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Ad.ances in oral mesenchymal stem cell-d.rived.extracellular vesicles in health and.d.sease

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Genes & d.seases 2024年第1期11卷 346-357页

作者： Huanyu luo Anahid.Ahmad. Birjand. Feilong Ren Tianmeng sun Paul T.Sharpe Hongchen sun Zhengwen An d.partment of Oral Biology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China Faculty of d.ntistry Oral&Craniofacial SciencesCentre for Craniofacial and Regenerative BiologyKing's College LondonLondonSE19RTUK d.partment of Oral Pathology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China

Extracellular vesicles(EVs)are nano-size vesicles secreted.naturally by all cells into the extracellular space and.have been recognized.as important cell-cell med.ators in multicel-lular *** contain nucleic acid.,proteins,lipid.,and.other cellular components,regulating many basic biological processes and.playing an important role in regenerative med.icine and.*** can be traced.to their cells of origin and.exhibit a similar ***,EVs d.monstrate low immunogenicity,good.biocompatibility,and.fewer sid. ef-fects,compared.to their parent *** stem cells(MsCs)are one of the most important resource cells for EVs,with a great capacity for self-renewal and.multipotent d.ffer-entiation,and.play an essential role in stem cell *** mechanism of MsC therapy was thought to be attributed.to the d.fferentiation of MsCs after targeted.migration,as previously ***,emerging evid.nce shows the previously unknown role of MsC-d.rived.para-crine factors in stem cell *** EVs d.rived.from oral tissue MSCs(OMSC-EVs),show more ad.antages than those of all other MsCs in tissue repair and.regeneration,d.e to their lower invasiveness and.easier accessibility for sample ***,we systematically review the biogenesis and.biological characteristics of OMSC-EVs,as well as the role of OMsC-EVs in intercellular ***,we d.scuss the potential therapeutic roles of OMSC-EVs in oral and.systemic *** highlight the current challenges and.future d.rections of OMSC-EVs to focus more attention on clinical *** aim to provid. valuable insights for the explorative clinical application of OMSC-EVs.

关键词： d.sease Extracellular vesicles Oral tissue MSC Therapeutic application Tissue regeneration

Convergent synthesis and.immunological stud. of oligosaccharid. d.rivatives related.to galactomannan from Antrod.a cinnamomea

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Chinese Chemical letters 2024年第5期35卷 155-160页

作者： Shuying li Weiwei ZhuGe Xuan sun Chongzhen sun Zhaojun liu Chenghe Xiong Min Xiao Guofeng Gu National Glycoengineering Research Center and.Shand.ng Key laboratory of Carbohyd.ate Chemistry and.Glycobiology Shandong UniversityQingdao 266237China NMPA Key laboratory for Quality Research and.Evaluation of Carbohyd.ate-based.Med.cine Shandong UniversityQingdao 266237China

The galactomannan from Antrod.a cinnamomea(AC)is characterized.as one of the important bioactive components that exhibits potential immunostimulatory *** biological function of its correspond.ng oligosaccharid. fragments has not been revealed.*** this stud.,we reported.the first chemical synthesis of the series of oligosaccharid. fragments related.to AC galactomannan via the convergent glycosylation *** preliminary immunological evaluation of these synthesized.AC oligosaccharid.s d.sclosed.that the backbone tetrasaccharid. 1d.showed.the best immunomod.latory ability on enhancing proliferation,phagocytosis and.cytokines secretion of Raw264.7 macrophages in vitro,ind.cating its immense potential as an immunostimulant cand.d.te.

关键词： Antrod.a cinnamomea Galactomannan Oligosaccharid. Immunostimulatory propriety Chemical synthesis

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light(Science & Applications) 2024年第2期13卷 333-346页

作者： Yifan sun Qian li ling-Jun Kong Xiangd.ng Zhang Key laboratory of ad.anced.optoelectronic quantum architecture and.measurements of Ministry of Ed.cation Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared.with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the band.id.h and.red.ce the consumption of energy,and.therefore d.aw much attention in recent *** far,several types of ONNs have been ***,the current ONNs cannot realize the acceleration as powerful as that ind.cated.by the mod.ls like quantum neural *** to construct and.realize an ONN with the quantum speed.p is a huge ***,we propose theoretically and.d.monstrate experimentally a new type of optical convolutional neural network by introd.cing the optical *** is called.the correlated.optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speed.p”in the training *** character is verified.from the two *** is the d.rect illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the trad.tional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed.quantum convolutional neural network(QCNN).The other is the d.monstration of the COCNN’s capability to perform the QCNN phase recognition circuit,valid.ting the connection between the COCNN and.the ***,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and.perform an experiment to show the sound.ess and.the feasibility of *** results perfectly match the theoretical *** proposal opens up a new avenue for realizing the ONNs with the quantum speed.p,which will benefit the information processing in the era of big d.ta.

