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Bioactive Materials 2023年第10期28卷 402-419页

作者： Richard Frank Richter Corina Vater Margarete Korn Tilman Ahlfeld Martina Rauner Winnie Pradel Bernd Stadlinger Michael Gelinsky Anja Lode paula Korn Centre for Translational Bone Joint and Soft Tissue ResearchUniversity Hospital Carl Gustav Carus and Faculty of MedicineTechnische Universitat DresdenDresdenGermany Department of Oral and Maxillofacial Surgery University Hospital Carl Gustav CarusTechnische Universitat DresdenGermany Department of Medicine III and Center for Healthy Aging University Hospital Carl Gustav CarusTechnische Universitat DresdenGermany Clinic of Cranio-Maxillofacial and Oral Surgery Center of Dental MedicineUniversity of ZurichSwitzerland

Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still growing. We demonstrate that a combination of CPC with mesoporous bioactive glass (MBG) particles led to an enhanced degradation in vitro and in a critical alveolar cleft defect in rats. Additionally, to support new bone formation the MBG was functionalized with hypoxia conditioned medium (HCM) derived from rat bone marrow stromal cells. HCM-functionalized scaffolds showed an improved cell proliferation and the highest formation of new bone volume. This highly flexible material system together with the drug delivery capacity is adaptable to patient specific needs and has great potential for clinical translation.

关键词： Drug delivery 3D plotting Alveolar cleft defect Calcium phosphate cement Mesoporous bioactive glass

Influence of quarantine during the coronavirus disease 2019(COVID-19)pandemic on physical and psychosocial aspects:perceptions of 214 Brazilian athletes

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Global Health Journal 2023年第1期7卷 49-54页

作者： Eliane de Morais Machado Leonardo Luiz Barretti Secchi paula Rezende Camargo Luciana De Michelis Mendonca Physical Therapy Department Universidade Federcd de Sao Carlos(UFSCar)Sao CarlosSP CEP 13565-905Brazil Physical Therapy Department Universidade Federal de Minas Gerais(UFMG)Belo Horizonte MG CEP 31270-901Brazil

Background:Social distancing may affect athletes,training,causing negative effects on mental and physical ***:This study therefore aimed to characterize the perception of Brazilian athletes about their physical and psychosocial aspects,sleep quality and coping strategies during the quarantine of the coronavirus disease 2019(COVID-19)***:This was a cross-sectional study with online survey,performed with Brazilian athletes(amateur and professional)over 18 *** main outcomes measures assessed were physical and psychosocial aspects,sleep quality and coping ***:A total of 214 athletes were *** average weekly hours of training during the quarantine was 4.71±3.71 h,of which 64.5%athletes(138/214)were oriented by medical staff during *** 52.8%(113/214)of athletes,training intensity during the quarantine was different/very different from the intensity before the quarantine.79.4%athletes(170/214)reported moderate to extreme difficulties in keeping the same level of training during the quarantine.77.1%athletes(165/214)had moderate to extreme anxiety and each of the athletes had concern about his or her athletic career future,including return to the sport.72.9%athletes(156/214)reported change in sleep schedule during the quarantine ***:The quarantine period during COVID-19 pandemic negatively affected the athlete^perception about training routine,since athletes reported reduction in training hours and training ***,the athletes reported that they were moderately to extremely *** also had concerns about their career in the future,as well as concerns regarding return to sport.

关键词： Social isolation Performance Psychological aspects Sleep quality Sport

Ecosystem service value of artificial reef area in Qingdao Luhaifeng sea ranching:A meta-analysis and benefit transfer valuation

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Ecological Economy 2022年第4期18卷 261-273页

