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考试（高考英语） 2011年第8期 30-31页

作者： pauline D.Loh 桑实 China Daily

Tea,coffee and chocolate(cocoa)are probably the most popular beverages in the *** it comes to vintage,tea leaps ahead by *** other beverage actually has agod devoted to its cultivation and culture and an almost evangelistic spread throughout the world?(这段生词不少,我们通读后先留个印象,知道段落提及了茶、咖啡和可可,还简要的对他们加以区别。

关键词：中学英语教学教学方法阅读教学

教育和技能开发能否符合地方情况、反映地方工作模式和行业发展——以英国创意产业为例

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职业技术教育 2019年第6期40卷 12-15页

作者： pauline Tambling 李玉静(编译) 英国伦敦大学学院教育研究院创意与文化技能部吉林工程技术师范学院职业技术教育研究院吉林工程技术师范学院教育科学学院长春130052

将教育机构、学习者和行业发展统筹起来,为学习者提供有效的技能开发机会,创造一个更加适切的工作-就业-学习范式,是全球化和数字化背景下各国需要解决的重要问题。以英国创意产业为例,研究认为,'学校—学院或者大学—职业生涯'的传统... 详细信息

将教育机构、学习者和行业发展统筹起来,为学习者提供有效的技能开发机会,创造一个更加适切的工作-就业-学习范式,是全球化和数字化背景下各国需要解决的重要问题。以英国创意产业为例,研究认为,'学校—学院或者大学—职业生涯'的传统线性教育范式已经不适应新的时代背景要求,将文化部门、创意产业和教育部门联合起来,为青年人提供更多的技能更新或提升机会,可以为本地经济增长和就业创造更多机会,也有利于实现学习者个体生涯的可持续发展。

关键词：技能开发创意产业工作模式

Glycosylation engineering of therapeutic IgG antibodies： challenges for the safety, functionality and efficacy

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Protein & Cell 2018年第1期9卷 47-62页

作者： Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto pauline M. Rudd Department of Clinical Research NHO Yamaguchi-Ube Medical Center 685 Higashi-Kiwa Ube 755-0241 Japan Laboratory of Molecular Biology and Bioresponse Division of Integrated Life Science Graduate School of Biostudies KyotoUniversity Kitashirakawa Oiwake-Cho Sakyo-Ku Kyoto 606-8502 Japan NIBRT GlycoScience Group National Institute for Bioprocessing Research and Training Mount Merrion Blackrock Dublin 4Ireland Center for Regenerative Medicine Yamaguchi University Graduate School of Medicine 1-1-1 Minami Kogushi Ube 755-8505 Japan Center for Gene Research Yamaguchi University 1-1-1 Minami-Kogushi Ube 755-8505 Japan Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University 1-308 Suematsu Nonoichi Ishikawa 921-8836 Japan

Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary *** oligosaccharide attached to Asn297 of the Fc is essen- tial for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that gen- erate structural heterogeneity （glycoforms） exhibit unique biological activities. Hence, efficient and quan- titative glycan analysis techniques have been increas- ingly important for the development and quality control of therapeutic antibodies, and g｜ycan profiles of the Fc are recognized as critical quality attributes. In the past decade our understanding of the influence of glycosy- lation on the structure/function of IgG-Fc has grown rapidly through X-ray crystallographic and nuclear magnetic resonance studies, which provides possibili- ties for the design of novel antibody therapeutics. Fur- thermore, the chemoenzymatic glycoengineering approach using endoglycosidase-based glycosyn- thases may facilitate the development of homogeneous IgG glycoforms with desirable functionality as next- generation therapeutic antibodies. Thus, the Fc glycans are fertile ground for the improvement of the safety,functionality, and efficacy of therapeutic IgG antibodies in the era of precision medicine.

关键词： chemoenzymatic glycoengineering crysta structure endoglycosidase fucose glycosylation,intravenous immunoglobulin sialic acid transglycosylation,ultra performance liquid chromatography

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辽宁早白垩世会鸟一新种(英文)

古脊椎动物学报 2009年第3期47卷 194-207页

作者： pauline PROVINI 周忠和张福成巴黎高等师范学院地球科学系巴黎75230 中国科学院古脊椎动物与古人类研究所脊椎动物进化系统学重点实验室北京100044

记述了辽宁朝阳大平房早白垩世九佛堂组湖相地层中发现的会鸟化石一新种,窄脊会鸟(Sapeornis angustis ***.)。尽管新种正型标本属于一亚成年个体,但除个体较小外,还在许多特征上很容易与属型种(朝阳会鸟)相区别。例如,不超过6枚荐椎,... 详细信息

