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Risk stratification and geographical mapping of Brazilian inflammatory bowel disease patients during the COVID-19 outbreak:Results from a nationwide survey

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World Journal of Gastroenterology 2021年第12期27卷 1226-1239页

作者： Natália Sousa Freitas Queiroz Fábio Vieira Teixeira Marina Pamponet Motta Liliana Andrade Chebli Adriano Akira Ferreira Hino Camilla de Almeida Martins Abel Botelho Quaresma Alexandre Augusto de Paula da Silva Adérson Omar Mourão Cintra Damião Rogerio Saad-Hossne paulo gustavo kotze Department of Gastroenterology University of São Paulo School of MedicineSão Paulo 05403-000SPBrazil IBD Unit Gastroenterology DepartmentGastrosaúde ClinicMarilia 17509190SPBrazil School of Medicine Federal University of BahiaSalvador 40020-025BHBrazil IBD Outpatient Clinics Universidade Federal de Juiz de ForaJuiz de Fora 36010-010MGBrazil Health Sciences Postgraduate Program Pontifícia Universidade Católica do Paraná(PUCPR)Curitiba 80440-220PRBrazil Departamento de Ciências da Saúde Universidade do Oeste de Santa Catarina(UNOESC)Joaçaba 89600-000SCBrazil Botucatu Medical School Paulista State University(UNESP)Botucatu 18600-050SPBrazil IBD Outpatient Clinics Pontificia Universidade Católica do Paraná(PUCPR)Curitiba 80440-220PRBrazil

BACKGROUND Coronavirus disease 2019(COVID-19)pandemic is still evolving globally,and Brazil is currently one of the most affected *** is still debated whether patients with inflammatory bowel disease(IBD)are at a higher risk for developing COVID-19 or its *** To assess geographical distribution of IBD patients at the highest risk and correlate these data with COVID-19 mortality rates in *** The Brazilian IBD Study Group(Grupo de Estudos da Doença Inflamatória Intestinal do Brasil)developed a web-based survey adapted from the British Society of Gastroenterology *** included categories were demographic data and inquiries related to risk factors for complications from *** were categorized as highest,moderate or lowest individual *** Spearman correlation test was used to identify any association between highest risk and mortality rates for each state of the *** A total of 3568 patients(65.3%females)were *** participants were from the southeastern and southern regions of Brazil,and 84.1%were using immunomodulators and/or *** patients(55.1%)were at moderate risk,23.4%were at highest risk and 21.5%were at lowest risk of COVID-19 *** association between the proportion of IBD patients at highest risk for COVID-19 complications and higher mortality rates was identified in different Brazilian states(r=0.146,P=0.467).CONCLUSION This study indicates a distinct geographical distribution of IBD patients at highest risk for COVID-19 complications in different states of the country,which may reflect contrasting socioeconomic,educational and healthcare *** association between high risk of IBD and COVID-related mortality rates was identified.

关键词： Crohn’s disease Colitis,Ulcerative COVID-19 Inflammatory bowel disease Brazil

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Annual variation of adult survival of a south-temperate House Wren population in Argentina

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Avian Research 2024年第2期15卷 229-237页

作者： gustavo J.Fernandez Mariana E.Carro paulo E.Llambías Grupo de Investigacion en Ecofisiología de Fauna Silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population *** numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the ***,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of House Wrens(Troglodytes aedon bonariae).We evaluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival *** found that the probability of adult survival decreased as the abundance of breeding adults *** density-dependent effect could be related to the resident lifestyle of southern House Wrens,which could determine an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CJS Density-dependence Survival Troglodytes aedon bonariae

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Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases:new perspectives

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Neural Regeneration Research 2021年第12期16卷 2425-2426页

作者： gustavo de Bem Silveira Alexandre Pastoris Muller Ricardo Andrez Machado-de-Ávila paulo Cesar Lock Silveira Laboratory of Experimental Pathophysiology Graduate Program in Health SciencesUniversidade do Extremo Sul CatarinenseCriciúmaSCBrazil Programa de Pós Graduação em Farmacologia UFSCFlorianópolisSCBrazil

Various conditions affecting nerve cells and the nervous system due to the loss of neurons and their connecting networks are described under the superordinate phrase“Neurodegenerative diseases”.Such diseases lead to disability due to gradual neuronal death in both the central nervous system and the peripheral nervous *** many of these diseases have unknown causes,sometimes these are due to medical conditions such as alcoholism,a tumor,or a stroke,or other causes which may include genetic mutations,toxins,chemicals,and viruses.

