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肺栓塞为伴有心力衰竭的成年死亡患者死因之一

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 10-11页

作者： Be.math A. Skaf e. Ste.n P.D. 罗亮 St.Jose.h Me.cy Oakland Hospital PontiacMIUnited States Dr.

尽管心力衰竭(HF)为肺栓塞(pe)的一个已知危险因素,但是对伴有HF的死亡患者中因pe死亡的发生率却知之甚少。本调查以美国人口调查局列出的死亡证明资料为基础。

关键词：肺栓塞死亡证明人口调查死亡原因

肺栓塞的诊断:妇科肿瘤学中螺旋CT肺动脉造影术的应用经验

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 42-43页

作者： Martino M.A. Williamson e. Sie.frie. S. 刘亦恒 De.artme.t of Obste.rics and Gyne.ology University of South Florida Harbourside Medical Towers 4 Columbia Drive Tampa FL 33606 United States

Obje.tive.. To re.ie. our e.perie.ce.with the.diagnosis and prognosis of pulmonary e.bolism (pe) in gyne.ologic oncology patie.ts. Me.hods. Spiral CT pulmonary angiography (CTPA) studie. on gyne.ologic oncology patie.ts we.e.colle.te. from our radiology database.from 6/2001 to 6/2003. Patie.t charts we.e.re.rospective.y re.ie.e.. Data we.e.abstracte. re.ative.to pre.e.ting symptoms, de.ographics and laboratory and diagnostic e.aluations. Patie.t data we.e.compare. using chi-square.continge.cy table. and logistic re.re.sion analysis. Survival was studie. using the.Kaplan-Me.e. me.hod and the.log rank te.t. The.e.fe.t of pe on survival was adjuste. using a proportional hazards re.re.sion mode.. Re.ults. One.hundre. and e.e.e. CTPA studie. we.e.performe. ove. 2 ye.rs and 25 patie.ts we.e.diagnose. with *** pe (n = 25) and non-pe (n = 86) groups we.e.similar for age. race. BMI and cance. diagnosis. Tachycardia (P = 0.02, OR = 3.03 95% CI 1.16-7.94 ) and le.kocytosis (P = 0.04, OR = 2.93 95% CI 1.05-8.18 ) we.e.more.fre.ue.t among pe patie.ts and confirme. as inde.0}nde.tly prognostic of *** othe. clinical and laboratory findings we.e.similar be.we.n patie.ts with and without pe. Ove.all survival for patie.ts with and without pe was 63% ve.sus 94% , re.pective.y, at 2 ye.rs (P = 0.02). Conclusion. In a gyne.ologic oncology patie.t with high clinical suspicion for pe, our clinical pre.te.t probability was 23.0% . Two-ye.r mortality rate. we.e.6-fold highe. for patie.ts diagnose. with pe. The.significant ove.lap in clinical pre.e.tations, multiple.risk factors and highe. mortality rate. e.courage.the.aggre.sive.diagnosis and tre.tme.t of pe among this population. Furthe. work is ne.de. to re.uce.the.incide.ce.and mortality rate.of pe.

关键词：妇科肿瘤学动脉造影术肺栓塞妇科肿瘤患者癌症诊断存活者列联表诊断评价模型校正年死亡率

Manage.e.t of periprosthe.ic infe.tions

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World Journal of Clinical Infe.tious Dise.se. 2017年第2期7卷 11-20页

作者： Félix Vilche.-Cavazos Gre.orio Villarre.l-Villarre.l Victor pe?a-Martine. Carlos Acosta-Olivo Orthopedics and Trauma-tology Hospital Universitario "Dr.José E.Gonzalez"

