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Kaphta:Text mining web tool to extract information on the anticancer activity of polyphenols

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Journal of Polyphenols 2022年第2期4卷 87-100页

作者： Ramon Gustavo Teodoro Marques da Silva Samuel Lucas Santos Gomes paulo muniz deávila Gustavo Joséda Silva Ana Lucia Fachin Edilson Carlos Caritá Mozart Marins Biotechnology Unit University of Ribeirão PretoAv.Costábile Romano 2201Ribeirão PretoSP 14096-900Brazil Federal Institute of Education Science and Technology of South of Minas Gerais–IFSULDEMINASPouso AlegreMG 37550-000Brazil Medicine School University of Ribeirão PretoRibeirão PretoSP 14096-900Brazil Centro de Ciências Exatas Naturais e TecnológicasUniversidade de Ribeirão PretoRibeirão Preto SP 14096-900Brazil

In this paper,we describe the application of Kaphta architecture,a resource for text mining of the anticancer activity of *** anticancer activity of these compounds against different types of cancer has been widely reported in the literature and they are one of the most promising molecules for the development of anticancer *** architecture,which comprises four sequential and well-defined steps,uses a hybrid approach composed of a dictionary,rules and machine learning to identify abstracts containing sentences with associations between polyphenol,cancer and gene *** application of the architecture on 23826 PubMed abstracts generated a knowledge base of indexed abstracts with 172169 sentences containing,polyphenol-cancer and polyphenol-gene associations.A Web tool was implemented that allowed the user to search for information on 2006 polyphenols,240 cancers and 3121 genes entities,and 11750 polyphenol-cancer and 9160 polyphenol-gene associations indexed in the knowledge base.A ranking algorithm calculates scores for each indexed abstract considering the number and type of sentences with entities and rules recognized.A test with users demonstrated that the visualization resources on the web tool contributes to the understanding of the association between polyphenols,genes and cancers,in comparison with the PubMed *** Kaphta architecture and web tool permits to extract knowledge on the anticancer activity of polyphenols and can thus contribute to the exploration of these molecules in the development of anticancer therapies.

关键词： polyphenols cancer text-mining

Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh Vivek Gupta Yuyi You Joao A.paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases:new perspectives

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Neural Regeneration Research 2021年第12期16卷 2425-2426页

作者： Gustavo de Bem Silveira Alexandre Pastoris Muller Ricardo Andrez Machado-de-Ávila paulo Cesar Lock Silveira Laboratory of Experimental Pathophysiology Graduate Program in Health SciencesUniversidade do Extremo Sul CatarinenseCriciúmaSCBrazil Programa de Pós Graduação em Farmacologia UFSCFlorianópolisSCBrazil

Various conditions affecting nerve cells and the nervous system due to the loss of neurons and their connecting networks are described under the superordinate phrase“Neurodegenerative diseases”.Such diseases lead to disability due to gradual neuronal death in both the central nervous system and the peripheral nervous *** many of these diseases have unknown causes,sometimes these are due to medical conditions such as alcoholism,a tumor,or a stroke,or other causes which may include genetic mutations,toxins,chemicals,and viruses.

关键词： diseases degenerative treatment

Rainfall erosivity and erosivity density through rainfall synthetic series for Sao paulo State,Brazil:Assessment,regionalization and modeling

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International Soil and Water Conservation Research 2022年第3期10卷 355-370页

作者： David Bruno de Sousa Teixeira Roberto Avelino Cecílio Joao paulo Bestete de Oliveira Laura Thebit de Almeida Gabrielle Ferreira Pires department of Agricultural Engineering Federal University of ViçosaViçosaMG36570-900Brazil department of Forest and Wood Sciences Federal University of Espírito SantoJer^onimo MonteiroES29550-000Brazil Federal Institute of Espírito Santo Campus AlegreAlegreES29520-000Brazil

