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Therapeutic Approach for Hair Growth and Regeneration Using Bioactive Formulation Containing Mesenchymal Stromal Cell-Derived Conditioned Medium

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 182-208页

作者： pawan Kumar Gupta Samatha Bhat Suresh Kannan Raviraja N. Seetharam Udaykumar Kolkundkar Stempeutics Research Pvt. Ltd. 3rd Floor Manipal Hospitals Whitefield Pvt. Ltd. Bengaluru India Stempeutics Research Pvt. Ltd. 4th Floor Shirdi Sai Baba Cancer Hospital Manipal India

Background and Aims: Androgenetic alopecia (AGA) is a common form of hair loss in both men and women. Despite its high prevalence and associated patient morbidity, the approved therapeutic options are limited to finasteride and minoxidil. The present study is aimed at assessing the efficacy of hair serum formulation, Trichosera®containing Bone marrow-derived mesenchymal stromal cells conditioned media as an active ingredient, for hair fall control and hair regrowth in healthy Indian human volunteers. Methods: The product was made using a 20% concentration of 10X Conditioned Media along with excipients. The final product was tested for physicochemical parameters, biomarkers, total protein content and microbial limits as per our in-house specifications. Results: The primary irritation patch test showed that the product is non-irritant and dermatologically safe. A clinical study on 40 subjects was conducted to evaluate the effectiveness of the bioactive formulation in hair fall control and hair regrowth in healthy volunteers. Phototrichogram measurement showed hair density and hair growth rate increased significantly by 11.54% and 18.66% at week 24. Hair tensile strength also increased significantly by 41.10% at 12 weeks follow-up. Hair pull test, to see a reduction in pulled hair and comb’s test to show a decrease in hair fall significantly improved from week 4 onwards. There were no significant adverse events in response to the product application. Conclusion: It is concluded that the hair serum product is completely safe on direct application to the scalp and showed significant improvement in the hair growth rate, hair density, scalp condition and reduction in hair fall. .

关键词： Trichosera® Bone Marrow Derived Mesenchymal Stromal Cells Conditioned Media Hair Fall Hair Regrowth Human Volunteer Study

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An Unusual Case of Right Transmesocolic Hernia with Ureter at the Neck of Sac

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Surgical Science 2011年第6期2卷 341-343页

作者： Mahendra Singh Gond Arjun Saxena pawan Agarwal Uday Somashekar Dhananjaya Sharma Department of Surgery Government NSCB Medical College Jabalpur (MP) INDIA

The purpose of the present article is to present an unusual case of internal herniation. In this case small bowl obstruction was due to congenital right trans-mesocolic hernia which had the right ureter at the neck of the sac forming a constriction band. This requires careful widening of neck of hernia, so as to avoid iatrogenic trauma to ureter. This unusual presentation needs dissemination as this type of internal hernia is extremely rare.

关键词： Hernia Abdominal/Surgery Intestinal Obstruction/Etiology/Surgery Mesocolon/Pathology/ Surgery

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Evaluation of Outcome of Ureteroscopic Pneumatic Lithotripsy in Single Lower Ureteric Calculus and Its Association with CT Parameters

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Open Journal of Urology 2019年第10期9卷 153-161页

作者： Rahul Bhatia Tariq Hameed pawan Lal Lovenish Bains Gaurish Sawant Haraesh Maranna Department of Surgery Maulana Azad Medical College New Delhi India

Objective: To evaluate the outcome of ureteroscopic pneumatic lithotripsy in single lower ureteric calculus and correlate its success with different CT parameters like HU, size of calculus and hydrnephrosis, if present. Patients and Methods: This study was conducted from October 2017 to March 2019 in Department of General Surgery, Maulana Azad Medical College, New Delhi. 30 patients (out of which 6 were excluded due to spontaneous passage of calculus), with single lower ureteric calculus were chosen and the outcome of URSL was compared with respect to CT parameters of Size, HU and Hydronephrosis and intra-operative clearance of calculus. Results: Success rate of URSL in single lower ureteric calculus was found to be 75%. Lower HU (774.12 ± 212.85) was associated with higher success rate. Similarly smaller size of calculus (9 ± 2.1) mm was associated with success group. Patients with gross hydronephrosis had a poor outcome of URSL. Lower urinary tract infection (8.33%) was the most common complication. Conclusion: Patients with small size calculus, low HU and absence of hydronephrosis have a better outcome of URSL.

关键词： Computed Tomography (CT) Ureteroscopic Lithotripsy (URSL) Hounsfield Unit (HU) Hydronephrosis (HDN)

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A New Classification Scheme of Fluorite Deposits

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International Journal of Geosciences 2017年第4期8卷 599-610页

作者： Rajni Magotra Stanzin Namga pawan Singh Neha Arora P.K. Srivastava Economic Geology Research Group Department of Geology University of Jammu Jammu India

Fluorite deposits occur in a variety of geologic environments throughout the globe. It may occur as the main or only economically recoverable ore mineral in deposits or may present as the accessory gangue minerals with other ores. It is therefore necessary to understand various genetic types of the fluorite deposit. The present paper synthesises the information of some of the known fluorite mineralisation from the world so that an understanding of them can help in establishing reliable criteria for further search of fluorite deposit. On the basis of a combination of geological background information and fluorite geochemistry, a new classification scheme is proposed.

