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Sintering effects on chemical and physical properties of bioactive ceramics

Journal of Advanced Ceramics 2013年第3期2卷 274-284页

作者： Lukasz WITEK James SMAY Nelson R.F.A.SILVA Teja gUDA Joo L.ONg paulo g.coelho School of Chemical Engineering Oklahoma State University423 Engineering NorthStillwaterOKUSA Department of Biomaterials and Biomimetics New York University345 East 24th Street804S New YorkNYUSA Department of Operative Dentistry Universidade Federal de Minas GeraisPampulhaBelo HorizonteMGBrazil Department of Biomedical Engineering University of Texas San AntonioOne UTSA CircleSan AntonioTXUSA Department of Periodontology and Implant Dentistry College of DentistryNew York University345 East 24th StreetNew YorkNYUSA

The objective of this study was to characterize the chemical and physical properties of bioactive ceramics prepared from an aqueous paste containing hydroxyapatite(HA)and beta tri-calcium phosphate(β-TCP).Prior to formulating the paste,HA andβ-TCP were calcined at 800℃and 975℃(11 h),milled,and blended into 15%/85%HA/β-TCP volume-mixed *** cylindrical rods were subsequently sintered to 900℃,1100℃or 1250℃.The sintered specimens were characterized by helium pycnometry,X-ray diffraction(XRD),Fourier transform-infrared(FT-IR),and inductively coupled plasma(ICP)spectroscopy for evaluation of porosity,crystalline phase,functional-groups,and Ca:P ratio,*** properties were assessed via 3-point bending and diametral *** microstructural evaluation using scanning electron microscopy(SEM)showed larger pores and a broader pore size distribution(PSD)for materials sintered at 900℃and 1100℃,whereas the 1250℃samples showed more uniform *** quantification showed significantly higher porosity for materials sintered to 900℃and 1250℃(pg sintering where lower amounts of HA were observed when sintering temperature was *** testing demonstrated significant differences between calcination temperatures and different sintering regimes(pg.

关键词： bone graft material chemical/physical characterization sintering bi-phasic calcium phosphate(BCP)

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Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

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Journal of Biomaterials and Nanobiotechnology 2011年第3期2卷 318-328页

作者： Patricia C.Salgado Plinio C.Sathler Helena C.Castro gutemberg g.Alves Aline M.de Oliveira Rodrigo Cde Oliveira Monica D.C.Maia Carlos R.Rodrigues paulo g.coelho Andre Fuly Lúcio M.Cabral Jose M.granjeiro Program of Post-graduation in Medical Sciences Fluminense Federal UniversityNiteróiBrazil Post-graduation in Biology of Interactions Institute of BiologyFluminense Federal UniversityNiteróiBrazil Program of Post-graduation in Pathology Fluminense Federal UniversityNiteróiBrazil Clinical Research Unit Antonio Pedro HospitalNucleus of Cell TherapyFluminense Federal UniversityNiteróiBrazil School of Odontology Fluminense Federal UniversityNiteróiBrazil Department of Biological Sciences Dental School of BauruSão Paulo UniversitySão PauloBrazil School of Pharmacy Federal University of Rio de JaneiroRio de JaneiroBrazil Department of Biomaterials and Biomimetics New York UniversityNew YorkUSA

Presently, several different graft materials are employed in regenerative or corrective bone surgery. However current misconceptions about these biomaterials, their use and risks may compromise their correct application and development. To unveil these misconceptions, this work briefly reviewed concepts about bone remodeling, grafts classification and manufacturing processes, with a special focus on calcium phosphate materials as an example of a current employed biomaterial. Thus a search on the last decade was performed in Medline, LILACS, Scielo and other scientific electronic libraries using as keywords biomaterials, bone remodeling, regeneration, biocompatible materials, hydroxyapatite and therapeutic risks. Our search showed not only an accelerated biotechnological development that brought significant advances to biomaterials use on bone remodeling treatments but also several therapeutic risks that should not be ignored. The biomaterials specificity and limitations to clinical application point to the current need for developing safer products with better interactions with the biological microenvironments.

