检索结果-南通市图书馆

Therapeutic Approach for Hair Growth and Regeneration Using Bioactive Formulation Containing Mesenchymal Stromal Cell-Derived Conditioned Medium

引用

Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 182-208页

作者： pawan kumar gupta Samatha Bhat Suresh Kannan Raviraja N. Seetharam Udaykumar Kolkundkar Stempeutics Research Pvt. Ltd. 3rd Floor Manipal Hospitals Whitefield Pvt. Ltd. Bengaluru India Stempeutics Research Pvt. Ltd. 4th Floor Shirdi Sai Baba Cancer Hospital Manipal India

Background and Aims: Androgenetic alopecia (AGA) is a common form of hair loss in both men and women. Despite its high prevalence and associated patient morbidity, the approved therapeutic options are limited to finasteride and minoxidil. The present study is aimed at assessing the efficacy of hair serum formulation, Trichosera®containing Bone marrow-derived mesenchymal stromal cells conditioned media as an active ingredient, for hair fall control and hair regrowth in healthy Indian human volunteers. Methods: The product was made using a 20% concentration of 10X Conditioned Media along with excipients. The final product was tested for physicochemical parameters, biomarkers, total protein content and microbial limits as per our in-house specifications. Results: The primary irritation patch test showed that the product is non-irritant and dermatologically safe. A clinical study on 40 subjects was conducted to evaluate the effectiveness of the bioactive formulation in hair fall control and hair regrowth in healthy volunteers. Phototrichogram measurement showed hair density and hair growth rate increased significantly by 11.54% and 18.66% at week 24. Hair tensile strength also increased significantly by 41.10% at 12 weeks follow-up. Hair pull test, to see a reduction in pulled hair and comb’s test to show a decrease in hair fall significantly improved from week 4 onwards. There were no significant adverse events in response to the product application. Conclusion: It is concluded that the hair serum product is completely safe on direct application to the scalp and showed significant improvement in the hair growth rate, hair density, scalp condition and reduction in hair fall. .

关键词： Trichosera® Bone Marrow Derived Mesenchymal Stromal Cells Conditioned Media Hair Fall Hair Regrowth Human Volunteer Study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population

引用

Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 118-132页

作者： Mukta Sachdev Anoop Chullikana Raviraja N. Seetharam Rachana Shilpakar R. Sapna Keerthi Velugotla Ritambhara Anish S. Majumdar pawan kumar gupta Manipal Hospital Bangalore India MS Skin Centre Bangalore India Stempeutics Research Pvt. Ltd. Bangalore India

Introduction: The use of growth factors and cytokines in skin rejuvenation and reversal of photo ageing is a novel anti-ageing treatment. These factors provide a microenvironment that seems to favor tissue repair and regeneration. Methods: An open label, monocentric, single arm study to evaluate anti-ageing efficacy of conditioned medium obtained from adult human bone-marrow derived allogenic mesenchymal stromal cells (BMMSC) along with excipients formulated into a cosmetic serum, was conducted in 40 Indian female population aged 35 to 60 years, belonging to skin type IV - VI of Norwood Scale for a duration of 90 days. Parameters—fine lines, wrinkles, crow’s feet, evenness of skin tone, skin firmness/laxity, hydration of skin, homogeneity of age spots, and visible pores were used to evaluate the anti-ageing and rejuvenating properties of the test product. Results and Discussion: Improvement was seen in majority of parameters starting from 15 - 30 days. Product was safe and well tolerated as per the dermatologist and subjects’ self-assessment.

关键词： Cytokines Conditioned Media Crow’s Feet Anti-Ageing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intricacies during pregnancy with gestational diabetes mellitus

引用

World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla gupta Arvind kumar Morya Ripunjay Prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Formalising and Detecting Community Structures in Real World Complex Networks

引用

Journal of Systems Science & Complexity 2021年第1期34卷 180-205页

作者： kumar pawan DOHARE Ravins School of Sciences Indira Gandhi National Open UniversityNew Delhi 110068India Centre for Interdisciplinary Research in Basic Sciences Jamia Millia IslamiaNew Delhi 110025India

Community structure is an integral characteristic of real world networks whichever processes or areas they emerge from. This paper addresses the problem of community structure detection theoretically as well as computationally. The authors introduce a number of concepts such as the neighbourhood and strength of a subgraph, p-community, local maximal p-community, hubs, and outliers that play elemental role in formalising the concept of community structure in complex networks. A few preliminary results have been derived that lead to the development of an algorithm for community structure detection in undirected unweighted networks. The algorithm is based on a local seed expansion strategy that uses the concept of interaction coefficient. The authors have analysed the algorithm on a number of parameters such as accuracy, stability, and quality on synthetic and real world networks from different areas.