作者： LIU Ya-jun paula NOVO The University of Leeds Leeds LS29JTUK

This study evaluates the ecosystem service value of Qingdao Luhaifeng Sea Ranch artificial reef area through the established meta-analysis value transfer model,and the results show that the total value will be 150 million yuan in *** to the regression results of the meta-analysis,the types of ecosystem services,the types of pasture sediment,the population density of the pasture area,and the economic level all have a significant impact on the wetland *** model in this paper passes the validity test,and the conclusions are the same as many current empirical *** shows that the benefit transfer method meta-analysis can save assessment labor,time and capital,and the decision-makers can make judgments ***-analysis is an effective and fast ex ante evaluation *** reliability of the value transfer method of meta-analysis largely depends on the quantity and quality of existing studies and the establishment of mathematical *** is necessary to expand the number of literature ***,the current evaluation method of ecosystem services in China has just started,so the government needs to encourage research institutions to evaluate the value of ecosystem services to provide more effective and abundant research literature.

关键词： sea ranching artificial reef ecosystem services benefit transfer meta-analysis

Limited long-distance dispersal success in a Western European fairy shrimp evidenced by nuclear and mitochondrial lineage structuring

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Current Zoology 2020年第3期66卷 227-237页

作者： paula C.RODRIGUEZ-FLORES Ernesto RECUERO Yolanda JIMENEZ-RUIZ Mario garcIA-PARIS Museo Nacional de Ciencias Naturales(MNCN-CSIC) Jose Gutierrez Abascal2Madrid 28006Spain Centre d'Estudis Avanqats de Blanes(CEAB-CSIC) C.d'Acces Cala Sant Francesc 14Blanes 17300Spain

Anostraca are known by their ability for long-distance dispersal,but the existence in several species of deep,geographically structured mtDNA lineages suggests their populations are subjected to allopatric differentiation,isolation,and prevalence of local scale *** stagnalis is one of the most widespread species of Anostraca and previous studies revealed an unclear geographical pattern of mtDNA genetic ***,we analyze populations from the Iberian and Italian Peninsulas,Central Europe,and Scandinavia,with the aim to characterize the patterns of genetic diversity in a spatio-temporal framework using mtDNA and nuclear markers to test gene flow among close *** these aims we built a time-calibrated phylogeny and carried out Bayesian phylogeographic analyses using a continuous diffusion *** results indicated that *** presents a deeply structured genetic diversity,including 7 ancient lineages,some of them even predating the *** Iberian Peninsula harbors high diversity of lineages,with strong isolation and recent absence of gene flow between *** at local scale seems to be the prevailing dispersal mode of ***,which exhibits a pattern of isolation-bydistance in the Iberian *** remark the vulnerability of most of these lineages,given the limited known geographic distribution of some of them,and the high risk of losing important evolutionary potential for the species.

关键词： allopatric fragmentation Anostraca Crustacea nuclear markers Pleistocene phylogeography

Distinguishing normal brain aging from the development of Alzheimer＇s disease：inflammation,insulin signaling and cognition

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Neural Regeneration Research 2018年第10期13卷 1719-1730页

作者： Paul Denver paula L.McClean Greater Los Angeles Veterans Affairs Healthcare System West Los Angeles Medical Center and Department of NeurologyUniversity of CaliforniaLos AngelesCAUSA Centre for Molecular Biosciences University of UlsterColeraine Northern Ireland UK Northern Ireland Centre for Stratified Medicine ClinicalTranslational and Research Innovation Centre (C-TRIC)University of UlsterDerry/Londonderry Northern Ireland UK

As populations age, prevalence of Alzheimer＇s disease（AD） is rising. Over 100 years of research has provided valuable insights into the pathophysiology of the disease, for which age is the principal risk factor. However, in recent years, a multitude of clinical trial failures has led to pharmaceutical corporations becoming more and more unwilling to support drug development in AD. It is possible that dependence on the amyloid cascade hypothesis as a guide for preclinical research and drug discovery is part of the problem. Accumulating evidence suggests that amyloid plaques and tau tangles are evident in non-demented individuals and that reducing or clearing these lesions does not always result in clinical improvement. Normal aging is associated with pathologies and cognitive decline that are similar to those observed in AD, making differentiation of AD-related cognitive decline and neuropathology challenging. In this mini-review, we discuss the difficulties with discerning normal, age-related cognitive decline with that related to AD. We also discuss some neuropathological features of AD and aging, including amyloid and tau pathology, synapse loss, inflammation and insulin signaling in the brain, with a view to highlighting cognitive or neuropathological markers that distinguish AD from normal aging. It is hoped that this review will help to bolster future preclinical research and support the development of clinical tools and therapeutics for AD.