关键词： Biocompatible materials Bone remodeling Hydroxyapatite Therapeutic risks

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Laparoscopic resection for hepatocellular carcinoma: eastern and western experiences

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Chinese Journal of Cancer Research 2014年第3期26卷 234-236页

作者： paulo Herman Fabricio Ferreira coelho Liver Surgery Unit Department of GastroenterologyUniversity of Sao Paulo Medical School

Hepatocellular carcinoma （HCC） is the most common primary liver cancer （1）. The incidence is rising in the last decades due to many factors, especially hepatitis C, alcoholic liver disease and non-alcoholic steatohepatitis. Moreover, the introduction of screening programs in patients with chronic liver disease has led to an increase in HCC diagnosis （1,2）. In the western world, 80% to 90% of HCC eases occur in patients with liver cirrhosis （3） while this proportion is lower in some regions in Asia and sub-Saharian Africa, where hepatitis B remains as an important etiologic factor for chronic liver disease （2,4）. In 1990, the annual world frequency of HCC was 437,000 cases/year （1）, and in 2012 the number reached 782,200 cases/year being responsible for 746,000 deaths （5）. Nowadays, HCC represents the 6th most frequent neoplastic disease in the world and the 3rd in mortality （5）.

关键词： HCC eastern and western experiences Laparoscopic resection for hepatocellular carcinoma

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Novel preoperative strategies to improve hepatocellular carcinoma resectability

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 140-141页

作者： Francisco Tustumi Fabricio Ferreira coelho paulo Herman Department of gastroenterology Universidade de São PauloSao PauloBrazil Department of Surgery Hospital Israelita Albert EinsteinSao PauloBrazil

Peng et al.(1)performed a pretty interesting article,reporting the proposal of a new strategy to improve resectability for hepatocellular carcinoma(HCC).Their findings are *** strategies to improve liver resection are methods for promoting future liver remnant(FLR)growth in a timely manner before cancer *** main strategies are portal vein embolization(PVE)and associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).

关键词： hepatocellular liver

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Repeat hepatectomy for recurrent colorectal liver metastases:A comparative analysis of short-and long-term results

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 162-167页

作者： paulo Figueiredo Costa Fabricio Ferreira coelho Vagner Birk Jeismann Jaime Arthur Pirola Kruger gilton Marques Fonseca Ivan Cecconello paulo Herman Digestive Surgery Brazilian College of Digestive Surgery(Colégio Brasileiro de Cirurgia Digestiva-CBCD) São PauloBrazil Digestive Surgery Division Department of GastroenterologyUniversity of São Paulo School of MedicineSão PauloBrazil Instituto do Câncer do Estado de São paulo(ICESP) São PauloBrazil

Background: Liver recurrence after resection of colorectal liver metastases(CRLM) is frequent. Repeat hepatectomy has been shown to have satisfactory perioperative results. However, the long-term outcomes and the benefts for patients with early recurrence have not been clarifed. The aim of this study was to compare the short-and long-term outcomes of patients undergoing single hepatectomy and repeat hepatectomy for CRLM. Additionally, the oncological outcomes of patients with early( ≤ 6 months) and late recurrence who underwent repeat hepatectomy were compared. Methods: Consecutive adult patients undergoing hepatectomy for CRLM between June 20 0 0 and February 2020 were included and divided into two groups: single hepatectomy and repeat hepatectomy. Results: A total of 709 patients were included: 649 in the single hepatectomy group and 60 in the repeat hepatectomy group. Patients in the repeat hepatectomy group underwent more cycles of preoperative chemotherapy [4(3-6) vs. 3(2-4), P = 0.003]. Patients in the single hepatectomy group more frequently underwent major hepatectomies(34.5% vs. 16.7%, P = 0.004) and had a greater number of lesions resected(2.9 ± 3.6 vs. 1.9 ± 1.8, P = 0.011). There was no increase in operative time, estimated blood loss, length of hospital stay, complications, or mortality in the repeat hepatectomy group. There were no differences in overall survival( P = 0.626) and disease-free survival( P = 0.579) between the two groups. Similarly, for patients underwent repeat hepatectomy, no difference was observed between the early and late recurrence groups in terms of overall survival( P = 0.771) or disease-free survival( P = 0.350). Conclusions: Repeat hepatectomy is feasible and safe, with similar short-and long-term outcomes when compared to single hepatectomy. Surgical treatment of early liver recurrence offers similar oncological outcomes to those obtained for late recurrence.

