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Role of the CXCR4-SDF1-HmGB1 pathway in the directional migration of cells and regeneration of affected organs

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World Journal of Stem Cells 2020年第9期12卷 938-951页

作者： Nazmul Haque Ismail m Fareez Liew fong fong Chanchal mandal Noor Hayaty Abu Kasim Kranthi RajaKacharaju Pratiwi Soesilawati Department of Oral Biology and Biomedical Sciences Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia Biotechnology and Genetic Engineering Discipline Life ScienceKhulna UniversityKhulna 9208Bangladesh Faculty of Dentistry University Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Dental medicine Universitas AirlanggaSurabaya 411007Indonesia Department of Conservative Dentistry Faculty of Dentistry MAHSA UniversitySelangor 42610Malaysia Department of Oral Biology Faculty of Dental MedicineUniversitas AirlanggaSurabaya 60115Indonesia

In recent years,several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted *** findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor ***,this notion has also led scientists to question the role of proteins in the secretome produced by cells,tissues or organisms under certain conditions or at a particular time of regenerative *** studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected *** could also facilitate the migration of immune,progenitor and stem cells within the body to the site of *** these different paracrine factors present within the secretome,researchers have given proper consideration to stromal cell-derived factor-1(SDF1)that plays a vital role in tissue-specific migration of the cells needed for *** researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HmGB1-SDF1-CXCR4 pathways which is vital for tissue *** in this study,we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HmGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed.

关键词： C-X-C motif chemokine 12 mesenchymal stem cells monocytes Neutrophils Peripheral blood mononuclear cells Receptor for advanced glycation end products

NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice

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World Journal of Gastroenterology 2016年第46期22卷 10158-10165页

作者： fong-fong Chu R Steven Esworthy James H Doroshow Binghui Shen Department of Gastroenterology and Hepatology The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Department of Cancer Genetics and Epigenetics Beckman Research Institute of City of Hope Center for Cancer Research and Division of Cancer Treatment and Diagnosis National Cancer Institute

AIm To test whether Nox1 plays a role in typhlitis induced by Salmonella enterica serovar Typhimurium(S. Tm) in a mouse *** Eight-week-old male wild-type(WT) and Nox1 knockout(KO) C57BL6/J(B6) mice were administered metronidazole water for 4 d to make them susceptible to S. Tm infection by the oral route. The mice were given plain water and administered with 4 different doses of S. Tm by oral gavage. The mice were followed for another 4 d. From the time of the metronidazole application, the mice were observed twice daily and weighed daily. The ileum, cecum and colon were removed for sampling at the fourth day post-inoculation. Portions of all three tissues were fixed for histology and placed in RNAlater for m RNA/c DNA preparation and quantitative real-time PCR. The contents of the cecum were recovered for estimation of S. Tm *** We found Nox1-knockout(Nox1-KO) mice were not more sensitive to S. Tm colonization and infection than WT B6 mice. This conclusion is based on the following observations:(1) S. Tm-infection induced similar weight loss in Nox1-KO mice compared to WT mice;(2) the same S. Tm CFU was recovered from the cecal content of Nox1-KO and WT mice regardless of the inoculation dose, except the lowest inoculation dose(2 × 106 CFU) for which the Nox1-KO had one-log lower CFU than WT mice;(3) there is no difference in cecal pathology between WT and Nox1-KO groups; and(4) there are no S. Tm infection-induced changes in gene expression levels(IL-1b, TNF-α, and Duox2) between WT and Nox1-KO groups. The Alpi gene expression was more suppressed by S. Tm treatment in WT than the Nox1-KO cecum. CONCLUSION Nox1 does not protect mice from S. Tm colonization. Nox1-KO provides a very minor protective effect against S. Tm infection. Using NOX1-specific inhibitors for colitis therapy should not increase risks in bacterial infection.

