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中华医学杂志 1933年第5期19卷 811-812页

作者： Arch. ped., 1932, 49. 614

Strong氏谓:入学前即六月以上六岁以下之婴儿,除有一定变态反应趋向(allergic tendencies)者外,皆应施行白喉自动免疫

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Simulation of the oxidative metabolization pattern of netupitant,an NK1 receptor antagonist,by electrochemistry coupled to mass spectrometry

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Journal of Pharmaceutical Analysis 2021年第5期11卷 661-666页

作者： Ruxandra Chira Jens Fangmeyer Ioan o.Neaga Valentin Zaharia Uwe Karst Ede Bodoki Radu oprean Analytical Chemistry Department “Iuliu Hat¸ieganu”University of Medicine and Pharmacy400349Cluj-NapocaRomania University of Münster Institute of Inorganic and Analytical Chemistry48149MünsterGermany organic Chemistry Department “Iuliu Hat¸ieganu”University of Medicine and Pharmacy400012Cluj-NapocaRomania

Considering the frequent use of netupitant in polytherapy,the elucidation of its oxidative metabolization pattern is of major ***,there is a lack of published research on the redox behavior of this novel neurokinin-1 receptor ***,this study was performed to simulate the intensive hepatic biotransformation of netupitant using an electrochemically driven *** of the known enzyme-mediated reactions occurring in the liver(i.e.,N-dealkylation,hydroxylation,and Noxidation)were successfully mimicked by the electrolytic cell using a boron-doped diamond working *** products were separated by reversed-phase high-performance liquid chromatography and identified by high-resolution mass *** from its ability to pinpoint formerly unknown metabolites that could be responsible for the known side effects of netupitant or connected with any new perspective concerning future therapeutic indications,this electrochemical process also represents a facile alternative for the synthesis of oxidation products for further in vitro and in vivo studies.

关键词： Netupitant oxidative metabolism Neurokinin-1 antagonist EC/LC/MS

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Ecology of Upland Rice Plants and Seeds Subjected to Growth Regulator

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American Journal of Plant Sciences 2018年第1期9卷 60-73页

作者： Felipe Koch Manoela Andrade Monteiro Joao Roberto Pimentel Cristian Troyjack Itala Thaisa Padilha Dubal Eduardo Goncalves Borges Vinícius Jardel Szareski Gustavo Henrique Demari Lanes Beatriz Acosta Jaques Ivan Ricardo Carvalho Francisco Amaral Villela Tiago pedó Tiago Zanatta Aumonde Federal University of Pelotas Capao do LeaoBrazil

The objective of this work is to verify the influence of the plant regulator trinexapac-ethyl on plant growth and physiological quality of upland rice seeds. We used an upland rice genotype, and the growth regulator was the trinexapac-ethyl. The experiment was completely randomized in a 4 × 8 factorial design related to four concentrations of the plant regulator trinexapac-ethyl [0 (without growth regulator), 0.25, 0.50, and 0.75 L c.p. ha-1] and 7 plant collection times [14, 28, 42, 56, 70, 84, 98 days after emergence (DAE)], with four replicates. To determine growth attributes, we evaluated total dry matter, dry matter production rate, relative growth rate, leaf area ratio, leaf matter, leaf area index, solar energy conversion efficiency and partition of assimilates. The physiological quality of the seeds was evaluated based on germination, first germination count, field emergence, emergence speed index and seedling dry matter. Plant growth was affected by the growth regulator. Total dry matter, dry matter production rate and solar energy conversion efficiency decreased, while leaf area index, leaf area ratio and leaf matter increased due to the effects of the growth regulator. The dry matter partition of plants changed in plants subjected to the growth regulator, with a delay in the targeting of assimilates to reproductive organs and a greater allocation to roots at the end of the cycle in plants subjected to the doses 0.50 and 0.75 L·ha-1 of growth regulator. Seed vigor was adversely affected by the growth regulator.