关键词： Alzheimer's disease aging inflammation cognitive function spatial learning insulin signaling synapses cytokines

Recruitment of Minorities into Nursing, Best Practices: A Scoping Review

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Open Journal of Nursing 2022年第10期12卷 683-701页

作者： paula R. Klemm Hason Jafrey School of Nursing University of Delaware Newark Delaware USA Christiana Care Health System Newark Delaware USA

The recruitment and retention of minorities into nursing is a pressing need given the evolving racial makeup of the U.S. A scoping review of the literature was conducted to identify and map evidence of the best practices and timing for recruitment and retention of minorities in nursing. This review utilized methods described by Asksey and O’Malley. PubMed, CINAHL, SCOPUS, Cochrane, Web of Science, and ProQuest were searched from 2000 to 2022. Data were extracted from 20 full text papers published in English in the U.S. Recruitment usually begins in middle or high school, but several authors recommended beginning as early as elementary school to establish positive views of nursing. Retention methods included multi-pronged approaches tailored by the academic institutions. Most received federal funding. Financial aid is key to the success for many minority nursing students, but must be aligned with other supports (e.g., academic, social, mentoring) in recruitment and retention efforts. Partnerships with local elementary, middle, and high schools, hospitals, community agencies and centers, businesses, and minority groups are necessary. Future research that measures outcomes of early recruitment of minorities and their choice of nursing as a career is needed. Recruitment and retention efforts should include information on potential sources of funding prior to student enrollment. More information is needed on recruitment and retention programs that are successful without funding and those that remain robust after funding ends.

关键词： Recruitment and Retention African American Nursing

Analysis of the Most Likely Regions of Stability of an NCS and Design of the Corresponding Event-driven Controller

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International Journal of Automation and computing 2018年第1期15卷 39-51页

作者： Ana paula Batista Fabio Goncalves Jota Centre for Intelligent Energy Research Federal Centre of Technological Education of Minas Gerais Belo Horizonte Brazil Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil

In this paper, some issues related to design and analysis of real networked control systems （NCS） under the focus of the most likely region of stability are addressed. Such a system is cumbersome due to its inherent variable time delays, ranging from microseconds to hours. To show the influence of such huge variations in the control performance, a laboratory-scale luminosity system has been setup using the Internet as part of the control loop with dominant time constant in the order of milliseconds. Proportional and integral （PI） control strategies with and without explicit compensation for the time-delay variations were implemented using an event-driven controller. Using the well-known Monte Carlo method and subsequent analyses of time responses, it has been possible to identify the most likely region of stability. Some experimental results show the influence of the statistical parameters of the delays on the determination of the most likely regions of stability of the NCS and how these can be used in assessment and redesign of the control system. The experiments show that much larger delays than one sample period can be supported by real NCSs without becoming unstable.

关键词： Networked control systems real NCS delay compensation most likely regions of stability delay statistics.

Kindlin-1 drives early steps of breast cancer metastasis

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Cancer Communications 2022年第10期42卷 1036-1040页

作者： Florian Bonin Aurélie Chiche Zakia Tariq paula Azorin Sébastien Nola Rosette Lidereau Keltouma Driouch Genetics Department Institut CurieParis 75005France Cell Biology and Cancer Department/Unit 144 Institut Curie/Centre National de Recherche ScientifiqueParis 75005France Department of Developmental&Stem Cell Biology/Unit 3738 Institut Pasteur/Centre National de Recherche ScientifiqueParis 75015France Membrane Traffic in Health And Brain Disease/Unit 1266 Institute of Psychiatry and Neuroscience of Paris/Institut National de la Santéet de la Recherche MédicaleUniversitéde ParisParis 75014France

Dear Editor,Kindlin-1 plays a major role in the activation of integrins[1].Kindlin-1 is often overexpressed in ***-1 overexpression has been associated with a higher propensity of breast cancer patients to metastasize to the lungs[2,3].Furthermore,Kindlin-1 depletion in mouse models was found to inhibit tumor growth and lung metastasis[3,4].However,the underlying mechanisms remain poorly explored.

