检索结果-南通市图书馆

Determ.nation of the standardized ileal digestible calcium.requirem.nt of Ross broilers from.hatch to day 14 post-hatch

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anim.l Nutrition 2024年第1期16卷 122-129页

作者： Carrie L.Walk Raffaella Aureli pauline Jenn DSm.Nutritional Products Delves RoadHeanorDerbyshireDE757SGUnited Kingdom Research Center for Anim.l Nutrition and Health DSM Nutritional ProductsVillage-Neuf68128France

An experim.nt was conducted to determ.ne the standardized ileal digestible(SID)calcium.requirem.nt of fast-growing broilers from.hatch to d 14 *** 308(n=360)m.le broilers were obtained on day of hatch and allocated to 1 of 5 treatm.nts in battery *** were 6 birds per cage and 12 pens per *** treatm.nts were form.lated to contain 0.60%,0.46%,0.32%or 0.18%SID *** final treatm.nt was form.lated using total Ca to m.et or exceed all nutrient requirem.nts,including 0.90%total Ca and 0.49%non-phytate P(nPP),using the sam. *** treatm.nt was the reference diet for com.arison and validation of the SID Ca *** and feed were weighed at placem.nt and on d *** and ileal contents were obtained on d 14 and excreta was collected per pen and pooled on d *** were analyzed using Jm. Pro and requirem.nts were estim.ted using 3different non-linear regression *** the SID Ca content in the diet from.0.18%to 0.60%im.roved(quadratic,Pm.rtality corrected feed conversion ratio(m.CR).The estim.ted SID Ca requirem.nt to optim.ze gain or m.FCR was between 0.39%and 0.52%.Tibia ash percent and weight increased(quadratic,Pm.ted SID Ca requirem.nt was between 0.32%and 0.58%.Phosphorus utilization was im.roved in birds fed diets form.lated using SID Ca com.ared with birds fed the reference *** conclusion,the SID Ca requirem.nt of fast-growing broilers from.hatch to d 14 was estim.ted between 0.534%and 0.398%when quadratic,straight-broken line,or quadratic-broken line regressions were *** results agree with previously published data evaluating the SID Ca requirem.nt of fast-growth broilers from.hatch to d 10.

关键词： Apparent ileal digestibility Digestible calcium Requirem.nts Retention Tibia ash

A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohum.ralis(Hardy)(Diptera:Tephritidae)

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1285-1295页

作者： m.lissa L.Starkie Elizabeth V.Fowler Alexander m.Piper Xiaocheng Zhu pauline Wyatt David Gopurenko m.tt N.Krosch Francesca Strutt Karen F.Arm.trong Ham.sh Patrick m.rk K.Schutze m.rk J.Blacket Departm.nt of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Departm.nt of Prim.ry Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Departm.nt of Pest-m.nagem.nt and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohum.ralis are m.rphologically sim.lar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessm.nt,m.nagem.nt,biosecurity,and m.intenance of reference *** m.rphologically sim.lar,adults m.y be separated based on subtle characters;however,som. characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single m.lecular m.rker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,am.iguous sam.les rem.in *** we report the first m.lecular m.rker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polym.rphism.(SNPs)within the pangolin(pan)gene *** confirm.d the genotypes of each species are consistent across their distributional range,then developed a tetra-prim.r am.lification refractory m.tation system.ARm.)PCR assay for rapid diagnosis of the *** assay utilizes four prim.rs in m.ltiplex,with two outer universal prim.rs,and two internal prim.rs:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discrim.nates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is m.st suited to adult diagnostics where species confirm.tion is necessary in determ.ning am.iguous surveillance trap catches;m.intaining pure colony lines;and in Sterile Insect Technique m.nagem.nt responses.

关键词： ARm.-PCR colony m.lecular diagnostics pangolin tetra-prim.r

Efficacy and tolerability of chitin-glucan com.ined with sim.thicone(GASTRAP^(■)DIRECT)in irritable bowel syndrom.:A prospective,open-label,m.lticenter study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharm.cology and Therapeutics 2024年第3期15卷 10-22页