关键词： Colorectal cancer Metastasis Hepatectomy Postoperative complications Survival analysis

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Marigold(Tagetes erecta): The Potential Value in the Phytoremediation of Chromium

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Pedosphere 2017年第3期27卷 559-568页

作者： Lívia C.coelho Ana Rosa R.BASTOS paulo J.PINHO guilherme A.SOUZA Janice g.CARVALHO Viviane A.T.coelho Luiz Carlos A.OLIVEIRA Rimena R.DOMINgUES Valdemar FAQUIN Soil Science Department Federal University of Lavras Chemistry Department Federal University of Minas Gerais

Environmental pollution with chromium （Cr） is harmful to humans, animals and plants, while in plants it causes diminished growth, anatomical alterations and death. In the present study, the potential value of marigold （Tagetes erecta） in the phytoremediation of Cr has been investigated. The randomized experimental design involved the exposure of plants to nutrient solutions containing 0.00, 0.04, 0.08, 0.12, 0.16 or 0.24 mmol L-1 Cr（III）. Chromium toxicity was observed at Cr（III） concentrations ≥ 0.12 mmol L-1 as demonstrated by diminished growth of the aerial parts and reduced density of the root system. Increasing Cr（III） concentrations in the nutrient solution resulted in a higher bioaccumulation of total Cr in the tissues, although translocation from roots to aerial parts was not efficient （maximum value of 25% at 0.12 mmol L-1 Cr（III））. The Cr bioaccumulation was up to 11-fold greater in roots than in the aerial parts. Tagetes erecta exhibited leaf plasticity when exposed to Cr, indicating the existence of a tolerance mechanism to Cr in this species. Chromium caused a reduction in xilem vases, resulting in a plastic effect in T. erecta leaves that increased the metal tolerance in culture solution. Tagetes spp. are potential Cr hyperaccumulators; at Cr（III） concentrations up to 0.12 mmol L-1, the plants accumulated levels above that proposed for hyperaccumulators and still maintained a considerable growth and even flourished. However, this study was conducted in nutrient solution, and studies on species confirmation as Cr hyperaccumulator should be conducted in soils for further clarification.

关键词： anatomical alterations heavy metal hyperaccumulor leaf anatomy toxicity

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Duodenal stenting for malignant gastric outlet obstruction:Prospective study

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World Journal of gastroenterology 2012年第9期18卷 938-943页

作者： Eduardo guimaräes Hourneaux Moura Flávio coelho Ferreira Spencer Cheng Diogo Turiani Hourneaux Moura paulo Sakai Bruno Zilberstain gastrointestinal Endoscopy Unit University of Sao Paulo Department of gastroenterology University of Sao Paulo

AIM： To evaluate the results of duodenal stenting for palliation of gastroduodenal malignant obstruction by using a gastric outlet obstruction score （gOOS）.

关键词： Enteral stenting gastric outlet obstructionscoring system gastroduodenal malignancy Self-expan-dable metal stent

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Does microfinance foster the development of its clients?A bibliometric analysis and systematic literature review

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Financial Innovation 2022年第1期8卷 1023-1057页

作者： João paulo coelho Ribeiro Fábio Duarte Ana Paula Matias gama CIICESI ESTGPolitécnico do PortoPortoPortugal School of Economics and Management and cef.upUniversity of PortoPortoPortugal Research Center in Business Science(NECE) University of Beira InteriorCovilhãPortugal

This paper conducts a scientometric analysis and systematic literature review to identify the trends in microfinance outcomes from the perspective of their recipients,specifically more vulnerable people,while also focusing on the demand *** the keywords“co-occurrence networks”and“citation networks,”we examined 524 studies indexed on the ISI Web of Science database between 2012 and March *** subsequent content analysis of bibliometric-coupled articles concerns the main research topics in this field:the socioeconomic outcomes of microfinance,the dichotomy between social performance and the mission drift of microfinance institutions,and how entrepreneurship and financial innovation,specifically through crowdfunding,mitigate poverty and empower the more *** findings reinforce the idea that microfinance constitutes a distinct field of development thinking,and indicate that a more holistic approach should be adopted to boost microfinance outcomes through a better understanding of their *** trends in this field will help policymakers,regulators,and academics to examine the nuts and bolts of microfinance and identify the most relevant areas of intervention.

关键词： Microfinance Microcredit Bibliometric analysis Economics Business finance

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The alchemist

The alchemist

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作者： paulo coelho translated by Alan R. Clark.

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Splenic artery ligature associated with endoscopic banding for schistosomal portal hypertension

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World Journal of gastroenterology 2014年第44期20卷 16734-16738页

作者： Renata Potonyacz Colaneri Fabrício Ferreira coelho Roberto de Cleva Marcos Vinícius Perini paulo Herman Department of gastroenterology University of S?o Paulo Medical School

AIM: To propose a less invasive surgical treatment for schistosomal portal hypertension.

关键词： Endoscopic banding Esophageal varices Portal hypertension Schistosomiasis Variceal bleeding

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