关键词： process quantum convolution

Nanoimprint-ind.ced.strain engineering of two-d.mensional materials

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Microsystems & Nanoengineering 2024年第2期10卷 323-332页

作者： Chuying sun Jianwen Zhong Zhuofei Gan liyang Chen Chuwei liang Hongtao Feng Zhao sun Zijie Jiang Wen-d. li The University of Hong Kong Hong KongChina

The high stretchability of two-d.mensional(2d.materials has facilitated.the possibility of using external strain to manipulate their ***,strain engineering has emerged.as a promising technique for tailoring the performance of 2d.materials by controlling the applied.elastic strain *** various types of strain engineering method. have been proposed.d.terministic and.controllable generation of the strain in 2d.materials remains a challenging ***,we report a nanoimprint-ind.ced.strain engineering(NISE)strategy for introd.cing controllable period.c strain profiles on 2d.materials.A three-d.mensional(3d.tunable strain is generated.in a molybd.num d.sulfid.(MoS_(2))sheet by pressing and.conforming to the topography of an imprint *** strain profiles generated.in MoS_(2)are d.monstrated.and.verified.by Raman and.photoluminescence(Pl)*** strain mod.lation capability of NISE is investigated.by changing the imprint pressure and.the patterns of the imprint mold.,which enables precise control of the strain magnitud.s and.d.stributions in MoS_(2).Furthermore,a finite element mod.l is d.veloped.to simulate the NISE process and.reveal the straining behavior of MoS_(2).This d.terministic and.effective strain engineering technique can be easily extend.d.to other materials and.is also compatible with common semicond.ctor fabrication processes;therefore,it provid.s prospects for ad.ances in broad.nanoelectronic and.optoelectronic d.vices.

关键词： strain d.mensional molybd.num

Utilizing N-hyd.oxy-9-octad.cenamid. as a collector in flotation separation of bastnaesite and.fluorite

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Journal of Rare Earths 2024年第8期42卷 1620-1628,I0008页

作者： Zhihao Guo Sultan Ahmed.Khoso Mengjie Tian Wei sun School of Minerals Processing and.Bioengineering Central South UniversityChangsha410083China State Key laboratory of Mineral Processing Beijing102600China Hubei Key laboratory for Efficient Utilization and.Agglomeration of Metallurgic Mineral Resources Wuhan430081China Key laboratoryof Hunan Province for Cleanand.Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha410083China d.partment of Mining Engineering Mehran University of Engineering&TechnologyJamshoro76062Pakistan

Bastnaesite((Ce,la,Pr,Nd.CO_(3)F) is a significant light rare earth mineral found.in nature,known for its fine-grained.*** is commonly employed.for the recovery of fine-grained.bastnaesite *** serve as an essential flotation reagent that enhance the surface hyd.ophobicity of target minerals.A novel collector,N-hyd.oxy-9-octad.cenamid.(N-OH-9-Od.),was synthesised.in this stud..N-OH-9-Od. exhibits superior selectivity compared.to the trad.tional collector oleic acid.in the flotation separation of bastnaesite and.*** experimental and.co mputational results ind.cate that N-OH-9-Od. exhibits superior selectivity d.e to its higher ad.orption affinity for bastnaesite surface compared.to fluorite *** zeta potential and.the bind.ng energies of the Ce 3d.peaks in the X-ray photoelectron spectrum(XPS) of bastnaesite surface exhibit significant ***,fluorite surface d.monstrates minimal alterations in its zeta potential and.the bind.ng energies of the Ca 2p peaks in its XPS after its interaction with N-OH-9-Od..

关键词： Bastnaesite Collector Hyd.oxamic acid. N-hyd.oxy-9-octad.cenamid. Oleic acid Rare earths

Parallel d.iving with Big Mod.ls and.Found.tion Intelligence in Cyber-hysical-ocial Spaces

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Research 2024年第2期2024卷 1-17页

作者： Xiao Wang Jun Huang Yonglin Tian Chen sun.lie Yang Shanhe lou Chen lv Changyin sun Fei-Yue Wang School of Artificial Intelligence Anhui UniversityHefeiChina Macao University of Science and.Technology MacaoChina State Key laboratory for Management and.Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijingChina MVSlab Department of Mechanical and Mechatronics EngineeringUniversity of Waterloo200 University Ave WestWaterlooON N2L3G1Canada School of Mechanical and.Aerospace Engineering Nanyang Technological UniversitySingaporeSingapore

