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缤纷 2014年第5期 15-15页

作者：陈学霞 pauline Darley Maxime Stange

近期，法国摄影师paulineDarley，MaximeStange携手发型师师PierreSaintSever，化妆师MademoiselleMu打造了具有无限视觉冲击力的发型与妆容设计的摄影作品。

关键词：动感视觉冲击力摄影作品发型师摄影师化妆师

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泰国芭堤雅希尔顿酒店

设计家 2011年第5期 92-99页

作者： Amata Luphaiboon Twitee Vajrabhaya Teparkum waraphan watanakaroon Prow Puttorngul Tharadon Teerawanitchanan Picha Thadaniti wipavee Kueasirikul Sasicholwaree Sawatdisawanee Rattanapon Monmahachinda Sutah Schonrungroj Atirojt Rojratanawalee worawut Oer-Areemitr Kanin Manthanachart wison Tungthunya pauline Pan Department of ARCHITECTURE Co. Ltd.

位于14楼的餐厅也面对着海景，拥有多个大型开放式厨房，并提供国际化食物。餐厅空间构造设计的主要手段是利用优越的地理位置把海景最大化地呈现给客人们。面朝大海的餐厅空间，沿着玻璃墙呈线形延伸开来．其中的天花板有8米多高。座... 详细信息

位于14楼的餐厅也面对着海景，拥有多个大型开放式厨房，并提供国际化食物。餐厅空间构造设计的主要手段是利用优越的地理位置把海景最大化地呈现给客人们。面朝大海的餐厅空间，沿着玻璃墙呈线形延伸开来．其中的天花板有8米多高。座位区域呈两层阶梯状．后面一层高出来．确保开阔的观景视野。在餐厅前面的户外露台上也能欣赏到令人印象深刻的海洋全景．露台的地平面比餐厅下降了一个阶梯的高度，不妨碍餐厅里的客人观景。

关键词：希尔顿酒店泰国开放式厨房地理位置构造设计阶梯状餐厅国际化

区域性系统调查方法在典型遗址研究中的应用——以吉林大安汉书遗址为例

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边疆考古研究 2017年第2期 297-312页

作者：刘晓溪史宝琳李扬王立新吉林大学边疆考古研究中心吉林省文物考古研究所法国国立科学研究中心(CNRS UMR8155CRCAO) 温州博物馆

2012~2014年,后套木嘎遗址考古队连续三年在大安市新荒泡与月亮泡周边作了区域性系统调查[1]。'区域系统调查(Systematic Regional Survey),又称作全覆盖式调查(Full-Coverage Survey),是以聚落形态为目的的考古调查方法。'[2]2014年度... 详细信息

2012~2014年,后套木嘎遗址考古队连续三年在大安市新荒泡与月亮泡周边作了区域性系统调查[1]。'区域系统调查(Systematic Regional Survey),又称作全覆盖式调查(Full-Coverage Survey),是以聚落形态为目的的考古调查方法。'[2]2014年度在该区域调查时途经汉书遗址,并运用区域性系统调查方法对该遗址进行了调查、采集和记录。本次调查将全部队员分为四组(J、K、I、L组)。

关键词：汉书二期文化白金宝文化区域性

Quality Control of Paracetamol Generic Tablets Marketed in Benin and Search of Its Two Impurities P-Aminophenol and P-Nitrophenol by HPLC-UV/Visible

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Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

American Journal of Analytical Chemistry（美国分析化学） 2022年第11期

作者： yemoa loconon achille agbokponto janvier engelbert assanhou assogba gabin adetona pauline doffon parfait ganfon habib roland marini djang’eing’a

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National Science Review 2022年第3期9卷 96-109页

作者： weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez pauline Jieqi Chen Mei Mei Chang Lingyan wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh wei Keat wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney wei Qiang Leow Valerie Chew Yock Young Dan wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). we found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： hepatocellular carcinoma intra-tumor heterogeneity phenotypic evolution tumor evolution

Subclinical proximal tubulopathy in hepatitis B:The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

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world Journal of Hepatology 2020年第12期12卷 1326-1340页

