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Phenotypic Characterization of the Response to Infection with <i>Trichinella spiralis</i>in Genetically Defined Mouse Lines of the CBi-IGE Stock

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Open Journal of Veterinary Medicine 2015年第5期5卷 111-122页

作者： María D. Vasconi Griselda Bertorini Ana V. Codina paula indelman Ricardo J. Di Masso Lucila I. Hinrichsen Instituto de Genética Experimental Facultad de Ciencias Médicas Universidad Nacional de Rosario Rosario Argentina rea Parasitología Facultad de Ciencias Bioquímicas y Farmacéuticas Universidad Nacional de Rosario Rosario Argentina CIC-UNR Universidad Nacional de Rosario Rosario Argentina

Trichinella spiralis (T. spiralis), which is a cosmopolitan nematode that infects humans among other species, presents a complex host-parasite relationship that hinders the development of tools to eradicate the parasitosis. The aim of this research was to analyze the host response during a primary infection with T. spiralis in five genetically different mouse lines of the CBi-IGE stock. Adult males from the CBi+, CBi−, CBi, CBi/L and CBi/C lines were infected with 1, 2 or 4 L1 larvae per g of body weight. In the chronic stage, the number of parasites per g of tissue (relative larval load, rLL) showed a significant host genotype-dose interaction, since it did not increase in the same way in the five genotypes. At the lowest dose, both CBii−and CBi/L mice were resistant while CBi+, CBi/C, and CBi were susceptible. At the highest dose, only CBi/L remained resistant, and CBi+ was the most susceptible. The reproductive capacity index of adult worms (RCI = rLL/infective dose) evinced only a genotype effect, allowing rating each line as resistant or susceptible regardless of dose. Animals receiving 2 L1 larvae were also sacrificed in the intestinal phase (6 and 13 days p-i) to determine the number of adult parasites (nAP) recovered in a small intestine segment, and female fecundity (Ff). No differences in nAP were observed among genotypes on day 6 p-i. nAP decreased between days 6 and 13 p-i, this reduction being different among genotypes and significant only in CBi/L and CBi/C. Ff decreased in CBi/L and CBi/C on day 13 p-i. At the time of infection, serum cytokine baseline values showed a Th1 orientation for genotype CBi/L (high IFN-γ and IL-2) and a Th2 for CBi+ (high IL-4 and IL-10).The variability in the response observed in this murine model suggests its potential usefulness to gain insight into the mechanisms that regulate host-parasite relationship.

关键词： Host Genotype-Parasite Relationship Gastrointestinal Nematode Trichinella spiralis Infectivity Resistance

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