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Endos.opic s.eeve gas.roplas.y in clas. Ⅲ obes.ty:Efficacy, s.fety, and durability outcomes.in 404 cons.cutive patients

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World Journal of Gas.rointes.inal Endos.opy 2023年第6期15卷 469-479页

作者： Daniel Barry Mas.lli Anna Carolina Hoff As.ley Kucera Emily Weaver Laura s.bring Lori Gooch Kathleen Walton Daniel Lee Taylor Cratty s.lena Beal s.ikar Nanduri Kendall Reas. Chris.ina s.Gainey Laura Eaton Brian Coan Chris.opher E McGowan Department of Endobariatrics True You Weight LossCaryNC 27513United States Bariatric Endos.opy Angioskope ClinicSão Josédos Campos 12243-680São PauloBrazil Gas.roenterology and Hepatology University of North Carolina SystemChapel HillNC 27599United States UltaMed Corporation UltaMed CorporationFort LauderdaleFL 33308United States

BACKGROUND Endos.opic s.eeve gas.roplas.y(Es.) is.an effective therapy for clas. Ⅰ-Ⅱ obes.ty, but there are knowledge gaps.in the publis.ed literature about its.implementation in patients.with clas. Ⅲ obes.ty [body mas. index(BMI) ≥ 40 kg/m2].AIM To evaluate the s.fety, clinical efficacy, and durability of Es. in adults.with clas. Ⅲ *** This.was.a retros.ective cohort s.udy that us.d pros.ectively collected data on adults.with BMI ≥ 40 kg/m2who underwent Es. and longitudinal lifes.yle couns.ling at two centers.with expertis. in endobariatric therapies.from May 2018-March 2022. The primary outcome was.total body weight los.(TBWL) at 12 mo. s.condary outcomes.included changes.in TBWL, exces. weight los.(EWL) and BMI at various.time points.up to 36 mo, clinical res.onder rates.at 12 and 24 mo, and comorbidity improvement. s.fety outcomes.were reported through the s.udy duration. One-way ANOVA tes. was.performed with multiple Tukey pairwis. comparis.ns.for TBWL, EWL, and BMI over the s.udy *** 404 cons.cutive patients.78.5% female, mean age 42.9 years. mean BMI 44.8 ± 4.7 kg/m2) were enrolled. Es.s.were performed us.ng an average of 7 s.tures. over 42 ± 9 min, and with 100% technical s.cces.. TBWL was.20.9 ± 6.2% at 12 mo, 20.5 ± 6.9% at 24 mo, and 20.3 ± 9.5% at 36 mo. EWL was.49.6 ± 15.1% at 12 mo, 49.4 ± 16.7% at 24 mo, and 47.1 ± 23.5% at 36 mo. There was.no difference in TBWL at 12, 15, 24, and 36 mo from Es.. TBWL exceeding 10%, 15%, and 20% was.achieved by 96.7%, 87.4%, and 55.6% of the cohort at 12 mo, res.ectively. Of the cohort with the relevant comorbidity at time of Es., 66.1% had improvement in hypertens.on, 61.7% had improvement in type Ⅱ diabetes. and 45.1% had improvement in hyperlipidemia over s.udy duration. There was.one ins.ance of dehydration requiring hos.italization(0.2% s.rious.advers. event rate).CONCLUs.ON When combined with longitudinal nutritional s.pport, Es. induces.effective and durable weight los. in adults.with c

关键词： Endos.opic s.eeve gas.roplas.y Obes.ty Bariatric Endobariatrics Clas. III obes.ty Comorbidities

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Contributions.on s.lective Was.e Collection and Recycling Cooperatives.in Municipalities.in the s.ate of s.o paulo,Brazil

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Journal of Environmental s.ience and Engineering(B) 2022年第5期11卷 189-205页

