检索结果-南通市图书馆

Brazilian vaccinia virus strains show a classical orthopoxvirus infection course and cross-protection

Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 21-26页

作者： Jaqueline Maria Siqueira ferreira Betnia Paiva Drumond J?natas Santos Abraho Zélia Inês Portela Lobato cláudio Ant?nio Bonjardim paulo césar peregrino ferreira Erna Geessien Kroon Laboratorio de Virus Departamento de MicrobiologiaInstituto de Ciencias Biologicas Departamento de Medicina Veterinaria Preventiva Escola de VeterindriaUniversidade Federal de Minas Gerais.Avenida Antonio Carlos6627caixa postal 486CEP 31270-901 Belo HorizonteMGBrazil

Objectives:The purpose of this work was to study the infection course and cross-protection in mice after intradermal injection of Vaccinia virus(VAcV) strain Western Reserve and three Brazilian VAcV strains: Aracatuba,Muriae and BeAn58058 isolated from cow,human and rodent,respectively.Methods:Balb/c mice were inoculated by footpad and back scarification and daily monitored regarding lesion development and weight loss.To check cross protection after intradermal VAcV inoculation,mice were subsequendy infected with different VAcV strains and monitored to check lesion development.Serum neutralization assays were performed to check for the presence of antibodies against Orthopoxvirus.Results:After VAcV intradermal inoculation the lesion development pattern was similar in mice infected with the different virus strains.By using the footpad scarification model,cross-protection among VAcV strains was observed.Moreover,neutralizing antibodies against Orthopoxvirus were detected in sera from mice infected with all VAcV strains.conclusion:Although it was not possible to observe virulence differences among VAcV strains isolated from cow,rodent and human using the murine model,this inoculation route showed to be an appropriated model to study lesions development since it mimics natural infections by VAcV in nature.

关键词： Orthopoxvirus Zoonoses Balb/c mice Intradermal injection Vaccinia virus Bovine vaccinia outbreaks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：