Rainfall is the main cause of erosion of Brazilian soils,which makes assessing the rainfall erosivity factor(RE)and the erosivity density(ED)fundamental for soil and water ***,the objectives of this study were:i)to estimate the RE and ED for Sao paulo State,Brazil,using synthetic series of pluviographic data;ii)to define homogeneous regions regarding rainfall erosivity;and iii)to generate regression models for rainfall erosivity estimates in each of the homogeneous *** series of pluviographic data were initially obtained on a sub-daily scale from the daily rainfall records of 696 rainfall *** RE values were then estimated from the synthetic rainfall data,and ED was calculated from the relationship between erosivity and rainfall *** and annual maps for RE and ED were *** clustering analysis was used to define homogeneous regions in terms of rainfall erosivity,and regionalized regression models for estimating RE were *** results demonstrate high spatial variability of RE in Sao paulo,where the highest annual values were observed in the coastal *** to March concentrate approximately 60%of the intra-annual *** highest values of annual ED were observed in regions with intense agricultural *** definition of five homogeneous regions concerning the rainfall erosive potential evidenced distinct seasonal patterns of the spatial distribution of ***,the high predictive accuracy of the regionalized models obtained characterizes them as essential tools for reliable estimates of rainfall erosivity,and contribute to better soil conservation planning.

关键词： Soil erosion Stochastic weather generator Homogeneous regions Modified Fournier index Regression models

Advances in gastric cancer research will light the way to control this cancer

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Chinese Journal of Cancer Research 2022年第6期34卷 575-578页

作者： paulo Pimentel de Assumpcao Rommel Rodrigues Burbano Universidade Federal do Para Nucleo de Pesquisas em OncologiaBelem-Para-Brasil 66075-110Brazil Hospital Ophir Loyola Laboratorio de Biologia MoleculaBelém-Para-Brasil 66063-240Brazil

Gastric adenocarcinoma(GC)is one of the most heterogeneous cancers,posing challenges to wide applications of the discoveries when compared to other ***,the benefits of research in the fight against GC are extraordinary,and even taking in mind the immense complexity of this disease,optimism is a great message to take *** advances in GC research will pave the way for GC effective control,helping to save lives,together with permitting sustainable real-life support for those needing complex and high-expense interventions.

关键词： Gastric cancer research innovations

Communicating with the non-dominant hemisphere:Implications for neurological rehabilitation

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Neural Regeneration Research 2013年第13期8卷 1236-1246页

作者： Fabricio Ferreira de Oliveira Sheilla de Medeiros Correia Marin paulo Henrique Ferreira Bertolucci department of Neurology and Neurosurgery Escola Paulista de Medicina Federal University of So Paulo (UNIFESP) So Paulo SP

Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language tasks are undertaken. Mechanisms of language recovery after brain injury to the dominant hemisphere seem to be relatively stereotyped, including activations of perilesional areas in the acute phase and of homologues of language areas in the non-dominant hemisphere in the subacute phase, later returning to dominant hemisphere activation in the chronic phase. Plasticity mechanisms reopen the critical period of language development, more specifically in what leads to disinhibition of the non-dominant hemisphere when brain lesions affect the dominant hemisphere. The non-dominant hemisphere plays an important role during recovery from aphasia, but currently available rehabilitation therapies have shown limited results for efficient language improvement. Large-scale randomized controlled trials that evaluate well-defined interventions in patients with aphasia are needed for stimulation of neuroplasticity mechanisms that enhance the role of the non-dominant hemisphere for language recovery. Ineffective treatment approaches should be replaced by more promising ones and the latter should be evaluated for proper application. The data generated by such studies could substantiate evidence-based rehabilitation strategies for patients with aphasia.

关键词： neural regeneration reviews linguistics aphasia language speech non-dominant hemisphere disability evaluation prognosis cerebrum function grants-supported paper neuroregeneration

Chronic hepatitis C genotype 1 virus:Who should wait for treatment?

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World Journal of Gastroenterology 2014年第11期20卷 2867-2875页

作者： Cristiane Valle Tovo Angelo Alves de Mattos paulo Roberto Lerias de Almeida department of Gastroenterology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90430-080Brasil department of Gastroenterology Hospital Nossa Senhora da Concei??oPorto Alegre 91350-200Brasil

Elucidation of the natural history of chronic hepatitis C (CHC) and the identification of risk factors for its progression to advanced liver disease have allowed many physicians to recommend deferral treatment (triple therapy) in favour of waiting for new drug availability for patients who are at low risk of progression to significant liver disease. Newer generation drugs are currently under development, and are expected to feature improved efficacy and safety profiles, as well as less complex and shorter duration delivery regimens, compared to the current standards of care. In addition, patients with cirrhosis and prior null responders have a low rate (around 15%) of achieving sustained virological response (SVR) with triple therapy, and physicians must also consider the decision to wait for new treatments in the future for these patients as well. Naïve patients are the most likely to achieve a close to 100% SVR rate; therefore, it may be advisable to recommend that patients with mild to moderate CHC should wait for the newer therapy options. In contrast, patients with advanced fibrosis and cirrhosis will be those with the greatest need for expedited therapeutic intervention. There remains a need, however, for establishing definitive clinical management guidelines to maximize the benefit of waiting for new drugs and minimize risk of side effects and non-response to the current triple therapy.