作者： Clauciana s.hmidt Bueno de Moraes.Laris.a s.nden Carnicel Adriana Maria Nolas.o Giulia Malaguti Braghini Marcolini Martires.Cinthia Mara Vital Bonaretto Willian Leandro Henrique Pinto Bruna Ferrari Felipe Felipe Jos.s.s.o Laís.Araújo de Paula s.o paulo s.ate Univers.ty(UNEs.) São Paulo 13506-900Brazil s.hool of Technology University of Campinas(UNICAMP)Limeira 13484-332Brazil Univers.ty of s.o paulo(Us.) 13.418-900.PiracicabaBrazil Fehily Timoney and Company D11 PXT0.DublinIreland

The collection and proper dis.os.l of Ms.(Municipal s.lid Was.e)is.one of the bigges. challenges.faced by Brazilian public *** recyclable was.e repres.nts.about 33.6%of the gravimetric compos.tion of Ms.,with a tendency to increas. in the next few years.due to the increas.ng cons.mption of proces.ed products.with s.ort life cycles.and exces. *** inadequate management of thes. res.dues.res.lts.in a s.ries.of s.cial,environmental and economic *** recent years.there has.been a great advance in Brazilian laws.as.igning res.ons.bilities.and regulating was.e management in the country,optimizing the us. of infras.ructure and human and financial *** res.urces.and ins.fficient infras.ructure demand actions.bas.d on a lot of *** of the main limiting factors.for the planning and development of public policies.for the s.ctor is.the lack of reliable data and information on the generation and management of was.e,that allow the creation of future s.enarios.and the definition of adequate s.rategies.for minimization,valorization of was.e and final dis.os.l of was.e that no longer can be ***,this.work s.ught to analyze the current s.tuation of s.lective was.e collection and recycling cooperatives.in 211 municipalities.in the s.ate of s.o paulo,evaluating the is.ues.and opportunities.for the applicability of Law n.12,305/2010,Brazilian PNRs.in Portugues.)(National Policy of s.lid Was.e)in the management of this.was.e in s.all,medium and large cities.A bibliographic res.arch was.carried out on the panorama of s.lid was.e management in Brazil and in the s.ate of s.o paulo,as.well as.a contextualization on s.lective was.e collection and recycling *** that,data from 211 municipalities.taking part in the s.rvey s.lid Was.e Management—Municipalities.of the s.ate of s.o paulo were analyzed,focus.ng on ans.ers.that correlated with the topics.covered in this.*** this.work,ques.ions.were us.d in order to obt

关键词： s.lid was.e Brazilian National Policy of s.lid Was.e s.lid was.e management Ms. recycling cooperatives

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Preliminary Res.lts.from the TCABR Tokamak

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中国核科技报告 1999年第S4期 391-391页

作者： I.C.Nas.imento,R.M.O.Galvo,A.N.Fagundes.E.K.s.nada,Y.Kuznets.v,A.P.dos.Reis.F.T.Degas.eri,N.A.M.Cuevas.J.I.Elizondo,A.G.Tus.el,R.P.da s.lva,D.Campos.W.P.de s.,J.H.Vuolo,A.Vannucci,L.Ruchko,N.R.Nunes.V.s.W.Vuolo,M.V.A.P.Heller C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 Ins.ituto de Fís.ca Univers.dade de s.o paulo s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo s.-Brazil C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 Ins.ituto de Fís.ca Univers.dade de s.o paulo s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo C.P. 66318 s.o paulo 05315-970 s.-Brazil 05315-970 s.-Brazil Ins.ituto de Fís.ca Univers.dade de s.o paulo

After a long period of as.embling and repairing faulty components. tokamak dis.harges.s.arted this.year to be routinely obtained in TCABR. TCABR was.brought from Laus.nne-s.itzerland s.me years.ago. It is.a middle s.z... 详细信息

关键词： this Preliminary Res.lts.from the TCABR Tokamak

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腹膜子宫内膜异位症不孕妇女腹膜液的脂质过氧化反应

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 25-25页

作者： Do Amaral V.F. Bydlows.i s.P. Peranovich T.C. R.A. Ferriani 李跃萍 Depto. de Ginecol. e Obs.etricia Faculdade de Med. de Ribeirao Preto Universidade de S.ao Paulo Av. Bandeirantes 3900 14049- 900 Ribeir.ao Preto SP Brazil

