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Network analysis of suicide ideation and depression-anxiety symptoms among Chinese adolescents

General Psychiatry 2024年第2期37卷 216-223页

作者： Shuyin Xu Yumeng Ju Xiyu Wei Wenwen Ou mohan Ma Guanyi Lv Xiaotian Zhao Yaqi Qin Yunjing Li Liang Li Mei Huang Siqi Yang Yimei Lu Yafei Chen Junwu Liu Jin Liu Bangshan Liu Yan Zhang Department of Psychiatry National Clinical Research Center for Mental Disordersand National Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangshaHunanChina Mental Health Institute of Central South University China National Technology Institute on Mental DisordersHunan Technology Institute of PsychiatryHunan Key Laboratory of Psychiatry and Mental HealthHunan Medical Center for Mental HealthChangshaHunanChina

Background The co-occurrence of depression and anxiety among adolescents is typically associated with suicide *** The study aimed to investigate the symptom-level relationship between suicide ideation and the comorbidity of depression and *** 1501 adolescents aged 12-19 years were assessed using the Patient Health Questionnaire(PHQ-9)and the Generalized Anxiety Disorder Scale,and 716 adolescents who scored≥5 on both scales were selected as *** analysis was used to identify the network structure of depressive symptoms and anxiety *** were categorised into either the suicide ideation or non-suicide ideation groups based on their scoring on the suicide-related item in PHQ-9.A comparison was made between the depression-anxiety symptom networks of the two ***‘Restlessness’,‘sad mood’and‘trouble relaxing’were the most prominent central symptoms in the depression-anxiety symptom network,and‘restlessness’,‘nervousness’and‘reduced movement’were the bridge symptoms in this network.‘Sad mood’was found to be directly related to‘suicide ideation’with the highest *** network structure was significantly different in properties between the suicide ideation group and the non-suicide ideation group,with‘restlessness’and‘sad mood’exhibiting significantly higher influence in the network of the suicide ideation group than that in the non-suicide ideation *** Restlessness and sad mood could be targeted for the intervention of depression-anxiety symptoms among adolescents with suicide ideation.

关键词： symptoms adolescent assessed

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The outcomes and safety of patients undergoing endoscopic retrograde cholangiopancreatography combining a single-use cholangioscope and a single-use duodenoscope:A multicenter retrospective international study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 71-76页

作者： Alessandro Fugazza Matteo Colombo Michel Kahaleh V.Raman Muthusamy Bick Benjamin Wim Laleman Carmelo Barbera Carlo Fabbri Jose Nieto Abed Al-Lehibi mohan Ramchandani Amy Tyberg Haroon Shahid Avik Sarkar Dean Ehrlich Stuart Shermand Cecilia Binda Marco Spadaccini Andrea Iannone Kareem Khalaf Nageshwar Reddy Andrea Anderloni Alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSVia Manzoni 5620089RozzanoMilanoItaly Gastroenterology Rutgers Robert Wood JohnsonNew BrunswickNew JerseyUSA Vatche and Tamar Manoukian Division of Digestive Diseases University of CaliforniaLos Angeles School of Medicine at UCLALos AngelesCaliforniaUSA Division of Digestive and Liver Disorders Indiana University School of MedicineIndianapolisINUSA Department of Gastroenterology and Hepatology University Hospitals LeuvenKU Leuven3000 LeuvenBelgium U.O.C.di Gastroenterologia ed Endoscopia Digestiva Ospedale Giuseppe MazziniASL TeramoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsAUSL RomagnaForlì-CesenaItaly Borland Groover Clinic JacksonvilleFloridaUSA Department of Gastroenterology and Hepatology King Fahad Medical CityRiyadhSaudi Arabia Asian Institute of Gastroenterology HyderabadIndia Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly

Background: Duodenoscope-related multidrug-resistant organism(MDRO) infections raise concerns. Disposable duodenoscopes have been recently introduced in the market and approved by regulatory agencies with the aim to reduce the risk of endoscopic retrograde cholangiopancreatography(ERCP) associated infections. The aim of this study was to evaluate the outcome of procedures performed with single-use duodenoscopes in patients with clinical indications to single-operator cholangiopancreatoscopy. Methods: This is a multicenter international, retrospective study combining all patients who underwent complex biliopancreatic interventions using the combination of a single-use duodenoscope and a single-use cholangioscope. The primary outcome was technical success defined as ERCP completion for the intended clinical indication. Secondary outcomes were procedural duration, rate of cross-over to reusable duodenoscope, operator-reported satisfaction score(1 to 10) on performance rating of the single-use duodenoscope, and adverse event(AE) rate. Results: A total of 66 patients(26, 39.4% female) were included in the study. ERCP was categorized according to ASGE ERCP grading system as 47(71.2%) grade 3 and 19(28.8%) grade 4. The technical success rate was 98.5%(65/66). Procedural duration was 64(interquartile range 15-189) min, cross-over rate to reusable duodenoscope was 1/66(1.5%). The satisfaction score of the single-use duodenoscope classified by the operators was 8.6 ± 1.3 points. Four patients(6.1%) experienced AEs not directly related to the single-use duodenoscope, namely 2 post-ERCP pancreatitis(PEP), 1 cholangitis and 1 ***: Single-use duodenoscope is effective, reliable and safe even in technically challenging procedures with a non-inferiority to reusable duodenoscope, making these devices a viable alternative to standard reusable equipment.

