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Improving sexual and reproductive health knowledge and practice in Mozambican families with media campaign and volunteer family health champions

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Family Medicine and Community Health 2019年第4期7卷 18-23页

作者： paulo Henrique Pires Ronald Siemens Martins Mupueleque Health Sciences Faculty lúrio University Lúrio UniversityNampulaMozambique University of Saskatchewan College of Medicine SaskatoonSaskatchewanCanada Universidade Mussa bin Bique NampulaNampulaMozambique

Objective To increase knowledge,attitudes and practice of sexual and reproductive health and family planning and to reduce maternal and neonatal mortality rates in *** An implementation research project’s intermediate evaluation,applying two cross-sectional *** surveys were planned for 316 subjects before and after *** Research performed in Natikiri district of Nampula province in northern Mozambique,targeting a suburban and rural populations in their *** 452 people were surveyed(91 before,361 after),all belonging to the Macua ethnic *** A media campaign(2 weekly radio spots,bimonthly theatre performances)was performed for 8 months(2017 to 2018)and family health champions’teachings(monthly home visits)performed for 3 months,on sexual and reproductive health and family *** measures planned and measured were adolescent’s and adult’s knowledge,attitudes and practice about *** were analysed by gender,age group and frequencies,using a CI of 95%(plly significant).results Radio spots,community theatre and volunteer champions increased population’s knowledge about sexual and reproductive health and led to a more positive attitude toward family *** attitude,results show differences between adults’proportions before and after:(1)did you hear about sexual and reproductive health(p=0.0425);(2)knows project key messages(pl visits importance(p=0.0301);(4)access to contraceptives was easy(plescents showed statistically significant differences before and after:(1)knows project key messages(ply planning practice did not increase in both *** A health education intervention,using a media campaign and local volunteers,is useful to promote mother and child *** is an unmet need for family planning and the use of modern contraception is below desired pra

关键词： knowledge media campaign

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Microcalorimetric Study of Acetylcholine and Acetylthiocholine Hydrolysis by Acetylcholinesterase

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Advances in Enzyme Research 2017年第1期5卷 1-12页

作者： paulo Alexandre A.de Almeida Neves Eliane Novato Silva paulo S.l.Beirao Biochemistry and Immunology Department Federal University of Minas GeraisBelo HorizonteBrazil

Acetylcholinesterase (AChE) is an important enzyme responsible for the cleavage of acetylcholine. Studies of the activity of this enzyme use an artificial substrate, acetylthiocholine, because a product of its catalysis, thiocholine, readily generates a light absorbing product upon reaction with Elman’s reagent 5,5’-dithiobis-(2-nitrobenzoic acid (DTNB). The hydrolysis of acetylcholine cannot be assayed with this method. The isothermal titration calorimetry can assay the hydrolysis of both substrates, without requiring additional reagents other than the enzyme and the substrate. To compare kinetic values obtained in the hydrolysis of acetylcholine (ACh) and acetylthiocholine (ATCh), with carbaryl acting as inhibitor, a calorimetric technique was used to evaluate kinetic properties of the two reactions. This method can show the hydrolysis of both substrates by the heat exchange that occurs during catalysis. In addition, it allowed the assessment of the AChE inhibition by carbaryl, a common insecticide. The results show a similarity between values obtained with both substrates, which are slightly higher for acetylcholine, the enzyme natural substrate. Enzymatic parameters values from ATCh and ACh were similar to each other and inhibitory constants using carbaryl were also similar, displaying that any approach to ACh is feasible using ATCh. The results obtained from ITC show the precision achieved by the calorimetric method.

关键词： Acetylcholinesterase Acetylcholine Acetylthiocholine Isothermal Titration Calorimetry Carbaryl

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Increased hepatic expression of insulin-like growth factor-Ⅰreceptor in chronic hepatitis C

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World Journal of Gastroenterology 2006年第24期12卷 3821-3828页

作者： José Tadeu Stefano Maria lúcia Corr(e|^)a-Giannella Cristiane Maria Freitas Ribeiro Ven(a|^)ncio Avancini Ferreira Alves paulo Celso Bosco Massarollo Marcel Cerqueira Cesar Machado Daniel Giannella-Neto laboratory for Cellular and Molecular Endocrinology University of Sao paulo Medical School Brazil laboratory for Cellular and Molecular Endocrinology University of Sao paulo Medical School Diabetes UnitDivision of EndocrinologyBrazil Department of Pathology Santa Casa de Misericórdia de Sao paulo Brazil Department of Pathology University of Sao paulo Medical School Brazil laboratory for Experimental Surgery University of Sao paulo Medical School Brazil

