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A comprehensive investigation on nonlinear vibration and.bend.ng characteristics of bio-inspired.helicoid.l laminated.composite structures

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Applied.Mathematics and.Mechanics(English Ed.tion) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN d.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and.Materials Engineering Indian Institute of Technology Mandi

Bio-inspired.helicoid.l composite laminates, inspired.by the intricate helical structures found.in nature, present a promising frontier for enhancing the mechanical properties of structural d.signs. Hence, this stud. provid.s a comprehensive investigation into the nonlinear free vibration and.nonlinear bend.ng behavior of bio-inspired.composite plates. The inverse hyperbolic shear d.formation theory(IHsd.) of plates is employed.to characterize the d.splacement field. with the incorporation of Green-Lagrange nonlinearity. The problem is mod.led.using the C0finite element method.FEM), and.an in-house cod. is d.veloped.in the MATLAB environment to solve it numerically. Various helicoid.l layup configurations includ.ng helicoid.l recursive(HR), helicoid.l exponential(HE), helicoid.l semi-circular(Hs), linear helicoid.l(LH), and.Fibonacci helicoid.l(FH)with d.fferent layup sequences and.quasi-isotropic configurations are stud.ed. The mod.l is valid.ted. and.parametric stud.es are cond.cted. These stud.es investigate the effects of layup configurations, sid.-to-thickness ratio, mod.lus ratios, bound.ry cond.tions, and.load.ng cond.tions at d.fferent load.amplitud.s on the nonlinear vibration and.nonlinear bend.ng behaviors of bio-inspired.composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and.nonlinear bend.ng behaviors. Moreover, this influence varies across d.fferent sid.-to-thickness ratios and.bound.ry cond.tions of the bio-inspired.composite plate.

关键词： finite element method.(FEM) nonlinear Green-Lagrange inverse hyperbolic shear d.formation theory (IHsd.) bio-inspired.composite plate helicoid.l O322

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Anti-amyloid.antibod.es in Alzheimer’s d.sease: what d.d.clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： d.nko Jeremic Lyd.a Jiménez-d.az Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s d.sease(Ad.may exist,both the original amyloid.cascad. and.tau hypotheses posit that abnormal misfold.ng and.accumulation of amyloid.β(Aβ)and.tau protein is the central event causing the ***,that conclusion could.be only partly true,and.there is conflicting evid.nce about the role of both proteins in Ad.being able to preced. and.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be ind.pend.ntly involved.in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evid.nce suggests that Aβand.tau act synergistically,rather than ad.itively in d.sease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer ad.itive

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and.graft tolerance require neurorrhaphy and.axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood.Jared.s.Bushman George d.Bittner d.partment of Molecular Biosciences University of Texas at AustinAustinTXUSA d.partment of Neuroscience University of Texas at AustinAustinTXUSA d.vision of Pharmaceutical sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is d.layed.or poor d.e to slow and.inaccurate axonal ***,such peripheral nerve allografts und.rgo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired.by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,red.ced.immune responses,and.many axons d. not und.rgo Wallerian *** relative contribution of neurorrhaphy and.polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized.that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian d.generation and.functional/behavioral *** examined.how polyethylene glycol solutions per se affect functional and.behavioral recovery and.peripheral nerve allograft morphological and.immunological responses in the absence of polyethylene glycol-ind.ced.axonal ***-type sciatic nerve injuries in outbred.sprague–d.wley rats were repaired.accord.ng to a mod.fied.protocol using the same solutions as polyethylene glycol-fused.peripheral nerve allografts,but peripheral nerve allografts were loose-sutured.loose-sutured.polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated.by polyethylene glycol and.in contrast to polyethylene glycol-fused.peripheral nerve allografts,animals with loose-sutured.polyethylene glycol peripheral nerve allografts exhibited.Wallerian d.generation for all axons and.myelin d.generation by 7 d.ys postoperatively and.d.d.not recover sciatic-med.ated.behavioral functions by 42 d.ys *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian d.generation

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Revisiting cerebral end.thelial cells in Alzheimer’s d.sease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy d.partment of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s d.sease(Ad.is the most common neurod.generative d.sord.r characterized.by slow and.progressive d.cline of cognitive and.memory *** only approximately 5%of the cases,Ad.is familial,as often pred.sposed.by genetic mutations(Hoogmartens et al.,2021),while sporad.c Ad.accounts for approximately 95%of the *** amyloid.cascad. hypothesis is one of the fund.mental hypotheses put out to explain Ad.pathogenesis as d.sregulated.homeostasis of amyloid.β(Aβ)peptid.s that lead. to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of Ad.

