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Unveiling the silent link:Normal-tension glaucoma's enigmatic bond with cardiac blood flow

World Journal of Cardiology 2024年第1期16卷 10-15页

作者： Prasanna Venkatesh Ramesh Arvind Kumar Morya Ajanya K Aradhya pavithra pannerselvam Sai Thaejesvi Gopalakrishnan Shruthy Vaishali Ramesh Aji Kunnath Devadas Navaneeth Krishna Department of Glaucoma and Research Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Optometry and Visual Science Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Mahathma Eye Hospital Private Limited Trichy 620017Tamil NaduIndia Department of Cataract and Refractive Surgery Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia

This comprehensive review embarks on a captivating journey into the complex relationship between cardiology and normal-tension glaucoma(NTG),a condition that continues to baffle clinicians and researchers alike.NTG,characterized by optic nerve damage and visual field loss despite normal intraocular pressure,has long puzzled clinicians.One emerging perspective suggests that alterations in ocular blood flow,particularly within the optic nerve head,may play a pivotal role in its pathogenesis.While NTG shares commonalities with its high-tension counterpart,its unique pathogenesis and potential ties to cardiovascular health make it a fascinating subject of exploration.It navigates through the complex web of vascular dysregulation,blood pressure and perfusion pressure,neurovascular coupling,and oxidative stress,seeking to uncover the hidden threads that tie the heart and eyes together in NTG.This review explores into the intricate mechanisms connecting cardiovascular factors to NTG,shedding light on how cardiac dynamics can influence ocular health,particularly in cases where intraocular pressure remains within the normal range.NTG's enigmatic nature,often characterized by seemingly contradictory risk factors and clinical profiles,underscores the need for a holistic approach to patient care.Drawing parallels to cardiac health,we examine into the shared vascular terrain connecting the heart and the eyes.Cardiovascular factors,including systemic blood flow,endothelial dysfunction,and microcirculatory anomalies,may exert a profound influence on ocular perfusion,impacting the delicate balance within the optic nerve head.By elucidating the subtle clues and potential associations between cardiology and NTG,this review invites clinicians to consider a broader perspective in their evaluation and management of this elusive condition.As the understanding of these connections evolves,so too may the prospects for early diagnosis and tailored interventions,ultimately enhancing the quality of life for those living with NTG.

关键词： Normal tension glaucoma Vascular dysregulation Ocular blood flow Blood pressure Perfusion pressure Oxidative stress

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Navigating the intersection of psychiatry and ophthalmology:A comprehensive review of depression and anxiety management in glaucoma patients

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World Journal of Psychiatry 2024年第3期14卷 362-369页

作者： Prasanna Venkatesh Ramesh Arvind Kumar Morya Ashik Azad pavithra pannerselvam Aji Kunnath Devadas Sai Thaejesvi Gopalakrishnan Shruthy Vaishali Ramesh Ajanya K Aradhya Department of Glaucoma and Research Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Optometry and Visual Science Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Junior Resident Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Cataract and Refractive Surgery Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia

Glaucoma,a prevalent and debilitating eye disease,has long been associated with vision impairment and blindness.However,recent research has shed light on the often-underestimated psychological dimensions of this condition.Anxiety and depression,two pervasive psychiatric comorbidities,have been increasingly recognized among glaucoma patients.This comprehensive review aims to explore the intricate relationship between psychiatry and ophthalmology,in the context of managing depression and anxiety in glaucoma patients.By meticulously examining peer-reviewed literature,we synthesize current knowledge on the prevalence,risk factors,and underlying mechanisms of anxiety and depression in glaucoma.The evidence reveals that glaucoma patients face an elevated risk of experiencing these mood disorders.Factors such as progressive vision loss,complex medication regimens,and the fear of further visual deterioration contribute to their vulnerability.Moreover,we delve into the bidirectional relationship between glaucoma and mood disorders,shedding light on the complex interplay between ocular and emotional health.Our review investigates the implications of anxiety and depression on glaucoma management,including their potential impact on treatment adherence,disease progression,and overall quality of life.We also explore the neurobiological pathways linking glaucoma and mood disorders,providing a foundation for future research and potential therapeutic interventions.In conclusion,recognizing the psychological burden carried by glaucoma patients is essential for holistic and patient-centered care.This review underscores the pressing need for integrated approaches that bring together ophthalmological and psychiatric expertise to optimize the well-being of individuals facing the challenges of glaucoma.By addressing anxiety and depression in glaucoma care,healthcare providers can enhance the overall quality of life for these patients,ultimately leading to improved outcomes and a brighter future for those affected by this condition.This

关键词： Glaucoma Psychiatry Depression Anxiety Risk factors Bidirectional relationship

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