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The mini player with diverse functions:extracellular vesicles in cell biology,disease,and therapeutics

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Protein & Cell 2022年第9期13卷 631-654页

作者： Abhimanyu Thakur Xiaoshan Ke Ya-Wen Chen pedram motallebnejad Kui Zhang Qizhou Lian Huanhuan Joyce Chen The Pritzker School of Molecular Engineering The University of ChicagoChicagoIllinoisUSA The Ben May Department for Cancer Research The University of ChicagoChicagoIllinoisUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineKeck School of MedicineHastings Center for Pulmonary ResearchUniversity of Southern CaliforniaLos AngelesCA 90089USA Department of Stem Cell Biology and Regenerative Biology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089USA Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong Prenatal Diagnostic Center and Cord Blood Bank Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina HKUMed Laboratory of Cellular Therapeutics the University of Hong KongPok Fu LamHong Kong

Extracellular vesicles(EVs)are tiny biological nanovesicles ranging from approximately 30–1000 nm in diameter that are released into the extracellular matrix of most cell types and in *** classification of EVs includes exosomes,microvesicles,and apoptotic bodies,dependent on various factors such as size,markers,and biogenesis *** transition of EV relevance from that of being assumed as a trash bag to be a key player in critical physiological and pathological conditions has been revolutionary in many *** have been recently revealed to play a crucial role in stem cell biology and cancer progression via intercellular communication,contributing to organ development and the progression of *** review focuses on the significant research progress made so far in the role of the crosstalk between EVs and stem cells and their niche,and cellular communication among different germ layers in developmental *** addition,it discusses the role of EVs in cancer progression and their application as therapeutic agents or drug delivery *** such discoveries have been facilitated by tremendous technological advancements in EV-associated research,especially the microfluidics *** pros and cons in the context of characterization of EVs are also extensively discussed in this *** review also deliberates the role of EVs in normal cell processes and disease conditions,and their application as a diagnostic and therapeutic ***,we propose future perspectives for EV-related research in stem cell and cancer biology.

关键词： extracellular vesicles exosomes stem cells cancer exosomal communication exosomal therapeutics

Identification of time-varying system and energy-based optimization of adaptive control in seismically excited structure

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 227-240页

作者： Elham Aghabarari Fereidoun Amini pedram Ghaderi Department of Civil Engineering Iran University of Science and TechnologyTehran 16844Iran

The combination of structural health monitoring and vibration control is of great importance to provide components of smart *** synthetic algorithms have been proposed,adaptive control that is compatible with changing conditions still needs to be used,and time-varying systems are required to be simultaneously estimated with the application of adaptive *** this research,the identification of structural time-varying dynamic characteristics and optimized simple adaptive control are ***,reduced variations of physical parameters are estimated online using the multiple forgetting factor recursive least squares(MFRLS)***,the energy from the structural vibration is simultaneously specified to optimize the control force with the identified parameters to be *** is also performed based on the probability density function of the energy under the seismic excitation at any ***,the optimal control force is obtained by the simple adaptive control(SAC)algorithm and energy coefficient.A numerical example and benchmark structure are employed to investigate the efficiency of the proposed *** simulation results revealed the effectiveness of the integrated online identification and optimal adaptive control in systems.

关键词： integrated online identification time-varying systems structural energy multiple forgetting factor recursive least squares optimal simple adaptive control algorithm

Exploring the Association between Oral Microbiome and Mild Cognitive Impairment: A Narrative Review

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Advances in Alzheimer's Disease 2024年第2期13卷 27-34页

作者： Arghavan Tonkaboni Maryam Sayyari pedram Khodadadzadeh Sotude Khorshidi Shaghayegh Golalipour Leyli Haghighi Department of Oral Medicine School of Dentistry Tehran University of Medical Sciences Tehran Iran Grupo de Investigacion en Patologia Oral Medico Quirurgica Universidade de Santiago de Compostela Santiago de Compostela Spain Faculty of Dentistry Tehran University of Medical Sciences Tehran Iran Faculty of Dentistry Tehran Islamic Azad University Tehran Iran Department of Prosthodontics (Dental Branch) Islamic Azad University Tehran Iran Department of Pediatrics School of Dentistry Islamic Azad University of Medical Sciences Tehran Iran