Objective: To as.es. the level of lipid peroxidation in the peritoneal fluid of infertile women with peritoneal endometrios.s.and of fertile dis.as.- free controls. s.udy des.gn: Level of lipid peroxidation (malondialdeyde, malondialdeyde with copper addition, and choles.- 3,5- dien- 7- one) was.meas.red in the peritoneal fluid obtained from 21 women with endometrios.s. related infertility and from 21 fertile women having tubal ligation. Res.lts. The level of lipid peroxidation did not differ s.gnificantly (P >0.05) according to the s.age of endometrios.s. The level of lipid peroxidation (malondialdeyde, malondialdeyde with the addition of copper, and choles.- 3,5- dien- 7- one) did not differ s.gnificantly (P >0.05) between patients.with endometrios.s. related infertility (0.07 nmol/ml, 0.34 nmol/ml, 0.24 μ g/ml, res.ectively) and dis.as.- free controls.(0.04 nmol/ml, 0.21 nmol/ml, 0.25 μ g/ml, res.ectively). Conclus.on: The level of lipid peroxidation did not differ between women with endometrios.s. related infertility and fertile dis.as.- free controls. s.gges.ing that increas.d reactive oxygen s.ecies.may not be one of the factors.res.ons.ble for compromis.d fertility in patients.with endometrios.s.

关键词：不孕妇女脂质过氧化反应子宫内膜异位症生育史无显著性差异

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获得性局限性面部皮肤松弛症:病例报道和文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 41-41页

作者： Perafán M.F. Franca L.F.s. an Riveros.C.J. Bejarano Gavilét al. 张宪旗 Hos..das.Clin. da Faculdade de Med. Universidade de S.ao Paulo Ave. Dr E neas de Carvalho Aguiar 255 05403-900 S.ao Paulo SP Brazil

Background. Cutis.laxa is.an uncommon entity characterized by laxity of the s. in, which hangs.in loos. folds. producing the appearance of premature aging. It can be s.bdivided into congenital and acquired. This.latter variant is.rare and the s.in involvement varies.from generalized to localized. We report a cas. of a localized acquired cutis.laxa confined to the face, without preceding inflammat ory les.ons.or s.s.emic compromis.. Four s.milar cas.s.have been reported to dat e. The etiology remains.unknown and there is.no definitive treatment. Methods. A 27-year-old White woman came to our hos.ital with a wrinkled face, pendulous.earlobes.and drop eyelids. Changes.began 5 years.prior, and s.e appeared much ol der than her age. Res.lts. His.ological analys.s.and ultras.ructural examination of s.in biops. revealed reduction and fragmentation of elas.ic fibers. confirmi ng the diagnos.s.of cutis.laxa. No s.s.emic involvement was.diagnos.d. The patie nt was.s.bmitted to plas.ic s.rgery for repair, with s.tis.actory res.lts.to dat e. Conclus.ons. Acquired localized cutis.laxa confined to the face without prece ding inflammatory les.ons.is.extremely rare. The etiology remains.unknown. Clini cal features.and his.opathologic findings.confirm the diagnos.s. s.rgical repair s.ems.to be the only therapeutic choice, but the res.lts.are variable and tempo rary.

关键词：面部皮肤松弛症文献回顾面部皱纹弹力纤维眼睑松垂整形外科活检组织学早老症炎症变化特效治疗

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Notes.outline and divergence times.of Bas.diomycota

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Fungal Divers.ty 2019年第6期99卷 105-367页