作者： Anais Brayette Marie Essig Paul Carrier Marilyne Debette-Gratien Anais Labrunie Sophie Alain Marianne Maynard Nathalie Ganne-Carrie Eric Nguyen-Khac pauline Pinet Victor De Ledinghen Christophe Renou Philippe Mathurin Claire Vanlemmens Vincent Di Martino Anne Gervais Juliette Foucher Fouchard-Hubert Isabelle Julien Vergniol Isabelle Hourmand-Ollivier Daniel Cohen Xavier Duval Thierry Poynard Marc Bardou Armand Abergel Manh-Thong Dao Thierry Thevenot Jean-Baptiste Hiriart Valerie Canva Guillaume Lassailly Christine Aurières Nathalie Boyer Dominique Thabut Pierre-Henri Bernard Matthieu Schnee Dominique Larrey Bertrand Hanslik Severine Hommel Jeremie Jacques Veronique Loustaud-Ratti U1248 INSERM Department of Hepatology and GastroenterologyUniv.LimogesCHU LimogesLimoges F-87000France U1248 INSERM Department of Nephrology and TransplantationCHU LimogesLimoges F-87000France Department of Center of Epidemiology Biostatistics and Research MethodologyCHU LimogesLimoges F-87000France U1092 INSERM Department of VirologyCHU LimogesLimoges F-87000France Department of Hepatology Croix-Rousse University Hospital of LyonLyon 69004France Department of Hepatology Jean Verdier University Hospital of BondyBondy 93140France Department of Hepato-Gastroenterology Amiens University HospitalAmiens 80054France Department of Infectious Diseases CHU LimogesLimoges F-87000France Department of Hepatology Haut Leveque HospitalBordeaux University HospitalPessac 33604France Department of Gastroenterology Hyeres HospitalHyeres 83407France Department of Hepato-Gastroenterology Claude Huriez University HospitalLille 59037France Department of Hepatology Jean Minjoz University HospitalBesançon 25030France Department of Infectious Diseases Bichat University HospitalParis 75018France Department of Hepatology University Hospital of AngersAngers 49933France Department of Hepato-Gastroenterology and Nutrition University Hospital of CaenCaen 14033France Department of General Medecine University Hospital of CaenCaen 14000France Department of Hepatology La Pitié-Salpêtrière University HospitalParis 75651France Department of Hepatology and Gastroenterology Dijon University HospitalDijon 21079France Department of Hepatology and Gastroenterology Estaing University HospitalClermont Ferrand 63003France Department of Hepatology Beaujon University HospitalClichy 92110France Department of Hepatology Saint-AndréUniversity HospitalBordeaux 33000France Department of Hepatology and Gastroenterology La Roche-Sur-Yon Hospital CenterLa Roche-Sur-Yon 85000France Department of Hepatology and Gastroenterology University Hospital of MontpellierMontpellier 34295France Department of Addictology Hospita

BACKGROUND The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity,such as estimated glomerular filtration rate(eGFR)and phosphatemia,are late markers of proximal *** early markers are available,but no consensus exists on their *** To determine the 24 mo prevalence of subclinical proximal tubulopathy(SPT),as defined with early biomarkers,in treated vs untreated hepatitis B virus(HBV)-monoinfected *** A prospective,non-randomized,multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was *** patients were separated into three groups:Naïve,starting entecavir(ETV)treatment,or starting tenofovir disoproxil(TDF)*** on the early markers of SPT,the eGFR and phosphatemia,were collected *** was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%.The prevalence and cumulative incidence of SPT at month 24(M24)were *** data were analyzed using analyses of variance or Kruskal-wallis tests,whereas chi-squared or Fisher’s exact tests were used to analyze qualitative *** analyses were used to adjust for any potential confounding *** Of the 196 patients analyzed,138(84 naïve,28 starting ETV,and 26 starting TDF)had no SPT at *** M24,the prevalence of SPT was not statistically different between naïve and either treated group(21.1%vs 30.7%,Pwer than 50 mL/min/1.73 m²or phosphatemia less than 0.48 mmoL/*** the multivariate analysis,no explanatory variables were identified after *** cumulative incidence of SPT over 24 mo(25.5%,13.3%,and 52.9%in the naïve,ETV,and TDF groups,respectively)tended to be higher in the TDF group vs the naïve group(hazard ratio:2.283,P=0.05).SPT-free survival at M24 was 57.6%,68.8%,and 23.5%for the naïve,ETV,and TD

关键词： Hepatitis B virus Proximal tubulopathy Biomarkers Renal insufficiency Nucleoside analogues

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丹麦NOMA食品实验室

设计家 2012年第2期 84-89页

作者： KIm Herforth Nielsen Kasper Guldager J rgensen Andr van leth lila Held Morten Norman Lund Lars-Erik Eriksson Pedram Seddighzadeh Matthew Scarlett BjHrk Christensen Kyle Baumgardner Elliot Mistur Tore Banke Simon McKenzie Jacob Hilmer pauline Pan GXN

由3XN负责的NOMA食品实验室室内设计项目巧妙地将烹饪与建筑融为一体．并为北欧菜肴打造出最佳的效果呈现舞台。

关键词： NOMA 实验室食品丹麦设计项目

Meta-Analysis Study of the Effects of Yeast Probiotic Supplementation on Milk Production and Energy Corrected Milk of Lactating Dairy Cows

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孕前母亲和父亲的持久性有机污染物暴露与后代出生的大小:LIFE研究