periprosthe.ic joint infe.tion(PJI) is conside.e. one.of the.most challe.ging complications compromising patie.t he.lth and is conside.e. an e.onomic *** all strate.ie. PJI pre.ale.ce.is be.we.n 1%-2%. Conside.able.e.forts have.be.n inve.tigate. in the.past de.ade.to diminish or e.radicate.PJI pre.ale.ce. This article.manage. the.de.inition of PJI and the.ne. major and minor crite.ia from Parvizi e. al The. a scie.tific analysis of e.e.y minor and major crite.ia. Multidisciplinary manage.e.t is re.comme.de. according to guide.ine.. A nume.ous of surgical options e.ist e.ch and e.e.yone.with its indications,contraindications and specific antibiotic the.apy re.ime.. Surgical options are.(1) irrigation and cle.ning with re.e.tion of the.prosthe.is with a succe.s rate.0%-89%;(2) single.stage.re.ision surge.y with a succe. rate.of > 80%; and(3) two-stage.re.ision surge.y(authors pre.e.re. me.hod) with a succe. rate.of 87%. Radical tre.tme.t options like.arthrode.is and amputation are.re.e.ve. for specific group of patie.ts,with a succe. rate.varying from 60%-100%. The.future.of PJI is focuse. on improving the.diagnostic tools and to combat biofilm. The.corne.stone.of manage.e.t consists in a rapid diagnosis and specific the.apy. This article.pre.e.ts the.most curre.t diagnostic and tre.tme.t crite.ia as we.l as the.diffe.e.t surgical tre.tme.t options de.0}nding on the.type of infe.tion,bacte.ial virule.ce.and patie.t comorbiditie..

关键词： periprosthe.ic joint infe.tion Arthroplasty Arthroce.te.is Infe.tion Diagnosis Staphylococcus aure.s

Pse.domonas e.otoxin antise.se.RNA se.e.tive.y kills he.atitis B virus infe.te. ce.ls

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World Journal of Gastroe.te.ology 2008年第18期14卷 2810-2817页

作者： pe.e. Hafke.e.e. Ulrich Brinkmann e.izabe.h Brinkmann Ira Pastan Hube.t e.Blum Thomas F Baume.t De.artme.t of Me.icine.Ⅱ University Hospital Freiburg Hugstetterstrasse 55 Freiburg D-79106 Germany Roche.Diagnostics Nonnenwald 2 Penzberg D-82377 Germany National Cance. Institute National Institutes of Health Bethesda United States Inse.m unit 748 Université Louis Pasteur 3 Rue Koeberle Strasbourg F-67000 France

AIM: To pre.e.t an approach for se.e.tive.y killing re.rovirus-infe.te. ce.ls that combine. the.toxicity of Pse.domonas e.otoxin (pe) and the.pre.e.ce.of re.e.se.transcriptase.(RT) in infe.te. ce.ls. Me.HODS: pe antise.se.toxin RNA has palindromic ste. loops at its 5' and 3' e.ds e.abling se.f-prime. ge.e.ation of cDNA in the.pre.e.ce.of RT. The.RT activity e.pre.se. in re.rovirus-infe.te. ce.ls conve.ts "antise.se.toxin-RNA" into a le.hal toxin ge.e.e.clusive.y in the.e.ce.ls. Re.ULTS: Using cotransfe.tion studie. with pe.e.pre.sing RNAs and β-gal e.pre.sing re.orte. plasmids, we.show that, in He.G2 and He.G2.2.15 he.atoma ce.ls as we.l as in duck he.atitis B virus (DHBV) infe.te. ce.ls, HBV or DHBV-polyme.ase.re.e.se.transcribe.a le.hal cDNA copy of an antise.se.toxin RNA, which is compose. of se.ue.ce. comple.e.tary to a pe ge.e.and e.karyotic transcription and translation signals. CONCLUSION: This finding may have.important implications as a nove. the.apeutic strate.y aime. at the.e.imination of HBV infe.tion.

关键词： Ge.e.the.apy Pse.domonas e.otoxin Re.rovirus Re.e.se.transcription

Physical activity and nutrition attitude. in obe.e.Hispanic childre. with non-alcoholic ste.tohe.atitis

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World Journal of Gastroe.te.ology 2011年第39期17卷 4396-4403页

作者： Lana N Hattar The.e.a A Wilson Le.ne. A Tabotabo e.O'Brian Smith Ste.hanie.H Abrams Division of pediatric Gastroe.te.ology Hepatologyand NutritionBaylor College of Medicine Ste.hanie.H Abrams Department of PediatricsBaylor College of Medicine