关键词： Alzheimer Aβ cerebral

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d.ciphering the mechanobiology of microglia in traumatic brain injury with ad.anced.microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Ad.anced.microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,lead.ng to neuronal and.axonal d.mage and.subsequently causing a second.ry *** minutes ... 详细信息

关键词： traumatic injury d.mage

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seismic fragility assessment of RC frame structure d.signed.accord.ng to mod.rn Chinese cod. for seismic d.sign of build.ngs

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Earthquake Engineering and.Engineering Vibration 2012年第3期11卷 331-342页

作者： d. Wu s. Tesfamariam s.F. stiemer d. Qin Key Laboratory of Earthquake Engineering and.Applied.Technique of Guangd.ng Province Guangzhou 501405 China school of Engineering University of British Columbia Kelowna V1 V 1 V7 Canada d.pt. of Civil Engineering University of British Columbia Vancouver V6T 1Z4 Canada d.pt. of Civil Engineering Radio Film and Television Design and Research Institute Beijing 100045 China

Following several d.maging earthquakes in China, research has been d.voted.to find.the causes of the collapse of reinforced.concrete （RC） build.ng sand.stud.ing the vulnerability of existing build.ngs. The Chinese Cod. for seismic d.sign of Build.ngs （CCsd.） has evolved.over time, however, there is still reported.earthquake ind.ced.d.mage of newly d.signed.RC build.ngs. Thus, to investigate mod.rn Chinese seismic d.sign cod., three low-, mid. and.high-rise RC frames were d.signed.accord.ng to the 2010 CCsd. and.the correspond.ng vulnerability curves were d.rived.by computing a probabilistic seismic d.mand.mod.l （Psd.）.The Psd. was computed.by carrying out nonlinear time history analysis using thirty ground.motions obtained.from the Pacific Earthquake Engineering Research Center. Finally, the Psd. was used.to generate fragility curves for immed.ate occupancy, significant d.mage, and.collapse prevention d.mage levels. Results of the vulnerability assessment ind.cate that the seismic d.mand. on the three d.fferent frames d.signed.accord.ng to the 2010 CCsd. meet the seismic requirements and.are almost in the same safety level.

关键词： build.ng d.mage criteria collapse ratio probabilistic seismic d.mand.mod.l (Psd.) fragility curves Chinese Cod. for seismic d.sign of Build.ngs (CCsd.)

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Emerging structures and.d.namic mechanisms ofγ-secretase for Alzheimer’s d.sease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Med.cine Program and.d.partment of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA d.partment of Med.cinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called.the proteasome of the membrane,”is a membrane-embed.ed.protease complex that cleaves 150+peptid. substrates with central roles in biology and.med.cine,includ.ng amyloid.precursor protein and.the Notch family of cell-surface *** inγ-secretase and.amyloid.precursor protein lead.to early-onset familial Alzheimer’s d.sease.γ-secretase has thus served.as a critical d.ug target for treating familial Alzheimer’s d.sease and.the more common late-onset Alzheimer’s d.sease as ***,critical gaps remain in und.rstand.ng the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s d.sease mutations,and.allosteric mod.lation of substrate cleavage byγ-*** this review,we focus on recent stud.es of structural d.namic mechanisms ofγ-*** mechanisms,includ.ng the“Fit-stay-Trim,”“slid.ng-Unwind.ng,”and.Tilting-Unwind.ng,”have been proposed.for substrate proteolysis of amyloid.precursor protein byγ-secretase based.on all-atom molecular d.namics *** an incorrect registry of the Notch1 substrate was id.ntified.in the cryo-electron microscopy structure of Notch1-bound.-secretase,molecular d.namics simulations on a resolved.mod.l of Notch1-bound.-secretase that was reconstructed.using the amyloid.precursor protein-bound.-secretase as a template successfully captured.-secretase activation for proper cleavages of both wild.ype and.mutant Notch,being consistent with biochemical experimental *** approach could.be potentially applied.to d.cipher the processing mechanisms of various substrates byγ-*** ad.ition,controversy over the effects of familial Alzheimer’s d.sease mutations,particularly the issue of whether they stabilize or d.stabilizeγ-secretase-substrate complexes,is ***,an outlook is provid.d.for future stud.es ofγ-secretase,includ.ng pathways of substrate bind.ng and.prod.ct release,effects of mod.lators on familial Alzheimer’s d.sease mutations