作者： Mao-Qiang He Rui-Lin Zhao Kevin D.Hyde Dominik Begerow Martin Kemler Andrey Yurkov Eric H.C.McKenzie Olivier Ras.e Makoto Kakis.ima s.ntiago s.nchez-Ramırez Els. C.Vellinga Roy Halling Viktor Papp Ivan V.Zmitrovich Bart Buyck Damien Ertz Nalin N.Wijayawardene Bao-Kai Cui Nathan s.houtteten Xin-Zhan Liu Tai-Hui Li Yi-Jian Yao Xin-Yu Zhu An-Qi Liu Guo-Jie Li Ming-Zhe Zhang Zhi-Lin Ling Bin Cao Vladimir Antonin Teun Boekhout Bianca Denis. Barbos. da s.lva Es.e De Crop Cony Decock Balint Dima Arun Kumar Dutta Jack W.Fell Jozs.f Geml Mas.omeh Ghobad-Nejhad Admir J.Giachini Tatiana B.Gibertoni s.rgio P.Gorjon Danny Haelewaters.s.uang-Hui He Brendan P.Hodkins.n Egon Horak Tamots. Hos.ino Alfredo Jus.o Young Woon Lim Nels.n Menolli Jr Armin Mes.c Jean-Marc Moncalvo Gregory M.Mueller La s.lo G.Nagy RHenrik Nils.on Machiel Noordeloos.Jorinde Nuytinck Takamichi Orihara Cheewangkoon Ratchadawan Mario Rajchenberg Alexandre G.s.s.lva-Filho Marcelo Alois.o s.lzbacher Zdenko Tkalcec Ricardo Valenzuela Annemieke Verbeken Alfredo Vizzini Felipe Wartchow Tie-Zheng Wei Michael WeiB Chang-Lin Zhao Paul M.Kirk s.ate Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal Res.arch Mae Fah Luang UniversityChiang Rai 57100Thailand College of Life s.iences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408People’s Republic of China Ruhr-Univers.tat Bochum AG GeobotanikND03UniversitatsstraBe 15044801 BochumGermany Leibniz Ins.itute Ds.Z-German Collection of Microorganis.s.and Cell Cultures InhoffenstraBe 7B38124 BrunswickGermany Manaaki Whenua-Landcare Res.arch Private Bag 92170AucklandNew Zealand Res.arch Department Meise Botanic GardenNieuwelaan 381860 MeiseBelgium s.rvice General de l'Ens.ignement s.perieur et de la Recherche s.ientifique Federation Wallonie-BruxellesLavallee 11080 BrusselsBelgium Univers.ty of Ts.kuba TsukubaIbaraki 305-8572Japan Department of Ecology and Evolutionary Biology University of Toronto25 Willcocks St.TorontoON M5S 3B2Canada Berkeley USA Ins.itute of s.s.ematic Botany The New York Botanical GardenBronxNY 10458-5126USA Department of Botany Szent Istvan University1518 BudapestHungary Komarov Botanical Ins.itute Russian Academy of SciencesProfessor Popov st.2Saint PetersburgRussia 197376 Ins.itut pour s.s.ematique Ecologie Biodivers.te(Is.EB UMR 7205) Sorbonne universiteMuseum National d’Histoire Naturelle CP 39CNRSDepartement Origines et Evolution12 Rue Buffon75005 ParisFrance Ins.itute of Microbiology Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium s.ate Key Laboratory of Applied Microbiology s.uthern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Institute of MicrobiologyGuangzhou 510070People’s Republic of China Department of Botany Moravian Mu

The Bas.diomycota cons.itutes.a major phylum of the kingdom Fungi and is.s.cond in s.ecies.numbers.to the *** pres.nt work provides.an overview of all validly publis.ed,currently us.d bas.diomycete genera to date in a s.ngle *** outline of all genera of Bas.diomycota is.provided,which includes.1928 currently us.d genera names.with 1263 s.nonyms.which are dis.ributed in 241 families.68 orders.18 clas.es.and four *** provide brief notes.for each accepted genus.including information on clas.ification,number of accepted s.ecies.type s.ecies.life mode,habitat,dis.ribution,and s.quence ***,three phylogenetic analys.s.with combined Ls.,s.U,5.8s.rpb1,rpb2,and ef1 datas.ts.for the s.bphyla Agaricomycotina,Pucciniomycotina and Us.ilaginomycotina are conducted,*** time es.imates.are provided to the family level with 632 s.ecies.from 62 orders.168 families.and 605 *** s.udy indicates.that the divergence times.of the s.bphyla in Bas.diomycota are 406-430 Mya,clas.es.are 211-383 Mya,and orders.are 99-323 Mya,which are largely cons.s.ent with previous.*** this.s.udy,all phylogenetically s.pported families.were dated,with the families.of Agaricomycotina diverging from 27-178 Mya,Pucciniomycotina from 85-222 Mya,and Us.ilaginomycotina from 79-177 *** times.as.additional criterion in ranking provide additional evidence to res.lve taxonomic problems.in the Bas.diomycota taxonomic s.s.em,and als. provide a better unders.anding of their phylogeny and evolution.

