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Efficacy of acupuncture on cancer pain:A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第3期22卷 235-244页

作者： Miguel Faria Mónica Teixeira Maria João Pinto paulo Sargento Núcleo de Investigação em Ciências e Tecnologias da Saúde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica São João de Deus 1700-048 LisboaPortugal REQUIMTE/LAQV(Rede de Química e Tecnologia/Laboratório Associado para a Química Verde) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal Hospital SOERAD 2560-312 Torres VedrasPortugal Centro de Estudos Avançados em Direito“Francisco Suarez ”1749-024 LisboaPortugal

Background:Pain associated with cancer is one of the greatest causes of reduced quality of life in *** is one of the treatments used to address this issue,with the great advantage of having little or no side effects,especially when compared with pharmacological ***:The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer *** strategy:Six electronic databases(PubMed,EBSCO,Cochrane Library,Scielo,b-On and Scopus)were searched for relevant articles about pain relief in cancer patients from their beginning until 2022using MeSH terms such as“acupuncture,”“electroacupuncture,”“ear acupuncture,”“acupuncture analgesia,”“oncological pain,”and“cancer pain.”Inclusion criteria:Studies included were randomized controlled trials(RCTs)where acupuncture was compared with no treatment,placebo acupuncture or usual *** extraction and analysis:Three independent reviewers participated in data extraction and evaluation of risk of bias,and a meta-analysis was *** primary outcome was pain intensity,measured with the visual analog scale,numeric rating scale,or brief pain *** outcomes also assessed were quality of life,functionality,xerostomia,pain interference,and analgesic *** were expressed as standardized mean difference(SMD)with 95%confidence interval(CI).Results:Sixteen RCTs with a total of 1124 participants were included in the meta-analysis,with the majority of the studies presenting a low or unclear risk of *** was more effective in reducing pain than no treatment(SMD=–0.90,95%CI[–1.68,–0.12]),sham acupuncture(SMD=–1.10,95%CI[–1.59,–0.61])or usual care(SMD=–1.16,95%CI[–1.38,–0.93]).Conclusion:The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with *** some limitations due to the low quality and small sample size of some included st

关键词： Acupuncture Cancer pain Meta-analysis Systematic review

Effect of a cardiac telerehabilitation program during COVID-19 associated social isolation

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Sports Medicine and Health Science 2024年第3期6卷 273-278页

作者： Joao paulo Prado Giovane Galdino Institute of Motricity Sciences Federal University of AlfenasAlfenasMinas GeraisBrazil

This study aimed to compare the impact of a cardiac telerehabilitation(CTR)protocol aimed at patients with cardiovascular diseases(CVDs)during the period of coronavirus disease 2019(COVID-19)associated with social *** retrospective cohort study included 58 participants diagnosed with stable cardiovascular diseases(CVDs),which were divided into three groups:conventional cardiac rehabilitation(CCR)group(n=20),composed of patients undergoing conventional cardiac rehabilitation;cardiac telerehabilitation(CTR)group(n=18),composed of patients undergoing cardiac telerehabilitation and control group(n=20),composed of patients admitted for cardiac rehabilitation who had not started training *** results showed that body mass index was reduced(p=0.019)and quality of life was improved(e.g.,limitations due to physical aspects[p=0.021),vitality[p=0.045]and limitations due to emotional aspects[p=0.024])by CCR compared to *** outcomes were not improved by CTR(p>0.05).However,this strategy prevented clinical deterioration in the investigated *** CCR achieved a superior effect on clinical improvement and quality of life,CTR was relevant to stabilize the blood pressure and quality of life of patients with cardiovascular diseases during the period of COVID-19-associated social isolation.

关键词： COVID-19 Cardiac telerehabilitation Quality-of-life

Recent progress in water splitting and hybrid supercapacitors based on nickel-vanadium layered double hydroxides

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Journal of Energy Chemistry 2021年第6期30卷 496-515,I0012页

作者： JosuéM.Gonçalves paulo R.Martins Koiti Araki Lucio Angnes Department of Fundamental Chemistry Institute of ChemistryUniversity of São PauloAv.Prof.Lineu Prestes 74805508-000 São PauloSPBrazil Institute of Chemistry Federal University of GoiasAv.EsperançaGoianiaGO 74690900Brazil