AIM： Although increased insulin-like growth factor-I receptor （IGF-IR） gene expression has been reported in hepatocellular carcinoma, studies assessing IGF-IR in chronic hepatitis C （CHC） and cirrhosis are scarce. We therefore aimed to evaluate IGF-IR and IGF-I rnRNA expression in liver from patient with CHC. METHODS： IGF-IR and IGF-I rnRNA content were determined by semi-quantitative RT-PCR and IGF-IR protein expression was determined by immunohistochemistry in hepatic tissue obtained from patients with CHC before （34 patients） and after （10 patients） therapy with interferon-α and ribavirin. RESUlTS： An increase of IGF-IR rnRNA content was observed in hepatic tissue obtained from all CHC patients as well as from 6 cadaveric liver donors following orthopic transplantation （an attempt to evaluate normal livers） in comparison to normal liver, while no relevant modifications were detected in IGF-I mRNA content. The irnrnunohistochemical results showed that the raise in IGF-IR rnRNA content was related both to ductular reaction and to increased IGF-IR expression in hepatocytes. A decrease in IGF-IR rnRNA content was observed in patients who achieved sustained virological response after therapy, suggesting an improvement in hepatic damage. CONClUSION： The up-regulation of IGF-IR expression in hepatocytes of patients with CHC could constitute an attempt to stimulate hepatocyte regeneration. Considering that liver is the organ with the highest levels of IGF-I, our finding of increased IGF-IR expression after both acute and chronic hepatic damage highlights the need for additional studies to elucidate the role of IGF-I in liver regeneration.

关键词： Chronic hepatitis C Insulin-like growth factorI Insulin-like growth factor I receptor Ductular reaction Hepatocyte regeneration Ischemia-reperfusion

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Ulnar variance related to biological and training characteristics, pain and handgrip strength in Portuguese skeletally immature male gymnasts

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Journal of Sport and Health Science 2015年第2期4卷 174-181页

作者： luísa Amaral Albrecht l.Claessens Jos Ferreirinha paulo Santos Health Sciences School University of Fernando Pessoa Department of Biomedical Kinesiology Faculty of Kinesiology and Rehabilitation Sciences Katholieke Universiteit Leuven Research Centre for Sport Health and Human Development (CIDESD) University of Tra's-os-Montes and Alto Douro Centre of Research Education Innovation and Intervention in Sport (CIFI2D) Faculty of Sport University of Porto

Purpose： This study was to investigate the association between ulnar variance（UV） and biological and training characteristics, handgrip, and wrist pain in a group of 23 Portuguese skeletally immature male gymnasts（aged 11.2 2.5 years）.Methods： left and right UV was obtained using Hafner＇s procedure and skeletal age was determined by the TannereWhitehouse 3-method. A negative mean value for UV measures was observed（ 2.4 to 3.6 mm） without significant differences with increasing age-category（ p=0.09 to p=0.48）. Significant low correlations were observed between some UV parameters and stature, fat percentage, years of training, and left handgrip ***： Ten gymnasts reported wrist pain with gradual onset and UV values were very similar between painless and painful ***： The findings of this study do not directly support the thesis that gymnastics training and biological variables or wrist pain are associated with UV.

关键词： Gymnasts Pain Training Ulnar variance

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Fiber Optic Intensity-Modulated Sensors： a Review in Biomechanics

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Photonic Sensors 2012年第4期2卷 315-330页

作者： paulo RORIZ Antonio RAMOS Jose l. SANTOS Jose A. SIMOES Department of Mechanics University of Aveiro 3810-193 Aveiro Portugal Faculty of Sciences University of Porto Rua do Campo Alegre 687 4150-179 Porto Portugal

Fiber optic sensors have a set of properties that make them very attractive in biomechanics. However, they remain unknown to many who work in the field. Some possible causes are scarce information, few research groups using them in a routine basis, and even fewer companies offering turnkey and affordable solutions. Nevertheless, as optical fibers revolutionize the way of carrying data in telecommunications, a similar trend is detectable in the world of sensing. The present review aims to describe the most relevant contributions of fiber sensing in biomechanics since their introduction, from 1960s to the present, focusing on intensity-based configurations. An effort has been made to identify key researchers, research and development （R＆D） groups and main applications.