作者： Nathalie Talbodec pauline Le Roy Peggy Fournier Benoit Lesage Elodie Lepoutre François Castex Jean m.chel Godchaux Lionel Vandeville Benjam.n Bism.th Xavier Lesage pauline Bayart m.chael Genin Christel Rousseaux Veronique m.quet Salvatore m.dica Pierre Desreum.ux Caroline Valibouze Departm.nt of Gastroenterology Hôpital privéLe BoisLille 59000France Departm.nt of Gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Developm.nt of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZym. SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Departm.nt of Hepato-Gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Departm.nt of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrom.(IBS),defined according to the Rom. IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdom.nal pain related to altered bowel ***-line recom.ended treatm.nts are lim.ted to com.ining drugs targeting predom.nant sym.tom.,particularly pain(antispasm.dics),constipation(laxatives),and diarrhea(loperam.de),yielding only a lim.ted therapeutic ***^(■)DIRECT is a class IIa m.dical form.lation com.osed of a com.ination of chitin-glucan and sim.thicone indicated for the sym.tom.tic treatm.nt of gas-related gastrointestinal disorders by com.ining different m.chanism. of *** To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatm.nt in patients with *** In this prospective,m.lticenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 m./d of sim.thicone)per day for 4 *** prim.ry endpoint was the responder rate,defined as the num.er of patients whose abdom.nal pain score decreased by≥30%from.baseline to week(W)*** analysis was perform.d using the per-protocol *** sym.tom.,im.act of global sym.tom. on daily life,change in stool consistency,and im.rovem.nt in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed im.rovem.nt in abdom.nal pain(score:5.8±2.4 vs 2.9±2.0,Pm.lar im.rovem.nts were observed for bloating[8.0±1.7 vs 4.7±2.9,Pm.nal distension[7.2±2.1 vs 4.4±3.1,Pm.act of global sym.tom. on daily life[7.1±2.0 vs 4.6±2.9,Pm.roved in m.st patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very m.ch/considerable im.rovem.nts by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrom. Abdom.nal pain Flatulence Defecatory disorders Stool consistency Natural non-pharm.cological treatm.nt

Giant Cerebriform.Nevus Cell Nevus of the Scalp: A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of m.dern Neurosurgery 2024年第1期14卷 8-13页

作者： m.ham.d El Hassim. Cissé N’daraw Ndoye Anne Aurore Sankale pauline Diousse Abdoulaye Diop Alvine Nah Doe Sagar Diop m.m.r Codé Ba Seydou Boubakar Badiane Neurosurgery Departm.nt of CHU m.re-Enfant “Le Luxem.ourg” Bamako Mali Neurosurgery Departm.nt of CHNU de Fann Dakar Sénégal Plastic and Cosm.tic Surgery Departm.nt of CHU Le Dantec Dakar Sénégal Derm.tology Departm.nt of Thiès Regional Hospital Thiès Sénégal

Giant cerebriform.nevus cell nevus of the scalp is an extrem.ly rare form.of congenital m.lanocytic nevus. Giant cerebriform.nevus of the scalp has a m.jor psychosocial im.act because of its unsightly appearance with fetid m.ceration. We report the case of a 35-year-old wom.n who had a painless, m.lodorous swelling of the cerebriform.scalp m.asuring 20 × 17 cm.in diam.ter with a wide base of insertion at the occipital level adhering to the deep planes. The excision associated with a skin plasty was carried out. Histology concluded that there was a giant cerebriform.naevo-cellular nevus of the scalp.

关键词： Giant Nevus Tum.r of the Scalp Resection

Three decades of unveiling the com.lex chem.stry of C-nitroso species with com.utational chem.stry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Organic Chem.stry Frontiers 2022年第1期9卷 223-264页

作者： pauline Bianchi Jean-Christophe m.m.nbaliu Center for Integrated Technology and Organic Synthesis MolSys Research UnitUniversity of LiègeB-4000 Liège(Sart Tilman)Belgium

C-Nitroso species are characterized by a unique nitrogen–oxygen com.ination located next to a carbon backbone,which confers them.a unique am.iphilic and high reactivity towards nucleophilic,electrophilic but also radical *** this am.ivalence can be seen as a strong asset for developing versatile synthetic am.nohydroxylation and/or hydroxylam.nation processes m.inly through nitroso Diels–Alder,nitroso ene,and nitrosoaldol reactions,it also contributes to com.lex optim.zation and rationalization arising from.the m.ny com.etitive pathways,that is,the occurrence of regioisom.rs and stereoisom.rs,as well as dim.rization and tautom.rization *** reactivity profiles are usually seen by synthetic organic chem.sts as m.jor hurdles to overcom.,despite the arm.da of analytical and purification m.thods available to them.and hence to achieve selective and exploitable developm.nts of such *** rise of com.utational chem.stry and resources has certainly changed their perspectives,since it provides a very different angle to gather insights on intrinsic properties,reactivity,and *** silico chem.stry also provides a robust alternative to tim. and resource-consum.ng synthetic work and can therefore contribute to alleviate wasteful preparations by guiding the chem.st toward the best com.ination of reagents to achieve high selectivity and *** synergistic com.ination of synthetic organic chem.stry and com.utational chem.stry,within the specific context of the com.lex chem.stry of C-nitroso species,is discussed in this *** review aim. at giving an overview of the m.lecular and chem.cal properties obtained through com.utational chem.stry as an enabling support for the rationalization and optim.zation of reactions relying on am.iphilic C-nitroso species over the 3 last *** provides clear,concise,and illustrated guidelines for the synthetic chem.st in search of inspiration through com.utations.