Environmentally friendly energy sources alternatives to fossil fuels such as solar and wind are strategic for meeting the needs of an increasingly energy demanding society,despite their periodic/intermittent ***,urge the development of clean and renewable energy sources such as based on solar energy and water in a cyclic way,by photoinduced water-splitting and regeneration in fuel *** this context,energy storage devices such as hybrid supercapacitors become fundamental for realization of a sustainable *** this review,the early discovery and recent advances concerning synthetic strategies,hierarchical structures,and oxygen evolution reaction(OER)/hydrogen evolution reactions(HER) catalytic performances of nickel-vanadium double hydroxides(NiV-LDHs) based nanomaterials are summarized.A discussion about the role of vanadium ions in HER/OER was also included,highlighting the recent progress in theoretical calculations in this ***,some hybrid supercapacitor electrode materials based on NiV-LDHs are described,including the strategies to circumvent the parasitic oxygen evolution reaction during charge-discharge of those energy storage *** short,catalysts for HER/OER and hybrid supercapacitor electrode materials based on NiV-LDHs were reviewed considering their key multifunctional role in the way to a more sustainable society.

关键词： Nickel-vanadium double hydroxides Hybrid supercapacitors Water splitting Oxygen evolution reaction Hydrogen evolution reaction Charge storage OER parasitism

Fracture Loci in Sheet Metal Forming: A Review

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Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1415-1425页

作者： M.Beatriz Silva Kerim Isik A.Erman Tekkaya paulo A.F.Martins IDMEC Instituto Superior Técnico Universidade de Lisboa Institute of Forming Technology and Lightweight Construction Technical University of Dortmund

Fracture in sheet metal forming usually occurs as ductile fracture, rarely as brittle fracture, at the operating temperatures and rates of loading that are typical of real processes in two different modes：（1） tensile and（2） in-plane shear（respectively, the same as modes I and II of fracture mechanics）. The circumstances under which each mode will occur are identified in terms of plastic flow and ductile damage by means of an analytical approach to characterize fracture loci under plane stress conditions that takes anisotropy into consideration. Fracture loci was characterized by means of the fracture forming limit line and by the shear fracture forming limit line in the fracture forming limit diagram. Experiments were performed with single point incremental forming and double-notched test specimens loaded in tension, torsion and in-plane shear give support to the presentation and allow determining the fracture loci of AA1050-H111 aluminium sheets with1 mm thickness. The relation between fracture toughness and the fracture forming limits was also investigated by comparing experimental values of the strains at fracture obtained from a truncated conical part produced by single point incremental forming and from double-notched test specimens loaded in tension.

关键词： Sheet forming Fracture Fracture forming limit diagram

Tapir health and conservation medicine

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Integrative Zoology 2012年第4期7卷 331-345页

作者： paulo Rogerio MANGINI Emilia Patrícia MEDICI Renata Carolina FERNANDES-SANTOS Lowland Tapir Conservation Initiative IPÊ-Institute for Ecological ResearchNazaréPaulistaSão PauloBrazil Brazilian Institute for Conservation Medicine-TRÍADE RecifePernambucoBrazil IUCN/SSC Tapir Specialist Group(TSG) GlandSwitzerland IUCN/SSC Wildlife Health Specialist Group(WHSG) New YorkNYUSA IUCN/SSC Peccary Specialist Group(PSG) GlandSwitzerland Escola Superior de Conservação Ambiental e Sustentabilidade(ESCAS/IPÊ) NazaréPaulistaSão PauloBrazil IUCN/SSC Conservation Breeding Specialist Group(CBSG) Brazil NetworkCampo GrandeBrazil

Tapirs have unique nutritional needs,as well as anatomical,physiological,behavioral and ecological adapta-tions that must be considered when managing their health,both in the wild and in *** about how tapirs live in their natural habitats can provide crucial knowledge to prevent many of the health problems found in captivity such as infectious and parasitic diseases,reproductive issues and nutritional and behavior-al ***,proper management in captivity can significantly contribute to in situ conservation *** medicine is a science created to address the global health crisis that jeopardizes biodiver-sity causing imbalances among ecosystem,human,animal and vegetal *** this context,common threats to tapir health and conservation,such as isolated and small populations surrounded by human activity,chemical pollution,domestic animals and their pathogenic agents,need to be better *** manuscript provides information about the health of tapirs both in captivity and in the wild and aims to encourage tapir conservation-ists worldwide to gather information about pathogen and disease dynamics and manifestation,as well as impli-cations for tapir conservation.

