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高糖高脂诱发骨髓间充质干细胞损伤及铁死亡通路信号异常

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中国临床药理学杂志 2024年第17期40卷 2508-2512页

作者：阿布都拉·米热合买提祖丽胡马·热合曼李包娟叶雨萌张䶮之新疆医科大学药学院新疆维吾尔自治区乌鲁木齐830011 新疆天然药物活性组分与释药技术重点实验室新疆维吾尔自治区乌鲁木齐830011

目的探讨高糖高脂环境诱导骨髓间充质干细胞(BMSCs)损伤及其与铁死亡的相关性。方法将BMSCs分为正常组(5.50 mmol·L^(-1)葡萄糖)和高糖高脂组(25.00 mmol·L^(-1)葡萄糖+0.25 mmol·L^(-1)棕榈酸)。用β-半乳糖苷酶染色评估细胞衰老情... 详细信息

目的探讨高糖高脂环境诱导骨髓间充质干细胞(BMSCs)损伤及其与铁死亡的相关性。方法将BMSCs分为正常组(5.50 mmol·L^(-1)葡萄糖)和高糖高脂组(25.00 mmol·L^(-1)葡萄糖+0.25 mmol·L^(-1)棕榈酸)。用β-半乳糖苷酶染色评估细胞衰老情况;用酶联免疫吸附试验(ELISA)法检测肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL^(-1)0)水平;用试剂盒检测谷胱甘肽(GSH)、丙二醛(MDA)、亚铁离子(Fe2+);用蛋白质印迹法检测酰基辅酶A合成酶长链家族成员4(ACSL4)、花生四烯酸15脂氧合酶(ALOX15)、谷胱甘肽过氧化物酶4(GPX4)的蛋白表达水平。结果正常组、高糖高脂组的细胞衰老比率分别为(6.80±1.60)%和(13.00±1.58)%,TNF-α含量分别为(122.54±3.94)和(169.77±2.89)pg·mL^(-1),IL^(-1)0含量分别为(155.16±3.97)和(105.15±7.30)pg·mL^(-1),GSH含量分别为4.30±0.33和1.55±0.14,MDA含量分别为2.94±0.10和5.84±0.10,Fe2+含量分别为6.22±0.35和16.13±0.36,ACSL4蛋白相对表达水平分别为0.42±0.05和0.84±0.10,ALOX15蛋白相对表达水平分别为0.61±0.25和1.06±0.11,GPX4蛋白相对表达水平分别为1.13±0.17和0.33±0.08。高糖高脂组的上述指标与正常组比较,在统计学上差异均有统计学意义(均P<0.01)。结论高糖高脂诱导BM⁃SCs的损伤,在这一过程中铁死亡扮演了重要角色。

关键词：高糖高脂骨髓间充质干细胞铁死亡

PA-MOFs及其衍生物用于环境修复研究进展

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应用化工 2024年第5期53卷 1191-1194页

作者：李伏坤周佳雯曾热倩重庆工商大学环境与资源学院、催化与环境新材料重庆市重点实验室重庆400067

探讨了PA-MOFs及其衍生的光催化剂在光催化水裂解制氢、光催化CO_(2)还原、光降解新兴危险污染物这三个方面的优点,综述了PA-MOFs及其衍生的光催化剂在这三方面的研究进展情况。讨论目前用于多种光催化应用的PA-MOFs和MOF衍生光催化剂... 详细信息

探讨了PA-MOFs及其衍生的光催化剂在光催化水裂解制氢、光催化CO_(2)还原、光降解新兴危险污染物这三个方面的优点,综述了PA-MOFs及其衍生的光催化剂在这三方面的研究进展情况。讨论目前用于多种光催化应用的PA-MOFs和MOF衍生光催化剂的生产工作。基于PA-MOFs和MOFs衍生物的研究现状,对其目前面临的挑战以及未来发展方向进行了简要的展望。

关键词：金属-有机框架材料催化微环境研究进展

A taxonomic revision of Musa aurantiaca (Musaceae) in Southeast Asia

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植物分类学报 2008年第1期46卷 89-92页

作者： Markku HKKINEN Henry Vre Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Menglun Mengla Yunnan 666303 China Botanic Garden University of Helsinki P.O. Box 44 (Jyrngntie 2) FI-00014 Finland Finnish Museum of Natural History Botanical Museum University of Helsinki P.O. Box 7 (Unioninkatu 44) FI-00014 Finland)

Since the initial description, the name Musa aurantiaca Baker (1893) has been unclear to most botanists. The aim of this study is to settle its true identity and to update the description. The plant is distributed in the regions of Upper Assam and Arunachal Pradesh, India, Northern Myanmar and Tibet, China where it occurs commonly but it is not mentioned in Chinese literature at all. In this paper, the authors also review the description and the literature history of M. aurantiaca from 1893 to the present. Musa aurantiaca Baker is typified here.

