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Cell Research 2006年第5期16卷 479-488页

作者： paulus m fong Z Jeffrey Chen Department of Soil and Crop Sciences Texas A&M UniversityCollege StationTX 77843USA molecular Cell and Developmental Biology University of Texas at AustinAustinTX78712USA

Arabidopsis thaliana histone deacetylase 1 (AtHD1 or AtHDA19),a homolog of yeast RPD3,is a global regulator ofmany physiological and developmental processes in *** spite of the genetic evidence for a role of AtHD1 in plantgene regulation and development,the biochemical and cellular properties of AtHD1 are poorly *** we reportcellular localization patterns of AtHD1 in vivo and histone deacetylase activity in *** transient and stable expres-sion of a green fluorescent protein (GFP)-tagged AtHD1 in onion cells and in roots,seeds and leaves of the transgenicArabidopsis,respectively,revealed that AtHD1 is localized in the nucleus presumably in the euchromatic regions andexcluded from the *** localization patterns of AtHD1 are different from those of AtHD2 and AtHDA6 thatare involved in nucleolus formation and silencing of transgenes and repeated DNA elements,*** addition,a histone deacetylase activity assay showed that the recombinant AtHD1 produced in bacteria demonstrated a specifichistone deacetylase activity in *** data suggest that AtHD1 is a nuclear protein and possesses histone deacetylaseactivities responsible for global transcriptional regulation important to plant growth and development.

关键词： Arabidopsis histone deacetylase RPD3 subcellular localization gene silencing chromatin

Unknown DDoS Attack Detection with Fuzzy C-means Clustering and Spatial Location Constraint Prototype Loss

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Computers, materials & Continua 2024年第2期78卷 2181-2205页

作者： Thanh-Lam Nguyen HaoKao Thanh-Tuan Nguyen mong-fong Horng Chin-Shiuh Shieh Department of Electronic Engineering National Kaohsiung University of Science and TechnologyKaohsiung807618Taiwan Department of Electronic and Automation Engineering Nha Trang UniversityNha Trang650000Vietnam

Since its inception,the Internet has been rapidly *** the advancement of science and technology and the explosive growth of the population,the demand for the Internet has been on the *** applications in education,healthcare,entertainment,science,and more are being increasingly deployed based on the ***,malicious threats on the internet are on the rise as *** Denial of Service(DDoS)attacks are among the most common and dangerous threats on the internet *** scale and complexity of DDoS attacks are constantly *** Detection Systems(IDS)have been deployed and have demonstrated their effectiveness in defense against those *** addition,the research of machine Learning(mL)and Deep Learning(DL)in IDS has gained effective results and significant ***,one of the challenges when applying mL and DL techniques in intrusion detection is the identification of unknown *** attacks,which are not encountered during the system’s training,can lead to misclassification with significant *** this research,we focused on addressing the issue of Unknown Attack Detection,combining two methods:Spatial Location Constraint Prototype Loss(SLCPL)and Fuzzy C-means(FCm).With the proposed method,we achieved promising results compared to traditional *** proposed method demonstrates a very high accuracy of up to 99.8%with a low false positive rate for known attacks on the Intrusion Detection Evaluation Dataset(CICIDS2017)***,the accuracy is also very high,reaching 99.7%,and the precision goes up to 99.9%for unknown DDoS attacks on the DDoS Evaluation Dataset(CICDDoS2019)*** success of the proposed method is due to the combination of SLCPL,an advanced Open-Set Recognition(OSR)technique,and FCm,a traditional yet highly applicable clustering *** has yielded a novel method in the field of unknown attack *** further expands the trend of applying DL and m

关键词： Cybersecurity DDoS unknown attack detection machine learning deep learning incremental learning convolutional neural networks(CNN) open-set recognition(OSR) spatial location constraint prototype loss fuzzy c-means CICIDS2017 CICDDoS2019

Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in malaysia

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Asian Pacific Journal of Tropical medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim Chua Clement Heng Yew fong Ban Hao Brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao m.Kandiah Faculty of medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(Pmer smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(Pmoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(Pmportance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART middle-aged Lifestyle Physical activity Psychosocial stress

Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet Gauhar Khi Yung fong mario Sofer moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay mahajan mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman Gadzhiev mohammed Taif Bendigeri Jeremy Yuen-Chun Teoh marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(mUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,Pmonths,the overall rate ofincontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/mUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia michael J.Bannon Irma Alicia martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo minerva maldonado-Berny mE Gutierrez-Castillo Armando J.Espadas-Alvarez manuel A.Fernandez-Parrilla Juan U.mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel martinez-fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red mEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

A lateral ankle sprain during a lateral backward step in badminton:A case report of a televised injury incident

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Journal of Sport and Health Science 2023年第1期12卷 139-144页

作者： Daniel T.P.fong Kam-ming mok Isobel m.Thompson Yuehang Wang Wei Shan mark A.King National Centre for Sport and Exercise medicine School of SportExercise and Health SciencesLoughborough UniversityLoughboroughLE113TUUK Office of Student Affairs Lingnan UniversityHong Kong 999077China Department of Orthopaedics and Traumatology Prince of Wales HospitalFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China China Institute of Sport and Health Science Beijing Sport UniversityBeijing 100084China

Background:This study presents a kinematic analysis of an acute lateral ankle sprain incurred during a televised badminton *** kinematics of this injury were compared to those of 19 previously reported cases in the published ***:Four camera views of an acute lateral ankle sprain incurred during a televised badminton match were synchronized and rendered in3-dimensional animation software.A badminton court with known dimensions was built in a virtual environment,and a skeletal model scaled to the inj ured athlete’s height was used for skeletal *** ankle joint angle and angular velocity profiles of this acute injury were compared to the summarized findings from 19 previously reported cases in the published ***:At foot strike,the ankle joint was 2° everted,33° plantarflexed,and 18° internally *** inversion of 114° and internal rotation of 69° was achieved at 0.24 s and 0.20 s after foot strike,*** the foot strike,the ankle joint moved from an initial position of plantarflexion to dorsiflexion-from 33° plantarflexion to 53° dorsiflexion(range=86°).maximum inversion,dorsiflexion,and internal rotation angular velocity were 1262°/s,961°/s,and 677°/s,respectively,at 0.12 s after foot ***:A forefoot landing posture with a plantarflexed and internally rotated ankle joint configuration could incite an acute lateral ankle sprain injury in *** of lateral ankle sprains in badminton should focus on the control and stability of the ankle joint angle during forefoot landings,especially when the athletes perform a combined lateral and backward step.

关键词： Ankle Biomechanics Injury prevention Ligament injuries Sports medicine

Sequence-sorted redox-switchable hetero[3]rotaxanes

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Organic Chemistry Frontiers 2022年第1期9卷 64-74页

作者： marius Gaedke Henrik Hupatz Felix Witte Susanne m.Rupf Clara Douglas Hendrik V.Schröder Lukas Fischer moritz malischewski Beate paulus Christoph A.Schalley Institut für Chemie und Biochemie der Freien Universität Berlin Arnimallee 2014195 BerlinGermany Institut für Chemie und Biochemie der Freien Universität Berlin Arnimallee 2214195 BerlinGermany Institut für Chemie und Biochemie der Freien Universität Berlin Fabeckstr.34/3614195 BerlinGermany

From a library of five crown ether macrocycles with different ring sizes and redox-active moieties,such as tetrathiafulvalene(TTF)and naphthalene dimiide(NDI),directional heterocircuit[3]rotaxanes were *** an axle with two binding sites with different steric accessibility,the concept of integrative self-sorting was applied to program the sequence of functional units in heteropseudo[3]*** on binding strength and ring size of the smaller macrocycles,different heteropseudo[3]rotaxane selectivities and stabilities were determined by 2D NmR spectroscopy and tandem mass spectrometry.A heteropseudo[3]rotaxane with rotaxane-like behaviour was isolated chromatographically,displaying electrochemically“frustrated”properties.A robust synthetic procedure was developed allowing the synthesis of four new hetero[3]rotaxanes incorporating specific sequences of functional *** pseudoisomeric rotaxanes which have the naphthalene diimide subunit at two different positions show distinct electrochemical *** calculations suggest that this differences could arise from a folding of the structure,in which the redox-active moieties stack with a stopper *** study presents a blueprint for the construction of hetero[3]rotaxanes with sequential control of the functional units along the track of the axle and paves the way to extend the functionality of mechanically interlocked molecules.