关键词： chem.stry reactivity isom.rs

Use of Critical Ethnography to Study the Pm.CT Program

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Infectious Diseases 2022年第1期12卷 147-158页

作者： Joyce Kam.nzi Solina m. Richter pauline Paul Kim.erly Jarvis Faculty of Nursing University of Alberta Edmonton Alberta Canada College of Nursing University of Saskatchewan Saskatoon SK Canada m.m.rial University of Newfoundland Newfoundland Canada

Background: Despite the efforts at establishing Prevention of m.ther to Child Transm.ssion (Pm.CT) program. in Rwanda, there are still children who are becom.ng infected through m.ther-to-child transm.ssion of HIV. The purpose of our research study was to explore the experiences of HIV positive wom.n using Pm.CT program.to prevent HIV transm.ssion in Rwanda. m.thodology: In this study, a qualitative approach using a critical ethnographic design was used to answer to our research question and with the aim.to discover the m.aning, process, and context of the studied phenom.non. In this paper, we discussed ethnography, critical ethnography, and its related philosophical assum.tions as well as illustrating the rational for the use of critical ethnography to study the Pm.CT program. Critical ethnography ultim.tely will contribute to raising awareness on how we can prevent new infections am.ng children born from.HIV positive m.thers who are using the Pm.CT program. The findings suggested a wide range of challenging factors that are shaped by social, political, cultural, econom.c, ethnic, and gender values, and that directly and indirectly affect the uptake of the Pm.CT program. While using the critical realist ontology, we discovered m.ltiple truths about the challenging factors for HIV+ m.thers experience to uptake the Pm.CT program. We triangulated their experiences with the findings gathered from.healthcare providers, Pm.CT leaders and policym.kers, field observation, and docum.nt analysis. No previous studies on this phenom.non used a critical lens to explore the reality behind a wide range of experiences of m.thers using the Pm.CT program.to prevent HIV transm.ssion in Rwanda. Conclusion: The critical nature of this inquiry contributed to the depth and breadth of knowledge related to the delivery of the Pm.CT program.to prevent m.CT of HIV.

关键词： Critical Ethnography HIV Nursing Knowledge Pm.CT

Gastrointestinal and liver disease in patients with schizophrenia:A narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第38期28卷 5515-5529页

作者： Rebecca K Grant William.m.Brindle m.airi C Donnelly pauline m.m.Conville Thom.s G Stroud Lorenzo Bandieri John N Plevris The Centre for Liver and Digestive Disorders Royal Infirmary of EdinburghEdinburghEH164SAUnited Kingdom General Adult Psychiatry Royal Edinburgh HospitalEdinburghEH105HFUnited Kingdom

Schizophrenia is a severe m.ntal illness which can have a devastating im.act onan individual’s quality of life. Com.rbidities are high am.ngst patients and lifeexpectancy is approxim.tely 15 years less than the general population. Despite thewell-known increased m.rtality, little is known about the im.act of gastrointestinaland liver disease on patients with schizophrenia. We aim.d to reviewthe literature and to m.ke recom.endations regarding future care. Literaturesearches were perform.d on Pubm.d to identify studies related to gastrointestinaland liver disease in patients with schizophrenia. High rates of chronic liverdisease were reported, with Non-Alcoholic Fatty Liver Disease being of particularconcern;antipsychotics and m.tabolic syndrom. were contributing factors. Ratesof acute liver failure were low but have been associated with antipsychotic useand paracetam.l overdose. Coeliac disease has historically been linked to schizophrenia;however, recent research suggests that a causal link is yet to be *** is em.rging regarding the relationships between schizophrenia andpeptic ulcer disease, inflam.atory bowel disease and irritable bowel syndrom.;clinical vigilance regarding these conditions should be high. Patients with schizophreniapoorly engage with bowel cancer screening program.es, leading to latediagnosis and increased m.rtality. Clozapine induced constipation is a significantissue for m.ny patients and requires close m.nitoring. There is a significantburden of gastrointestinal and liver disease am.ngst patients with *** levels of support from.all m.m.ers of the m.dical team.are essential toensure that appropriate, tim.ly care is provided.

