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Antitumor effect of Cationic INKKI Peptide from Bovine <i>β</i>-Casein on Melanoma B16F10

Journal of Cancer Therapy 2012年第4期3卷 237-244页

作者： Ricardo Alexandre Azevedo Adilson Kleber ferreira Aline Vivian Vatti Auada Kerly Fernanda Mesquita Pasqualoto Rafael Marques-Porto Durvanei Augusto Maria Ivo Lebrun Butantan Institute Biochemistry and Biophysical Laboratory Sao Paulo Brazil

Cationic peptide with the sequence INKKI 41-45 was isolated from bovine β-casein after tryptic hydrolysis and synthetized. The aim of this work was to evaluate the antiproliferative activity in vitro and antitumor effect in animal model. The in vitro cytotoxicity was evaluated on B16F10 melanoma cells by MTT assay. Detection of apoptosis was measured using the annexin V/PI double staining and cell cycle analysis performed flow cytometry. Caspase-3 activity was analyzed with substrate specific fluorogenic DeVD-MCA. In vivo, antitumor activity was evaluated in B16F10 melanoma tumor-bearing C57BL/6J mice. The animals were treated with 55 mg/kg INKKI administered into peritumoral region, while control group received saline solution. The following antitumor parameters were examined: tumor volume, number of metastases, tumor delayed time, tumor doubling time. Histological analyses were performed with H & e staining. The results showed that INKKI induced dose-response cytotoxicity selective for B16F10 melanoma cells (IC50 1.7 μM) and did not present cytotoxic effects for FN1 fibroblast cells. INKKI-induced apoptosis detected trough of annexin V/PI assay and it was accompanied with an increase of sub-G1 apoptotic fractions and significant increase of caspase-3 cleavage. The tumor-bearing mice treated with INKKI showed a significant reduction in tumor volume of 72.62% and decreased of metastasis number loci. In addition, INKKI caused a significant delay in tumor growth and prolonged the tumor doubling time. Histological analysis revealed an increased of necrosis areas and reduction of tumor cells in tumor treated with INKKI, it was a many hallmark of its antitumor effects observed from in vivo experiments. In conclusion, we show that INKKI is a peptide that could be considered a new putative candidate development to anticancer therapy drug.

关键词： β-Casein Peptide Apoptosis Metastasis Tumor Growth Melanoma

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Immobilization in Spheres of a Cocktail Rich in Xylanase Produced by the Fungus <i>Fusarium sp</i>. eA 1.3.1 for Hydrolysis of Sugarcane Bagasse

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Advances in Bioscience and Biotechnology 2021年第12期12卷 436-457页

作者： Alice Gomes Miranda Tarcisio Michael ferreira Soares de Oliveira Rosymar Coutinho de Lucas David Lee Nelson Juan Pedro Bretas Roa Vivian Machado Benassi Programa de Pós-Graduaç ã o em Biocombustíveis Universidade Federal dos Vales do Jequitinhonha e Mucuri campus JK Diamantina Minas Gerais Brazil Instituto de Ciê ncia e Tecnologia Universidade Federal dos Vales do Jequitinhonha e Mucuri campus JK Diamantina Minas Gerais Brazil Instituto de Ciê ncias Biológicas Departamento de Parasitologia Microbiologia e Imunologia Universidade Federal de Juiz de Fora Minas Gerais Brazil Faculdade de Medicina de Ribeirã o Preto Departamento de Bioquímica Universidade de S&#227 o paulo Ribeir&#227 o Preto S&#227 o paulo Brazil