关键词： metastasis Kindlin breast

Brazilian adolescents’lifestyle in the COVID‑19 pandemic:a mixed‑methods study

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World Journal of Pediatrics 2022年第8期18卷 553-557页

作者： Caroline Lima Fonseca Carolina Ferreira Peterle Bruna Hinnah Borges Martins de Freitas Maria Aparecida Munhoz Gaíva paula Manuela Jorge Diogo Juliano Bortolini Federal University of Mato Grosso 2367 Fernando Corrêa da Costa AvBoa EsperançaCuiabáMT 78060-900Brazil Lisbon College of Nursing LisbonPortugal

The COVID-19 pandemic has forced the health authorities and governments worldwide to engage in a battle against the disease,adopting several mitigation strategies[1].Since then,the world population has been afected by various changes in its *** imposed by the COVID-19 pandemic are believed to have had an impact on adolescents'lifestyle(LS)[2].The LS is determined by discernible behavior patterns that can trigger efects on adolescents'health and is related to countless aspects that refect attitudes,values and life opportunities[3].Therefore,LS can be observed from the habits,behaviors and activities performed by people in their daily lives[4].

关键词： has routine COV

Quality of life,depression and anxiety in potential living liver donors for pediatric recipients:A retrospective single center experience

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World Journal of Hepatology 2022年第10期14卷 1899-1906页

作者： paula K Reine Flavia Feier Eduardo Antunes da Fonseca Rosely G Hernandes Joao Seda-Neto Department of Psychology Hospital Sirio-LibanesSao Paulo 01308901Brazil Department ofLiver Transplantation Santa Casa de Porto AlegrePorto Alegre 90020090Brazil Department of Liver Transplantation Hospital Sirio-LibanesSao Paulo 01308901Brazil

BACKGROUND Living donor liver transplantation is a safe alternative for patients on a liver transplant *** evaluation goes beyond physical variables to include social,emotional,and ethical *** role of pre-donation sociopsychological evaluation of the donor candidate is as important to the success of the procedure as is the medical *** implies recovery from the operation and pro-mpt engagement in pre-transplant professional and social activities,without leading to psychological or physical *** profiling of potential living liver donors(PLLD)and evaluation of quality of life(QOL)can influence *** To evaluate the socio-demographics and psychological aspects(QOL,depression,and anxiety)of PLLD for pediatric liver transplantation in a cohort of 250 *** This was a retrospective cohort study of 250 PLLD who underwent psychological pre-donation evaluation between 2015 and *** the recipients were *** Beck anxiety inventory,Beck depression inventory,and 36-item short-form health survey(SF-36)scores were used to evaluate anxiety(Beck anxiety inventory),depression(Beck depression inventory),and QOL,*** A total of 250 PLLD were *** of them were women(54.4%),and the mean age was 29.2±7.2 years.A total of 120(48.8%)PLLD were employed at the time of evaluation for donation;however,most had low income(57%earned<2 times the minimum wage).A total of 110 patients(44%)did not finish the donation process,and 247 PLLD answered a questionnaire to evaluate depression,anxiety,and QOL(SF-36).Prevalence of depression was of 5.2%and anxiety 3.6%.Although most of the PLLD were optimistic regarding the donation process and never had doubts about becoming a donor,some traces of ambivalence were observed:46%of the respondents said they would feel relieved if a deceased donor became *** PLLD had a low prevalence of anxiety and *** foundation for effective and sa

关键词： Liver transplantation Children Outcomes Living donation