关键词： properties redox Sequence

Genetics in medical school curriculum:A look at the University of Rochester School of medicine and Dentistry

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第1期9卷 10-15页

作者： Deanne m. ROBINSON Chin-To fong Department of Pediatrics University of Rochester School of Medicine and DentistryRochesterNY 14642USA

Genetics is assuming an increasingly important role in medicine. As a result,the teaching of genetics should also be increased proportionally to ensure that future physicians will be able to take advantage of the new genetic technology,and to understand the associated ethical,legal and social issues. At the University of Rochester School of medicine and Dentistry,we have been able to incorporate genetic education into a four-year medical curriculum in a fully integrated fashion. This model may serve as a template for other medical curriculum still in development.

关键词：遗传学高等教育医学教学课程改革罗彻斯特大学

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砂土地层圆形深基坑三维分析与测斜仪测量

岩土力学 2023年第4期44卷 1142-1152页

作者： HANIFAH Hermil Rizki RAHARDJO paulus Pramono LIm Aswin 万隆天主教大学土木工程系印度尼西亚万隆40141

介绍了铁皮坑开挖中测斜仪监测和三维有限元反分析的结果。所研究的铁皮坑为深度27 m、总直径26 m的圆形深基坑,最终开挖面以上土层以砂土为主。每个开挖阶段采用腰梁加固的咬合桩作为挡土墙对基坑进行支护。采用硬化土模型作为土体本... 详细信息

介绍了铁皮坑开挖中测斜仪监测和三维有限元反分析的结果。所研究的铁皮坑为深度27 m、总直径26 m的圆形深基坑,最终开挖面以上土层以砂土为主。每个开挖阶段采用腰梁加固的咬合桩作为挡土墙对基坑进行支护。采用硬化土模型作为土体本构模型,反分析结果表明,桩墙位移的趋势与测斜仪测量的结果接近,最大位移为5.1mm。案例中胶结土的有效黏聚力c′取决于胶结砂层的厚度,约为50~200kPa。NSPT为标准贯入试验中分离式取样器打入土体30cm的锤击数。模拟结果表明,砂土模量约为1 400NSPT~2 000NSPT(单位:k Pa),而对于胶结砂,其模量为7 000NSPT。还研究了腰梁和外部荷载对咬合桩变形和受力的影响。结果表明,外部荷载对桩墙位移具有主导作用;同时,腰梁对减少桩墙位移没有明显作用。

关键词：圆形深基坑测斜仪反分析胶结砂三维有限元

Adsorption Isotherm Study of Activated Fruit Peels for Copper Removal

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Journal of Harbin Institute of Technology(New Series) 2022年第3期29卷 93-100页

作者： S.Y.Tai L.L.fong m.K.Chan P.K.Bullar Centre for Water Research Faculty of EngineeringBuilt Environment and Information TechnologySEGi University Sdn BhdPetaling Jaya 47810SelangorMalaysia

Heavy metal polluted water threatens the integrity of *** use of agricultural waste as adsorbent becomes popular due to its biodegradability and ***,limited research works has been done to process agricultural waste for heavy metal adsorption *** objective of this study is to propose a new approach to treat banana peel using ZnCl_(2) prior to alkali and acid treatment and explore the potential of dragon fruit peels as the adsorbent for Cu^(2+)*** adsorption isotherm was adopted to identify the adsorption mechanism and four statistical parameters were calculated for model verification *** experiment was conducted by dispersing ZnCl_(2) treated and untreated adsorbents into Cu^(2+) *** showed that ZnCl_(2) treated adsorbents performed better in terms of Cu^(2+) removal compared with untreated adsorbents due to higher surface area for Cu^(2+) *** treated banana peel(Act.-B)performed approximately 30%better than the treated dragon fruit peel(Act.-D)due to the presence of hydroxyl and carboxyl *** equilibrium adsorptive capacity of Act.-B was 1872.8 mg Cu^(2+)/g and the experimental data fitted Freundlich isotherm well with R^(2)=0.9978,0.0161 of residual sum of error(SSE),0.0068 of χ^(2),and 0.0567 of root mean square error(RmSE)*** suggests non⁃linear adsorption and multilayer adsorption on heterogenous ***,it is recommended to further improve the surface properties of Act.-B by steam pyrolysis and surface modification.

关键词： banana peel adsorbents dragon fruit peel adsorbents copper FTIR isotherm