关键词： Hepatitis C virus Chronic hepatitis C Treatment of hepatitis C Cirrhosis Protease inhibitors

Indicators to the Consumption of Electric Energy and Agriculture Cattle Farming Production for the Elaboration of Clusters with Cities of the State of S^o paulo, Brazil

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Journal of Agricultural Science and Technology(A) 2012年第8期2卷 944-951页

作者： paulo Andre de Oliveira Elias Jose Simon department of Agribusiness Faculty of Technology Paula Souza Center Botucatu S6o Paulo 18606-855 Brazil department of Agribusiness Management and Technology Sao Paulo State University Botueatu S6o Paulo 186010-307 Brazil

The issue in this matter is that rules for use of electricity in rural areas are limited to the provision of inputs. Adopting guidelines to consider managed sub regions can generate poor results. The focus of this study was to present parameters for indicators of electric energy and agricultural production to allow the formation of city groups in Sao paulo State, Brazil, with similar electric energy consumption and rural agricultural production. The methodology was the development of indicators that characterize the electric energy consumption/agricultural production and the preparation of groups using indicators with ward of statistical method of groups. The main conclusions were the formation of six homogeneous groups with similar characteristics regarding agricultural production/consumption of electricity. The application of these groups in cities with similar characteristics would produce more satisfactory results than the division of administrative Rural development Offices （RDO）.

关键词： Clusters indicators productive energy.

Presence of c.3956del C mutation in familial adenomatous polyposis patients from Brazil

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World Journal of Gastroenterology 2015年第31期21卷 9413-9419页

作者： Caroline Aquino Moreira-Nunes Diego di Felipe ávila Alcantara Sérgio Figueiredo Lima-Júnior Sandro Roberto de Araújo Cavalléro Juan Antonio Rey Giovanny Reboucas Pinto paulo Pimentel de Assumpcao Rommel Rodriguez Burbano Biological Science Institute Federal University of Pará Nucleus of Research in Oncology Federal University of Pará Molecular Neuro-oncogenetics Laboratory Research Unit-Unidad de InvestigaciónHospital Universitario La Paz Genetics and Molecular Biology Laboratory Federal University of Piaui

AIM: To characterize APC gene mutations and correlate them with patient phenotypes in individuals diagnosed with familial adenomatous polyposis(FAP) in northern Brazil. METHODS: A total of 15 individuals diagnosed with FAP from 5 different families from the north of Brazil were analyzed in this study. In addition to patients with histopathological diagnosis of FAP,family members who had not developed the disease were also tested in order to identify mutations and for possible genetic counseling. All analyzed patients or their guardians signed a consent form approved by the Research Ethics Committee of the Jo?o de Barros Barreto University Hospital(Belem,Brazil). DNA extracted from the peripheral blood of a member of each of the affected families was subjected to direct sequencing. The proband of each family was sequenced to identify germline mutations using the Ion Torrent platform. To validate the detected mutations,Sanger sequencing was also performed. The samples from all patients were also tested for the identification of mutations by real-time quantitative polymerase chain reaction using the amplification refractory mutation system. RESULTS: Through interviews with relatives and a search of medical records,it was possible to construct genograms for three of the five families included in the study. All 15 patients from the five families with FAP exhibited mutations in the APC gene,and all mutations were detected in exon 15 of the APC gene. In addition to the patients with a histological diagnosis of FAP,family members without disease symptoms showed the mutation in the APC gene. In the present study,we detected two of the three most frequent germline mutations in the literature: the mutation at codon 1309 and the mutation at codon 1061. The presence of c.3956 del C mutation was found in all families from this study,and suggests that this mutation was introduced in the population of the State of Pará through ancestor immigration(i.e.,a de novo mutation that arose

关键词： Familial adenomatous polyposis APC Torrent sequencing Colorectal cancer