关键词：香蕉科东南亚分类学野生香蕉芭蕉

内蒙古自治区中西部Lg波衰减及场地响应特征研究

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地震 2024年第1期44卷 109-117页

作者：贾昕晔白少奇贾彦杰刘芳娜热内蒙古自治区锡林浩特地震监测中心站内蒙古锡林浩特027000 内蒙古自治区地震局内蒙古呼和浩特010010

基于Lg波谱比与台站场地响应联合反演的方法,选取2016-2020年内蒙古自治区及邻区地震台网记录到的ML≥2.8地震事件78次,开展内蒙古自治区中西部地震波衰减和场地响应分析研究。结果显示,三分向衰减参数分别为Q_(UD)(f)=372·f^(0.54),Q_... 详细信息

基于Lg波谱比与台站场地响应联合反演的方法,选取2016-2020年内蒙古自治区及邻区地震台网记录到的ML≥2.8地震事件78次,开展内蒙古自治区中西部地震波衰减和场地响应分析研究。结果显示,三分向衰减参数分别为Q_(UD)(f)=372·f^(0.54),Q_(EW)(f)=287·f^(0.59),Q_(NS)(f)=382·f^(0.43)。分析34个台站场地响应可得,EKH、 BYT、 HYS台站在1~7 Hz频段内有明显放大效应,BHS、 XLT、 RLT台站在1~3 Hz频段有明显放大效应,可能与台站所处复杂的地质构造有关。

关键词：内蒙古自治区中西部 Lg波衰减参数场地响应

外源钙添加对有机物料改良滨海盐碱土固碳潜力的影响

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林业科学 2024年第2期60卷 32-41页

作者：史文竹孙禧邵旭升热由索姆王艮梅张焕朝项剑南京林业大学南方现代林业协同创新中心、南京林业大学林学院南京210037

【目的】研究外源钙添加对有机物料改良滨海盐碱土过程中土壤CO_(2)排放和土壤碳库的影响,以期为滨海盐碱土的改良利用与固碳潜力提升提供理论依据。【方法】采用室内培养试验,在施用玉米秸秆生物炭+鸡粪(BM)以及水稻秸秆+鸡粪(SM)的基... 详细信息

【目的】研究外源钙添加对有机物料改良滨海盐碱土过程中土壤CO_(2)排放和土壤碳库的影响,以期为滨海盐碱土的改良利用与固碳潜力提升提供理论依据。【方法】采用室内培养试验,在施用玉米秸秆生物炭+鸡粪(BM)以及水稻秸秆+鸡粪(SM)的基础上,以氢氧化钙和硅酸钙作为钙源,按照等钙量原则,分别设置了6种处理:不施用硅酸钙和氢氧化钙(CK)、施用12.4 g·kg^(-1)硅酸钙(Ca1)、施用24.8 g·kg^(-1)硅酸钙(Ca2)、施用7.9 g·kg^(-1)氢氧化钙(Ca3)、施用15.8 g·kg^(-1)氢氧化钙(Ca4)以及施用12.4 g·kg^(-1)硅酸钙+7.9 g·kg^(-1)氢氧化钙(Ca5),进行1个月的培养试验。【结果】培养期间外源钙的添加能显著降低CO_(2)累积排放;有机物料的施用会导致土壤有机碳(SOC)的损失,外源钙的添加不会显著影响SOC矿化但会导致土壤无机碳(SIC)含量显著增加,从而弥补SOC的损失,增加土壤的总碳量,实现土壤固碳的目的,适当增加氢氧化钙的添加量对固碳量有促进作用;外源钙添加导致的减排作用主要是通过增加吸收矿化产生的CO_(2),并转化为碳酸钙的形式而固定。【结论】在改良盐碱土的过程中,有机物料配施硅酸钙和氢氧化钙的改良措施能实现土壤固碳减排。

关键词：滨海盐碱土二氧化碳土壤固碳土壤无机碳

A Mode-Switching Motion Control System for reactive Interaction and Surface Following Using Industrial Robots

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IEEE/CAA Journal of Automatica Sinica 2018年第3期5卷 670-682页

作者： Danial Nakhaeinia Pierre Payeur Robert Laganière School of Electrical Engineering and Computer Science University of Ottawa

This work proposes a sensor-based control system for fully automated object detection and exploration(surface following) with a redundant industrial robot. The control system utilizes both offline and online trajectory planning for reactive interaction with objects of different shapes and color using RGBD vision and proximity/contact sensors feedback where no prior knowledge of the objects is available. The RGB-D sensor is used to collect raw 3D information of the environment. The data is then processed to segment an object of interest in the scene. In order to completely explore the object, a coverage path planning technique is proposed using a dynamic 3D occupancy grid method to generate a primary(offline) trajectory. However, RGB-D sensors are very sensitive to lighting and provide only limited accuracy on the depth measurements. Therefore, the coverage path planning is then further assisted by a real-time adaptive path planning using a fuzzy self-tuning proportional integral derivative(PID)controller. The latter allows the robot to dynamically update the 3D model by a specially designed instrumented compliant wrist and adapt to the surfaces it approaches or touches. A modeswitching scheme is also proposed to efficiently integrate and smoothly switch between the interaction modes under certain conditions. Experimental results using a CRS-F3 manipulator equipped with a custom-built compliant wrist demonstrate the feasibility and performance of the proposed method.