关键词： Algorithm hub local maximal p-community outlier p-community strength of a subgraph

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A neighborhood proximity based algorithm for overlapping community structure detection in weighted networks

引用

Frontiers of Computer Science 2019年第6期13卷 1353-1355页

作者： pawan kumar Ravins DOHARE Centre for Interdisciplinary Research in Basic Sciences Jamia Millia IslamiaNew Delhi-110025India

1 Introduction Many real networks are inherently composed of overlapping structure at modular level where nodes have multiple ***,many real networks are equipped with several metadata such as ground truth,node and edge weights which make the whole business of community detection ***,there are a few well known algorithms,e.g.,CPMw[1]that can detect overlapping community structure in weighted *** it comes to the application of an algorithm,the desired output depends on the right choice of parameters.

关键词： networks structure algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Coordination polymers： Challenges and future scenarios for capture and degradation of volatile organic compounds

引用

Nano Research 2016年第11期9卷 3181-3208页

作者： Kowsalya Vellingiri pawan kumar Ki-Hyun Kim Department of Civil and Environmental Engineering Hanyang uniVersity 222 Wangsimni-RoSeoul 04763Republic of Rorea Department of Nano Sciences and Materials Central University of Jammu Jammu 181143 India

Over the past few decades, coordination polymers/metal organic frameworks （CPs/MOFs） have drawn a great deal of attention for diverse applications due to their advantages of intrinsically ttLnable chemical structure, flexible architecture, high pore volume, high surface area, multifunctional properties, etc. To date, numerous CPs/MOFs have been developed and employed for the treatment and control of gaseous pollutants, such as volatile organic compounds （VOCs）, through capture, sorptive removal, and catalytic degradation. Nevertheless, there are also some key drawbacks and challenges for the practical application of these systems （e.g., poor selectivity, high energy （and fiscal） cost, high synthesis cost, low capacity, and difficulties in regeneration and recycling）. In this review, recent developments in CPs/MOFs research are described with their associated mechanisms for capture, sorptive removal, and catalytic degradation of VOCs. To this end, we discuss the key variables and challenges for afforded abatement of VOCs through CPs/MOFs technologies. Hopefully, this review will help the scientific community set future directions for the advancement of CPs/MOFs techniques for the effective management of diverse environmental issues.

关键词： coordination polymers/metal organic frameworks(CPs/MOFs) volatile organic compounds sorptive removalcatalytic degradation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent development in upconversion nanoparticles and their application in optogenetics:A review

引用

Journal of Rare Earths 2022年第6期40卷 847-861,I0001页

作者： Madhumita Patel Maninder Meenu Jitender kumar Pandey pawan kumar Rajkumar Patel Department of Chemistry and Nano Science Ewha Womans UniversitySeodaemun-guSeoul120-750South Korea College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China School of Basic and Applied Sciences Adamas UniversityKolkata700126India Institut National de la Recherche Scientifique-Centreénergie Materiaux Télecommunications(INRS-EMT) VarennesQCCanada Department of Chemistry and Biochemistry University of Oklahoma101 Stephenson ParkwayNormanOK73019United States Energy&Environmental Science and Engineering(EESE) Integrated Science and Engineering Division(ISED)Underwood International CollegeYonsei University85 Songdogwahak-roYeonsu-guIncheon21983South Korea

Ion channels present in the plasma membrane are responsible for integration and propagation of electric signals,which transmit information in nerve *** of these ion channels leads to many neurological ***,optogenetic technology has gained a lot of attention for the manipulation of neuronal *** is a neuromodulation approach that has been developed to control neuronal functions and activities using *** lanthanide-doped upconversion nanoparticles(UCNPs)absorb low energy photons in near-infrared(NIR) window and emit high energy photons in the visible spectrum region via nonlinear *** the last few decades,UCNPs have gained great attention in various bio-medical applications such as bio-imaging,drug delivery and *** near-infrared illumination is considered more suitable for optogenetics application,due to its lower degree of light attenuation and higher tissue penetration compared to visible ***,UCNPs have been considered as the new promising candidates for optogenetics *** nanoparticlemediated optogenetic systems provide a great opportunity to manipulate the ion channel in deep ***,we summarize the upconversion photoluminescence in lanthanide doped nanomaterials and its mechanisms and several approaches adopted to tune emission color or enhance upconversion *** advances of lanthanide-doped UCNPs design strategy and their mechanism are ***,we discuss the neural circuitry modulation using upconversion nanoparticles mediated ***,the future perspectives towards optogenetics are also included.

