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Morphometric evaluation of wound healing in burns treated with Ulmo (Eucryphia cordifolia) honey alone and supplemented with ascorbic acid in guinea pig (Cavia porcellus)

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Burns & Trauma 2016年第4期4卷 264-272页

作者： Carolina Schencke Adriana Vasconcellos Cristian Sandoval paulina torres Francisca Acevedo Mariano del Sol Doctoral Program in Morphological Sciences Universidad de La FronteraTemucoChile CONICYT-PCHA/National Doctorate Programme/2014-21141130 SantiagoChile Facultad de Medicina Universidad de La FronteraTemucoChile Doctoral Program in Morphological Sciences Universidad de La FronteraTemucoChile CIMA Research Group Facultad de OdontologíaUniversidad de La FronteraTemucoChile CONICYT-PCHA/Doctorado Nacional/2015-21150991 SantiagoChile Scientific and Technological Bioresource Nucleus Universidad de La FronteraTemucoChile Facultad de Medicina Universidad de La FronteraTemucoChile Centro de Excelencia en Estudios Morfológicos y Quirúrgicos(CEMyQ) Universidad de La FronteraTemucoChile Centro de Investigación en Ciencias Biomédicas Universidad Autónoma de ChileTemucoChile

Background:In the context of the search for cost-efficient treatments,Ulmo(Eurcyphia cordifolia)honey is an excellent alternative for treating burn wounds and could have a profound medical,social,and economic *** acid is an enzymatic co-factor necessary for the synthesis of collagen and the proliferation of fibroblasts and has been proposed as a coadjuvant to strengthen the healing effects of *** aim of this work was to evaluate by morphometric studies the healing wounds caused by burns treated with Ulmo honey alone and supplemented with ascorbic acid in guinea pig(Cavia porcellus).Methods:Fifteen guinea pigs were used and divided randomly into three groups:positive control(C+),experimental with unsupplemented honey(H),and experimental with supplemented honey(SH).A uniform deep burn covering 1 cm2of the back skin was *** following indices were calculated for the morphometric study:superficial contraction index of the wound,deep contraction index of the wound,wound severity index,global healing index,global contraction index,and dermal proliferation ***:The superficial contraction index of the wound,global healing index,global contraction,and dermal proliferation area values of the experimental with supplemented honey group were higher than the other groups(P<0.05).Conclusions:According to these results,the combination of honey with an antioxidant(ascorbic acid)promotes an appropriate action to support the healing *** study showed that by supplementing the Ulmo honey with ascorbic acid,the healing and contraction effects can be strengthened in burn wounds compared to unsupplemented *** results were proof of the synergy between honey and ascorbic acid in healing burn wounds.

关键词： Honey Ascorbic acid Burn Morphometry Wound healing

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TNF system in eutopic endometrium from women with endometriosis

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Open Journal of Obstetrics and Gynecology 2013年第2期3卷 271-278页

作者： María Angélica Boric Marisa torres Claudio Pinto Maricela Pino paulina Hidalgo Fernando Gabler Ariel Fuentes María Cecilia Johnson Institute of Maternal and Child Research Faculty of Medicine University of Chile Santiago Chile

The role of the tumor necrosis factor (TNF) system in endometriosis is not completely clear and therefore was the focus of this study. In eutopic endometria obtained from women with (n = 41) and without (controls;n = 34) endometriosis during laparoscopy, the subcellular location and the percentages for TNF, TNFR1, TNFR2 and CD45 positive-cells were determined (immunohistochemistry);the protein concentration (ELISA) of the soluble receptors (sTNFR1 and sTNFR2) were measured in 4h-explants culture media and the TNF concentration was performed in ex vivo endometrial homogenates. The TNF, TNFR1 and TNFR2 mRNAs were analyzed by real-time PCR. In control endometria, TNF, TNFR1 and sTNFR1 proteins increased during the late secretory phase. In endometriosis endometria, the protein highest level of TNFR1 was reached during the early and the mid secretory phases and of sTNFR1 concentration during the proliferative phase;however, during the late secretory phase, both TNFR1 and sTNFR1 protein levels were reduced compared to the control endometria (p sTNFR2 concentrations, and TNF and TNFR2 mRNAs were similar in control and endometriosis endometria. Although TNFR1 mRNA was highly expressed, no significant differences were found between control and endometriosis endometria. In summary, this study establishes that TNF and TNFR1 protein expressions and the sTNFR concentrations in eutopic endometria from women with and without endometriosis are dependent on the menstrual cycle. The differences on the TNFR1 and sTNFR1 protein pattern between both groups, mainly during the mid and late secretory phases may play a role in the lower implantation rates observed in women with endometriosis, and also could be related to the altered cell death, which favor the augmented cell viability facilitating the characteristic endometrial implantation and growth outside the uterus in this disease.

关键词： Endometriosis Eutopic Endometrium TNF sTNFR1 sTNFR2

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