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Objectively-measured compliance to atropine penalization treatment in children with amblyopia: a pilot study

眼科学报：英文版 2016年第3期31卷 146-152页

作者： Jingyun Wang Lyne Racette paxton ott Dana L.Donaldson Daniel E.Neely David A.Plager Pennsylvania College of Optometry Salus University Glick Eye Institute Indiana University School of Medicine

Background:To date,compliance to atropine penalization in amblyopic children has only been assessed through *** goal of this pilot study is to measure compliance to atropine penalization ***:Seven amblyopic children(3-8 years;20/40-20/125 in the amblyopic eye) were *** had been treated with atropine *** were prescribed either a twice per week or daily atropine regimen by their *** was defined as the percentage of days in which the atropine eye drop was taken compared to the number of doses *** used medication event monitoring system(MEMS) caps to objectively measure *** MEMS caps are designed to electronically record the time and date when the bottle is *** parents of the children were provided a calendar log to subjectively report *** were scheduled for return visits at 4 and 12 *** compliance was ***:At 4 weeks,objective compliance averaged 88%(range,57-100%),while subjective compliance was 98%(range,90-100%).The actual dose in grams and visual acuity(VA) response relationship(r=0.79,P=0.03) was significantly better than the relationship between regimen and response(r=0.41,P>0.05),or the relationship between actual dose in drops and response(r=0.52,P>0.05).Conclusions:Objective compliance to atropine penalization instructions can be monitored with MEMS,which may facilitate our understanding of the dose-response *** compliance with atropine penalization decreases over time and varies with *** average,subjective parental reporting of compliance is overestimated.

关键词： Atropine penalization amblyopia treatment compliance

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