关键词： captive management conservation medicine tapirs wildlife health

Genetic variation at the p53 locus of two ecologically divergent Microtus pine voles:identification of molecular markers for species assignment

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Integrative Zoology 2022年第6期17卷 1179-1192页

作者： Ana Sofia QUINA João paulo TAVANEZ Maria da Luz MATHIAS CESAM-Centro de Estudos do Ambiente e do Mar Departamento de BiologiaUniversidade de AveiroAveiroPortugal CESAM-Centro de Estudos do Ambiente e do Mar Faculdade de CiênciasUniversidade de LisboaLisboaPortugal Departamento de Biologia Animal Faculdade de CiênciasUniversidade de LisboaLisboaPortugal Global Health and Tropical Medicine(GHTM) Instituto de Higiene e Medicina Tropical(IHMT)Universidade NOVA de Lisboa(UNL)Portugal

The Lusitanian(Microtus lusitanicus)and the Mediterranean(Microtus duodecimcostatus)pine voles are recently diverged sister species endemic of the Iberian Peninsula that can be identiﬁed with ecological and morphological characters,but in areas where the 2 species co-occur,species designation may be difﬁ*** discrimination between *** and *** has not been achieved yet possibly because of their estimated re-cent split and an evolutionary history that includes inter-species geneﬂ*** our previous observations on exons 5–7 of the p53 gene,here we analyze the potential use of the p53 genomic region as a discrimination marker of these species by extending our analyses to several kb upstream and downstream of the p53 gene and charac-terizing the degree of genetic differentiation in 7 markers within this ***,we fully sequenced the P53 protein of both *** observed:(i)generally high differentiation in this region;(ii)*** showed in general higher values of nucleotide and haplotype diversities;(iii)the concatenated phylogenetic tree separates the 2 species;(iv)the 2 P53 proteins only differ in 1 amino acid;(v)4 of the markers,2 in p53,one in Atp1b2,and another in Wrap53,contain species-speciﬁc genetic variation thus allowing a reliable discrimination between specimens from both species,irrespective of sampling location or introgression *** provide ad-ditional data on the putative role of p53 in the evolution of these species and present researchers with a fast and cost-effective resource for *** and *** identiﬁcation.

关键词： ecological stress genetic variation Microtus molecular marker p53

Graduation of Patients at the University:An Innovative Program to Train Patients as Care Partners in Oncology

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Psycho-Oncologie 2024年第1期18卷 9-15页

作者： Lennize Pereira paulo Catherine Tourette-Turgis Marie-Paule Vannier Universitédes patient.es Sorbonne UniversitéParis75013France CNAM-EA7529 Conservatoire National des Arts et MétiersParis75003France CREN-EA2661 Centre de Recherche en Education de NantesNantes44000France

This article presents the history and challenges of patient graduation,positioning it as a means of supporting patient engagement and user involvement in the healthcare system.A set of laws related to patient rights and healthcare quality allows for the integration of patients into the healthcare system,but they face the unpreparedness of institutions in this new field of *** graduation requires transformations in the modes of reception and financing of universities,as well as in the pedagogical methods that need to be tailored to the reception and training of individuals in vulnerable *** article provides a detailed description of the example,history,and effects of the creation of the first open diploma in oncology for patient partners in France and concludes by emphasizing the need for concrete mechanisms for social recognition of user engagement in the healthcare system.

关键词： University of Patients patients partners health democracy cancer

Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos Daskalakis paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

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磁控溅射制备ZnO薄膜及其声表面波特性

物理学报 2007年第6期56卷 3515-3520页

作者：杨光 Santos paulo V. 华中科技大学武汉光电国家实验室激光科学与技术研究部 Paul-Drude固体电子学研究所

通过射频磁控溅射技术在GaAs,Au/GaAs,Si和玻璃基片上成功制备了ZnO多晶薄膜,利用X射线衍射对ZnO薄膜的取向、结晶性进行了表征,结果表明ZnO薄膜呈完全c轴取向,Au缓冲层可以有效地改善ZnO薄膜的晶体质量,X射线摇摆曲线结果表明ZnO(002)... 详细信息

通过射频磁控溅射技术在GaAs,Au/GaAs,Si和玻璃基片上成功制备了ZnO多晶薄膜,利用X射线衍射对ZnO薄膜的取向、结晶性进行了表征,结果表明ZnO薄膜呈完全c轴取向,Au缓冲层可以有效地改善ZnO薄膜的晶体质量,X射线摇摆曲线结果表明ZnO(002)衍射峰的半高宽仅为2.41°,同时发现Au缓冲层的结晶质量对ZnO薄膜的c轴取向度有很大影响,通过扫描电子显微镜对ZnO/GaAs和ZnO/Au/GaAs薄膜的表面形貌进行了观测,利用网络分析仪对IDT/ZnO/GaAs薄膜的声表面波特性进行了测量.

关键词： ZnO薄膜 X射线衍射声表面波