记述了辽宁朝阳大平房早白垩世九佛堂组湖相地层中发现的会鸟化石一新种,窄脊会鸟(Sapeornis angustis ***.)。尽管新种正型标本属于一亚成年个体,但除个体较小外,还在许多特征上很容易与属型种(朝阳会鸟)相区别。例如,不超过6枚荐椎,肱骨的三角脊和气窗均较细窄,三角脊远端的背突不显著尖锐,乌喙骨具有较长的肩峰突,叉骨枝较细,叉骨突较短,第一掌骨以及耻骨突均相对较短等。和始祖鸟以及其他已报道的会鸟标本一样,新种材料没有保存胸骨,肋骨上也未见钩状突起,推测这两种结构可能在个体发育的晚期才开始骨化,上述标本均为发育早中期的个体。会鸟新种的发现为这一基干的原始鸟类提供了新的解剖特征,并表明在会鸟的演化过程中存在个体的逐步增大以及一些形态特征的特化现象。这一新的发现还为分析早白垩世陆地生态系统的鸟类多样性增添了新的资料。

关键词：中国辽宁早白垩世会鸟新种

Optimal Unknown Pollution Source Characterization in a Contaminated Groundwater Aquifer—Evaluation of a Developed Dedicated Software Tool

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Journal of Geoscience and Environment Protection 2014年第5期2卷 41-51页

作者： Bithin Datta Om Prakash pauline Cassou Mathieu Valetaud Discipline of Civil and Environmental Engineering School of Engineering and Physical Sciences James Cook University Townsville QLD 4811 AUSTRALIA & CRC for Contamination Assessment and Remediation of the Environment Mawson Lakes SA 5095 Australia école Nationale Supérieure d’Ingénieurs de Limoges (ENSIL) Université de Limoges 87068 Limoges France

Precise identification of the pollutant source characteristics is the first step for designing an effective groundwater contamination remediation strategy. In this study a linked simulation-optimization based methodology is utilized for identification of unknown groundwater pollution sources in a real life contaminated aquifer in New South Wales, Australia where the source locations and source flux release history are the explicit unknown variables. The methodology is applied utilizing an in house software package GWSID developed at James Cook University for optimal determination of the unknown source characteristics. The methodology incorporates linked simulation optimization approach and utilizes simulated Algorithm as an evolutionary optimization algorithm. The performance evaluation results show practical utility of the methodology and of the associated developed computers software in identifying the unknown source characteristics.

关键词： Groundwater Contamination Source Characterization Linked Simulation-Optimization

Birch Sap (Betula alba) and Chaga Mushroom (Inonotus obliquus) Extracts Show Anti-Oxidant, Anti-Inflammatory and DNA Protection/Repair Activity In Vitro

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Journal of Cosmetics, Dermatological Sciences and Applications 2019年第2期9卷 188-205页

作者： Mohamed Softa Giuseppe Percoco Elian Lati pauline Bony INDERMA Dermatological Laboratory Ivry sur SeineFrance BIO-EC Laboratory LongjumeauFrance

OBJECTIVE: The skin interacts strictly with the surrounding environment. Despite an efficient system of protection, its integrity is continuously assaulted by a massive group of external stresses. UV irradiations represent one of the most harmful factors for the cutaneous tissue. Both UV-A and UV-B can induce deep modifications of the different layers of the skin, including a weakening of its barrier function properties, DNA damages and degradation of the extracellular matrix. The aim of this project was to assess the UV protection activity of two natural compounds, the birch sap from Betula alba and organic extract from Inonotus obliquus (chaga mushroom) used separately or in a complex. METHODS: The anti-oxidant (ROS and MDA quantification, catalase and SOD activity measurement), anti-inflammatory (IL-1β, IL-6, IL-8, IL-10, TNF-α and INF-γ dosages) and the DNA protection/repair activities (DNA lesion site analysis) of birch sap and chaga mushroom extracts tested separately or in a complex containing organic birch sap 5% and Inonotus obliquus extracts 2% were evaluated in vitro after exposure of cultured keratinocytes and fibroblasts or reconstructed epidermis to UV-A/UV-B irradiations. RESULTS: We observed that birch sap from Betula alba and extracts from Inonotus obliquus prevent the formation of ROS and decrease the oxidative stress induced under UV irradiations, suggesting a strong anti-oxidant activity. In addition, the tested products showed an immunomodulatory effect by reducing the quantity of pro-inflammatory cytokines upon UV irradiations. UV-induced DNA damages of keratinocytes were also reduced by birch sap and chaga mushroom extracts. CONCLUSION: Here, for the first time, we have shown the photo-protection activity of extracts obtained from Betula alba and Inonotus obliquus mushroom on skin cells exposed to UV-A and UV-B irradiations. Due to their anti-oxidant, anti-inflammatory and DNA protection/repair activities, the tested products represent promisi

关键词： Birch Sap Chaga Mushroom UV Irradiations Oxidative Stress Photo-Aging Natural Compounds

