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How Growth Ability of Multidrug-Resistant Escherichia coli Is Affected by Abiotic Stress Factors

Open Journal of Preventive Medicine 2014年第5期4卷 250-256页

作者： Lucinda Janete Bessa Vania Filipa Dias Angelo Mendes Paula martins-costa Helena Ramos paulo martins da costa CIIMAR—Interdisciplinary Center for Marine and Environmental Research University of PortoPortoPortugal ICBAS—Institute Abel Salazar for the Biomedical Sciences University of PortoPortoPortugal FCUP—Faculty of Sciences University of PortoPortoPortugal Servico de Microbiologia Centro Hospitalar do PortoHospital Geral de Santo AntonioPortoPortugal

The ability of multidrug-resistant Escherichia coli to adapt and grow in a wide range of different environmental conditions may be crucial to the global spread of antimicrobial resistance. The aim of this study was to evaluate the survival ability of 54 multidrug-resistant E. coli strains, isolated from three different biotopes (clinical setting, gull intestine, river water) when subjected to variations in pH (from 3 to 11) and salinity (from 0.5% to 6% of NaCl) and to nutrient deprivation. The growth of each isolate as well as of a reference strain was assessed during 168 h in every varying condition. Slight variations in the growth ability under some abiotic stress factors were recorded among the isolates from the different biotopes. Multidrug-resistant isolates from gull feces were found to be the more tolerant to environmental abiotic changes, while isolates from river water were the less tolerant. In addition, it was notorious that the carriage of antimicrobial resistance has a clear fitness cost in comparison with the susceptible (reference) strain, highlighting the necessity of reducing the selective pressure exerted by antibiotics. This study underlines the ecological hardness of multidrug-resistant E. coli isolates with a consequent ability to reach and colonize new host and environments.

关键词： Escherichia coli Multidrug Resistance Nutrient Deprivation pH Salinity

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Presence of Multidrug-Resistant E. coli, Enterococcusspp. and Salmonellaspp. in Lakes and Fountains of Porto, Portugal

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Journal of Water Resource and Protection 2013年第11期5卷 1117-1126页

作者： Carlos E. Flores Luís Loureiro Lucinda J. Bessa paulo martins da costa 1ICBAS-Abel Salazar Biomedical Sciences Institute University of Porto Porto Portugal 2CIIMAR-Interdisciplinary Center for Marine and Environmental Research University of Porto Porto Portugal 1ICBAS-Abel Salazar Biomedical Sciences Institute University of Porto Porto Portugal 2Faculty of Sciences (FCUP) University of Porto Porto Portugal CIIMAR-Interdisciplinary Center for Marine and Environmental Research University of Porto Porto Portugal Tulane University School of Public Health and Tropical Medicine New Orleans USA

Urban lakes and fountains provide recreational activities that could facilitate the contact between humans, animals and biological agents. The objective of this work was to assess the water quality and safety of 17 lakes and 13 fountains in the city of Porto (Portugal), by detecting the presence of Escherichia coli, enterococci and Salmonella spp., and analyzing their antimicrobial resistance. (For more information,please refer to the pdf.)

关键词： Antimicrobial Resistance Enterococcus spp. Escherichia coli Salmonella spp. Fountains Lakes

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Liver graft vascular variant with 3 extra-hepatic arteries

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Hepatobiliary & Pancreatic Diseases International 2010年第3期9卷 319-320页

作者： paulo N martins Department of Surgery Division of Hepatobiliary Surgery and TransplantationNew York Medical College

Vascular anatomy of the liver is varied,and the 'standard'anatomy is seen in 55%-80%of *** is very important that extrahepatic arteries are identified precisely at the time of graft procurement to avoid injuries that might compromise the liver *** the present case the liver donor had the vascular anatomy of Michels typeⅦ,e.g.a hepatic artery originating from the celiac trunk and going to the left lobe,an accessory left hepatic artery coming from the left gastric artery,and a replaced right hepatic artery coming from the superior mesenteric *** pattern of vascular supply is uncommon,representing less than 5%of *** replaced hepatic artery was reconstructed in the back-table with polypropylene suture 7.0 by connecting it to the stump of the splenic artery,and the celiac trunk of the graft was anastomosed to the recipient common hepatic artery.