Objective: Some studies have investigated the association between oral microbiome and mild cognitive impairment (MCI). However, there needs to be more narrative reviews synthesizing this evidence. This study aimed to bridge this gap in the current knowledge. Methods: A comprehensive search was conducted on PubMed (MEDLINE) to identify studies examining the association between the oral microbiome and MCI. Search parameters and inclusion criteria were clearly defined, encompassing terms related to the oral microbiome, MCI, and their association. Two authors independently selected relevant studies and performed data extraction. Result: Four studies were included. Two cohort studies and two case-control reported an association between the oral microbiome and MCI. Conclusion: Based on the evidence synthesized from the included studies, the review suggests an association between MCI and the oral microbiome. Specifically, all included studies identified significant differences in the abundance of specific microbial species between individuals with MCI and those with normal cognitive function, underscoring the potential role of these species in neuroinflammatory diseases.

关键词： Microbiota Neurocognitive Disorders Neuroinflammations Alzheimer’s Disease Cognitive Dysfunction Neuroinflammatory Disorder

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木质素衍生腐植酸制备与应用最新进展

腐植酸 2024年第2期 9-23页

作者： Shrikanta Sutradhar pedram Fatehi 袁晓娜(译) 加拿大湖首大学生物精炼研究所桑德贝P7B5E1 中国腐植酸工业协会北京100120

腐殖质(HS)来源于自然腐烂的生物质。HS的主要产物是腐植酸、黄腐酸和腐黑物。HS是从自然资源(如煤、褐煤、森林和河流沉积物)中提取的。然而,从这些资源生产HS并不环保,可能会对生态系统造成影响。早期的理论认为HS可以通过酶促或有氧... 详细信息

腐殖质(HS)来源于自然腐烂的生物质。HS的主要产物是腐植酸、黄腐酸和腐黑物。HS是从自然资源(如煤、褐煤、森林和河流沉积物)中提取的。然而,从这些资源生产HS并不环保,可能会对生态系统造成影响。早期的理论认为HS可以通过酶促或有氧氧化从木质素转化而来;另一方面,木质素是纸浆和纸张生产过程的副产物,可通过商业获得,然而它仍未得到充分的利用。为了解决环境友好型HS生产和适应木质素增值化进程的挑战,木质素衍生HS的生产引起了人们的关注。目前木质素转化为类HS物质的化学改性途径有碱性有氧氧化、碱性氧化消化、氧化氨解等。本文全面论述了木质素转化为HS的基本要素。综述了天然HS和木质素衍生HS在土壤富集、肥料、废水处理、水净化、医药等领域的应用。此外,还介绍了目前木质素生产和利用HS所面临的挑战。

关键词：腐植酸木质素肥料腐殖化氧化

In-situ polymerization of lignocelluloses of autohydrolysis process with acrylamide

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生物质资源与工程(英文) 2023年第3期8卷 235-245页

作者： Haosong Zhao Weijue Gao pedram Fatehi Biorefining Research Institute and Chemical Engineering Department Lakehead UniversityThunder Bay P7B 5E1Canada

In the present study,the hydrolysates generated via autohydrolysis of spruce wood chips were di-rectly used as feedstock for producing *** in-situ polymerization of acrylamide(AM)and lignocellulose(LC)of hydrolysates was successfully *** reaction was optimized to generate lignocellulose-acrylamide(LC-AM)with the highest molecular weight(41,060 g/mol)and charge density(-0.25 meq/g)under the optimum conditions,which were 3 h,60◦C,4%(w)initiator based on the dried mass of hydrolysate,and an AM/LC molar ratio of 5.63.A nuclear magnetic resonance(NMR)spectroscopy confirmed the grafting of acrylamide on *** prop-erties of LC-AM were characterized by the elemental analyzer,zeta potential analyzer,gel per-meation chromatography(GPC),and particle charge detector(PCD).The LC-AM was applied as a coagulant for removing ethyl violet dye from a simulated dye *** results indicated that 47.2%dye was removed from the solution at a low dosage of 0.2 g/*** dual flocculation of LC-AM with other polymers for dye removal is suggested to further improve its effectiveness.