Agricultural Sciences（农业科学） 2023年第9期

作者： Nizar Salah HéloïseLegendre pauline Peltier Pain Clara Berger Valentin Nenov Francois Machuron Maxime Briche Phileo by Lesaffre Marcq-en-Baroeul France

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环境与职业医学 2015年第4期32卷 357-357页

作者： Candace A.Robledo Edwina Yeung pauline Mendola Rajeshwari Sundaram Jose Maisog Anne M.Sweeney Dana Boyd Barr Germaine M.Buck Louis

[背景]持久性有机污染物（POPs）是发育毒物,但母亲和父亲均受到POPs暴露对其后代出生大小的影响尚不清楚。[目的]探讨母亲和父亲63种POPs（其中包括五大类污染物）的血清浓度与其后代出生大小测量值之间的关联。[方法]测定234对夫妇在... 详细信息

[背景]持久性有机污染物（POPs）是发育毒物,但母亲和父亲均受到POPs暴露对其后代出生大小的影响尚不清楚。[目的]探讨母亲和父亲63种POPs（其中包括五大类污染物）的血清浓度与其后代出生大小测量值之间的关联。[方法]测定234对夫妇在受孕前血清中的9种有机氯杀虫剂、1种多溴联苯（PBB）、7种全氟烷基化学物（PFCs）、10种多溴联苯醚（PBDEs）和36种多氯联苯（PCBs）的浓度。采用多元线性回归估计化学物浓度的自然对数转换（ln转换）值每增加1 SD,所导致的出生体重、身长、头围和婴儿重量指数的差异。对每一对父母单独进行模型估计,调整母亲的年龄、孕前体质指数（kg/m2）等其他混杂因素,并且所有的模型都包含婴儿性别与各种化学品的交互作用项。[结果]女童（n=117）出生体重显著较低（范围为84-195 g）与母亲血清DDT、PBDE-28、PBDE-183浓度的ln转换值增加每增加1 SD、以及父亲血清PBDE-183和PCB-167浓度的ln转换值每增加1 SD相关联。男童（n=113）出生体重较低（范围为98-170 g）与母亲（PCBs 138、153、167、170、195、209和全氟辛基磺酰）和父亲（PCB-172和PCB-195）的POPs血清浓度具有统计学意义的关联,而父亲血清中PBDE-66和PBDE-99浓度均与较高的出生体重相关联。后代头围、身长和婴儿重量指数的差异也与父母的POPs暴露相关联。

关键词： LIFE POPs 有机氯杀虫剂血清浓度多溴联苯醚婴儿性别重量指数头围多元线性回归模型估计

New Data on the Genesis and Evolution of the Primitive Magmas of Mount Cameroon: Contribution of Melt Inclusions

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Journal of Geological Research 2020年第4期2卷 46-61页

作者： Legrand Joseph Tchop pauline wokwenmendam Nguet Benjamin Ntieche Victor Metang Jacques Dili Rake Merlin Isidore Teitchou Jacqueline Vander Auwera Georges Emmanuel Ekodeck Charles Nkoumbou Department of Earth Sciences Faculty of SciencesUniversity of YaoundéIPO Box 812 YaoundéCameroon Geophysical and Volcanological Research Unit Institute of Geological and Mining ResearchPO Box 370 BueaCameroon Higher Teacher Training College University of Yaounde1 PO Box 812 YaoundéCameroon Deparement de Geology University of Liège B-4000 Sart-TilmanBelgium

Mount Cameroon is a Plio-Quaternary volcanic massif, without a centralcrater, made up of more than 140 pyroclastic cones. It is one of theactive volcanoes of the Cameroon Volcanic Line. Mount Cameroon meltinclusions are found in microdroplets trapped in the early minerals (olivines)from the pyroclastic products. The analysis of these melt inclusions allowedus to find primitive liquids compared to lavas. Major elements study ofthe magmatic inclusions, trapped in the most magnesian olivines (Mg#84-86) of Mount Cameroon revealed “primitive” liquids of basanite and alkalibasalt type with variable composition compared to the much more uniformbasalts of the magmatic series of Mount Cameroon. The study of thesetrapped liquids shows that: (1) the original primitive lavas did not undergothe process of evolution by FC, but rather underwent fundamentally (orexclusively) the process of partial melting;(2) the emitted lavas, evolvedessentially by FC;(3) the variations in the trace element contents of theprimitive liquids directly reflect a variation in the rate of partial melting ofa homogeneous mantelic source. The very high La/Yb ratios of the MountCameroon melt inclusions (> 20) characterize a garnet lherzolite *** of the melt inclusions show a negative anomaly or depletion in K,Rb and Ba as those of HIMU. The “primitive” liquids and lavas of MountCameroon represent a co-genetic sequence formed by varying degrees ofpartial melting of a source considered as homogeneous.

关键词： Primitive magma Partial melting Fractional crystallization Alkali basalt Mount Cameroon Active volcano