关键词： liver transplantation liver anatomy vascular variations right replaced artery accessory artery

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EFFECTIVE NETWORKS FOR REAL-TIME DISTRIBUTED PROCESSING

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Journal of Systems Science & Complexity 2011年第1期24卷 39-50页

作者： Gonzalo TRAVIESO Luciando da Fontoura costa Instituto de Fisica de Sao Carlos Universidade de Sao Paulo Av. do Trabalhador SSo-Carlensc 400 13566 - 590 Sao Carlos SP Brazil.

This paper applies the concepts and methods of complex networks to the development of models and simulations of master-slave distributed real-time systems by introducing an upper bound in the allowable delivery time of the packets with computation results. Two representative intercom nection models are taken into account： Uniformly random and scale free （Barabasi-Albert）, including the presence of background traffic of packets. The obtained results include the identification of the uniformly random interconnectivity scheme as being largely more efficient than the scale-free counterpart. Also, increased latency tolerance of the application provides no help under congestion.

关键词： Complex networks distributed computing real-time.

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Conservative strategy for treatment of stable coronary artery disease

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World Journal of Clinical Cases 2015年第2期3卷 163-170页

作者： paulo Cury Rezende Thiago Luis Scudeler Leandro Menezes Alves da costa Whady Hueb Department of Atherosclerosis Heart Institute (InCor) of the University of S?o Paulo

Patients with coronary artery disease vary widely in terms of prognosis, which is mainly dependent on ventricular function. In relation to the major outcomes of death and myocardial infarction, it is not clear in the literature if an invasive strategy of myocardial revascularization is superior to a conservative strategy of optimized medical therapy. Moreover, with the exception of patients with left main coronary disease, this similarity in prognosis also occurs in different subgroups of patients.

关键词： Coronary artery disease Angina pectoris Myocardial revascularization Coronary angioplasty Myocardial infarction Prognosis Disease-free survival

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Follicular dendritic cell sarcoma of the liver:unusual presentation of a rare tumor and literature review

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Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 443-445页

作者： paulo N martins Sanjay Reddy Ann-Britt martins Marcelo Facciuto Department of Surgery Division of Hepatobiliary Surgery and TransplantationNew York Medical CollegeNew YorkUSA Department of Surgery New York Medical CollegeSt.Vincent's Catholic Medical CenterNew YorkUSA

BACKGROUND:Hepatic follicular dendritic cell (FDC) sarcoma is an extremely rare *** commonly,FDC sarcoma presents as a solitary mass in lymph nodes,however,several extra-nodal locations have been ***:We report a case of a 53-year-old female who presented with symptoms of abdominal pain,fever,anemia,and *** an extensive review of the literature,we have found only 12 cases of hepatic FDC ***:The tumor was 11.5 cm in diameter and composed of spindle and epithelioid cells with ovoid nuclei and associated with mixed inflammatory *** stains were positive for CD35 and *** patient underwent a left hepatic ***:Liver follicular dendritic cell sarcoma is a very rare *** cases present with abdominal pain and weight loss,and most of them can be managed by hepatic resection with excellent short-term outcomes.

关键词： follicular dendritic cell tumor liver neoplasms sarcoma jaundice

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Mitomycin C in pterygium treatment

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 465-468页

作者： Thiago Goncalves dos Santos martins Ana Luiza Fontes de A zevedo costa Milton Ruiz Alves Roger Chammas paulo Schor Federal University of Sao paulo (UNIFESP) Sao Paulo 04023062 Brazil University of Sao paulo (USP) Sao Paulo 01246903 Brazil

Pterygium is a benign lesion usually growing from the nasal side of the conjunctiva onto the *** cases of pterygium does not cause problem or requires specific *** exact cause of pterygium is not clear yet,but some factors are pointed as causes,being the most important the long-term ultraviolet ray *** surgery is usually considered when there are symptoms that do not respond to conservative *** is the main complication of the surgery,and much has been done to avoid *** C（MMC） has been used as a fibroblast proliferation inhibitor during the surgery to reduce the chance of recurrence of the *** review describes the use of MMC as an adjunctive,the optimal dosage,the duration of administration of MMC and possible complications,when used during,after and before the *** studies suggest that increased exposure（dose or duration） of MMC is associated with a lower recurrence,but with higher risks of complications.