Second generation ethanol is produced from the degradation of lignocellulosic biomass using enzymes as catalysts, with emphasis on xylanases. These biocatalysts are often costly, but stable at high temperatures, and their reuse is of great value, so the immobilization of the enzymes can increase their applicability on an industrial scale. We sought to immobilize a cocktail rich in xylanase produced by the fungus Fusarium sp. eA 1.3.1 in alginate spheres, optimize the immobilization method, characterize the immobilized derivatives, improve their physical-chemical characteristics, and perform the hydrolysis of sugarcane bagasse to release sugars. The Fusarium sp. eA 1.3.1 has been identified and used for cocktail rich in xylanase production that was immobilized in alginate spheres. During this process, the drip equipment, and the concentration of the solutions of sodium alginate and calcium chloride were evaluated. The best results were obtained with the glass rod and with concentrations of 3.14% and 2.10% for the solutions, respectively. The apparent optimum conditions of pH and temperature reaction were studied, and the values of pH 6.5 and 60°C were obtained. The immobilized conjugate also presented greater stability at this temperature than that of the soluble cocktail. The conjugate could be recycled up to six times, and its activity was maintained after 75 days of storage. Finally, the hydrolysis in natural sugarcane bagasse was achieved, and greater amounts of reducing sugars were obtained in the reaction with the conjugate. Thus, the cocktail rich in xylanase produced by the fungus Fusarium sp. eA1.3.1 was successfully immobilized on alginate spheres and possesses the potential to be used as a catalyst in industrial processes such as the lignocellulosic ethanol industry.

关键词： Xylanase Cocktail Spheres Immobilization Lignocellulolytic enzymes Biomass Hydrolysis

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Decommissioning of Uranium Pilot Plants at IPeN-CNeN/SP： Facilities Dismantling, Decontamination and Reuse as New Laboratories for Strategic Programs

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Journal of environmental Science and engineering(B) 2016年第5期5卷 237-242页

作者： paulo emesto de Oliveira Lainetti Antonio Alves de Freitas Francisco Mairio Feijo Vasques Robson de Jesus ferreira Marycel elena Barbosa Cotrim Maria Aparecida Faustino Pires Instituto de Pesquisas energeticas e Nucleares-IPeN-CNeN/SP National Nuclear Energy Commission-CNEN C. Universitaria Butanta Sao Paulo-SP CEP 05508-000 Brazil Instituto de Pesquisas energeticas e Nucleares-IPeN-CNeN/SP National Nuclear Energy Commission-CNEN C. Universitaria Butanta Sao Paulo CEP 05729-090 Brazil

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Isolation of Filamentous Fungi from the Caatinga Region and Production of Amylolytic enzymes of Great Industrial Interest

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Journal of Biosciences and Medicines 2020年第11期8卷 152-164页

作者： Ingrid Cristina Soares Amorim Gessica Oliveira Marinho Tarcisio Michael ferreira Soares de Oliveira Juan Pedro Bretas Roa Arlete Barbosa dos Reis David Lee Nelson Thiago Machado Pasin Vivian Machado Benassi Instituto de Ciência e Tecnologia Universidade Federal dos Vales dos Jequitinhonha e Mucuri Campus JK Diamantina Brasil Programa de Pós-Gradua&ccedil &atilde o em Biocombustíveis Universidade Federal dos Vales dos Jequitinhonha e Mucuri Campus JK Diamantina Brasil Departamento de Bioquímica e Imunologia Faculdade de Medicina de Ribeir&atilde o Preto Universidade de S&atilde o paulo Ribeir&atilde o Preto Brasil

The industrial importance and the high cost of the commercial amylase require the study of microorganisms that produce these enzymes. For this reason, the objective of this work was to isolate filamentous fungi from a region of the caatinga and evaluate their potential for the production of amylase. Four soil samples were collected from a deactivated dump located in the city of Diamantina, MG, in a region of the caatinga. The analysis of amylolytic production in a submerged medium at the ideal temperature of each microorganism was performed using the saccharification method, and the reducing sugars formed were quantified by DNS. Fourteen filamentous fungi were isolated, which had different morphological aspects. Regarding amylase production, a mean activity of 0.477 U·mL-1 was obtained with the isolates I 1.2.1 and I 4.4.1. These results bring important information regarding the biodiversity of the caatinga, in addition to the isolation of microorganisms that can be used as biological machinery to obtain metabolites with high biotechnological and industrial potential.