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镁离子电池电解液的研究进展

Science Bulletin 2023年第16期68卷 1819-1842,M0004页

作者：满跃华 pauline Jaumaux 徐一帆费雅婷莫祥银汪国秀周小四 School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China Center for Clean Energy Technology School of Mathematical and Physical ScienceFaculty of ScienceUniversity of Technology SydneyNew South Wales 2007Australia

镁离子电池因其高理论容量和丰富的自然资源被认为是下一代储能系统的潜在候选者.然而,镁离子电池的发展受到镁负极与常见的镁盐和传统有机液体电解液溶剂不相容的限制.因此,电解液的发展是开发高效镁离子电池的决定性因素.镁离子电池... 详细信息

镁离子电池因其高理论容量和丰富的自然资源被认为是下一代储能系统的潜在候选者.然而,镁离子电池的发展受到镁负极与常见的镁盐和传统有机液体电解液溶剂不相容的限制.因此,电解液的发展是开发高效镁离子电池的决定性因素.镁离子电池的进一步应用所面临的一个主要挑战是开发具有适当的电化学窗口、与镁负极兼容、安全性高的电解液.当前,用于镁离子电池的主要电解液类型包括有机液体电解液、水系电解液、离子液体电解液和固态电解质.本文强调了每个类别中高性能镁离子电池电解液的最新进展,对先进电解液的设计策略进行了系统评估,分析了每种电解液的优点和局限性以及对现有问题的解决方案,并从电解液合成的角度讨论了镁离子电池的发展;最后,讨论并设想了镁离子电池电解液的未来设计,这将对进一步提高镁离子电池的性能提供支持.

关键词：固态电解质镁离子电池理论容量电化学窗口水系电解液有机液体储能系统系统评估

The regional employment implications of a net-zero economy in Costa Rica under uncertainty

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Advances in Climate Change Research 2023年第6期14卷 988-999页

作者： Maria JoséSAUMA CHACON Alejandro MATARRITA VALVERDE Bernardo ZUNIGA ALVARADO Monica RODRiGUEZ-ZUNIGA Jairo QUIROs-TORTOS Luis ViCTOR-GALLARDO pauline SCHAAL Paula CUBILLOS Thierry DUPLAN Matthieu ROBIN Slim DALI Universidad de Costa Rica San Jose 11501-2060Costa Rica Agence Frangaise de Developpement Paris 75598 France

This study estimates job creation from Costa Rica's transition to net-zero emissions by 2050,contrasting it with a business-as-usual scenario(BAU)using employment multipliers from Costa Rica's input-output *** model is soft-linked with a bottom-up technology-rich regional model of the CLEW sectors in Costa Rica.A robust decision-making-inspired approach is taken to assess the effects of uncertainty on the *** study addresses a literature gap in modeling subnational employment while accounting for long-term uncertainty and allows to identify economic activities affected by the transformation,so that policies regarding a just transition can be properly developed and stakeholders incentivized to take active participation in the *** baseline assumptions,a net-zero economy would have 135 thousand more jobs by 2050 than the BAU,equivalent to 7%of the employed population in ***-related jobs would triple by mid-21st century,and regions capitalizing on renewables would perceive the highest *** considering uncertainty,the net jobs range between 35-750 *** net positive outcomes in terms of jobs are feasible,global governance should focus efforts on policies that enhance these.

关键词： Decarbonization Environmental policy Input-output Employment multipliers Costa Rica

Solution Concepts and New Optimality Conditions in Bilevel Multiobjective Programming

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Applied Mathematics 2012年第10期3卷 1395-1402页

作者： Francisque Fouodji Dedzo Laure pauline Fotso Calice Olivier Pieume Department of Computer Sciences Faculty of Science University of Yaoundé I Yaoundé Cameroon Department of Mathematics Faculty of Science University of Yaoundé I Yaoundé Cameroon Regional Bureau for Education in Africa Pole de Dakar UNESCO Dakar Senegal

In this paper, new sufficient optimality theorems for a solution of a differentiable bilevel multiobjective optimization problem (BMOP) are established. We start with a discussion on solution concepts in bilevel multiobjective programming;a theorem giving necessary and sufficient conditions for a decision vector to be called a solution of the BMOP and a proposition giving the relations between four types of solutions of a BMOP are presented and proved. Then, under the pseudoconvexity assumptions on the upper and lower level objective functions and the quasiconvexity assumptions on the constraints functions, we establish and prove two new sufficient optimality theorems for a solution of a general BMOP with coupled upper level constraints. Two corollary of these theorems, in the case where the upper and lower level objectives and constraints functions are convex are presented.

关键词： Bilevel Multiobjective Optimization Multiobjective Optimization Sufficient Optimality Condition Strict Convexity Pseudoconvexity Quasiconvexity