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Real-World Evidence in Localized Pancreatic: Coping with Uncertainty in Unselected Populations

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Journal of Cancer Therapy 2024年第4期15卷 164-178页

作者： María I. Pamies Ramón Diana Ibarra Anguita paula Rodríguez Payá Alvaro Muñoz Abad David Sánchez García María Valero Revert Beatriz Grau Mirete Mariano Martínez Marín Alicia Calero Amaro Lorena Rodríguez Cazalla Javier Gallego Plazas Medical Oncology Department Elche University Hospital Elche (Alicante) Spain General Surgery Department Elche University Hospital Elche (Alicante) Spain General Surgery Department Vega Baja Hospital Orihuela (Alicante) Spain

Background: Localized pancreatic cancer, including resectable (R), borderline resectable (BR) and locally advanced unresectable disease (LAU), is considered in clinical guidelines for diverse treatment options based on clinical trials in selected populations. Hence, exploring with real world evidence (RWE) clinicians’ preferences for treatment options and their results seems pertinent. Methods: In a set of consecutive patients with localized pancreatic cancer assisted in a third level hospital from January 2013 to December 2022, medical records, symptoms, diagnostic process, distribution between subtypes, and treatment plans, with safety and efficacy results, were assessed. Results: A total of 152 patients with localized disease were included (43.4% R, 21.0% BR, 33.6% LAU). The population characteristics exemplified differences between daily practice and clinical trials. Tumor location and symptoms were as expected. Treatment plan was conditioned by PS or comorbidities in 23.0% of patients. In patients with R disease, surgery followed by different adjuvant chemotherapy (CT) regimes was the antineoplastic treatment of choice (64.8%) with efficacy results (OS 37.5 months;95% CI 18.4 - 56.7), in the range of contemporary standards. The common use of neoadjuvant CT for BR disease (94.4%), with surgery in 50% of them, and its results (OS 30.8 months;95% CI 10.5 - 51.2) reflected current controversies of treatment recommendations and evolution in this scenario. Paliative CT with or without radiotherapy was the standard specific treatment in LAU disease (95.1%) with survival results (PFS: 10.8 months;95% CI 8.8 - 12.7. OS: 20.3 months;95% CI 13.5 - 27.2) that justify the distinct character and the specific study of this entity. Conclusion: RWE for localized pancreatic cancer aroused from the analysis of this population confirms the distinct nature of patients assisted in daily practice, as well as mirrors the complexity of decision making in clinical assumptions in which a

关键词： Real-World Evidence Localized Pancreatic Cancer

Perovskite type lanthanum manganite：Morpho-structural analysis and electrical investigations

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Journal of Rare Earths 2018年第5期36卷 499-504页

作者： paula Sfirloaga Maria Poienar Iosif Malaescu Antoanetta Lungu Paulina Vlazan Institute for Research and Development in Electrochemistry and Condensed Matter P. Andronescu Street No.1 300224 Timisoara Romania West University of Timisoara Vasile Parvan 4 300223 Romania

Perovskite-type oxides of LaMnO3 were synthesized by means of the sol-gel method, in the presence of citric acid as gelling agent. The precursors used were Mn（NO3）2·H2O, La2O3, and NaOH,mixed in the stoichiometric ratio to obtain perovskite materials. The obtained gel was heat-treated at 400, 600 and 800 ℃ respectively, for 6 h. X-ray diffraction and FT-IR spectroscopy were used to analyze the phase transformation as a function of temperature, and the Rietveld refinement was used in order to characterize the materials obtained structurally. The average crystallite size of the products was calculated from XRD data and the average particle size was measured from the TEM micrographs. At 600 ℃, the synthesized compound is well-crystallized, showcases a perovskite structure（Pm-3m space group）, and exhibits uniform and homogeneous hexagonally-shaped particles, with sizes in the 20-50 nm *** impedance measurements in the 20-2 × 10^6 Hz frequency range were carried out at different temperatures（26-115 ℃）, and the electrical conduction mechanism is discussed.