关键词： Polymerization Hydrolysate Lignocellulose Acrylamide Biorefining

The application of ResU-net and OBIA for landslide detection from multi-temporal Sentinel-2 images

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Big Earth Data 2023年第4期7卷 961-985页

作者： Omid Ghorbanzadeh Khalil Gholamnia pedram Ghamisi alnstitute of Advanced Research in Artificial Intelligence(IARAl) ViennaAustria Department of Remote Sensing and GIS University of TabrizTabrizIran Machine Learning Group Helmholtz-Zentrum Dresden-RossendorfHelmholtz Institute Freiberg for Resource TechnologyFreibergGermany

Landslide detection is a hot topic in the remote sensing community,particularly with the current rapid growth in volume(and variety)of Earth observation data and the substantial progress of computer *** learning algorithms,especially fully convolutional networks(FCNs),and variations like the ResU-Net have been used recently as rapid and automatic landslide detection *** FCNs have shown cutting-edge results in automatic landslide detection,accuracy can be improved by adding prior knowledge through possible *** study evaluates a rulebased object-based image analysis(OBIA)approach built on probabilities resulting from the ResU-Net model for landslide *** train the ResU-Net model using a landslide dataset comprising landslide inventories from various geographic regions,including our study area and test the testing area not used for *** the OBIA stage,we frst calculate land cover and image difference indices for pre-and post-landslide multi-temporal ***,we use the generated indices and the resulting ResU-Net probabilities for image segmentation;the extracted landslide object candidates are then optimized using rule-based *** the result validation section,the landslide detection of the proposed integration of the ResU-Net with a rule-based classification of OBIA is compared with that of the ResU-Net *** proposed approach improves the mean intersection-over-union of the resulting map from the ResU-Net by more than 22%.

关键词： Deep learning(DL) Eastern Iburi Japan European Space Agency(ESA) Fully Convolutional Networks(FCNs) object-based image analysis(OBIA) rapid landslide mapping ResUnet Sentinel-2

A systematic review of occupational exposure to respirable coal mine dust(RCMD)in the *** industry

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International Journal of Coal Science & Technology 2023年第2期10卷 32-44页

作者： Younes Shekarian Elham Rahimi Mohammad Rezaee pedram Roghanchi John and Willie Leone Family Department of Energy and Mineral Engineering Earth and Mineral Sciences(EMS)Energy InstituteThe Pennsylvania State UniversityUniversity ParkUSA Department of Mineral Engineering New Mexico Institute of Mining and TechnologySocorroNMUSA

Cumulative inhalation of respirable coal mine dust(RCMD)can lead to severe lung diseases,including coal worker's pneu-moconiosis(CWP),silicosis,mixed dust pneumoconiosis,dust-related diffuse fibrosis(DDF),and progressive massive fibrosis(PMF).Statistics from the number of reported cases showed a significant decrease in the progression of respiratory diseases in the ***,an unexpected increase in the number of CWP cases was reported in the late *** date,there has been no comprehensive systematic review to assess all contributing factors to the resurgence of CWP *** study aims to investigate the effects of various mining parameters on the prevalence of CWP in coal mines.A systematic review using the preferred reporting items for systematic reviews and meta-analysis(PRISMA)method was conducted to investigate the health effects of RCMD exposure and identify the factors that may contribute to the recent resurgence of CWP *** systematic review yielded a total of 401 papers,which were added to the *** total number of 148 and 208 papers were excluded from the database in the process of screening and eligibility,***,18 papers were considered for data selection and full-text *** review revealed that factors including geographic location,mine size,mining operation type,coal-seam thickness,coal rank,changes in mining practices,technology advancement,and engi-neering dust control practices are contributing to the recent resurgence of CWP among coal ***,the evidence for root causes is limited owing to the methodological constraints of the studies;therefore,further detailed studies are needed.