关键词： Single-operator cholangioscopy Single-use duodenoscope Endoscopic retrograde cholangiopancreatography Indeterminate biliary stricture Difficult biliary stones

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习近平文化思想在中国式现代化进程中的重要价值意义

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思想战线 2024年第4期50卷 1-9页

作者：朱继东许莫晗东北大学马克思主义学院辽宁沈阳110167 中国社会科学院马克思主义研究院北京100732 中国社会科学院大学马克思主义学院北京100732

中国式现代化是物质文明与精神文明相协调的现代化,文化现代化是中国式现代化的应有之义。在习近平文化思想的指导下,我们党高度重视意识形态工作、宣传思想文化工作,我国的文化事业与文化产业繁荣发展,精神文明建设成效显著,文化现代... 详细信息

中国式现代化是物质文明与精神文明相协调的现代化,文化现代化是中国式现代化的应有之义。在习近平文化思想的指导下,我们党高度重视意识形态工作、宣传思想文化工作,我国的文化事业与文化产业繁荣发展,精神文明建设成效显著,文化现代化不断开辟出新的局面。在全面推进中国式现代化的进程中,习近平文化思想给予中国式现代化强大的思想文化支撑,引领中国式现代化的正确价值观方向,强化中国式现代化的意识形态保障,提升中国式现代化的文化发展优势,极大地推动了中国式现代化的又好又快发展,对以中国式现代化全面推进强国建设、民族复兴伟业具有重要的时代价值和深远意义。

关键词：习近平文化思想中国式现代化精神文明意识形态

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Analyses of Chicken Tenderness Traits Based on Transcriptome Sequencing

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Agricultural Biotechnology 2024年第2期13卷 17-19页

作者： Zengrong ZHANG mohan QIU Chunlin YU Xia XIONG Xiaoyan SONG Bo XIA Shiliang ZHU Jialei CHEN Chaowu YANG Sichuan Animal Science Academy Chengdu 610066China Animal Breeding and Genetics key Laboratory of Sichuan Province Chengdu 610066China

The calpain system is ubiquitous in cells, mainly comprising calpains and calpain inhibitors, and is a widespread calcium-dependent cysteine protease in organisms that is involved in many cellular processes such as muscle degradation in vivo and affects the tenderness of meat after animal slaughter. The study found 128 DEGs that probably regulated tenderness traits were selected from 16 significantly enriched GO terms by transcriptome sequencing analysis, and found that the developmental changes in the expression levels of the CAPN1 gene in the pectoral and leg muscles were significantly positively correlated ( P <0.05) with the cumulative growth values of live weight and comb weight. The developmental changes in the expression levels of the CAST gene in the pectoral and leg muscles were not significantly correlated with the cumulative growth values of live weight and comb weight. Our results helped demonstrate the potential molecular mechanisms of tenderness in chickens and provide valuable information for chicken breeding.

关键词： Chicken Tenderness traits Transcriptome sequencing

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Role of fecal microbiota transplant in management of hepatic encephalopathy: Current trends and future directions

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World Journal of Hepatology 2024年第1期16卷 17-32页

作者： Yash R Shah Hassam Ali Angad Tiwari David Guevara-Lazo Natalia Nombera-Aznaran Bhanu Siva mohan Pinnam Manesh Kumar Gangwani Harishankar Gopakumar Amir H Sohail SriLakshmiDevi Kanumilli Ernesto Calderon-Martinez Geetha Krishnamoorthy Nimish Thakral Dushyant Singh Dahiya Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Maharani Laxmi Bai Medical CollegeJhansi 284001India Faculty of Medicine Universidad Peruana Cayetano HerediaLima 15102Peru Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Department of Gastroenterology and Hepatology University of Illinois College of Medicine at PeoriaPeoriaIL 61605United States Department of Surgery University of New MexicoAlbuquerqueNM 87106United States Department of Internal Medicine GSL Medical CollegeRajamahendravaram 533296India Department of Internal Medicine Universidad Nacional Autonoma de MexicoCiudad De Mexico 04510Mexico Department of Digestive Diseases and Nutrition University of KentuckyLexingtonKY 40536United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States

