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Heterogeneous patterning of blood-brain barrier and adaptive myelination as renewing key in gray and white matter

Neural Regeneration Research 2024年第3期19卷 481-482页

作者： Barbara pavan Department of Neuroscience and Rehabilitation University of Ferraravia L BorsariFerraraItalyCenter for Translational Neurophysiology of Speech and Communication(CTNSC)Italian Institute of Technology(IIT)via Fossato di MortaraFerraraItaly

Background:Development and homeostasis of the brain are enabled through the precise control of the cell microenvironment by the blood-brain barrier(BBB),which interfaces between the brain parenchyma and the lumen of blood microvessels,and by the blood-cerebrospinal fluid barrier,which separates the cerebrospinal fluid from the blood vessels of the choroid plexus(Villabona-Rueda et al.,2019).Here,the focus will be on the BBB,the impairment of which is considered the earliest common denominator in neurovascular diseases.

关键词： homeostasis blood

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Review of operative considerations in spinal cord stem cell therapy

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World Journal of Stem Cells 2021年第2期13卷 168-176页

作者： pavan S Upadhyayula Joel R Martin Robert C Rennert Joseph D Ciacci Department of Neurological Surgery University of CaliforniaSan DiegoLa JollaCA 92037United States

Spinal cord injury(SCI)can permanently impair motor and sensory function and has a devastating cost to patients and the United States healthcare *** cell transplantation for treatment of SCI is a new technique aimed at creating biological functional *** techniques in stem cell transplantation for SCI are *** review various clinical treatment paradigms,surgical techniques and technical considerations important in SCI *** NCBI PubMed database was queried for“SCI”and“stem cell”with a filter placed for“clinical trials”.Thirty-nine articles resulted from the search and 29 were included and evaluated by study authors.A total of 10 articles were excluded(9 not SCI focused or transplantation focused,1 canine model).Key considerations for stem cell transplantation include method of delivery(intravenous,intrathecal,intramedullary,or excision and engraftment),time course of treatment,number of treatments and time from injury until *** are no phase III clinical trials yet,but decreased time from injury to treatment and a greater number of stem cell injections both seem to increase the chance of functional recovery.

关键词： Stem cell Spinal cord injury Operative techniques Stem cell transplantation Intramedullary

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