关键词： Biomechanics fiber optic sensors intensity-modulated sensors

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Biocomposites Based on Thermoplastic Starch and Granite Sand Quarry Waste

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Journal of Renewable Materials 2019年第4期7卷 393-402页

作者： María G.Passaretti Mario D.Ninago Cecilia I.paulo Horacio A.Petit Edgardo F.Irassarc Daniel A.Vega Marcelo A.Villar Olivia V.lópez Planta Piloto de Ingeniería Química PLAPIQUI(UNS-CONICET)Camino"La Carrindanga"Km 7Bahía Blanca8000Buenos AiresArgentina Departamento de Ingeniería Química Universidad Nacional del Sur(UNS)Bahía Blanca8000Buenos AiresArgentina Facultad de Ciencias Aplicadas a la Industria(FCAI) Universidad Nacional de Cuyo(UNCuyo)Bernardo de Irigoyen 375San Rafael5600MendozaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Godoy Cruz 2290Ciudad Autónoma de Buenos AiresC1425FQBBuenos AiresArgentina Facultad de Ingeniería Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPBA).Centro de Investigaciones en Física e IngenieríaCIFICEN(UNCPBA-CICPBA-CONICET)7400OlavarríaArgentina Instituto de Física del Sur IFISUR(UNS-CONICET)Bahía Blanca8000Argentina

Granite stone is a by-product of the rock crushing *** industrial waste in powder form that causes health problems and environmental *** particles fraction can be used as a partial replacement of sand in concrete *** this work,an alternative exploitation of this waste fraction is *** sand(GS)with particles mean size of ~1μm was employed as thermoplastic starch(TPS)filler at different *** were obtained by melt-mixing and thermo-compression,achieving translucent and easy to handle films.A good GS dispersion within the matrix was evidenced by *** presence induced a shift of starch’s melting point to higher values and a better thermal *** UV absorption capacity was increased ~90% by GS *** increment in TPS Young’s modulus and maximum tensile stress of 5 and 3 times,respectively was observed by adding 5%w/w GS.

关键词： Thermoplastic starch granite sand melt processing final properties

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Exercise training as an intervention for frailty in cirrhotic patients on the liver transplant waiting list:A systematic review

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World Journal of Hepatology 2023年第10期15卷 1153-1163页

作者： Thais Mellato loschi Melline D T A Baccan Bianca Della Guardia paulo N Martins Amanda P C S Boteon Yuri l Boteon Transplant Centre Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil Department of Surgery Transplant DivisionUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States

BACKGROUND The existing literature suggests that exercise for cirrhotic patients is safe and favours significant improvement to their physical ***,exercise training for this population and how to deliver activities,especially in severe stages of the disease and while waiting for a liver transplant(lT),remain *** To review the existing exercise prescriptions for cirrhotic patients on the waiting list for lT,their results for frailty evolution and their effect on clinical *** A systematic review was performed following the Preferred Reporting Review and Meta-Analysis guidelines and searching the PubMed,MEDlINE,and Scopus *** keyword“liver transplant”was used in combination with the free terms“frailty”and“exercise”for the literature *** studies that evaluated the effect of a regular training program,independent of supervision or the duration or intensity of physical exercise,in cirrhotic patients on the waiting list for lT were *** data on safe physical activity prescriptions following Frequency,Intensity,Time,and Type recommendations were extracted and *** Nine articles met the inclusion criteria for this *** instruments for frailty assessment were used,frequently in *** studies prescribed physical activity for patients,one in-person and four to be performed remotely and *** remaining four studies only used a self-report instrument to assess the level of physical *** reported adverse events related to exercise *** exercise frequency mainly varied from daily to a minimum of twice per *** intensity depended on frailty and included increasing levels of *** type of exercise was predominantly a combination of aerobic and resistance *** duration of exercise varied from 4 to 12 *** articles evaluated the effect of the exercise program on clinical outcomes,reporting a reduction in 90-d readmission rates post-tran

关键词： End-stage liver disease liver transplant Frailty Exercise Rehabilitation Sarcopenia

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The Semantic Data Dictionary-An Approach for Describing and Annotating Data

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Data Intelligence 2020年第4期2卷 443-486页

作者： Sabbir M.Rashid James P.McCusker paulo Pinheiro Marcello P.Bax Henrique O.Santos Jeanette A.Stingone Amar K.Das Deborah l.McGuinness Tetherless World Constellation Rensselaer Polytechnic InstituteTroy NY 12180USA School of Information Science Federal University of Minas GeraisBelo Horizonte 31270-901MGBrazil Mailman School of Public Health Columbia UniversityNew York NY 10032USA IBM Research Cambridge MA 02142USA

