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Coupled bio-chemo-hydro-mechanical modeling of microbially induced calcite precipitation process considering biomass encapsulation using a micro-scale relationship

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2775-2789页

作者： pavan kumar Bhukya Nandini Adla Dali Naidu Arnepalli Department of Civil Engineering Indian Institute of Technology MadrasChennai600036Tamil NaduIndia

Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering *** ground improvement techniques require enormous mechanical effort or synthetic *** stabilization technique such as microbially induced calcite precipitation(MICP)utilizes bacterial metabolic processes to precipitate cementitious calcium *** reactive transport of biochemical species in the soil mass initiates the precipitation of biocement during the MICP *** precipitated biocement alters the hydro-mechanical performance of the soil ***,the flow,deformation,and transport phenomena regulate the biocementation technique via coupled bio-chemo-hydro-mechanical(BCHM)*** all,one crucial phenomenon controlling the precipitation mechanism is the encapsulation of biomass by calcium *** encapsulation can potentially reduce the biochemical reaction rate and decelerate *** examination of the encapsulation process demands a thorough analysis of associated coupled *** this,a numerical model can assist in capturing the coupled processes influencing encapsulation during the MICP ***,most numerical models did not consider biochemical reaction rate kinetics accounting for the influence of bacterial *** this,the current study developed a coupled BCHM model to evaluate the effect of encapsulation on the precipitated calcite content using a micro-scale semiempirical ***,the developed BCHM model was verified and validated using numerical and experimental observations of soil column ***,the encapsulation phenomenon was investigated in the soil columns of variable maximum calcite crystal *** results depict altered reaction rates due to the encapsulation phenomenon and an observable change in the precipitated calcite content for each maximum crystal ***,the permeability and defor

关键词： Biocementation process Bio-chemo-hydro-mechanical(BCHM) model Reactive transport Encapsulation Micro-scale

Advancements in non-starch polysaccharides research for frozen foods and microencapsulation of probiotics

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Frontiers of Chemical Science and Engineering 2009年第4期3卷 413-426页

作者： pavan kumar soma Patrick D.WILLIAMS Y.Martin LO Department of Nutrition and Food Science University of MarylandCollege ParkMD 20742USA

Conventionally used in the food industry as stabilizing,thickening,gelling,and suspending or dispersing agents,non-starch polysaccharides such as xanthan gum are known to improve the texture of certain frozen *** polysaccharide that has received significant attention in recent years is chitosan,a natural biopolymer derived from *** the wake of growing interest in finding ideal encapsulating agents for probiotics,non-starch polysaccharides have been *** research can be found on the effect of each individual polysaccharide,but there remains a void in the literature in terms of closely comparing the characteristics of nonstarch polysaccharides for these applications,especially when more than one biopolymer is employed.A good understanding of the tools capable of elucidating the underlying mechanisms involved is essential in ushering further development of their ***,it is this review’s intention to focus on the selection criteria of non-starch polysaccharides based on their rheological properties,resistance to harsh conditions,and ability to improve sensory quality.A variety of critical tools is also carefully examined with respect to the attainable information crucial to frozen food and microencapsulation applications.

关键词： microencapsulation xanthan galactomannan chitosan curdlan

Coupled multiphysical model for investigation of influence factors in the application of microbially induced calcite precipitation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2232-2249页

作者： Xuerui Wang pavan kumar Bhukya Dali Naidu Arnepalli Shuang Chen Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)GGmbH Braunschweig38122Germany Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India Federal Institute for Geosciences and Natural Resources(BGR) Hannover30655Germany

The study presents a comprehensive coupled thermo-bio-chemo-hydraulic(T-BCH)modeling framework for stabilizing soils using microbially induced calcite precipitation(MICP).The numerical model considers relevant multiphysics involved in MICP,such as bacterial ureolytic activities,biochemical reactions,multiphase and multicomponent transport,and alteration of the porosity and *** model incorporates multiphysical coupling effects through well-established constitutive relations that connect parameters and variables from different physical *** was implemented in the open-source finite element code OpenGeoSys(OGS),and a semi-staggered solution strategy was designed to solve the couplings,allowing for flexible model ***,the developed model can be easily adapted to simulate MICP applications in different *** numerical model was employed to analyze the effect of various factors,including temperature,injection strategies,and application ***,a TBCH modeling study was conducted on the laboratory-scale domain to analyze the effects of temperature on urease activity and precipitated calcium *** understand the scale dependency of MICP treatment,a large-scale heterogeneous domain was subjected to variable biochemical injection *** simulations conducted at the field-scale guided the selection of an injection strategy to achieve the desired type and amount of ***,the study emphasized the potential of numerical models as reliable tools for optimizing future developments in field-scale MICP *** present study demonstrates the potential of this numerical framework for designing and optimizing the MICP applications in laboratory-,prototype-,and field-scale scenarios.