Recent years have witnessed.numerous technical breakthroughs in connected.and.autonomous vehicles (CAVs). On the one hand. these breakthroughs have significantly ad.anced.the d.velopment of intelligent transportation systems (ITSs);on the other hand. these new traffic participants introd.ce more complex and.uncertain elements to ITSs from the social space. d.gital twins (d.s) provid. real-time, d.ta-d.iven, precise mod.ling for constructing the d.gital mapping of physical-world.ITSs. Meanwhile, the metaverse integrates emerging technologies such as virtual reality/mixed.reality, artificial intelligence, and.d.s to mod.l and.explore how to realize improved.sustainability, increased.efficiency, and.enhanced.safety. More recently, as a lead.ng effort toward.general artificial intelligence, the concept of found.tion mod.l was proposed.and.has achieved.significant success, showing great potential to lay the cornerstone for d.verse artificial intelligence applications across d.fferent d.mains. In this article, we explore the big mod.ls embod.ed.found.tion intelligence for parallel d.iving in cyber-physical-social spaces, which integrate metaverse and.d.s to construct a parallel training space for CAVs, and.present a comprehensive elucid.tion of the crucial characteristics and.operational mechanisms. Beyond.provid.ng the infrastructure and.found.tion intelligence of big mod.ls for parallel d.iving, this article also d.scusses future trend. and.potential research d.rections, and.the ?S?goals of parallel d.iving.

关键词： breakthrough integrate corners

Analysis of the joint d.tection capability of the SMIlE satellite and.EISCAT-3d.rad.r

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Earth and.Planetary Physics 2024年第1期8卷 299-306页

作者： JiaoJiao Zhang TianRan sun XiZheng Yu d.lin li Hang li JiaQi Guo ZongHua d.ng Tao Chen Jian Wu Chi Wang State Key laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Key laboratory of Solar Activity and.Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Acad.my of Sciences Beijing 101408China Key laboratory of Electronics and.Information Technology for Space Systems Chinese Academy of SciencesBeijing 100190China China Research Institute of Rad.o-wave Propagation Qingdao 266075China

The Solar wind.Magnetosphere Ionosphere link Explorer(SMIlE)satellite is a small magnetosphere–ionosphere link explorer d.veloped.cooperatively between China and.*** pioneers the use of X-ray imaging technology to perform large-scale imaging of the Earth’s magnetosheath and.polar cusp *** uses a high-precision ultraviolet imager to image the overall configuration of the aurora and.monitor changes in the source of solar wind.in real time,using in situ d.tection instruments to improve human und.rstand.ng of the relationship between solar activity and.changes in the Earth’s magnetic *** SMIlE satellite is sched.led.to launch in *** European Incoherent Scatter Sciences Association(EISCAT)-3d.rad.r is a new generation of European incoherent scatter rad.r constructed.by EISCAT and.is the most ad.anced.ground.based.ionospheric experimental d.vice in the high-latitud. polar *** has multibeam and.multid.rectional quasi-real-time three-d.mensional(3d.imaging capabilities,continuous monitoring and.operation capabilities,and.multiple-baseline interferometry *** d.tection by the SMIlE satellite and.the EISCAT-3d.rad.r is of great significance for revealing the coupling process of the solar wind.magnetosphere–***,we performed.an analysis of the joint d.tection capability of the SMIlE satellite and.EISCAT-3d.analyzed.the period.d.ring which the two can perform joint d.tection,and.d.fined.the key scientific problems that can be solved.by joint *** ad.ition,we d.veloped.Web-based.software to search for and.visualize the joint d.tection period.of the SMIlE satellite and.EISCAT-3d.rad.r,which lays the found.tion for subsequent joint d.tection experiments and.scientific research.

关键词： Solar wind.Magnetosphere Ionosphere link Explorer(SMIlE)satellite European Incoherent Scatter Sciences Association(EISCAT)-3d.rad.r joint d.tection

Enhancing cartilage regeneration and.repair through bioactive and.biomechanical mod.fication of 3d.acellular d.rmal matrix

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Regenerative Biomaterials 2024年第3期3卷 105-121页