关键词： mitomycin C pterygium surgery recurrence rate

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Xanthogranulomatous cholecystitis mimicking gallbladder cancer and causing obstructive cholestasis

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 549-552页

作者： paulo N martins Patricia Sheiner Marcelo Facciuto Department of Surgery Transplant DivisionMassachusetts General HospitalHarvard Medical School Department of Surgery Division of Hepatobiliary Surgery and TransplantationNew York Medical College Division of Transplantation Mount Sinai Hospital

BACKGROUND: Xanthogranulomatous cholecystitis (XGC) is a destructive inflammatory disease of the gallbladder that can mimic gallbladder carcinoma. METHODS: We present the case of a 35-year-old Hispanic male complaining of right upper quadrant pain and jaundice for 2 months prior to admission. He denied a history of fever, nausea/ vomiting, and weight loss. The past medical history was relevant only for diabetes. He had no previous history of jaundice or previous operations. RESULTS: CA19-9 was slightly elevated (52 U/mL). Abdominal ultrasonography showed an irregular thickening of the gallbladder wall and no gallstones were detected. CT scan also revealed an irregular thickening of the wall of the gallbladder body suggestive of malignancy. At laparotomy, the mass was adherent to the duodenum and colon, and although the frozen section biopsy was negative, the intraoperative findings were suggestive of malignancy, and the patient underwent left liver trisegmentectomy, resection of the common bile duct and Roux-en-Y hepaticojejunostomy. Pathological examination unexpectedly revealed XGC without malignancy. CONCLUSIONS: Preoperative and intraoperative differential diagnosis of XGC from gallbladder carcinoma remains a challenge when it is associated with inflammatory involvement of surrounding tissues. Since gallbladder carcinoma and XGC may coexist, radical resection is justified when malignancy cannot be completely ruled out.

关键词： xanthogranulomatous cholecystitis gallbladder cancer obstructive cholestasis

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Ophthalmologic manifestations of celiac disease

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 159-162页

作者： Thiago Goncalves dos Santos martins Ana Luiza Fontes de Azevedo costa Maria Kiyoko Oyamada paulo Schor Aytan Miranda Sipahi Department of Ophthalmology Federal University of SgoPaulo Sao Paulo 04023-062 Brazil Department of Ophthalmology University of Sao Paulo Sao Paulo 04023-062 Brazil Departmem of Gastroenterology Clinicas Hospital of University of Sao Paulo and the Laboratory of Experimental Clinical Gastroenterology School of Medicine at the University ofSao Paulo LIM 07 Sao Paulo 04023-062 Brazil

Celiac disease is an autoimmune disorder that affects the small intestine of genetically predisposed *** manifestations are within the extra-intestinal manifestations,and can be divided into those of autoimmune disorders or those due to absorptive *** article reviewed the ophthalmologic manifestation of celiac *** symptoms are rare,but should be investigated in patients with celiac disease and taken into consideration as the first systemic manifestation.

关键词： ophthalmology celiac disease review

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Recent progress in water splitting and hybrid supercapacitors based on nickel-vanadium layered double hydroxides

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Journal of Energy Chemistry 2021年第6期30卷 496-515,I0012页

作者： JosuéM.Gonçalves paulo R.martins Koiti Araki Lucio Angnes Department of Fundamental Chemistry Institute of ChemistryUniversity of São PauloAv.Prof.Lineu Prestes 74805508-000 São PauloSPBrazil Institute of Chemistry Federal University of GoiasAv.EsperançaGoianiaGO 74690900Brazil

Environmentally friendly energy sources alternatives to fossil fuels such as solar and wind are strategic for meeting the needs of an increasingly energy demanding society,despite their periodic/intermittent ***,urge the development of clean and renewable energy sources such as based on solar energy and water in a cyclic way,by photoinduced water-splitting and regeneration in fuel *** this context,energy storage devices such as hybrid supercapacitors become fundamental for realization of a sustainable *** this review,the early discovery and recent advances concerning synthetic strategies,hierarchical structures,and oxygen evolution reaction(OER)/hydrogen evolution reactions(HER) catalytic performances of nickel-vanadium double hydroxides(NiV-LDHs) based nanomaterials are summarized.A discussion about the role of vanadium ions in HER/OER was also included,highlighting the recent progress in theoretical calculations in this ***,some hybrid supercapacitor electrode materials based on NiV-LDHs are described,including the strategies to circumvent the parasitic oxygen evolution reaction during charge-discharge of those energy storage *** short,catalysts for HER/OER and hybrid supercapacitor electrode materials based on NiV-LDHs were reviewed considering their key multifunctional role in the way to a more sustainable society.

关键词： Nickel-vanadium double hydroxides Hybrid supercapacitors Water splitting Oxygen evolution reaction Hydrogen evolution reaction Charge storage OER parasitism

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