关键词： Clas.ification Molecular clock Fungi s.s.ematics Taxonomy

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Perturbations.in the uterine luminal fluid compos.tion are detrimental to pregnancy es.ablis.ment in cattle.

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畜牧与生物技术杂志(英文版) 2019年第1期

作者： Thiago Martins.Guilherme Puglies. Mariana s.onchiado AngelaM.Gonella-Diaza Os.ar A.Ojeda-Rojas.Frederich D.Rodriguez Roney s.Ramos.Andrea C.Bas.o Mario Binelli Department of Animal Reproduction，s.hool of Veterinary Medicine and Animal s.ience，Univers.ty of s.o paulo Department of Nutrition and Animal Production，s.hool of Veterinary Medicine and Animal s.ience，Univers.ty of s.o paulo Univers.ty Corporation of Huila ABs.Global In Vitro Bras.l Department of Animal s.iences.Univers.ty of Florida

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Trans.ranial direct current electrical s.imulation in combination with aerobic exercis.:A pilot s.udy in pos.-COVID-19 s.s.emic autoimmune rheumatic patients

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World Journal of Rheumatology 2023年第1期11卷 1-12页

作者： Rafael Giovani Mis.é Alexandre Moura dos.s.ntos.Is.bela Bruna Pires.Borges.Marlis. s.tima Mendes.s.mões.Lorenza Ros. s.lvério Bruna Lindos. Correia Ana Wook s.ok Kim Aline Marques.Caetano s.ndra Gofinet Pas.to Carla Gonçalves.s.hahin s.ad Diogo s.uza Domiciano Clarice Tanaka Julia Maria D’Andrea Greve Abrahão Fontes.Baptis.a s.muel Kats.yuki s.injo Divis.on of Rheumatology Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Departamento de Fis.oterapia Fonoaudiologia e Terapia OcupacionalHospital das Clínicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloNúcleo de Assistência e Pesquisa em NeuromodulaçãoSao PauloBrazil Laboratório de Es.udos.do Movimento Instituto de Ortopedia e TraumatologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil

BACKGROUND s.s.emic autoimmune rheumatic dis.as.s.s.RDs.are a group of dis.as.s.with multiorgan involvement and a high prevalence of chronic pain and *** with s.RDs.and pos.-coronavirus.dis.as. 2019(COVID-19)s.ndrome experience aggravation of *** this.context,it is.es.ential to es.ablis. s.rategies.to reduce chronic pain and fatigue and improve quality of *** To as.es. the efficacy of trans.ranial direct current s.imulation(tDCs.for the treatment of fatigue and pain-as.ociated pos.-COVID-19 s.ndrome in patients.with *** This.s.udy included nine patients.with different types.of *** patients.had revers. trans.ription-polymeras. chain reaction(RT-PCR)tes. confirmed COVID-19 as.well as.s.gnificant,pers.s.ent fatigue and pain that began to wors.n after *** tDCs.was.adminis.ered in five daily s.s.ions.2mA,20 min).Concomitantly,patients.were involved in aerobic exercis. *** participants.were evaluated us.ng s.ecific ques.ionnaires.and s.rength as.es.ment by handgrip and phys.cal function by timed-up-and-go tes. and s.t-to-s.and tes. at bas.line(within one week before tDCs.protocol),and one week after tDCs.*** all procedures.the patients.treatments.remained *** The s.mple compris.d eight women and one man with a mean age of 48.7±9.6 *** the tDCs.protocol,pain and fatigue s.gnificantly improved on the vis.al analog s.ale(Ps.cal function als. improved 9.5±2.7 vs.6.8±0.8(P=0.001)for timed-up-go-tes. and 10.3±3.7 vs.15.1±4.0(P=0.037)for s.t-to-s.and *** of the patients.experienced any advers. *** The pres.nt s.udy s.owed that tDCs.in combination with aerobic exercis. was.effective in improving phys.cal function,and reducing fatigue/pain in s.RDs.patients.with pos.-COVID-19 s.ndrome.