关键词：猛烈老鼠 NADPH Oxidase-1 沙门氏菌 typhimurium 离脚玻璃杯或瓷杯房间反应的氧种类

Resection with limb salvage in an Asian male adolescent withEwing’s sarcoma: A case report

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World Journal of Clinical Cases 2022年第22期10卷 7960-7967页

作者： Chien-Ying Lai Kuan-Ju Chen Tsung-Yu Ho Ling-Yi Li Chien-Chung Kuo Hsien-Te Chen Yi-Chin fong Department of Orthopedic Surgery China Medical University HospitalTaichung 404Taiwan Spine Center China Medical University HospitalTaichung 404Taiwan School of medicine China Medical UniversityTaichung 404Taiwan

BACKGROUNDEwing’s sarcoma is a highly malignant primary bone tumor that commonly affectschildren. For young patients, multidisciplinary treatment and limb salvage arerecommended, and surgical plans considering the growth potential and boneactivity after tumor resection are *** SUmmARYAn 11-year-old Asian boy had a 1-mo history of a right-sided limping *** revealed a proximal tumor with bone destruction and physealinvolvement over the right femoral neck. He was diagnosed with stage IV(T1N0m1aG3) Ewing’s sarcoma with bilateral lung metastases. Neoadjuvantchemotherapy decreased the tumor size and confined it to the metaphysealregion. The patient underwent four stages of surgery: wide tumor excision plusreconstruction with vascular fibular bone graft plus internal fixation;repeat openreduction and internal fixation;femoral lengthening with orthosis after physealmaturity;and orthosis removal and bone elongation (approximately 6 cm).Following surgery, he could walk without discomfort and had almost equal-sizedbilateral femoral heads, indicating physis preservation. The surgery wassuccessful, and normal femoral head growth was achieved after completeremission. The patient was able to resume normal activities with equal length ofthe bilateral lower *** treatment and reconstruction following resection are important in skeletally immature patients with Ewing’s sarcoma to improve quality of life.

关键词： Ewing’s sarcoma Lower limb discrepancy Orthosis Vascular fibular graft Reconstruction Case report

Prospective evaluation of ^(18)F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 539-554页

作者： Tim Akhurst mithat Gönen Raymond E.Baser Lawrence H.Schwartz Scott Tuorto Lynn A.Brody Anne Covey Karen T.Brown Steven m.Larson Yuman fong Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Peter macCallum Cancer Centre VictoriaAustralia Department of Epidemiology and Biostatistics Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic ***:The current study is a prospective,blinded study comparing utility of[18F]2-fluoro-2-deoxyglucose positron emission tomography(18F-FDG-PET)to computed tomography(CT)and CT arterial portography(CTAP)as preoperative ***:The 125 planned subjects were *** seen on FDG-PET alone changed therapy for 23 of 125 patients(18%).FDG-PET confirmed other radiologic findings in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDG-PET was the most sensitive diagnostic imaging test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%*** the 28 cases of unresectable disease due to extrahepatic disease,FDG-PET findings solely changed therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDG-PET did not solely change therapy in ***,FDG-PET had the lowest sensitivity for hepatic sites compared with CT or *** particular,small(m)liver tumors were particularly poorly detected by *** area under the receiver operating characteristic(ROC)curve for small tumors was 0.58 and for patients on chemotherapy it was 0.66,a modest improvement over no ***:FDG-PET is an important test for preoperative staging of patients with hepatic colorectal metastases,affecting treatment decisions in nearly one-third of *** high yield is due mainly to detection of extrahepatic *** is therefore recommended in patients with extrahepatic lesions suspected to be disseminated cancer or those with high risk for extrahepatic *** is not a good test for identification of small tumors in the liver.