关键词： Lanthanide Upconversion Optogenetics Nanoparticles Neuronal modulation Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An indicator-based approach to assess village-level social and biophysical vulnerability of agriculture communities in Uttarakhand,India

引用

Journal of Mountain Science 2016年第12期13卷 2260-2271页

作者： Roopam SHUKLA Kamna SACHDEVA pawan kumar JOSHI Department of Natural Resources TERI University School of Environmental Sciences Jawaharlal Nehru University

With the growing recognition to myriad forms of current and future threats in the mountain agriculture systems,there is a pressing need to holistically understand the vulnerability of mountain agriculture *** study aims to assess the biophysical and social vulnerability of agriculture communities using an indicator-based approach for the state of Uttarakhand,India.A total of 14 indicators were used to capture biophysical vulnerability and 22 for social vulnerability profiles of15285 *** analysis was done at village level with weights assigned to each indicator using Analytical Hierarchical Process(AHP).The results of the study highlight the presence of very high biophysical vulnerability(0.82 ± 0.10) and high social vulnerability(0.65 ± 0.15) within the *** on the results,it was found that incidences of high biophysical vulnerability coincide with presence of intensified agriculture land and absence of dense *** social vulnerability scores were found in villages with an absence of local institutions(like Self Helping Groups(SHGs)),negligible infrastructure facilities and higher occupational dependence on agriculture.A contrast was observed in the vulnerability scores of villages present in the three different altitudinal zones in the study area,indicating respective vulnerability generating conditions existing in these three *** vulnerability was recorded to be highest in the villages falling in the lower zone and lowest in the upper zone villages;whereas,social vulnerability was found to be highest in the middle zone villages and lowest in lower zone *** study aids policy makers in identifying areas for intervention to expedite agriculture adaptation planning in the ***,the adaptation programmes in the region need to be more context-specific to accommodate the differential altitudinal vulnerability profiles.

关键词： Social vulnerability Biophysical vulnerability Mountain agriculture communities AHP Uttarakhand

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Active Learning Query Strategies for Classification,Regression,and Clustering:A Survey

引用

Journal of Computer Science & Technology 2020年第4期35卷 913-945页

作者： Punit kumar Atul gupta Indian Institute of Information Technology Design and ManufacturingJabalpurMadhya Pradesh 482005India

Generally,data is available abundantly in unlabeled form,and its annotation requires some *** labeling,as well as learning cost,can be minimized by learning with the minimum labeled data *** learning(AL),learns from a few labeled data instances with the additional facility of querying the labels of instances from an expert annotator or *** active learner uses an instance selection strategy for selecting those critical query instances,which reduce the generalization error as fast as *** process results in a refined training dataset,which helps in minimizing the overall *** key to the success of AL is query strategies that select the candidate query instances and help the learner in learning a valid *** survey reviews AL query strategies for classification,regression,and clustering under the pool-based AL *** query strategies under classification are further divided into:informative-based,representative-based,informative-and representative-based,and ***,more advanced query strategies based on reinforcement learning and deep learning,along with query strategies under the realistic environment setting,are *** a rigorous mathematical analysis of AL strategies,this work presents a comparative analysis of these ***,implementation guide,applications,and challenges of AL are discussed.

关键词： active learning active learning query strategy active classification active regression active clustering deep active learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Linear and nonlinear propagation characteristics of multi-Gaussian laser beams

引用

Chinese Physics B 2020年第11期29卷 370-379页

作者： Naveen gupta Sandeep kumar Lovely Professional University PhagwaraIndia

Theoretical investigation on the propagation characteristics of a new class of laser beams known as multi Gaussian(M.G)laser beams has been *** investigate the linear characteristics,propagation of the laser beam in vacuum has been ***,the nonlinear characteristics have been investigated in *** nonlinearity of the plasma has been modeled by relativistic mass nonlinearity of the plasma electrons in the field of laser *** is based on finding the semi analytical solution of the wave equation for the slowly varying envelope of the laser ***,the dynamical evolutions of the beam width and longitudinal phase of the laser beam have been investigated in detail.

关键词： self-focusing multi Gaussian self phase modulation self-channeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：