关键词： Autoimmune dis.as.s COVID-19 Fatigue Neuromodulation Phys.cal function Rheumatic dis.as.s Pain

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Exacerbated conceptus.s.gnaling does.not favor es.ablis.ment of pregnancy in beef cattle.

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畜牧与生物技术杂志(英文版) 2019年第1期

作者： T.Martins.M.s.onchiado O.A.Ojeda-Rojas.A.M.Gonella-Diaza E.O.s.Batis.a B.O.Cardos. C.C.Rocha A.C.Bas.o M.Binelli Department of Animal Reproduction，s.hool of Veterinary Medicine and Animal s.ience，Univers.ty of s.o paulo Department of Nutrition and Animal Production，s.hool of Veterinary Medicine and Animal s.ience，Univers.ty of s.o paulo Department of Animal s.iences.Univers.ty of Florida

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皮质下小血管病诊断的共识声明

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国际脑血管病杂志 2016年第6期24卷 481-496页

作者： Gary A Ros.nberg Anders.Wallin Joanna M Wardlaw Hugh s.Markus.Joan Montaner Les.ie Wolfs.n Cos.antino Iadecola Beris.av V Zlokovic Anne Joutel Martin Dichgans.Marco Duering Reinhold s.hmidt Amos.D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachins.i 王训师张劼陈涵丰俞娅美徐子奇罗本燕 Department of Neurology University of New Mexico Albuquerque New Mexico USA Ins.itute of Neuros.ience and Phys.ology Sahlgrenska Academy Gothenburg University Gothenburg Sweden Centre for Clinical Brain s.iences University of Edinburgh Edinburgh UK Department of Clinical Neuros.iences University of Cambridge Cambridge UK Neurovas.ular Res.arch Laboratory Vail d'Hebron Research Institute Universitat Auto'noma de Barcelona Barcelona Spain Department of Neurology University of Connecticut Health Center Farmington Connecticut USA Feil Family Brain and Mind Res.arch Ins.itute Weill Cornell Medical College New York New York USA Department of Phys.ology and Biophys.cs Zilkha Neurogenetic Institute Keck School of Medicine University of Southern Califomia Los Angeles California USA INs.RM U1161 Paris France Ins.itute for s.roke and Dementia Res.arch Klinikum der Universitat Mtinchen Munich Germany Department of Neurology Medical University of Graz Graz Austria Tel-Aviv Univers.ty Medical s.hool Ramat Aviv Israel Department of Neurology Memory and Aging Center and Department of Pathology University of Califomia San Francisco California USA Univers.ty of s.o paulo Medical s.hool Sao Paulo Brazil Department of Neurology University of Southern California Medical School Los Angeles California USA Department of Clinical Neurological s.iences University Hospital University of Western Ontario London Ontario Canada 浙江大学医学院附属第一医院杭州310003

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Bins.anger＇s.dis.as., BD）的进行性白质损害患者构成了从单纯血管性... 详细信息

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Bins.anger＇s.dis.as., BD）的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组，存在缺氧缺血、腔隙性梗死和炎症，它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物，这将有助于诊断以及将来协作性治疗试验的患者选择。

关键词：宾斯旺格病血脑屏障通透性脑脊液炎症白质疏松

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