关键词： Multiphysics Microbially induced calcite precipitation(MICP) Coupled thermo-bio-chemo-hydraulic(TBCH) model OpenGeoSys(OGS) Influence factors

Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies

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The Journal of Biomedical Research 2022年第1期36卷 11-19页

作者： Trupti N.Patel pavan kumar Dhanyamraju School of Biosciences and Technology Vellore Institute of TechnologyVellore CampusVelloreTamil Nadu 632014India Department of Pharmacology Penn State University College of MedicineHersheyPA 17033USA Penn State Cancer Institute HersheyPA 17033USA.

Development is a sophisticated process maintained by various signal transduction pathways,including the Hedgehog(Hh)*** important functions are executed by the Hh signaling cascade such as organogenesis,tissue regeneration,and tissue homeostasis,among various *** the multiple functions carried out by this pathway,any mutation causing aberrant Hh signaling may lead to myriad developmental abnormalities besides *** the present review article,we explored a wide range of diseases caused by aberrant Hh signaling,including developmental defects and ***,we concluded this mini-review with various treatment strategies for Hh-induced diseases.

关键词： cancer developmental anomaly hedgehog signal transduction drug treatment

Melanoma therapeutics: a literature review

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The Journal of Biomedical Research 2022年第2期36卷 77-97页

作者： pavan kumar Dhanyamraju Trupti N.Patel Department of Pediatrics and Pharmacology Pennsylvania State University College of MedicineHersheyPA 17033USA School of Biosciences and Technology Vellore Institute of TechnologyVellore CampusVelloreTamil Nadu 632014India

Melanoma is a relentless type of skin cancer which involves myriad signaling pathways which regulate many cellular *** makes melanoma difficult to treat,especially when identified *** present,therapeutics include chemotherapy,surgical resection,biochemotherapy,immunotherapy,photodynamic and targeted *** interventions are usually administered as either a single-drug or in combination,based on tumor location,stage,and patients'overall health ***,treatment efficacy generally decreases as patients develop treatment *** profiling of melanocytes and the discovery of novel molecular factors involved in the pathogenesis of melanoma have helped to identify new therapeutic *** this literature review,we examine several newly approved therapies,and briefly describe several therapies being assessed for *** goal is to provide a comprehensive overview of recent developments and to consider future directions in the field of melanoma.

关键词： cancer melanoma intervention target resistance

Mathematical Modeling and Evaluation of Reliability Parameters Based on Survival Possibilities under Uncertain Environment

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1943-1956页

作者： Alhanouf Alburaikan Hamiden Abd El-Wahed Khalifa pavan kumar SeyedaliMirjalili Ibrahim Mekawy Department of Mathematics College of Science and ArtsQassim UniversityAl-Badaya51951Saudi Arabia Department of Operations Research Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Division of Mathematics School of Advanced Science and LanguagesVIT Bhopal UniversitySehore466114India Centre for Artificial Intelligence Research and Optimization Torrens University AustraliaBrisbane4006Australia Department of Mathematics College of Science and ArtsQassim UniversityAr Rass6688Saudi Arabia YFL(Yonsei Frontier Lab) Yonsei UniversitySeoul03722Korea

In this article,mathematical modeling for the evaluation of reliability is studied using two *** of the methods,is developed based on possibility *** performance of the reliability of the system is of prime *** view of this,the outcomes for the failure are required to evaluate with utmost *** possibility theory,the reliability information data determined from decision-making experts are *** samemethod is also related to the survival possibilities as against the survival *** other method is the one that is developed using the concept of approximation of closed interval including the piecewise quadratic fuzzy *** this method,a decision-making expert is not sure of his/her estimates of the reliability *** experiments are performed to illustrate the efficiency of the suggested methods in this *** the end,the paper is concluded with some future research directions to be explored for the proposed approach.

关键词： Reliability function probabilistic function piecewise quadratic fuzzy numbers survival possibility failure rate possibility distribution state function closed interval approximation

Process-structure-property relationship for plasma-sprayed iron-based amorphous/crystalline composite coatings

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International Journal of Minerals,Metallurgy and Materials 2022年第1期29卷 144-152页

作者： Abhishek Pathak Biswajyoti Mukherjee Krishna Kant Pandey Aminul Islam pavan Bijalwan Monojit Dutta Atanu Banerjee Anup kumar Keshri Research and Development Unit Tata SteelJamshedpur 831001India Plasma Spray Coating Laboratory Metallurgical and Materials EngineeringIndian Institute of Technology PatnaBihta 801106India

This study explores the fabrication of Fe-based amorphous/crystalline coating by air plasma spraying and its dependency on the coating parameters(plasma power,primary gas flow rate,powder feed rate,and stand-off distance).X-ray diffraction of the coatings deposited at optimized spray parameters showed the presence of amorphous/crystalline *** deposited at a lower plasma power and highest gas flow rate exhibited better density,hardness,and wear *** coatings demonstrated equally good resistance against the corrosive environment(3.5wt%NaCl solution).Mechanical,wear,and tribological studies indicated that a single process parameter optimization cannot provide good coating performance;instead,all process parameters have a unique role in defining better properties for the coating by con-trolling the in-flight particle temperature and velocity profile,followed by the cooling pattern of molten droplet before impingement on the substrate.

