检索结果-南通市图书馆

Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice

在线全文

学校读者我要写书评

暂无评论

引用

Neural Regeneration Research 2022年第2期17卷 450-458页

作者： Carlos Pereira Martins Rodrigo Sebben Paes Gabriela Mantovani Baldasso Eduarda Gomes Ferrarini Rahisa Scussel Rubya Pereira Zaccaron Ricardo Andrez Machado-de-Avila Paulo Cesar Lock Silveira Rafael Cypriano Dutra Laboratory of Autoimmunity and Immunopharmacology Department of Health SciencesCampus AraranguaUniversidade Federal de Santa CatarinaAraranguáSCBrazil Post-Graduate Program of Neuroscience Center of Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSCBrazil Laboratory of Experimental Physiopathology Program of Postgraduate in Science of HealthUniversidade do Extremo Sul CatarinenseCriciumaSCBrazil

Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.

关键词： dopamine dopaminergic system fibromyalgia hyperalgesia pain pramipexole reserpine

Antimicrobial peptides as a feed additive alternative to animal production, food safety and public health implications: An overview

在线全文

学校读者我要写书评

暂无评论

引用

Animal Nutrition 2021年第3期7卷 896-904页

作者： Raiza F.silveira cesar A.Roque-Borda Eduardo F.Vicente Sao paulo State University School of Agricultural and Veterinarian SciencesJaboticabalSao PauloBrazil Sao paulo State University School of Sciences and EngineeringTupaSao PauloBrazil

In the last few years,feed additives have been used in animal nutrition to improve nutrient utilization,health parameters and animal performance.However,the use of antibiotics as feed additives has allowed the occurrence of antimicrobial resistance(AMR),which can bring as a consequence,an increase in the morbidity and mortality of diseases that were previously treatable with antibiotics.In this context,antimicrobial peptides(AMP)have appeared as a promising strategy because they have multiple bio-logical activities and represent a powerful strategy to prevent the development of resistant microor-ganisms.Despite the small number of studies applied in vivo,AMP appear as a potent alternative to the use of antibiotics in animal nutrition,due to an increase in feed efficiency and the prevention/treatment of some animal diseases.This review discusses the problems associated with antimicrobial resistance and the use of AMP as a strong candidate to replace conventional antibiotics,mainly in the animal industry.

关键词： Additive Antimicrobial peptide Broiler Cattle Laying hen Pig

Cleft Palate Surgical Skills Training Using an Alternative Synthetic Bench Model

在线全文

学校读者我要写书评

暂无评论

引用

Chinese Medical Journal 2016年第11期129卷 1382-1383页

作者： Andre silveira Pinho cesar Augusto Raposo-Amaral Cassio Eduardo Raposo-Amaral Rafael Denadai Institute of Plastic and Craniofacial Surgery SOBRAPAR Hospital Caixa Postal: 6028 Campinas Sao Paulo Brazil

To the Editor： Although there have been numerous reports of difl＇erent synthetic simulators that can provide cleft palate training,none offers a completely ideal model.

关键词：钙调蛋白结合蛋白质类磷蛋白磷酸酶类腭裂