AIM:To asse.s nutrition,physical activity and he.lth-ful knowle.ge.in obe.e.childre. with biopsy-prove. nonalcoholic ste.tohe.atitis(NASH or NA)compare. to childre. without live. ***:Childre. with biopsy-prove. NASH comprise. the.NASH ***,se. and e.hnicity matche. control groups consiste. of obe.e.OB)and le.n(CO) childre. with no live. *** we.e.adminis-te.e. the.School Physical Activity and Nutrition Surve. and one.blood draw was ***:Fifty-se.e. patie.ts we.e.e.rolle. with a me.n age.of 12.1±2.1 ye.rs,and all we.e.*** though the.OB and NA had a similar incre.se. body mass inde.(%),35%of the.NA group always re.d nutrition labe.s compare. to none.in the.OB(Pe.NA childre. fe.t the.r die. is"le.s he.lthy".NA consume. the.le.st amount of fruits with only 25%having≥1 fruit/d vs 45%in OB and 64.7% in CO(Pe.ts performe. light e.e.cise.vs 35%and 59%of OB and CO groups,re.pective.y(P=0.02).The.me.n physical activity score.was lowe.t in the.NA group(Pe.subje.ts with NASH,we.found that 100% of patie.ts with grade.2 or 3 fibrosis had a se.e.tary score.2 compare. to only 63.6%of those.with grade.1 or no fibrosis(Pe. with NASH had incre.se. se.e.tary be.avior,de.re.se. activity,and fruit *** studie. may de.e.mine.the.be.e.it of changing the.e.be.aviors as tre.tme.t for NASH.

关键词： Non-alcoholic ste.tohe.atitis Hispanic pe-diatric Nutrition Physical activity School physical activity Nutrition surve.

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肿瘤免疫毒素疗法的现状与展望

国外医学（肿瘤学分册） 1992年第3期19卷 156-158页

作者： Wawrzynczak e.J 张志强

近年来,免疫毒素的研究方兴未艾,其主要原因为常规治疗方法的失败,单克隆抗体的免疫治疗效果也令人失望。据报道,免疫毒素可以对抗大部分人类常见的肿瘤,在体外培养、动物实验及临床研究中显示出有效的选择性肿瘤细胞毒作用。一、毒素... 详细信息

近年来,免疫毒素的研究方兴未艾,其主要原因为常规治疗方法的失败,单克隆抗体的免疫治疗效果也令人失望。据报道,免疫毒素可以对抗大部分人类常见的肿瘤,在体外培养、动物实验及临床研究中显示出有效的选择性肿瘤细胞毒作用。一、毒素的结构与作用毒素蛋白具有抑制靶细胞蛋白合成的功能,较常见的有白喉毒素(DTX)、假单胞菌外毒素(pe)和蓖麻毒素。

关键词：肿瘤治疗学免疫疗法

陶瓷球头和金属球头配伍聚乙烯臼杯的20年长期对比磨损研究

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中华关节外科杂志（电子版） 2010年第3期4卷 63-65页

作者： Martin Ihle.Sabine.Mai We.ne. e. Sie.e.t 张卓（译）陈文（校） Orthooe.ic Hosoital Kasse.. Wilhe.mshoe.e. Alle. 345 D-34131 Kassel Germany 北京大学人民医院关节病诊疗研究中心 100044

背景关节承载面是假体磨损过程中的重要假体相关因素。目前已知聚乙烯磨损是全髋关节置换术后髋臼和股骨假体组件无菌性松动的主要原因。方法本项前瞻性研究中,共随机挑选了80例同时期患者共93个髋关节接受了非骨水泥髋关节置换术,使用... 详细信息

背景关节承载面是假体磨损过程中的重要假体相关因素。目前已知聚乙烯磨损是全髋关节置换术后髋臼和股骨假体组件无菌性松动的主要原因。方法本项前瞻性研究中,共随机挑选了80例同时期患者共93个髋关节接受了非骨水泥髋关节置换术,使用钛涂层的RM臼杯和CLS股骨柄。80例髋关节使用陶瓷球头,13例使用钴铬钼合金球头,所有股骨头直径均为32 mm。所有患者平均年龄为52岁,研究平均随访时间为19.3年。所有患者均获得随访。结果随访时使用e.RA系统对髋臼假体组件的磨损、倾斜和前倾角进行影像学评估。其中55例髋关节进行了磨损率的确认。翻修病例的平均磨损率为0.191 mm年/,而未翻修病例的平均磨损率为0.105 mm年/(P=0.041)。钴铬钼合金组平均磨损率为0.190 mm年/,陶瓷组平均磨损率为0.107 mm年/(P=0.025)。钴铬钼合金组的翻修率(13例中6例)明显高于陶瓷组(80例中11例)。股骨球头磨损率与其材料(P=0.025)、股骨柄周围骨溶解(P=0.003)、臼杯骨溶解(P=0.011)、臼杯翻修(P=0.041)以及臼杯倾斜(P=0.012)呈正性相关。结论本长期研究表明,在20年的时间里,陶瓷股骨头与钴铬钼合金股骨头相比造成的线性磨损更少,从而显著减少骨溶解的发生以及任一假体部件的翻修。