关键词： oryza sativa L. Trinexapac-Ethyl Leaf Area Dry Matter Seed Vigor

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滑坡地段隧道变形整治中抗滑桩的设计方法

山地学报 2003年第5期21卷 620-623页

作者：陶志平周德培西南交通大学土木工程学院西南交通大学土木工程学院四川成都610031

针对滑坡地段隧道变形整治中抗滑桩的设计问题,提出了典型的抗滑桩类型及各类抗滑桩的适用条件,指出了确定抗滑桩合理位置的方法,讨论了抗滑桩设计中应注意的问题,并对具体的设计过程进行了举例说明。

关键词：隧道变形抗滑桩设计方法

中、美高等学校体育竞赛组织与管理的比较研究

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山东体育学院学报 1997年第2期13卷 70-75页

作者：王永盛姜明青岛大学体育教学部副教授266071 山东体育学院田径教研室副教授济南250063

列举并分析了中、美两国高等学校体育竞赛的现状与特点,从两国国家、省(州)、市的不同层次的高校校际体育竞赛的组织和管理机构,到竞赛体制以及对运动员的学籍管理等方面进行了比较、分析研究,为我国高校体育竞赛制度的改革和完善提供... 详细信息

列举并分析了中、美两国高等学校体育竞赛的现状与特点,从两国国家、省(州)、市的不同层次的高校校际体育竞赛的组织和管理机构,到竞赛体制以及对运动员的学籍管理等方面进行了比较、分析研究,为我国高校体育竞赛制度的改革和完善提供借鉴。

关键词：中国美国高等学校体育协会体育竞赛组织机构

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Nitrogen Fertilization on Maize Sowing:Plant Growth and Seed Vigor

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American Journal of Plant Sciences 2018年第1期9卷 83-97页

作者： Cristian Troyjack Joao Roberto Pimentel Itala Thaísa Dubal Padilha Ruddy Alvaro Veliz Escalera Lanes Beatriz Acosta Jaques Felipe Koch Manoela Andrade Monteiro Gustavo Henrique Demari Vinicius Jardel Szareski Ivan Ricardo Carvalho Luis osmar Braga Schuch Tiago Zanatta Aumonde Tiago pedó Federal University of Pelotas Capao do LeaoBrazil

The management of fertilization in maize plants is a preponderant factor in the search for higher yields and obtaining quality seeds. In this sense, the study of nitrogen (N) management is predominant in improving the efficiency of its application. The objective of this study was to evaluate the growth, partition assimilation and vigor expression of maize seeds submitted at different doses of nitrogen applied at sowing. The treatments were constituted by different doses of nitrogen fertilization at sowing, being: 25%, 50%, 75% and 100% of the recommended dose for the crop, according to the recommendation of nitrogen fertilization. The plants were collected at regular intervals of 21 days after sowing until the end of the growth cycle. For the analysis of growth and partition of dry matter between the organs, the accumulation of dry matter and leaf area was measured. The experimental design was randomized blocks in a 4 × 7 factorial scheme (four N rates at sowing and seven collection times with three replications). The maize plants under the influence of nitrogen fertilization at sowing presented differential growth and distinct responses in the assimilated partition between their structures, with the intensity dependent on the dose used. Plants grown using 75% of the recommended dose of N at sowing had a higher relative growth rate, with more pronounced effects compared to the other doses. The expression of maize seed vigor increases to an increase of 82.5% N at sowing.

关键词： Emergence Speed Net Assimilation Rates Relative Growth Rates Zea mays L. Vigor

<i>oryza</i>Wild Species: An Alternative for Rice Breeding under Abiotic Stress Conditions

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American Journal of Plant Sciences 2018年第6期9卷 1093-1104页

作者： Viní cius Jardel Szareski Ivan Ricardo Carvalho Tiago Corazza da Rosa Simone Morgan Dellagostin Alan Junior de Pelegrin Mauricio Horbach Barbosa osmarino Pires dos Santos Dionei Schmidt Muraro Velci Queir&oacute z de Souza Tiago ped.oacute Tiago Zanatta Aumonde Camila Pegoraro Federal University of Pelotas Pelotas Brazil Federal University of Santa Maria Santa Maria Brazil Federal University of Pampa Bag&eacute Brazil

Rice (oryza sativa L.) presents a strategic role in social and economic levels. The aim of this study was to elucidate the presence of genetic variability for the genus oryza, and the possibility of using genotypes with wild characteristics in rice breeding programs. The oryza genus shows great genetic variability through wild genotypes available in the most varied environments around the world. The negative effects imposed by abiotic stresses such as flood, salinity, low temperatures, water deficiency and high temperatures may be minimized by the efficient identification of a genetic variability source from the oryza genus. Among the main wild species presented by the oryza genus, oryza glumaepatula stands out being an active source of germplasm. The occurrence and preservation of genetic variability of oryza genus is indispensable to obtain new rice genotypes, to guarantee food security for the human population, as well as to develop genotypes that adapt to climatic changes and natural adversities.