关键词： diseases degenerative treatment

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Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

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Integrative Zoology 2024年第3期19卷 400-416页

作者： paulo MEJIA gustavo Lima URBIETA Bruna da Silva XAVIER IsaíJorge de CASTRO JoséJúlio DE TOLEDO gustavo GRACIOLLI Lucio AndréVIANA DIAS William Douglas CARVALHO Programa de Pós-Graduação em Biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

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Entanglement,Identical Particles and the Uncertainty Principle

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Communications in Theoretical Physics 2016年第8期65卷 201-206页

作者： gustavo Rigolin Departamento de Fisica Universidade Federal de Sao Carlos 13565-905 Sao Carlos SP Brazil

A new uncertainty relation(UR) is obtained for a system of N identical pure entangled particles if we use symmetrized observables when deriving the inequality. This new expression can be written in a form where we identify a term which explicitly shows the quantum correlations among the particles that constitute the system. For the particular cases of two and three particles, making use of the Schwarz inequality, we obtain new lower bounds for the UR that are different from the standard one.

关键词： quantum mechanics uncertainty relations identical and entangled particles

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Femoral positioning influences ipsi-and contralateral anterior cruciate ligament rupture following its reconstruction:Systematic review and meta-analysis

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World Journal of Orthopedics 2017年第8期8卷 644-650页

作者： gustavo Constantino de Campos paulo Eduardo Portes Teixeira Alex Castro Wilson de Mello Alves Junior Department of Orthopaedics Campinas’s State University (UNICAMP) Instituto Wilson Mello Research and Study Center

AIM To systematically review the incidence of ipsilateral graft re-rupture and contralateral anterior cruciate ligament(ACL) rupture following its reconstruction, with special attention to the femoral drilling technique. METHODS Systematic review and meta-analysis of high-level prospective studies searched in MEDLINE database following PRISMA statement. The rate of ipsilateral graft re-rupture and contralateral rupture in patients submitted to either transtibial(TT) technique(isometric) or anteromedial(AM) technique(anatomic) was compared. RESULTS Eleven studies met the criteria and were included in final analysis. Reconstructions using the AM technique had a similar chance of contralateral ACL rupture when compared to the chance of ipsilateral graft failure(OR = 1.08, P = 0.746). In reconstructions using TT technique, the chance of contralateral ACL rupture was approximately 1.5 times higher than ipsilateral graft failure(OR = 1.49, P = 0.048). Incidence of contralateral lesions were similar among the techniques TT(7.4%) and AM(7.0%)(P = 0.963), but a trend could be noticed with a lower incidence of lesion in the ipsilateral limb when using the TT technique(4.9%) compared to the AM technique(6.5%)(P = 0.081).CONCLUSION ACL reconstruction by TT technique leads to lower incidence of graft re-injury than contralateral ACL lesion. There is no difference between the chance of re-injury after AM technique and the chance of contralateral ACL lesion(native ligament) with either technique.

关键词： Anterior cruciate ligament Anterior cruciate ligament reconstruction Arthroscopy Graft survival

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Chemical speciation of copper and manganese in solution of a copper-contaminated soil and young grapevine growth with amendment application

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Pedosphere 2023年第3期33卷 496-507页

作者： Daniela Basso FACCO Edicarla TRENTIN Gerson Laerson DRESCHER Rodrigo Knevitz HAMMERSCHMITT Carlos Alberto CERETTA Leandro Souza DA SILVA gustavo BRUNETTO paulo Ademar Avelar FERREIRA Department of Soil Science Federal University of Santa MariaSanta Maria 97105-900(Brazil) University of Arkansas System Division of Agriculture Arkansas 72704(USA) Federal University of Santa Maria Campus Cachoeira do SulCachoeira do Sul 96506-310(Brazil)