关键词：聚乙烯磨损全髋关节置换术后臼杯球头陶瓷钴铬钼合金股骨假体配伍

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慢性紧张型头痛患者的灰质萎缩

世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 31-32页

作者： Schmidt-Wilcke.T. Le.nisch e. Straube.A. A. May 陈海 De.artme.t of Syste.s Ne.roscie.ce Universitts-Krankenhaus Eppendorf (UKE) Martinistr. 52 D-20246 Hamburg Germany

Using MRI and voxe.-base. morphome.ry, the.authors inve.tigate. 20 patie.ts with chronic te.sion type he.dache.(CTTH) and 20 patie.ts with me.ication-ove.us e.he.dache.and compare. the. to 40 controls with no he.dache.history. Only patie.nts with CTTH de.onstrate. a significant gray matte. de.re.se.in re.ions known t o be.involve. in pain proce.sing. The.finding implie. that the.alte.ations are.s pecific to CTTH rathe. than a re.ponse.to chronic he.d pain or chronification pe r se.

关键词：慢性紧张型头痛头痛患者慢性头痛形态分析法慢性化

Le.e.遗传性视神经病变患者氧化应激诱导的细胞凋亡反应

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 4-5页

作者： Battisti C. Formichi P. Cardaioli e. A. Fe.e.ico 张磊 De.t. of Ne.rol. and Be.av. Scie.ce. Policlinico Le Scotte V. le Bracci 2 53100 Siena Italy Prof.

Obje.tive.: Le.e.’s he.e.itary optic ne.ropathy (LHON)is a mate.nally inhe. ite. dise.se.in which acute.or subacute.bilate.al visual loss occurs pre.e.e.tia lly in young me.. Ove. 95%of LHON case. are.associate. with one.of thre. mitoch ondrial DNA (mtDNA) point mutations, but only 50%of me. and 10%of wome. who ha rbour a pathoge.e.ic mtDNA mutation de.e.op optic ne.ropathy. This incomple.e.pe ne.rance.and pre.e.e.ce.for me. sugge.ts that additional ge.e.ic (nucle.r or mit ochondrial) and/or e.vironme.tal factors must modulate.phe.otype.e.pre.sion in L HON. A role.for re.ctive.oxyge. specie. (ROS) in mitochondrial dise.se., se.onda ry to mtDNA mutations, or as a re.ult of the.dire.t e.fe.t of ROS cytotoxicity, has be.n implicate. in many mitochondrial disorde.s, including LHON. The.purpo se.of this study was toinve.tigate.the.role.of oxidative.stre.sinduce. apoptosis in LHON. Me.hods: The.2-de.xyDribose.induce. apoptotic re.ponse.of periphe.ral blood lymphocyte. from six patie.ts with LHON and six he.lthy subje.ts was i nve.tigate. using light microscopy, flow cytome.ry, agarose.ge. e.e.trophore.is, and the.me.sure.e.t of mitochondrial me.brane.pote.tial. Re.ults: Ce.ls of pati e.ts with LHON had a highe. rate.of apoptosis than those.of controls and the.e.w as e.ide.ce.of mitochondrial involve.e.t in the.activation of the.apoptotic casc ade. Conclusions: The.e.diffe.e.ce. in oxidative.stre.s induce. apoptosis are.in line.with the.hypothe.is that re.ox home.stasis could play a role.in the.e.pre. sion of ge.e.ic mutations in diffe.e.t individuals and could re.re.e.t a pote.ti al targe. in the.de.e.opme.t of ne. the.apeutic strate.ie..

关键词：遗传性视神经病 Le.e. 凋亡反应氧化应激视神经病变线粒体膜电位因子影响活性氧遗传性疾病外显率