Fecal microbiota transplantation(FMT)offers a potential treatment avenue for hepatic encephalopathy(HE)by leveraging beneficial bacterial displacement to restore a balanced gut *** prevalence of HE varies with liver disease severity and *** pathogenesis involves ammonia toxicity,gut-brain communication disruption,and *** aims to restore gut microbiota balance,addressing these ***'s efficacy has been explored in various conditions,including *** suggest that FMT can modulate gut microbiota,reduce ammonia levels,and alleviate *** has shown promise in alcohol-associated,hepatitis B and C-associated,and non-alcoholic fatty liver *** include improved liver function,cognitive function,and the slowing of disease ***,larger,controlled studies are needed to validate its effectiveness in these *** have shown cognitive improvements through FMT,with potential benefits in cirrhotic ***,trials have demonstrated reduced serious adverse events and cognitive enhancements in FMT arms compared to the standard of *** evidence is promising,challenges remain:Limited patient numbers,varied dosages,administration routes,and donor *** large-scale,controlled trials are essential to establish standardized guidelines and ensure FMT's clinical applications and *** FMT holds potential for HE management,ongoing research is needed to address these challenges,optimize protocols,and expand its availability as a therapeutic option for diverse hepatic conditions.

关键词： Hepatic encephalopathy Fecal microbiota transplant Cognitive impairment Liver cirrhosis Chronic liver disease

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重复经颅磁刺激治疗幻听的临床应用与展望

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中国临床研究 2024年第7期37卷 1109-1112,1119页

作者：孙蕴怡孟雅婧阳雨露沈聃琳王道锦肖洪奇李青 Smruthi mohan 邱昌建四川大学华西医院心理卫生中心四川成都610044 四川大学华西临床医学院四川成都610044

近几年来重复经颅磁刺激(rTMS)治疗在幻听症状的临床应用研究上取得了较大进展。近期研究发现经颅磁刺激(TMS)某些特定的刺激模式和刺激靶点对精神分裂症患者的幻听症状有一定改善,一般认为优先选择靶点如颞顶区和背外侧前额叶区。低频... 详细信息

近几年来重复经颅磁刺激(rTMS)治疗在幻听症状的临床应用研究上取得了较大进展。近期研究发现经颅磁刺激(TMS)某些特定的刺激模式和刺激靶点对精神分裂症患者的幻听症状有一定改善,一般认为优先选择靶点如颞顶区和背外侧前额叶区。低频刺激左颞顶交界区(TPJ)皮质是辅助治疗言语性幻听(AVH)的主要选择,疗效相对明确。然而,目前缺少大样本随机对照试验(RCT)等循证医学证据,以及对TMS的疗效缺乏客观有力的评估工具,rTMS对幻听症状的临床应用仍处于观望状态。本文从rTMS治疗AVH的刺激靶点、连续性θ短阵快速脉冲、rTMS治疗AVH的增强方案和深部TMS等方面对近年TMS治疗AVH的研究进展进行综述,以期推动临床对rTMS在干预幻听症状方面的认识,为未来进行大样本的RCT、建立客观的疗效评估方式等循证医学证据提供研究方向。

关键词：经颅磁刺激幻听低频经颅磁刺激颞顶交界区 θ短阵快速脉冲

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Ern1调控肿瘤免疫原性机制的初步探索

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中国免疫学杂志 2024年第5期40卷 897-904页

作者：李莫寒夏琳马瑜婷南京医科大学肿瘤个体化医学协同创新中心中国医学科学院系统医学研究院/苏州系统医学研究所免疫与炎症全国重点实验室

目的：探讨内质网跨膜蛋白IRE1（由Ern1编码）对肿瘤细胞免疫原性和成瘤性的影响与机制。方法：挖掘肿瘤公共数据库中ERN1表达水平和患者生存的关联性。利用CRISPR-Cas9技术敲除小鼠肿瘤细胞系MCA205和TC-1的Ern1基因，借助CCK-8、流式... 详细信息