Copper(Cu)-based fungicide application to control foliar diseases in grapevine(Vitis vinifera L.)can increase soil Cu *** soils have high natural Cu and manganese(Mn)concentrations,increasing the potential for toxicity to grapevine *** of amendment substances can reduce the concentrations of toxic chemical species of Cu and Mn in soil solution,especially for the soils grown with young *** evaluated the chemical speciation of Cu and Mn in soil solution and young grapevine growth using a contaminated soil with amendment *** seedlings of Paulsen 1103rootstock were grown for 12 months on an old vineyard(>30 years of cultivation)soil without(control)and with vermicompost or limestone *** dry matter,root morphological characteristics,and plant tissue Cu and Mn concentrations were *** cation and anion concentrations,dissolved organic carbon,p H,and chemical speciation of Cu and Mn in soil solution from different soil layers were *** application did not reduce Cu and Mn phytotoxicity,and grapevine plants died after winter *** soluble Mn concentration in soil(5.56 mg L-1in 0–45 cm soil layer)and Mn concentration in plant tissue at pruning(380.8 mg kg-1)might be the primary cause of plant *** application reduced Cu2+and Mn2+chemical species in soil solution,thereby increasing plant *** Cu2+and Mn2+species were negatively correlated(P<0.05)with grapevine shoot production at pruning(r=-0.92 and-0.97,respectively)and at the end of the trial(r=-0.73 and-0.51,respectively).Limestone application increased grapevine shoot and root dry matter production by 36%and 41%,respectively,while also presenting the highest root length and volume in the 5–10 cm soil *** application is a viable and profitable alternative for reducing soil Cu and Mn availability and their phytotoxic effects.

关键词： bioavailability heavy metal limestone phytoxicity vermicompost vineyard Visual MINTEQ

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Reviewing perovskite oxide sites influence on electrocatalytic reactions for high energy density devices

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Journal of Energy Chemistry 2023年第6期81卷 1-19,I0002页

作者： Lorrane C.C.B.Oliveira Raissa Venâncio paulo V.F.de Azevedo Chayene G.Anchieta Thayane C.M.Nepel Cristiane B.Rodella Hudson Zanin gustavo Doubek Advanced Energy Storage Division Laboratory of Advanced Batteries(LAB)Center for Innovation on New Energies(CINE)School of Chemical EngineeringUniversity of Campinas(Unicamp)CampinasSao Paulo 13083-852Brazil Advanced Energy Storage Division Center for Innovation on New Energies(CINE)Brazilian Renewable Energies(BREnergies)groupManufacturing GroupSchool of Electrical and Computer EngineeringUniversity of Campinas(UNICAMP)CampinasSão Paulo 13083-852Brazil Paul Scherrer Institut(PSI) Swiss Light Source(SLS)Forschungsstrasse 1115232 Villigen PSIAargauSwitzerland Brazilian Center for Research in Energy and Materials(CNPEM)/Brazilian Synchrotron Light Laboratory(LNLS) CampinasSão Paulo 13083-100Brazil

Batteries,fuel cells,and supercapacitors are electrochemical devices already on the market and still need a boost in kinetics to match the high energy density demand of *** have attracted the scientific community's attention in the last decade due to their electrocatalytic activity,chemical and structural properties,tunability,low cost,and *** have been made to understand the active sites and the operational mechanisms in perovskite oxides to shape them as an electrocatalyst in advanced energy *** the role of perovskites is the key to engineering more controlled and efficient electrocatalysts via chemical synthesis,and there is still much to *** review highlights the use of perovskites in different energy storage and conversion *** A,B,and A&B doping-site effects are analyzed to understand the opportunities and challenges related to this class of *** addition,the synthesis methods and the properties related to the doping site are described and summarized.