关键词： Fluorite Classification Genetic Types REE Characteristics

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恶性疟原虫abstrakt同源基因的克隆及DEAD盒家族蛋白的序列分析(英文)

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动物学报 2004年第3期50卷 420-430页

作者：宋平张竞男 pawan MALHOTRA Narendra TUTEJA Virender Singh CHAUHAN 李奎华中农业大学动物科技学院武汉430070 武汉大学生命科学学院教育部发育生物学重点实验室武汉430072 联合国遗传工程和生物技术国际中心

DEAD盒蛋白家族的ATP依赖性的RNA解旋酶类参与细胞内几乎所有的RNA代谢过程 ,在几乎所有生物的细胞生长发育过程中扮演着众多不可或缺的角色。在本实验中 ,通过PCR和探针杂交相结合的筛选方法 ,筛选恶性疟原虫 (Plasmodiumfalciparum)... 详细信息

DEAD盒蛋白家族的ATP依赖性的RNA解旋酶类参与细胞内几乎所有的RNA代谢过程 ,在几乎所有生物的细胞生长发育过程中扮演着众多不可或缺的角色。在本实验中 ,通过PCR和探针杂交相结合的筛选方法 ,筛选恶性疟原虫 (Plasmodiumfalciparum)的基因组文库 ,克隆了FH1F———abstrakt同源基因的完整序列。通过搜索已经完成测序的恶性疟原虫基因组数据库 ,推测FH1F序列定位在第 5条染色体上。FH1F全长2 80 4bp,包含一个 1 1 6 1bp的完整阅读框 ,编码一个由 386个氨基酸组成的蛋白。对FH1F蛋白序列用BlastP进行搜索和分析以及用DNAStar与许多典型的DEAD盒蛋白序列进行比对分析 ,结果均提示FH1F蛋白应该是DEAD盒家族的一个Abstrakt蛋白。另一方面 ,用DNAStar对已知所有完整的DEAD盒蛋白进行详细的序列分析以及用Mega对这些序列进行系统发育研究的结果都显示 :DEAD盒家族的蛋白聚类成为若干不同的亚群 ;与DEAD盒蛋白的一般保守序列相比 ,Abstrakt,eIF 4A ,Vasa ,P6 8等不同亚群的DEAD盒蛋白在保守区具有各自不同的结构特征。本文对不同的DEAD盒蛋白的结构特征进行了总结并试图给出不同亚群分类上的结构标准。

关键词：恶性疟原虫 abstrakt 同源基因克隆 DEAD盒序列分析 RNA解旋酶

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Targeting biosignatures of hyperglycemia and oxidative stress in diabetes comorbid depressive rats: effectiveness of hydroethanolic extract of the whole plant of Ludwigia octovalvis

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Traditional Medicine Research 2023年第2期8卷 13-20页

作者： Stuti Pandey pawan Kumar Pandey Alakh Niranjan Sahu Himanshu Verma Manmath Kumar Nandi Department of Medicinal Chemistry Faculty of AyurvedaInstitute of Medical SciencesBanaras Hindu UniversityVaranasi 221005Uttar PradeshIndia Department of Pharmaceutical Engineering&Technology Indian Institute of Technology Banaras Hindu UniversityVaranasi 221005Uttar PradeshIndia

Background:The prime objective of the current research was to evaluate the whole plant hydroalcoholic extract of Ludwigia octovalvis(HLO)against hyperglycemia,and oxidative stress biomarkers in rats induced with diabetes comorbid depression,diabetes comorbid depression(streptozotocin-nicotinamide+electric footshocks).Methods:2,2-Diphenyl-1-picrylhydrazyl assay of HLO versus ascorbic acid was *** of 200 and 400 mg/kg body weight/day HLO doses versus 25 mg/kg body weight/day metformin was studied through insulin,glucose,superoxide dismutase,lipid peroxidation,catalase,and behavioral assessment(forced swim and open field tests).Results:IC50 values of HLO and ascorbic acid were 33.52 and 27.86μg/mL *** the HLO doses showed intended results with respect to oxidative stress biomarkers in diabetes comorbid depression rats in comparison to *** field test showed better results for HLO in diabetes comorbid depression ***,hypoglycemic effects,and forced swim test performance of metformin was slightly higher than the 400 mg dose,followed by the 200 mg dose of *** gallate,gallic acid,β-sitosterol,and quercetin in HLO might resulted in attenuating diabetic as well as depression ***:Inhibition of glucosidase and lipase activity,and AMP-activated protein kinase phosphorylation might be the possible biochemical changes occurred in HLO treated rats.