关键词： Positron emission tomography(PET) computed tomography(CT) colorectal hepatic metastases surgery

High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization

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Light(Science & Applications) 2018年第1期7卷 103-114页

作者： Wei Zhang Yanxiu Li Van Phuc Nguyen Ziyi Huang Zhipeng Liu Xueding Wang Yannis m.paulus Department of Biomedical Engineering University of MichiganAnn ArborMI 48105USA Institution of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China Department of Ophthalmology and Visual Sciences University of MichiganAnn ArborMI 48105USA Department of Ophthalmology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Radiology University of MichiganAnn ArborMI 48105USA

Photoacoustic microscopy(PAm)is an emerging imaging technology that can non-invasively visualize ocular structures in animal *** report describes an integrated multimodality imaging system that combines PAm,optical coherence tomography(OCT),and fluorescence microscopy(Fm)to evaluate angiogenesis in larger animal ***-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor(VEGF)-induced retinal neovascularization(RNV).The results demonstrate that our multimodality imaging system can noninvasively visualize RNV in both albino and pigmented rabbits to determine retinal pathology using PAm and OCT and verify the leakage of neovascularization using Fm and fluorescein *** work presents high-resolution visualization of angiogenesis in rabbits using a multimodality PAm,OCT,and Fm system and may represent a major step toward the clinical translation of the technology.

关键词： rabbit vivo resolution

meat juice contributes to the stability of ethanol adaptation in Salmonella enterica serovar Enteritidis

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Food Quality and Safety 2021年第3期5卷 291-296页

作者：何守魁 Karen fong 王思运史贤明 mOST-USDA Joint Research Center for Food Safety School of Agriculture and BiologyState Key Lab of Microbial MetabolismShanghai Jiao Tong UniversityShanghaiChina Food Nutrition and HealthFaculty of Land and Food SystemsThe University of British ColumbiaVancouverBCCanada

Stability assessme nt of observed tolerance phe no types is integral in un dersta nding stress adaptati on in food-borne ***,the current work was carried out to determine whether ethanol adaptation induced by exposure to 5 percent ethanol for 60 min is a stable phenomenon in Salmonella enterica serovar *** capacity of Salmonella Enteritidis(***)to maintain the acquired ethanol adaptation in the absenee of sublethal ethanol stress was investigated at 37℃,25℃ or 4℃ in Luria-Bertani broth and two types of meat *** was found that ethanol adaptation was completely reversed within 40 min at 37℃ or within 60 min at 25℃,but was stable at 4℃ for at least 48 h in the broth *** adaptation was retained in chicken juice during 60-min incubation at 25℃ or 48h incubation at 4℃.moreover,exposure to pork juice stored at either 25℃ or 4℃ sigrdficantly(Pmeat juices should be take n into acco unt whe n con ducting a comprehensive risk analysis during food processing.

关键词： Salmonella Enteritidis ethanol adaptation stability temperature meat juice.

On rotational normal modes of the Earth：Resonance,excitation,convolution, deconvolution and all that

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Geodesy and Geodynamics 2017年第6期8卷 371-376页

作者： Benjamin fong Chao Institure of Earth Sciences Academia Sinica Taipei Taiwan China

Earth＇s Coriolis force profoundly alters the eigen frequencies, eigen functions, and excitation of rotational normal modes. Some rotational modes of the solid mantle-fluid outer core-solid inner core Earth system are confirmed observationally and some remain elusive. Here we bring together from literature assertions about an excited resonance system in terms of the Green＇s function and temporal convolution. We raise caveats against taking the face values of the oscillational motion which have been ＂masqueraded＂ by the convolution, necessitating deconvolution for retrieving the excitation function which reflects the true variability. Lastly we exemplify successful applications of the deconvolution in estimating resonance complex frequencies.