关键词： oryza sativa Beeding Germplasm Source Genetic Variability

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先天性膈疝的临床特点及外科治疗经验

新生儿科杂志 2002年第6期17卷 250-251页

作者：王淑芹王平刘宝富北京大学第一医院小儿外科 100034

为提高新生儿先天性膈疝(CDH)的早期诊断、治疗及预后水平,对28例先天性膈疝病例进行临床特征、手术过程回顾性分析。全部进行正位及侧位胸部X-线检查,5例做上消化道造影,13例做血气分析。X-线证实胸腔内有含水的肠管,腹腔没有气体,部... 详细信息

为提高新生儿先天性膈疝(CDH)的早期诊断、治疗及预后水平,对28例先天性膈疝病例进行临床特征、手术过程回顾性分析。全部进行正位及侧位胸部X-线检查,5例做上消化道造影,13例做血气分析。X-线证实胸腔内有含水的肠管,腹腔没有气体,部分患儿有胃食管返流(GER)、存在吸入性肺炎或脑发育不全;血气分析显示部分婴儿严重的缺氧、呼吸性酸中毒;消化道造影显示结肠或小肠在胸腔内。结果:2例新生儿放弃治疗,26例患儿手术治疗,3例死亡,23例病人恢复良好。结论:对患有先天性膈疝的新生儿必须早期诊断和手术治疗。

关键词：先天性膈疝外科手术治疗临床经验预后临床特点

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轨道臌曲

中国铁道科学 1982年第1期 125-137页

作者： C.o.Frederick,玉瑞芝美国铁路总局技术中心研展部土木工程研究所副所长

本文评论热天无缝线路稳定性理论推导的发展及论述在锁定轨温以上时,计算钢轨最大安全升温值的最新方法。最近在实际线路上做的试验已用来检验此理论。描述了一种类似行车情况的机械装置,它能导致扩大线路方向偏差及最后发生臌曲。也描... 详细信息

本文评论热天无缝线路稳定性理论推导的发展及论述在锁定轨温以上时,计算钢轨最大安全升温值的最新方法。最近在实际线路上做的试验已用来检验此理论。描述了一种类似行车情况的机械装置,它能导致扩大线路方向偏差及最后发生臌曲。也描述了钢轨辗长及爬行等因素对钢轨纵向力的影响。

关键词：道床阻力纵向力锁定轨温钢轨轨枕

Gene transcription profiting of astheno-and normo-zoospermic sperm subpopulations

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Asian Journal of Andrology 2020年第6期22卷 608-615页

作者： ped.o Caballero-Campo Saul Lira-Albarran David Barrera Elizabeth Borja-Cacho Hector S Godoy-Morales Claudia Rangel-Escareno Fernando Larrea Mayel Chirinos Department of Reproduction Biology National Institute of Medical Sciences and Nutrition Salvador ZubiranMexico City 14080Mexico Tambre Foundation Madrid 28002Spain Reproductive Medicine Unit Angeles del Ped regal HospitalMexico City 10700Mexico Computational Genomic and Integrative Biology Laboratory National Institute of Genomic MedicineMexico City 14610Mexico

Spermatozoa contain a repertoire of RNAs considered to be potential functional fertility *** this study,the gene expression of human sperm subpopulations with high(F1)and low(F2)motility from healthy normozoospermic(N)and asthenozoospermic(A)individuals was evaluated using RNA microarray followed by functional genomic analysis of differentially expressed *** from A-F1 versus N-F1,A-F2 versus N-F2,N-F1 versus N-F2,and A-F1 versus A-F2 comparisons showed a considerably larger set of downregulated genes in tests versus *** ontology(Go)analysis of A-F1 versus N-F1 identified 507 overrepresented biological processes(BPs),several of which are associated with sperm *** addition,gene set enrichment analysis of the same contrast showed 110 BPs,36 cellular comp on ents,and 31 molecular functions,several of which are involved in sperm motility.A leadi ng・edge analysis of selected Go terms resulted in several down regulated genes encoding to dyn eins and kin esins,both related to sperm ***,the predicted activation state of asthenozoospermia was increased,while fertility,cell movement of sperm,and gametogenesis were ***,several downregulated genes characteristic of the canonical pathway protein ubiquitination were involved in asthenozoospermia ***,Go analysis of A-F2 versus N-F2 did not identify overrepresented BPs,although the gene set enrichment analysis detected six enriched BPs,one cellular component,and two molecular ***,the results show differences in gene transcription between sperm subpopulations from asthenozoospermic and normozoospermic semen samples and allowed the identification of gene sets relevant to sperm physiology and reproduction.

关键词： asthenozoospermia male in fertility microarray sperm transcriptome