目的：探讨内质网跨膜蛋白IRE1（由Ern1编码）对肿瘤细胞免疫原性和成瘤性的影响与机制。方法：挖掘肿瘤公共数据库中ERN1表达水平和患者生存的关联性。利用CRISPR-Cas9技术敲除小鼠肿瘤细胞系MCA205和TC-1的Ern1基因，借助CCK-8、流式细胞术、ELISA、荧光素酶报告系统、皮下植瘤、预免疫-再刺激等实验分析Ern1对肿瘤细胞体外增殖和体内成瘤能力、浸润肿瘤的免疫细胞比例、衣霉素诱导免疫原性细胞死亡和抗肿瘤效应T细胞活化的影响，比较Ern1-/-肿瘤在正常小鼠和Ifnar-/-小鼠体内生长速度的差异。结果：对多个癌种而言，肿瘤组织ERN1的表达水平与患者总生存时间呈负相关。虽然敲除Ern1不影响肿瘤细胞的体外增殖能力，但其在正常小鼠皮下的成瘤能力大幅降低，甚至会自发消退。与野生型相比，Ern1-/-肿瘤内中性粒细胞显著增多，CD4+T细胞浸润减少。衣霉素诱导内质网应激后，Ern1-/-细胞死亡更多，虽然其HMGB1释放和钙网蛋白暴露有所减少，但IFN-α/β分泌增多，能更强地激活效应T细胞分泌IFN-γ。与正常小鼠相比，Ifnar-/-免疫缺陷小鼠体内Ern1-/-肿瘤生长速度显著加快。结论：Ern1缺失可促进内质网应激肿瘤细胞的Ⅰ型干扰素应答，增强其免疫原性，促进抗肿瘤T细胞分泌IFN-γ，阻碍肿瘤生长。

关键词：未折叠蛋白反应肿瘤免疫原性干扰素内质网应激

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深度神经网络后门防御综述

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信息安全学报 2024年第4期9卷 47-63页

作者：江钦辉李默涵孙彦斌广州大学网络空间安全学院/网络空间先进技术研究院广州510006

深度学习在各领域全面应用的同时,在其训练阶段和推理阶段也面临着诸多安全威胁。神经网络后门攻击是一类典型的面向深度学习的攻击方式,攻击者通过在训练阶段采用数据投毒、模型编辑或迁移学习等手段,向深度神经网络模型中植入非法后门... 详细信息

深度学习在各领域全面应用的同时,在其训练阶段和推理阶段也面临着诸多安全威胁。神经网络后门攻击是一类典型的面向深度学习的攻击方式,攻击者通过在训练阶段采用数据投毒、模型编辑或迁移学习等手段,向深度神经网络模型中植入非法后门,使得后门触发器在推理阶段出现时,模型输出会按照攻击者的意图偏斜。这类攻击赋予攻击者在一定条件下操控模型输出的能力,具有极强的隐蔽性和破坏性。因此,有效防御神经网络后门攻击是保证智能化服务安全的重要任务之一,也是智能化算法对抗研究的重要问题之一。本文从计算机视觉领域出发,综述了面向深度神经网络后门攻击的防御技术。首先,对神经网络后门攻击和防御的基础概念进行阐述,分析了神经网络后门攻击的三种策略以及建立后门防御机制的阶段和位置。然后,根据防御机制建立的不同阶段或位置,将目前典型的后门防御方法分为数据集级、模型级、输入级和可认证鲁棒性防御四类。每一类方法进行了详细的分析和总结,分析了各类方法的适用场景、建立阶段和研究现状。同时,从防御的原理、手段和场景等角度对每一类涉及到的具体防御方法进行了综合比较。最后,在上述分析的基础上,从针对新型后门攻击的防御方法、其他领域后门防御方法、更通用的后门防御方法、和防御评价基准等角度对后门防御的未来研究方向进行了展望。

关键词：后门防御后门攻击人工智能安全神经网络深度学习

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Quantifying Kinematic Tremor in an NGLY1-Deficient Individual: A Case Study

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Case Reports in Clinical Medicine 2024年第1期13卷 25-36页

作者： Brock Futrell Christopher Alexander Malaya Dacia Martinez Diaz Christian Alfaro Hannah Elizabeth Gustafson Subhalakshmi Chandrasekaran Rhea mohan Phatak Bernhard Suter Charles Shannon Layne Department of Health and Human Performance University of Houston Houston USA Center for Neuromotor and Biomechanics Research University of Houston Houston USA Department of Computer Science and Engineering Texas A&M University College Station USA Blue Bird Circle Rett Center Texas Children’s Hospital Houston USA Baylor College of Medicine Houston USA Center for NeuroEngineering and Cognitive Science University of Houston Houston USA