关键词： Rotational modes Resonance Excitation Convolution Deconvolution

Antidiabetic profiling of veramycins,polyketides accessible by biosynthesis,chemical synthesis and precursor-directed modification

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Organic Chemistry Frontiers 2022年第6期9卷 1604-1615页

作者： Denis Dardić Nils Böhringer Alberto Plaza Florian Zubeil Juliane Pohl Svenja Sommer Leo Padva Jonathan Becker maria A.Patras mona-Katharina Bill michael Kurz Luigi Toti Sven W.Görgens Sören m.m.Schuler AndréBillion Oliver Schwengers paulus Wohlfart Alexander Goesmann Norbert Tennagels Andreas Vilcinskas Peter E.Hammann Till F.Schäberle Armin Bauer Fraunhofer Institute for molecular Biology and Applied Ecology(ImE) Branch for Bioresources35392 GießenGermany Justus-Liebig-University Gießen 35392 GießenGermany Sanofi-Aventis Deutschland GmbH R&D Integrated Drug Discovery65926 Frankfurt am MainGermany Sanofi-Aventis Deutschland GmbH R&D German Hub65926 Frankfurt am MainGermany German Center of Infection Research(DZIF) Partner Site Gießen-Marburg-Langen35392 GießenGermany

Seven new polyketides,termed veramycins,were isolated from a Streptomyces *** the Sanofi microbial strain collection along with their known congeners NFAT-133 and *** A,anα-pyrone congener of Tm-123 and NFAT-133 showed an increased baseline deoxy-glucose uptake in the absence of insulin in a modified L6 rat skeletal muscle cell line(L6 GLUT4 AS160-like cells).In addition,both compounds slightly increased the sensitivity to insulin in this cell *** syntheses of NFAT-133,Tm-123 and veramycin A were accomplished starting from a central building block,which bears the three contiguous stereogenic centers of this polyketide *** approach enables an efficient,selective and flexible access to all possible isomers of the stereotriad for further exploration of this series as a potential anti-diabetic lead structure as exemplified by the synthesis of an NFAT-133 ***,the corresponding biosynthetic gene cluster(BGC)was identified by genome sequencing and gene *** on feeding experiments,a biosynthetic pathway was proposed,which enabled access to new veramycin A analogs by precursor-directed biosynthesis.

关键词： synthesis directed isomers

Activating coordinative conjugated polymer via interfacial electron transfer for efficient CO_(2) electroreduction

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能源化学:英文版 2023年第8期83卷 313-323,I0009页

作者： Jing Zhang Jia-Jun Dai De-Quan Cao Heng Xu Xing-Yu Ding Chun-Hua Zhen Beate paulus Jin-Yu Ye Qian Liang Jun-Ke Liu Shi-Jun Xie Sai-Sai Deng Zhen Wang Jun-Tao Li Yao Zhou Shi-Gang Sun College of Energy XiamenUniversityXiamen 361005FujianChina College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005FujianChina Institute of Chemistry and Biochemistry Freie Universitat BerlinArnimallee 2214195 BerlinGermany

With tunable local electronic environment,high mass density of mN4sites,and ease of preparation,metal-organic conjugated coordinative polymer(CCP) with inherent electronic conductivity provides a promising alternative to the well-known m-N-C ***,the coordination reaction between Cu^(2+)and 1,2,4,5-tetraaminobenzene(TAB) was conducted on the surface of metallic Cu nanowires,forming a thin layer of CuN4-based CCP(Cu-TAB) on the Cu *** importantly,interfacial transfer of electrons from Cu core to the CuN4-based CCP nanoshell was observed within the resulting CuTAB@Cu,which was found to enrich the local electronic density of the *** such,the CuTAB@Cu demonstrates much improved affinity to the*COOH intermediate formed from the rate determining step;the energy barrier for C-C coupling,which is critical to convert CO_(2)into C2products,is also ***,it delivers a current density of-9.1 mA cm^(-2)at a potential as high as 0.558 V(***) in H-type cell and a Faraday efficiency of 46.4% for *** work emphasizes the profound role of interfacial interaction in tuning the local electronic structure and activating the CuN4-based CCPs for efficient electroreduction of CO_(2).

关键词： metal-organic solid compounds Conjugated coordinative polymer Solid-solid interfacial electron transfer mN_(4)sites Electrocatalysis