关键词： Amylolytic enzyme Bioprospecting Filamentous Fungi Industrial Interest

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Fluorescence of Chlorophyll a for Discovering Inhibitors of Photosynthesis in Plant extracts

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American Journal of Plant Sciences 2016年第11期7卷 1545-1554页

作者： Ana C. de Carvalho Jéssica P. Salvador Thais de M. Pereira Pedro Henrique A. ferreira João Carlos S. Lira Thiago A. M. Veiga Departamento de Ciências exatas e da Terra Universidade Federal de Sao Paulo (UNIFESP) Sao Paulo Brasil

Aims: Twelve crude extracts were prepared from different parts of Pluchea sagittalis, Cecropia palmata and Brachiaria brizantha, and their effect on the light reaction of photosynthesis. Study Design: Use of fluorescence of ChL a (Chlorophyll a) to detect inhibitors of photosynthesis in plant extracts. Place and Duration of Study: Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Departamento de Ciências exatas e da Terra, Universidade Federal de Sao paulo (UNIFeSP), between July 2015 and January 2016. Methodology: The samples had their effect on the light reaction of photosynthesis studied by Chlorophyll a (Chl a) fluorescence transient by the use of chloroplasts isolated from spinach leaves. As negative controls we used the same amounts of DMSO that have been employed to solubilize the samples, and as positive control we have used 10 μM of the commercial herbicide DCMU (Diuron). Results: The extracts inhibited the photosynthesis, and their inhibition sites were located in the range of electron flow from OeC complex and between P680 to QA of PS II, and inhibited the photosystem II (PS II) by inducing the appearance of the transient bands K and J. Conclusion: Our results suggest an indicative that the photochemical apparatus probably is failing at the donor and acceptor sides of PSII, causing damage to electron transport during the photosynthesis phenomenon.

关键词： Fluorescence of ChL a Dereplication Photosynthesis Natural Products

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Organic-Inorganic Hybrid Materials:Layered Double Hydroxides and Cellulose Acetate Films as Phosphate Recovery

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Journal of Agricultural Science and Technology(B) 2018年第6期8卷 360-374页

作者： Gustavo Franco de Castro Jader Alves ferreira Denise eulálio Allan Robledo Fialho e Moraes Vera Regina Leopoldo Constantino Frederico Garcia Pinto Roberto ferreira Novais Jairo Tronto Department of Soil University of VicosaAv.Peter Henry RolfsBulding Silvyo Starling BrandaoCEP 36570-000Vicosa(MG)Brazil Department of Chemistry University of VicosaRio Paranaiba CampusHighway MG-230KM 07CEP 38810-000Rio Paranaiba(MG)Brazil Department of Fundamental Chemistry University of Sao PauloAv.Prof.Lineu Prestes748CEP 05508-000Sao Paulo(SP)Brazil

With demand increasing for phosphate recovery,a considerable share of current research is dedicated to elaborate multifunctional *** this way,the objective of this work was to produce hybrid films from the combination of cellulose acetate(CA)biopolymer and magnesium and aluminium layered double hydroxides(LDHs)and investigate their performance for phosphate *** this work,the following materials were prepared and characterized:LDH,calcinated LDH(LDH-c),CA film(CAF),CA film with LDH(CAF-LDH)and CA film with LDH-c(CAF-LDH-c).The produced materials were characterized by X-ray diffraction,thermogravimetric analysis coupled with differential scanning calorimetry and mass spectrometry,attenuated total reflectance Fourier transform infrared spectroscopy and scanning electronic *** thickness,H2O absorption(AH2O),stability in H2O and phosphate adsorption of the produced films were *** adsorption capacity of films was compared to LDHs in powder *** CAF-LDH and CAF-LDH-c increased film thickness,where CAF-LDH-c was thicker than ***-LDH-c had higher AH2O than the other films,because of its increased thickness and mainly because of the H2O sorption process of these materials.H2O stability of 98.97%for CAF-LDH and 96.81%for CAF-LDH-c suggest the produced films can maintain their structural properties even after a long contact period with aqueous *** the CAF-LDH-c,the maximum adsorption capacity of phosphate,according to the Langmuir-Freundlich model,was 6.98 mg/*** adsorption value suggests that this film can be used as an efficient phosphorus(P)adsorbent from wastewater or a eutrophicated source.