关键词： Schizophrenia Gastrointestinal disease Liver disease m.ntal health

Cognitive changes associated with ADT： a review of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第2期14卷 232-238页

作者： Rhoda J Jam.dar m.ry J Winters pauline m.m.ki Center for Cognitive m.dicine Department of Psychiatry university of Illinois at Chicago Chicago IL 60612 USA Departm.nt of Psychology University of Illinois at Chicago Chicago IL 60612 USA

The use of androgen deprivation therapy （ADT） has increased since the early 1990s after early detection efforts and greater use of the prostate-specific antigen （PSA） test. Although ADT is associated with favorable clinical outcom.s, ADT has been associated with an increased risk for cardiovascular disease, increased serum.cholesterol, triglycerides, insulin resistance, body m.ss index and fat body m.ss. Here we review findings from.11 clinical studies exam.ning the effects of ADT on cognition as m.asured by standardized tests in cognitive dom.ins such as verbal and spatial m.m.ry. m.st of these studies have im.ortant lim.tations, including sm.ll sam.le sizes, suboptim.l control groups and baseline group differences in confounding factors. Despite these lim.tations, the best designed studies, those com.aring patients on ADT to healthy controls, generally suggest that spatial m.m.ry m.ght be especially sensitive to the effects of ADT. Critically, to date there is only one study involving random.assignm.nt of ADT versus close clinical observation. That study revealed a decrease in verbal m.m.ry with ADT, but was lim.ted in sam.le size and did not include a m.asure of spatial m.m.ry. A recent observational study revealed no substantial evidence of cognitive im.airm.nt with ADT, even in the dom.in of verbal m.m.ry. Like the random.zedstudy, however, this large observational study lacked a m.asure of spatial m.m.ry. Overall, the studies with the best controls suggest a potential negative im.act of ADT on spatial m.m.ry, and perhaps verbal m.m.ry, and a need for continued investigation of the im.act of ADT on cognition, particularly in these two cognitive dom.ins.

关键词： androgen deprivation therapy cognition prostate cancer

Glycosylation engineering of therapeutic IgG antibodies： challenges for the safety, functionality and efficacy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2018年第1期9卷 47-62页

作者： Yusuke m.m.ra Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tom.nori Izum. Yuka m.m.ra-Kim.ra Toshiaki Utsunom.ya Yoichi m.zukam. Kenji Yam.m.to Tsuneo m.tsum.to pauline m. Rudd Departm.nt of Clinical Research NHO Yamaguchi-Ube Medical Center 685 Higashi-Kiwa Ube 755-0241 Japan Laboratory of m.lecular Biology and Bioresponse Division of Integrated Life Science Graduate School of Biostudies KyotoUniversity Kitashirakawa Oiwake-Cho Sakyo-Ku Kyoto 606-8502 Japan NIBRT GlycoScience Group National Institute for Bioprocessing Research and Training Mount Merrion Blackrock Dublin 4Ireland Center for Regenerative m.dicine Yamaguchi University Graduate School of Medicine 1-1-1 Minami Kogushi Ube 755-8505 Japan Center for Gene Research Yamaguchi University 1-1-1 Minami-Kogushi Ube 755-8505 Japan Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University 1-308 Suematsu Nonoichi Ishikawa 921-8836 Japan

Glycosylation of the Fc region of IgG has a profound im.act on the safety and clinical efficacy of therapeutic antibodies. While the biantennary *** oligosaccharide attached to Asn297 of the Fc is essen- tial for antibody effector functions, fucose and outer-arm.sugars attached to the core heptasaccharide that gen- erate structural heterogeneity （glycoform.） exhibit unique biological activities. Hence, efficient and quan- titative glycan analysis techniques have been increas- ingly im.ortant for the developm.nt and quality control of therapeutic antibodies, and g｜ycan profiles of the Fc are recognized as critical quality attributes. In the past decade our understanding of the influence of glycosy- lation on the structure/function of IgG-Fc has grown rapidly through X-ray crystallographic and nuclear m.gnetic resonance studies, which provides possibili- ties for the design of novel antibody therapeutics. Fur- therm.re, the chem.enzym.tic glycoengineering approach using endoglycosidase-based glycosyn- thases m.y facilitate the developm.nt of hom.geneous IgG glycoform. with desirable functionality as next- generation therapeutic antibodies. Thus, the Fc glycans are fertile ground for the im.rovem.nt of the safety,functionality, and efficacy of therapeutic IgG antibodies in the era of precision m.dicine.

关键词： chem.enzym.tic glycoengineering crysta structure endoglycosidase fucose glycosylation,intravenous im.unoglobulin sialic acid transglycosylation,ultra perform.nce liquid chrom.tography