关键词： Fe-based alloys amorphous alloys plasma spray coating mechanical corrosion and wear

3D printing of bio-instructive materials:Toward directing the cell

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Bioactive Materials 2023年第1期19卷 292-327页

作者： Piotr Stanisław Zielinski pavan kumar Reddy Gudeti Timo Rikmanspoel Małgorzata Katarzyna Włodarczyk-Biegun Polymer Science Zernike Institute for Advanced MaterialsUniversity of GroningenNijenborgh 49747 AGGroningenthe Netherlands Biotechnology Centre The Silesian University of TechnologyB.Krzywoustego 844-100GliwicePoland

Fabrication of functional scaffolds for tissue engineering and regenerative medicine applications requires material systems with precise control over cellular performance.3D printing is a powerful technique to create highly complex and multicomponent structures with well-defined architecture and *** this review paper,we explore extrusion-based 3D printing methods(EBP,i.e.,Near Field Electrospinning(NFES),Melt Electrowriting(MEW),Fused Deposition Modeling(FDM),and extrusion bioprinting)in terms of their ability to produce scaffolds with bio-instructive *** material systems provide spatio-temporal guidance for cells,allowing controlled tissue regeneration and *** physical and biochemical cues introduced to the EBP scaffolds are evaluated in their ability to direct cell alignment,proliferation,differentiation,specific ECM production,and tissue *** indicate that the cues have different impacts depending on the material system,cell type used,or coexistence of multiple ***,they must be carefully chosen based on the targeted *** propose future directions in bio-instructive materials development,including such concepts as metamaterials,hybrid living materials,and 4D *** review gathers the knowledge essential for designing new materials with a controlled cellular response,fabrication of advanced engineered tissue,and developing a better understanding of cell biology,especially in response to the biomaterial.

关键词： Tissue engineering Additive manufacturing Melt electrowriting 3D scaffold Cell differentiation Biomaterials

Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice:involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms

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Neural Regeneration Research 2022年第1期17卷 185-193页

作者： Mushfiquddin Khan Fei Qiao pavan kumar S.M.Touhidul Islam Avtar K.Singh Jeseong Won Inderjit Singh Department of Pediatrics Medical University of South CarolinaCharlestonSCUSA Department of Pathology and Laboratory Medicine Medical University of South CarolinaCharlestonSCUSA Ralph H.Johnson VA Medical Center CharlestonSCUSA

Spinal cord injury(SCI)is associated with high production and excessive accumulation of pathological 4-hydroxy-trans-2-nonenal(4-HNE),a reactive aldehyde,formed by SCI-induced metabolic dysregulation of membrane *** aldehyde load causes redox alteration,neuroinflammation,neurodegeneration,pain-like behaviors,and locomotion *** scavenging of reactive aldehydes results in limited improved motor and sensory *** this study,we targeted the activity of mitochondrial enzyme aldehyde dehydrogenase 2(ALDH2)to detoxify 4-HNE for accelerated functional recovery and improved pain-like behavior in a male mouse model of contusion SCI.N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide(Alda-1),a selective activator of ALDH2,was used as a therapeutic tool to suppress the 4-HNE *** was induced by an impactor at the T9–10 vertebral *** animals were initially treated with Alda-1 at 2 hours after injury,followed by once-daily treatment with Alda-1 for 30 consecutive *** function was evaluated by the Basso Mouse Scale,and pain-like behaviors were assessed by mechanical allodynia and thermal ***2 activity was measured by enzymatic assay.4-HNE protein adducts and enzyme/protein expression levels were determined by western blot analysis and histology/*** resulted in a sustained and prolonged overload of 4-HNE,which parallels with the decreased activity of ALDH2 and low functional ***-1 treatment of SCI decreased 4-HNE load and enhanced the activity of ALDH2 in both the acute and the chronic phases of ***,the treatment with Alda-1 reduced neuroinflammation,oxidative stress,and neuronal loss and increased adenosine 5′-triphosphate levels stimulated the neurorepair process and improved locomotor and sensory ***,the results provide evidence that enhancing the ALDH2 activity by Alda-1 treatment of SCI mice suppresses the 4-HNE load that attenuates neuroinfl

关键词： 4-hydroxy-trans-2-nonenal Alda-1 ALDH2 Basso Mouse Scale score functional recovery mitochondrial function neuroinflammation neuroprotection pain spinal cord injury