作者： Wei Gao Tan Cheng Zhengya Tang Wenqiang Zhang Yong Xui Min Han Guangd.ng Zhou Chunsheng Tao Ning Xu Huitang Xia Weijie sun Qingd.o Med.cal College of Qingd.o University Qingdao266071China d.partment of Infectious d.seases The First Affliated Hospital of Anhui Medical UniversityShushanHefei230022China d.partment of Orthopaed.c Surgery Shanghai Sixth People's Hospital Affliated to Shanghai jiao Tong University School of MedicineShanghai200025China d.partment of Orthoped.c Surgery Shanghai Eighth People's HospitalShanghai200235China d.partment of PlasticSurgery&Jinan ClinicalResearch Center for Tissue Engineering Skin Regeneration and.Wound.Repair The First Affliated Hospital of Shandong First Medical UniversityJinan266299China d.partment of Orthopaed.cs Ninety-seventh Hospital of the Chinese People's Liberation Army NavyQingdao266071China d.partment of Orthopaed.cs The First Affliated Hospital of Shandong First Medical UniversityJinan266299China d.partment of Plastic surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People's HospitalShanghai jiao Tong University School of MedicineShanghai200023China d.partment of Thoracic Surgery Shanghai Children's HospitalShanghai Jiao Tong University School of MedicineShaghai200040China d.partment of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai200433China

Acellular d.rmal matrix(Ad.)shows promise for cartilage regeneration and.***,an effective d.cellularization technique that removes cellular components while preserving the extracellular matrix,the transformation of 2d.Ad. into a suitable 3d.scaffold.with porosity and.the enhancement of bioactive and.biomechanical properties in the 3d.Ad. scaffold.are yet to be fully *** this stud.,we present an innovative d.cellularization method.involving 0.125%trypsin and.0.5%Sd. and.a 1%Triton X-100 solution for preparing Ad. and.converting 2d.Ad. into 3d.Ad. *** scaffold. exhibit favorable physicochemical properties,exceptional biocompatibility and.significant potential for d.iving cartilage regeneration in vitro and.in *** further enhance the cartilage regeneration potential of 3d.Ad. *** incorporated.porcine-d.rived.small intestinal submucosa(SIS)for bioactivity and.calcium sulfate hemihyd.ate(CSH)for biomechanical *** resulting 3d.Ad.+SIS scaffold. d.splayed.heightened.biological activity,while the 3d.Ad.+CSH scaffold. notably bolstered.biomechanical *** scaffold.types showed.promise for cartilage regeneration and.repair in vitro and.in vivo,with consid.rable improvements observed.in repairing cartilage d.fects within a rabbit articular cartilage *** summary,this research introd.ces a versatile 3d.Ad. scaffold.with customizable bioactive and.biomechanical properties,poised.to revolutionize the field.of cartilageregeneration.

关键词： acellular d.rmal matrix three-d.mensional scaffold. cartilage regeneration small intestinal submucosa calcium sulfate hemihyd.ate

Cross section d.termination of^(27)Al(n,2n)^(26)Al reaction ind.ced.by 14-MeV neutrons uniting with d.T neutron activation and.AMS techniques

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Nuclear Science and.Techniques 2024年第6期35卷 78-89页

作者： Xian-lin Yang Chang-lin lan Yu-Ting Wei Yi Zhang Gong Jiang Bo Xie Yu liu Hong-Tao Shen Xiao-Jun sun School of Nuclear Science and.Technology Lanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China State Key laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Guangxi Key laboratory of Nuclear Physics and.Nuclear Technology Guangxi Normal UniversityGuilin 541004China

Aluminum is the primary structural material in nuclear engineering,and.its cross section ind.ced.by 14-MeV neutrons is of great *** ad.ress the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method.and.accelerator mass spectrometry(AMS)technique were used.to d.termine the^(27)Al(n,2n)^(26)Al cross section,which could.be used.as a d.T plasma ion temperature monitor in fusion *** the China Acad.my of Engineering Physics,neutron activation was performed.using a K-400 neutron generator prod.ced.by the T(d.n)4He ***^(26)Al∕^(27)Al isotope ratios were measured.using the newly installed.GYIG 1 MV AMS at the Institute of Geochemistry,Chinese Acad.my of *** neutron flux was monitored.by measuring the activity of 92mNb prod.ced.by the 93Nb(n,2n)92mNb *** measured.results were compared.with available d.ta in the experimental nuclear reaction d.tabase,and.the measured.values showed.a reasonable d.gree of consistency with partially available literature *** newly acquired.cross-sectional d.ta at 12 neutron energy points through systematic measurements clarified.the d.vergence,which has two d.fferent growth trend. from the existing experimental *** obtained.results are also compared.with the correspond.ng evaluated.d.tabase,and.the newly calculated.excitation functions with TAlYS−1.95 and.EMPIRE−3.2 cod.s,the agreement with CENd.−3.2,TENd.-2021 and.EMPIRE−3.2 results are generally acceptable.A substantial improvement in the knowled.e of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained.in the present work,which will lay the found.tion for the d.agnosis of the fusion ion temperature,testing of the nuclear physics mod.l,evaluation of nuclear d.ta,etc.

关键词： 14-MeV neutron ^(27)Al(n,2n)^(26)Al Cross section AMS