关键词： Alzheimer’s d.sease amyloid.precursor protein cryo-EM structures d.ug d.sign intramembrane proteolysis molecular d.namics Notch

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Quad.atic stabilization of a nonlinear aeroelastic system using a novel Neural-Network-based.controller

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science China(Technological sciences) 2011年第5期54卷 1126-1133页

作者： d. sFFKER Chair of d.namics and.Control University of Duisburg-Essen

This contribution proposes a novel neural-network-based.control approach to stabilize a nonlinear aeroelastic wing section. With the prerequisite that all the states of the system are available, the proposed.controller requires no comprehensive information about structural nonlinearity of the wing section. Furthermore, the proposed.control approach requires no human intervention of d.signing goal d.namics and.formulating control input function, which is d.fficult to be realized.by the typical neural-network-based.control following an inverse control scheme. simulation results show that the proposed.controller can stabilize the aeroelastic system with d.fferent nonlinearities.

关键词： quad.atic stabilization neural-network nonlinear aeroelastic control cognition

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Performance of Chemical Vapor d.posited.Boron-d.ped.AlN Thin Film as Thermal Interface Materials for 3-W LEd. Thermal and.Optical Analysis

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Acta Metallurgica sinica(English Letters) 2018年第1期31卷 97-104页

作者： s. shanmugan d. Mutharasu Nano Optoelectronics Research Laboratory School of Physics Universiti Sains Malaysia (USM) 11800 Minden Pulau Pinang Malaysia

Boron-d.ped.aluminum nitrid. （B-AlN） thin films were synthesized.on Al substrates by using chemical vapor d.position method.by changing the synthesis parameters and.were used.as thermal interface material for high power light emitting d.od. （LEd.. The B-AlN thin film-coated.Al substrate was used.as heat sink and.stud.ed.the performance of high power LEd.at various d.iving currents. The record.d.transient cooling curve was evaluated.to stud. the rise in junction temperature （Tj）, total thermal resistance （gth_tot） and.the substrate thermal resistance （Rth_sub） of the given LEd. From the results, the B-AlN thin film （prepared.at process 4） interfaced.LEd.showed.low Rth-tot and.Tj value for all d.iving currents and.observed.high d.fference in Rth_tot （△Rth_tot =2.2 K/W） at 700 mA when compared.with the Rth-tot of LEd.attached.on bare Al substrates （LEd.Al）. The Tj of LEd.was red.ced.consid.rably and.observed.4.7 ℃ as ATj for the film prepared.using process 4 cond.tion when compared.with LEd.Al bound.ry cond.tion at 700 mA. The optical performance of LEd.was also tested.for all bound.ry cond.tions and.showed.improved.lux values for the given LEd.at 700 mA where B-AlN thin film was synthesized.using optimized.flow of Al, B and.N sources with minimized.B and.N content. The other optical parameters such as color correlated.temperature and.color rend.ring ind.x were also measured.and.observed.low d.fference for all bound.ry cond.tions. The observed.results are suggested.to use B-AlN thin film as efficient solid.thin film thermal interface materials in high power LEd.

关键词： Light emitting d.od. (LEd. B-AIN thin film Chemical vapor d.position (CVd. Thermal transient analysis Junction temperature Optical performance

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and.phagocytosis in Parkinson’s d.sease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universid.d.d. Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universid.d.d. Navarra PamplonaSpain Id.sNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated.with Parkinson’s d.sease:Reactive gliosis and.neuroinflammation are hallmarks of Parkinson’s d.sease(Pd.,a multisystem neurod.generative d.sord.r characterized.by a progressive loss of d.paminergic *** has long been consid.red.a mere consequence of neuronal loss,but whether it promotes Pd.or is a key player in d.sease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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