关键词： Adaptive control fuzzy-PID controller manipulator control motion planning surface following

THreE DIMENSIONAL DYNAMIC ELASTICPLASTIC ANALYSIS OF THE INTERACTION OF A SET OF PERCUSSION BITS WITH ROCK MASSES

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Acta Mechanica Solida Sinica 1995年第4期8卷 364-374页

作者： Song, SC Knasmillner, re INNER MANGOLIA reS INST MET POB 4BAOTOU 014034PEOPLES R CHINA VIENNA TECH UNIV INST MECHA-1040 VIENNAAUSTRIA

A three dimensional dynamic elastic-plastic finite element analysis of the interaction of percussion bits with rock masses is presented. The dynamic contact problem was investigated with the numerical method developed for high velocity impact calculations[1]. The numerical analysis was carried out for three simultaneously loaded percussion bits arranged on a straight line on the rock surface, the loading time was kept constant throughout this work. The numerical calculation for various strengths of the dynamic load tm the percussion bits shows that a critical minimum dynamic load exists for the generation of plastic deformations in the rock. For this critical value of the load the maximum normal stress of the longitudinal wave in the percussion bit exceeds the yield stress of the rock mass.

关键词： rock masses percussion bits numerical analysis

Effect of brazing parameters on fillet size and microstructure of cladded fin-microchannel tube joints

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Transactions of Nonferrous Metals Society of China 2020年第12期30卷 3240-3253页

作者： J.C.GUÍA-TELLO M.I.pech-CANUL E.TRUJILLO-VÁZQUEZ M.A.pech-CANUL centro de investigación en materiales avanzados(cimav) laboratorio nacional de nanotecnologíamiguel de cervantes no.120chihuahuachi8.31136méxico centro de investigación y de estudios avanzados del instituto politécnico nacional-unidad saltillo av.industria metalúrgica no.1062parque industrial saltillo-ramos arizperamos arizpecoahuila25900méxico conacyt-facultad de ciencias físico matemáticas benemérita universidad autónoma de pueblaav.san claudiocd universitariajardines de san manuelpueblapuebla72570méxico cinvestav-mérida km 6 ant.carr.a progresoap 73 cordemexméridayu3.97310méxico

This work concerns the optimization of furnace brazing conditions for joining micro-multiport aluminum tubes and fins made with AA4343/AA3003/AA4343 brazing sheet in mini-assemblies mimicking the core of an automotive heat *** method was used for design of experiment,considering five process parameters with two levels of *** aim was to maximize the fillet size of the brazed joints,which has an important influence on the thermal integrity and mechanical *** length measurements of brazed joints were performed with a metallographic *** statistical analysis allowed to obtain the optimum values of process parameters(peak temperature,residence time,heating rate,microchannel tube type and flux).At a 95%confidence level,the variability of fillet length is most significantly affected by the peak brazing temperature(77%),residence time(15%)and heating rate(7%).The predicted maximum fillet length was(152±11)μm,which was corroborated by confirmation *** microstructural analysis of tube−fin joints showed that variations in peak temperature and residence time affect only the size of the eutectic zone of fillet formed,but not the nature or composition of the constituent phases.

关键词： brazing cladded fin Taguchi method fillet size microstructure aluminum peak temperature optimization

A new look on wetting models:continuum analysis

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Science China(Physics,Mechanics & Astronomy) 2012年第11期55卷 2158-2166页

作者： LIU JianLin XIA re ZHOU XiaoHua School of Pipeline and Civil Engineering China University of PetroleumQingdao 266555China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China Department of Mathematics and Physics Fourth Military Medical UniversityXi’an 710032China

In this study,we considered the wetting phenomenon on a general substrate from a new viewpoint of continuum *** analyses first show how the Wenzel and the Cassie models deviate the practical results in some special substrates,and then elucidate the mechanism of the triple contact line(TCL) *** upon variational theory of the total free functional dealing with the movable boundary condition,we show that the macroscopic contact angle(MCA) expression is the corresponding transversality *** manifests that the MCA depends only on the chemical and geometric property at the TCL,and is not affected by the gravity of the droplet and the contact area beneath the *** continuum model also shows the exploration of the pinning effect on a sharp wedge or the interface between two different *** investigation will help designing super-hydrophobic materials for novel micro-fluidic devices.

关键词： continuum field energy functional transversality condition mechanism-based model triple line moving