关键词： Perovskites Energy storage systems Electrocatalysts Battery Oxide fuel cells Capacitors

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Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices

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World Journal of Gastrointestinal Endoscopy 2014年第6期6卷 254-259页

作者： Matheus Cavalcante Franco gustavo Flores Gomes Frank Shigeo Nakao gustavo Andrade de paulo Angelo paulo Ferrari Jr Ermelindo Della Libera Jr Digestive Endoscopy Unit Division of GastroenterologyFederal University of Sao Paulo Endoscopy Division Fleury Medicina e Saúde Endoscopy Division Hospital Israelita Albert Einstein

AIM:To evaluate the efficacy and safety of undiluted N-butyl-2 cyanoacrylate plus methacryloxysulfolane(NBCM)as a prophylactic treatment for gastric varices(GV)***:This prospective study was conducted at a single tertiary-care teaching hospital between October 2009 and March *** with portal hypertension(PH)and GV,with no active gastrointestinal bleeding,were enrolled in primary prophylactic treatment with NBCM injection without lipiodol *** diagnosis of GV was based on endoscopy and confirmed with endosonography(EUS); the same procedure was used after treatment to confirm eradication of *** puncturing the GV with a regular injection needle,1 mL of undiluted NBCM was injected intranasally into *** injection was repeated as necessary to achieve eradication or until a maximum total volume of 3 mL of NBCM had been *** were followed clinically and evaluated with endoscopy at 3,6 and 12 *** follow-ups were performed *** main outcome measures were efficacy(GV eradication),safety(adverse events related to cyanoacrylate injection),recurrence,bleeding from GV and mortality related to GV ***:A total of 20 patients(15 male)with PH and GV were enrolled in the study and treated with undiluted NBCM *** 2(10%)patients had no esophageal varices(EV); 18(90%)patients were treated with endoscopic band ligation to eradicate EV before inclusion in the *** patients were followed clinically and endoscopically for a median of 31 mo(range:6-40 mo).Eradication of GV was observed in all patients(13 patients were treated with 1 session and 7 patients with 2 sessions),with a maximum injected volume of 2 mL *** patient had GV recurrence,confirmed by EUS,at 6-mo follow-up,and another had late recurrence with GV bleeding after 35 mo of follow-up; overall,GV recurrence was observed in 2 patients(10%),after 6 and 35 mo of follow-up,and GV bleeding rate was 5%(1 patient).Mild epigastric pain was r

关键词： Gastric varices Primary prevention Endoscopy Gastrointestinal Cyanoacrylates Gastrointestinal hemorrhage

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Fire dynamics in Mato Grosso State,Brazil:the relative roles of gross primary productivity

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Big Earth Data 2020年第1期4卷 23-44页

作者： Fernando Saragosa Rossi gustavo Andrede Araujo Santos State University of Mato Grosso(UNEMAT) Mato GrossoSinopBrazil Department of Exact Sciences São Paulo State University(FCAV–UNESP)Via de Acesso Prof.Paulo Donato Castellane s/n14884-900 JaboticabalSão PauloBrazil

The fires and biomass burning are responsible for affect ecosystem processes in a wide range of biomes at regional and global *** Brazil,the state of Mato Grosso is one of the most affected by the occurrence of forest ***,this study aims to quantify the longterm changes in the temporal and spatial patterns of fire occurrence and their effect on gross primary productivity(GPP)in the state of Mato Grosso,Brazil,considering the biomes that compose *** images used in the study were acquired by satellite Terra and Aqua combined in the product MCD64A1.006,a monthly resolution of 500m by the Moderate Resolution Imaging Spectroradiometer(MODIS)sensor,during the period from 01/10/2000 to 12/31/*** MOD17A2 product derived from the MODIS sensor provides the accumulated value of *** points without the presence of burning presented higher values of GPP for all studied *** some points with the presence of burning the GPP even decreased by 44.20%,30.04%and 55.78%for Amazonia,Cerrado,and Pantanal,*** to the results presented here,it is concluded that the burnings negatively impact gross primary production in the biomes of the state of Mato Grosso,Brazil and the dynamics of the burns do not keep up with the intensity of drought *** use of cluster analysis techniques,such as principal component analysis(PCA),is an alternative to bigdata analysis when the objective is to evaluate the presence of forest burning in more than one biome.

关键词： Carbon cycle remote sensing Amazon Cerrado Pantanal

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