关键词： Cellulose acetate films layered double hydroxides phosphorous adsorption phosphorous recovery

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Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion

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World Journal of Biological Chemistry 2013年第4期4卷 141-147页

作者： eduardo ferreira de Castro-Neto Rafael Henrique da Cunha Dartiu Xavier da Silveira Mauricio Yonamine Telma Luciana Furtado Gouveia esper Abr o Cavalheiro Débora Amado Maria da Gra a Naffah-Mazzacoratti Departamento Neurologia/Neurocirurgia Universidade Federal de S o Paulo Departamento de Psiquiatria Universidade Federal de S o Paulo Faculdade de Ciências Farmacêuticas Universidade de S o Paulo Departamento de Bioquímica Universidade Federal de S o Paulo

AIM: To evaluate changes in neurotransmission induced by a psychoactive beverage ayahuasca in the hippocampus and amygdala of naive rats. MeTHODS: The level of monoamines, their main metabolites and amino acid neurotransmitters concentrations were quantified using high performance liquid chromatography(HPLC). Four groups of rats were employed: saline-treated and rats receiving 250, 500 and 800 mg/kg of ayahuasca infusion(gavage). Animals were killed 40 min after drug ingestion and the structures stored at-80 ℃ until HPLC assay. The data from all groups were compared using Analysis of variance and Scheffé as post test and P epted as significant. ReSULTS: The results showed decreased concentrations of glycine(GLY)(0.13 ± 0.03 vs 0.29 ± 0.07, P e amygdala of rats that received 500 of ayahuasca. Animals that ingested 800 mg/kg of ayahuasca also showed a reduction of GLY level(0.11 ± 0.01 vs 0.29 ± 0.07, P e hippocampus, increased GABA levels were found in rats that received all ayahuasca doses: 250 mg/kg(1.29 ± 0.19 vs 0.84 ± 0.21, P eased utilization rate of all monoamines was found in the amygdala after ayahuasca administration in doses: 250 mg/kg(noradrenaline: 0.16 ± 0.02 vs 0.36 ± 0.06, P e: 0.39 ± 0.012 vs 2.39 ± 0.84, P erotonin: 1.02 ± 0.22 vs 4.04 ± 0.91, P enaline: 0.08 ± 0.02 vs 0.36 ± 0.06, P e: 0.33 ± 0.19 vs 2.39 ± 0.84, P erotonin: 0.59 ± 0.08 vs 4.04 ± 0.91, P enaline: 0.16 ± 0.04 vs 0.36 ± 0.06, P e: 0.84 ± 0.65 vs2.39 ± 0.84, P erotonin: 0.36 ± 0.02 vs 4.04 ± 0.91, P est increased release of inhibitory amin

关键词： Ayahuasca Amino Acids Monoamines Hippocampus Amygdala

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executive remuneration and financial performance in Brazilian companies

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Chinese Business Review 2010年第9期9卷 31-45页

作者： elizabeth Krauter Altair ferreira de Sousa Faculdade de economia Administracao e Contabilidade de Ribeirao Preto University of Sao Paulo Sao Paulo 14040-905 Brazil Faculdade de economia Administragao e Contabilidade University of Sao Paulo Sao Paulo 05508-100 Brazil

The objective of this study is to investigate the existence of a relationship between executive remuneration and financial performance in 28 Brazilian companies from the industrial sector. These companies have been selected among those companies elected as "The Best Companies to Work for in Brazil". In order to operationalize the remuneration variable, the authors use the monthly salary, the variable salary and three indexes—-of benefits, career and professional development—-which have been created especially for this survey. To measure financial performance, the authors use three accounting measures: sales growth, return on equity (ROe) and return on sales (ROS). The results point the existence of a relationship between executive remuneration and financial performance.

关键词：财务巴西产业部门专业发展回报率 ROS 收益率净资产

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Proposed nomenclature for Pseudallescheria,Scedosporium and related genera

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Fungal Diversity 2014年第4期67卷 1-10页