关键词： 2,2-diphenyl-1-picrylhydrazyl assay brain homogenate insulin superoxide dismutase content catalase activity lipid peroxidation

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Electron Monopole Duality in Quantum Hall Effect

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Journal of Electromagnetic Analysis and Applications 2011年第1期3卷 22-26页

作者： pawan Ku. Joshi Praveen Singh Bisht Om Prakash Singh Negi 不详

Starting from the duality between electric and magnetic field, we have made an attempt to discuss the quantum hall effect from the consideration of magnetic monopole in view of electron monopole duality. Starting from the dual dy-namics of electric and magnetic charges, we have reformulated a consistent theory of quantum hall effect in presence of monopole. Speculating the existence of magnetic monopoles in magnetic materials (metals), we have accordingly modi-fied the parameters;like drift velocity, current density, Hamiltonian and eigen values and eigen function for harmonic oscillator;resposible to examine the quantum Hall effect in metals.

关键词： Hall Effect Monopole Quantum Mechanics

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Unruptured Right Sinus of Valsalva Aneurysm Dissecting into Interventricular Septum Causing Complete Heart Block: Can Early Surgical Correction Revert Rhythm Disturbances?

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World Journal of Cardiovascular Diseases 2018年第7期8卷 353-359页

作者： Prerit Agarwal Ankit Jain pawan Singh Harpreet Singh Muhammad Abid Geelani Vimal Mehta Department of Cardiothoracic and Vascular Surgery Govind Ballabh Pant Institute of Post Graduate Medical Education and Research Delhi University New Delhi India Department of Cardiology Govind Ballabh Pant Institute of Post Graduate Medical Education and Research Delhi University New Delhi India

A sinus of Valsalva aneurysm (SOVA) is abnormal dilatation of the either aortic sinuses, area of the aortic root between the aortic valve annulus and the sinotubular junction. Their clinical presentation may range from being asymptomatic as an incidental finding on cardiac imaging to symptomatic presentations related to the compression of adjoining structures or intracardiac shunting caused by rupture of the SOVA mostly into the right side of the heart. The compression leads to findings of tricuspid valve regurgitation, right ventricular outflow tract (RVOT) obstruction and rarely complete heart block (CHB). Dissection or erosion into interventricular septum is one of the rarest complications of SOVA. The symptomatic presentation is almost always a surgical emergency. Here we present a case report of a patient with unruptured sinus of valsalva originating from right sinus dissecting into interventricular septum causing complete heart bock. In this case after surgical correction the complete heart block reverted to sinus rhythm.

关键词： Sinus of Valsalva Aneurysm (SOVA) Complete Heart Block (CHB)

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打破SoC原型的束缚

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中国集成电路 2015年第12期24卷 30-31页

作者： pawan Fangaria SemiWiki公司

本月早些时候，在我与Walden ***博士交谈的时候，他强调下一代的设计师们需要考虑整个SoC的系统级的需求，设计验证则会随着系统级的需求而发生重大改变。众所周知FPGA原型系统已经在很多的大型SoC项目中使用。设计者也因此对FPGA原型... 详细信息

本月早些时候，在我与Walden ***博士交谈的时候，他强调下一代的设计师们需要考虑整个SoC的系统级的需求，设计验证则会随着系统级的需求而发生重大改变。众所周知FPGA原型系统已经在很多的大型SoC项目中使用。设计者也因此对FPGA原型系统提出了越来越高的要求，比如需要在全球的不同角落都能够方便的远程访问FPGA原型系统、原型IP和SoC子系统等。

关键词：原型系统 SoC FPGA 设计验证远程访问设计师设计者子系统

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Ipilimumab associated colitis: An Ipi Colitis case series at Med Star Georgetown University Hospital

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World Journal of Gastroenterology 2015年第14期21卷 4373-4378页

作者： pawan Rastogi Mohamed Sultan Aline J Charabaty Michael B Atkins Mark C Mattar Department of Medicine MedS tar Georgetown University Hospital Department of Gastroenterology MedS tar Georgetown University Hospital Department of Oncology Georgetown Lombardi Comprehensive Cancer Center

Although ipilimumab has been shown to improve survival in patients with metastatic melanoma and cause regression of metastatic renal cell carcinoma, the associated immune-related toxicities are of *** resultant T cell activation by this monoclonal antibody causes an increased immune response, which has been associated with many immune-regulated adverse *** of the most concerning effects is the development of *** to 8% of patients have been reported to develop colitis, with 5% being severe(Grades 3-4).While initial treatment of such adverse effects is generally comprised of supportive and symptomatic treatment, more severe cases warrant the use of high dose ***, use of anti-TNF agents is usually reserved for those cases that prove to be refractory to *** describe a systematic case review of seven patients who developed gastrointestinal symptoms following initiation of ipilimumab immunotherapy, and present the steps in their evaluation, treatment and outcomes at our institution.

关键词： Colitis Ipilimumab Immunology Infliximab Immune-re

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