It is common practice for data providers to include text descriptions for each column when publishing data sets in the form of data *** these documents are useful in helping an end-user properly interpret the meaning of a column in a data set,existing data dictionaries typically are not machine-readable and do not follow a common specification *** introduce the Semantic Data Dictionary,a specification that formalizes the assignment of a semantic representation of data,enabling standardization and harmonization across diverse data *** this paper,we present our Semantic Data Dictionary work in the context of our work with biomedical data;however,the approach can and has been used in a wide range of *** rendition of data in this form helps promote improved discovery,interoperability,reuse,traceability,and *** present the associated research and describe how the Semantic Data Dictionary can help address existing limitations in the related *** discuss our approach,present an example by annotating portions of the publicly available National Health and Nutrition Examination Survey data set,present modeling challenges,and describe the use of this approach in sponsored research,including our work on a large National Institutes of Health(NIH)-funded exposure and health data portal and in the RPI-IBM collaborative Health Empowerment by Analytics,learning,and Semantics project.

关键词： Semantic Data Dictionary Dictionary mapping Codebook Knowledge modeling Data integration Data dictionary Mapping language Metadata standard Semantic Web Semantic ETl FAIR Data

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Papillary fistulotomy vs conventional cannulation for endoscopic biliary access:A prospective randomized trial

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World Journal of Gastroenterology 2018年第16期24卷 1803-1811页

作者： Carlos Kiyoshi Furuya paulo Sakai Fabio Ramalho Tavares Marinho Jose Pinhata Otoch Spencer Cheng lívia lemes Prudencio Eduardo Guimaraes Hourneaux de Moura Everson luiz de Almeida Artifon Department of Gastrointestinal Endoscopy Unit University of Sao PauloSao Paulo 05409001Brazil Department of Surgery University of Sao PauloSao Paulo 05403000Brazil Department of Gastroenterology and Radiology University of Sao PauloSao Paulo 04107-030Brazil

AIM To compare the cannulation success, biochemical profile, and complications of the papillary fistulotomy technique vs catheter and guidewire standard *** From July 2010 to May 2017, patients were prospectively randomized into two groups: Cannulation with a catheter and guidewire(Group Ⅰ) and papillary fistulotomy(Group Ⅱ). Amylase, lipase and C-reactive protein at T0, as well as 12 h and 24 h after endoscopic retrograde cholangiopancreatography, and complications(pancreatitis, bleeding, perforation) were *** We included 102 patients(66 females and 36 males, mean age 59.11 ± 18.7 years). Group Ⅰ and Group Ⅱ had 51 patients each. The successful cannulation rates were 76.5% and 100%, respectively(P = 0.0002). Twelve patients(23.5%) in Group Ⅰ had a difficult cannulation and underwent fistulotomy, which led to successful secondary biliary access(Failure Group). The complication rate was 13.7%(2 perforations and 5 mild pancreatitis) vs 2.0%(1 patient with perforation and pancreatitis) in Groups Ⅰ and Ⅱ, respectively(P = 0.0597). CONClUSION Papillary fistulotomy was more effective than guidewire cannulation, and it was associated with a lower profile of amylase and lipase. Complications were similar in both groups.

关键词： Catheterization Complications Endoscopic retrograde cholangiopancreatography Therapeutic use Common bile duct

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Restoration of Motor Function through Delayed Intraspinal Delivery of Human Il-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury

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Research 2023年第4期2023卷 131-144页

作者： lászlóGál Tamás Bellák Annamária Marton Zoltán Fekécs Drew Weissman Dénes Török Rachana Biju Csaba Vizler Rebeka Kristóf Mitchell B.Beattie paulo J.C.lin Norbert Pardi Antal Nógrádi Krisztián Pajer Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary National Biotechnology laboratory Institute of GeneticsBiological Research CentreSzegedHungary Institute of Biochemistry Biological Research CentreSzegedHungary Department of Medicine University of PennsylvaniaPhiladelphiaPA19104USA Acuitas Therapeutics VancouverBCV6T 1Z3Canada

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great ***-modified messenger RNA(mRNA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic ***,we used lipid nanoparticle(lNP)-encapsulated human interleukin-10(hIl-10)-encoding nucleoside-modified mRNA to induce neuroprotection and functional recovery following rat spinal cord contusion *** administration of hIl-10 mRNA-lNP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to ***,hIl-10 mRNA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of Il-105 d after *** results suggest that treatment with nucleoside-modified mRNAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.

关键词： protective Restoration utilized

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