作者： Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gené Fabiola Fernández Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea Garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente elena Piecková Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Francoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter fernando L.Hernando Andoni Ramirez-Garcia Aize Pellon Jashanpreet Kaur eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquerdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes Division of Hygiene and Medical Microbiology Innsbruck Medical UniversityInnsbruckAustria CBS Fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Medical University of Graz GrazAustria Centre for Infectious Diseases and Microbiology Westmead HospitalWestmeadAustralia Laboratoire de Parasitologie-Mycologie Centre Hospitalier UniversitaireAngersFrance Unitats de Microbiologia i d’Anatomia Patològica Facultat de Medicina i Ciències de la Salut IISPVUniversitat Rovira i VirgiliReusSpain Universidade Federal do estado do Rio de Janeiro Rio de JaneiroBrazil Institute of Medical Microbiology University Hospital RWTHAachenGermany Institute of Microbiology Academy of SciencesPragueCzech Republic Institut Pasteur Unitéde Mycologie MoléculaireCentre National de Référence Mycoses Invasives et AntifongiquesParisFrance Department of Medical Microbiology and Infectious Diseases Canisius-Wilhelmina HospitalNijmegenThe Netherlands Department of Medical Microbiology RadboudumcNijmegenThe Netherlands Institute of Microbiology eopold-Franzens-University InnsbruckInnsbruckAustria Molecular Mycology Research Laboratory Centre for Infectious Diseases and MicrobiologySydneyMedical School—Westmead HospitalMarie Bashir Institute for Infectious Diseases and BiosecurityThe University of SydneyWestmead Millennium InstituteWestmeadNSWAustralia Basic Pathology Department Federal University of ParanáStateCuritibaParanáBrazil Fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) BrasíliaBrazil Institute of Preventive and Clinical Medicine BratislavaSlovakia Institut für Hygiene und Mikrobiologie Landesklinikum St.Pölten St.PöltenAustria Institute of Medical Microbiology University Hospital EssenEssenGermany Nursing School of Unigranrio Rio de JaneiroBrazil Scientific Institute of Public Health Culture Collectio

As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be *** of the eCMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied *** generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic *** that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are *** minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and ***,*** prolificans is renamed as Lomentospora prolificans.

关键词： Graphium Lomentospora Petriella Scedosporium apiospermum complex Microascaceae Nomenclature

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evaluation of the toxic effect of insecticide chlorantraniliprole on the silkworm Bombyx mori(Lepidoptera:Bombycidae)

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Open Journal of Animal Sciences 2013年第4期3卷 343-353页

作者： Roxelle ethienne ferreira Munhoz Thais Souto Bignotto Naiara Climas Pereira Claudia Regina das Neves Saez Rafaela Bespalhuk Veronica Aureliana Fassina Graziele Milani Pessini Mayarha Patricia Dequigiovanni Baggio Lucineia de Fatima Chasko Ribeiro Rose Meire Costa Brancalhao Shunsuke Mizuno Willian Shigeaki Aita Maria Aparecida Fernandez Departamento de Biotecnologia Genetica e Biologia CelularUniversidade Estadual de MaringaMaringaBrasil Universidade estadual do Oeste do Parana CascavelBrasil Fiacao de Seda Bratac S.A.Bastos Sao PauloBrasil

The silkworm Bombyx mori feeds exclusively on mulberry leaves and is highly sensitive to pesticides in general. Although mulberry plantations are free of agrochemicals, pesticide drift can occur. Chlorantraniliprole, a novel insecticide of the anthranilic diamides class, has been used to control pests in field crops. In this study, we investigated the biological effects of different concentrations of chlorantraniliprole on B. mori silkworm commercial Brazilian hybrids. To evaluate the toxicity of chlorantraniliprole, bioassays were carried out and data on the lethal concentrations, symptomatology, morphology and variables of silk production were collected. Results indicated that B. mori is extremely sensitive to chlorantraniliprole, even in low concentrations. The highest silkworm mortality rates were observed in the two highest chlorantraniliprole concentrations, 0.2 and 0.1 ppm. Although lower chlorantraniliprole concentrations did not cause death of all the silkworm larvae, various symptoms of toxicity were observed: feeding cessation, regurgitation, late development and incomplete ecdysis. Such symptoms reflect the morphological changes we observed in the midgut epithelium, which affected nutrient uptake and metabolism, and even the production of cocoons. exposed larvae also produced?thin-shelled cocoons, which constitutes a serious economic problem because this type of cocoon is not useful for the silk industry. The results provided herein confirm the toxicity of chlorantraniliprole in silkworm larvae. Therefore, we strongly suggest that, competent authorities of the National Health Surveillance Agency, in pesticide management should take measures to reduce or eliminate the use of chlorantraniliprole in areas nearest to silkworm cultivation.

关键词： Silkworm Pesticide Drift Mortality Symptomatology Chlorantraniliprole

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