关键词： Respirable coal mine dust Systematic review Coal worker's pneumoconiosis Respiratory diseases Exposure limit Occupational exposure

Unpaired remote sensing image super-resolution with content-preserving weak supervision neural network

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Science China(Information Sciences) 2023年第1期66卷 324-325页

作者： Jie WU Runmin CONG Leyuan FANG Chunle GUO Bob ZHANG pedram GHAMISI College of Electrical and Information Engineering Hunan University Institute of Information Science Beijing Jiaotong University College of Computer Science Nankai University Department of Computer and Information Science University of Macau Helmholtz-Zentrum Dresden-Rossendorf Helmholtz Institute Freiberg for Resource Technology Institute of Advanced Research in Artificial Intelligence (IARAI)

Dear editor,Image super-resolution(SR) uses image processing methods to increase the resolution of the image without increasing any hardware cost. Remote sensing images with high spatial resolution contain rich imagery information, which can be utilized for object detection, building segmentation, building extraction, change detection, and so on.

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The type of lipid supplement has crucial implications for forage particle size in calf starter diets

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2525-2538页

作者： pedram Panahiha Hamidreza Mirzaei‑Alamouti Mehdi Kazemi‑Bonchenari Mehdi Poorhamdollah Mina Vazirigohar Jorg R.Aschenbach Department of Animal Science University of ZanjanZanjan 45371‑38791Iran. Department of Animal Science Faculty of Agriculture and Natural ResourcesArak UniversityArak 38156‑8‑8349Iran. Department of Animal Science College of Agriculture and Natural ResourcesUniversity of TehranKaraj 31587‑11167Iran. Zist Dam Group University of Zanjan Incubator CenterZanjan 45371‑38791Iran. Institute of Veterinary Physiology Freie Universitat BerlinOertzenweg 19B14163 BerlinGermany.

Background Forage inclusion in starters of young dairy calves has become an acceptable strategy in the last *** compensate for the lower energy provided by forage,concurrent lipid supplementation can be ***-ever,ruminal microbial activity and forage digestibility may be decreased by lipid *** hypothesized that the composite effect of forage and lipid supplements may be dependent on forage particle size and the type of lipid ***,we evaluated the effect of long(LP;geometric mean,4.97 mm)*** alfalfa hay particle sizes(SP;geometric mean,1.26 mm)with either soybean oil(SBO)or palm fatty acids(PLF)as lipid source in a 2×2 factorial design with treatments SP-SBO,SP-PLF,LP-SBO,and ***(n=13 with 6 males and 7 females each)were offered to Holstein calves(3 days old)with equal amounts of lipid(25 g/kg DM)through-out the experimental *** milk offering scheme(d 1 to 53)was equal for all *** collection continued until 20 d *** Interaction between forage particle size and lipid supplement was significant for the following readouts:the highest and lowest starter intakes during the pre-weaning period occurred in LP-PLF and LP-SBO,*** was associated with similarly contrasting changes in average daily gain(ADG)during the post-weaning period,body weight at the end of experiment,withers height,digestibility of organic matter and neutral detergent fiber,and blood serum concentrations of glucose,beta-hydroxybutyrate,and insulin during the pre-weaning ***-ing both pre-and post-weaning periods,the highest and lowest urinary excretion of allantoin and total purine deriva-tives,representing microbial protein synthesis,were observed in LP-PLF and LP-SBO,respectively,indicating that those diets were most and least favorable for rumen *** of forage particle size,supplemental SBO *** increased serum malondialdehyde as an oxidative stress indicator across p

关键词： Forage particle size Lipid supplement Oxidative stress Ruminal functional development