-TREE) Instituto de BiologiaUniversidade Federal da Bahia40170-115 SalvadorBahiaBrazil

Urbanization has dramatic impacts on natural habitats and such changes may potentially drive local adaptation of urban *** change has been specifically shown to facilitate the fast adaptation of birds to changing environments,but few studies have investigated the genetic mechanisms of this *** investigations could provide insights into questions about both evolutionary theory and management of urban *** this study,we investigated whether local adaptation has occurred in urban populations of a Neotropical bird species,Coereba flaveola,specifically addressing whether observed behavioral adaptations are correlated to genetic signatures of natural *** answer this question,we sampled 24 individuals in urban and rural environments,and searched for selected loci through a genome-scan approach based on RADseq genomic data,generated and assembled using a reference genome for the *** recovered 46 loci as putative selection outliers,and 30 of them were identified as associated with biological processes possibly related to urban adaptation,such as the regulation of energetic metabolism,regulation of genetic expression,and changes in the immunological ***,genes involved in the development of the nervous system showed signatures of selection,suggesting a link between behavioral and genetic *** findings,in conjunction with similar results in previous studies,support the idea that cities provide a similar selective pressure on urban populations and that behavioral plasticity may be enhanced through genetic changes in urban populations.

关键词： behavioral adaptation phenotypic plasticity selection selective sweep South America

Proportional-integral-derivative control of nonlinear half-car electro-hydraulic suspension systems

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浙江大学学报（英文版）A辑：应用物理与工程 2013年第6期14卷 401-416页

作者： John E. D. EKORU Jimoh O. pedro School of Mechanical Aeronautical and Industrial Engineering University of the Witwatersrand Private Bag 03 WITS 2050 Johannesburg South Africa

This paper presents the development of a proportional-integral-derivative (PID)-based control method for application to active vehicle suspension systems (AVSS). This method uses an inner PID hydraulic actuator force control loop, in combination with an outer PID suspension travel control loop, to control a nonlinear half-car AVSS. Robustness to model uncertainty in the form of variation in suspension damping is tested, comparing performance of the AVSS with a passive vehicle suspension system (PVSS), with similar model parameters. Spectral analysis of suspension system model output data, obtained by performing a road input disturbance frequency sweep, provides frequency response plots for both nonlinear vehicle suspension systems and time domain vehicle responses to a sinusoidal road input disturbance on a smooth road. The results show the greater robustness of the AVSS over the PVSS to parametric uncertainty in the frequency and time domains.

关键词： Force control Proportional-integral-derivative (PID) control Nonlinear half-car Active vehicle suspension system (AVSS) Hydraulic actuator dynamics Model uncertainty

A Script-Based Prototyping Framework to Boost Agile-UX Developments

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Journal of Computer Science & Technology 2016年第6期31卷 1246-1261页

作者： pedro Luis Mateo Navarro Gregorio Martinez Perez Diego Sevilla Ruiz Catedra Sociedad Anonima de Electrdnica Submarina ( SAES) Laboratories University of Murcia Murcia 30100 Spain

Prototypes are described as a successful mechanism to incorporate user-experience design （UX） into Agile de- velopments, but their integration into such developments is not exempt from difficulties. Prototypes and final applications are often developed using different tools, which hinders the collaboration between designers and developers and also compli- cates reuse. Moreover, integrating stakeholders such as clients and users into the Agile process of designing, evaluating, and refining a prototype is not straightforward mainly because of its iterative nature. In an attempt to tackle these problems, this work presents the design and implementation of a new framework in which scripting languages are used to code prototyped behaviors. Prototyping is then treated as a separate aspect that coexists and runs together with final functionality. Using this framework communication is enhanced because designers and developers work in parallel on the same software artifact. Prototypes are fully reused and iteratively added with final functionality while prototyped behaviors are removed. They can be also modified on the fly to implement participatory design techniques.

关键词： prototype Agile development aspect-oriented development scripting language participatory design

Anomalous behaviour detection using one-class support vector machine and remote sensing images: a case study of algal bloom occurrence in inland waters

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International Journal of Digital Earth 2021年第7期14卷 921-942页

作者： pedro Henrique Moraes Ananias Rogério Galante Negri Graduate Program in Natural Disasters UNESP/CEMADENSão Josédos CamposSão PauloBrazil Sciences Technology Institute São Paulo State University(UNESP)São Josédos CamposSão PauloBrazil

Algal blooms are a frequent subject in scientific discussions and are the focus of many recent studies,mainly due to their adverse effect on *** the lack of ground truth data and the need to develop tools for their detection and monitoring,this research proposes a novel method to automate *** derived from multi-temporal image series processing,spectral indices and classification with Oneclass Support Vector Machine(OC-SVM)are used in this *** from multi-spectral sensors on Landsat-8 and MODIS were acquired through the Google Earth Engine API(GEE API).In order to evaluate our method,two bloom detection case studies(Lake Erie(USA)and Lake Taihu(China))were *** were made with methods based on spectral index ***,to demonstrate the performance of the OC-SVM classifier compared to other machine learning methods,the proposal was adapted to be used with a Random Forest(RF)classifier,having its results added to the *** situ measurements show that the proposed method delivers highly accurate results compared to spectral index thresholding ***,a drawback of the proposal refers to its higher computational *** application of the new method to a real-world bloom case is demonstrated.

关键词： Remote sensing spectral indices unsupervised classification anomalies algal bloom detection