NGLY1 Deficiency is an autosomal recessive congenital disorder that has been identified in less than 100 individuals. Most individuals with NGLY1 Deficiency display hyperkinetic movement disorders, including choreiform, athetoid, dystonic myoclonic, dyskinetic, and dysmetric movements. Developing a consistent and concise consensus on the classification and evaluation of tremors is essential to forward the research and treatment of tremors. It has also been reported that some individuals with NGLY1 Deficiency demonstrate tremor, but such tremor has never been formally investigated. The primary objective of this study is to determine if an individual with NGLY1 Deficiency demonstrates an identifiable tremor during a series of arm movements and, if so, describe the frequency and power characteristics of that tremor. Arm movement kinematics were obtained using a 16-camera Vicon system, and time series trajectory waveforms for three planes of a marker placed on the hand were developed. Custom MATLAB scripts were utilized to compute Fast Fourier Transformations of the data within the identified waveform segments. A mean frequency of 2.30 Hz (SD = 1.05) with a mean power of 5.02 |P1(f)| (SD = 4.63) suggests that our participant’s kinematic data did display a persistent tremor in both hands across all tasks and movement planes. Analyses of the reaching hand and the non-reaching hand suggest the participant displayed an action tremor in both postural and intention (kinetic) tremors. Future directions should include assessing additional individuals with NGLY1 Deficiency to determine if the tremor is a distinguishable disorder behavior. Additionally, evaluating other anatomical sites, such as the elbow, head, and lower limbs, would provide further insights into the characteristics of this tremor.

关键词： Tremor NGLY Fast Fourier Transformation Reaching Hyperkinetic Movement

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Association between acute peripancreatic fluid collections and early readmission in acute pancreatitis:A propensity-matched analysis

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World Journal of Experimental Medicine 2024年第2期14卷 75-88页

作者： Hassam Ali Faisal Inayat Waqas Rasheed Arslan Afzal Ahtshamullah Chaudhry Pratik Patel Attiq Ur Rehman Muhammad Sajeel Anwar Gul Nawaz Muhammad Sohaib Afzal Amir H Sohail Subanandhini Subramanium Dushyant Singh Dahiya Deepa Budh Babu P mohan Douglas G Adler Department of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTX 79430United States Department of Internal Medicine St.Dominic’s HospitalJacksonMS 39216United States Department of Gastroenterology Mather Hospital and Hofstra University Zucker School of MedicinePort JeffersonNY 11777United States Department of Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Department of Internal Medicine Louisiana State University HealthShreveportLA 71103United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Division of Gastroenterology Hepatologyand MotilityThe University of Kansas School of MedicineKansas CityKS 64108United States Department of Internal Medicine St.Barnabas Hospital and Albert Einstein College of MedicineBronxNY 10457United States Department of Gastroenterology and Hepatology University of Utah School of MedicineSalt Lake CityUT 84132United States Center for Advanced Therapeutic Endoscopy Porter Adventist HospitalCentura HealthDenverCO 80210United States

BACKGROUND Patients with acute pancreatitis(AP)frequently experience hospital readmissions,posing a significant burden to healthcare *** peripancreatic fluid collection(APFC)may negatively impact the clinical course of *** could worsen symptoms and potentially lead to additional ***,clinical evidence regarding the specific association between APFC and early readmission in AP remains *** the link between APFC and readmission may help improve clinical care for AP patients and reduce healthcare *** To evaluate the association between APFC and 30-day readmission in patients with *** This retrospective cohort study is based on the Nationwide Readmission Database for *** with a primary diagnosis of AP were *** were categorized into those with and without APFC.A 1:1 propensity score matching for age,gender,and Elixhauser comorbidities was *** primary outcome was early readmission *** outcomes included the incidence of inpatient complications and healthcare *** analyses used Mann-Whitney U andχ2 tests,while Cox regression models assessed 30-day readmission risks and reported them as adjusted hazard ratios(aHR).Kaplan-Meier curves and log-rank tests verified readmission *** A total of 673059 patients with the principal diagnosis of AP were *** these,5.1%had APFC on initial *** propensity score matching,each cohort consisted of 33914 *** with APFC showed a higher incidence of inpatient complications,including septic shock(3.1%vs 1.3%,P<0.001),portal venous thrombosis(4.4%vs 0.8%,P<0.001),and mechanical ventilation(1.8%vs 0.9%,P<0.001).The length of stay(LOS)was longer for APFC patients[4(3-7)vs 3(2-5)days,P<0.001],as were hospital charges($29451 vs$24418,P<0.001).For 30-day readmissions,APFC patients had a higher rate(15.7%vs 6.5%,P<0.001)and a longer median readmission LOS(4 vs 3 days,P<0.001).The APF

关键词： Acute pancreatitis Acute peripancreatic fluid collections Readmission predictors Inpatient complications Healthcare utilization and costs

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