关键词： Rare earths Sol-gel method Physico-chemical properties Electrical investigations

The cost-effectiveness of hypertonic saline inhalations for infant bronchiolitis: a decision analysis

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World Journal of Pediatrics 2018年第1期14卷 26-34页

作者： paula Heikkila Minna Mecklin Matti Korppi Tampere Center for Child Health Research Universityof Tampere and Tampere University HospitalTampereFinland Department of Pediatrics Tampere University HospitalPOBOX200033521T ampereFinland

Background This study evaluated the cost-effectiveness of hypertonic saline (HS) inhalations for infant bronchiolitis, com-pared to normal saline inhalations or standard treatment without inhalations as controls. Methods The decision tree in the decision analysis was used to calculate the expected costs. Actual cost data were obtained from our retrospective case-control study on bronchiolitis treatment. The effectiveness of treatment, based on the hospitaliza-tion rate of those admitted to the emergency department and the length of stay (LOS) of those who were hospitalized, was collected from previous studies. For the effectiveness estimations, we made a meta-analysis summarizing the results of the meta-analysis of the Cochrane review in 2013 and the results of 10 studies published after it. Results The mean hospitalization rate was 24.7% in the HS inhalation group and 32.6% in the control group [risk ratio: 0.80, 95% confidence interval (CI) 0.67–0.96] and the mean LOS was 3.736 (HS group) and 4.292 (controls) days (mean difference: ? 0.55 days, 95% CI ? 0.96 to ? 0.15), respectively. The expected costs per patient, when both inpatients and outpatients were included, were €816 ($1111) in the HS inhalation group and €962 ($1310) in the control group. The expected costs per hospitalization, when only inpatients were included, were €2600 ($3540) in the HS inhalation group and €2890 ($3935) in the control group. Conclusions HS inhalations slightly reduced the expected hospitalization costs of infant bronchiolitis. However, the low effectiveness, rather than the cost, is the factor that will limit the use of HS inhalations in infant bronchiolitis.

关键词： Bronchiolitis Cost-effectiveness Decision analysis Hospitalization costs Hypertonic saline

Oxidative metabolism of photosynthetic species and the exposure to some freshwater and marine biotoxins

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BIOCELL 2021年第4期45卷 813-821页

作者： SUSANA PUNTARULO paula MARIELA GONZÁLEZ Universidad de Buenos Aires Facultad de Farmacia y BioquímicaFisicoquímicaBuenos AiresCP 1113Argentina CONICET-Universidad de Buenos Aires.Instituto de Bioquímica y Medicina Molecular(IBIMOL) Buenos AiresCP 1113Argentina

Environmental climate conditions could lead to an increasing global occurrence of microorganism blooms that synthesize toxins in the aquatic *** blooms could result in significantly toxic *** of photosynthetic organisms to adverse environmental conditions implicate reactive oxygen species generation;but,due to the presence of a varied cellular antioxidant defense system and complex signaling networks,this oxidative stress could act as an important factor in the environmental adaptive *** objective of this review was to assess how some biotoxins are implicated in the generation of oxidative and nitrosative metabolic changes,not only in biotoxin-producing organisms but also in non-producing ***,toxins may modify the oxidative cellular balance of several other ***,the effect of toxins on the oxidative and nitrosative conditions will be evaluated in freshwater and marine algae and vascular *** changing climate conditions could act as agents capable of modifying the community composition leading to alterations in the global health of the habitat,risking the survival of many species with ecological relevance.

关键词： Blooms Climate change Metabolic stress Photosynthetic organisms Toxins

Homeomorphic extension of strongly spirallike mappings in C^n

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Science China Mathematics 2010年第1期53卷 87-100页

作者： CURT paula KOHR Gabriela KOHR Mirela Faculty of Economics and Business Administration Babes-Bolyai University 58-60 Teodor Mihali Str.400591 Cluj-NapocaRomania Faculty of Mathematics and Computer Science Babes-Bolyai University1 M.Kogaǎlniceanu Str.400084 Cluj-NapocaRomania

In this paper we consider a proper subclass nA of the full class of spirallike mappings on the Euclidean unit ball Bn in Cn with respect to a given linear operator A. We use the method of subordination chains to obtain an upper growth result for nA , and we obtain various examples of mappings in the same class of normalized biholomorphic mappings on the unit ball Bn in Cn . We also prove that the class nA is compact, while the full class of spirallike mappings with respect to a linear operator need not be compact in dimension n≥2, even when the operator is diagonal. This is one of the motivations for considering the class nA . Finally we prove that if f is a quasiregular strongly spirallike mapping on Bn such that ||[Df(z)]-1 Af(z)|| is uniformly bounded on Bn , then f extends to a homeomorphism of R2n onto itself. In addition, if A + A* = 2aI n for some a >0, this extension is also quasiconformal on R2n .

关键词： Biholomorphic mapping quasiregular mapping quasiconformal mapping spirallikeness strongly spirallikeness subordination subordination chain

Flower heads in Asteraceae—recruitment of conserved developmental regulators to control the flower-like inflorescence architecture

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Horticulture Research 2018年第1期5卷 491-500页

作者： paula Elomaa Yafei Zhao Teng Zhang Department of Agricultural Sciences Viikki Plant Science CentreUniversity of HelsinkiP.O.Box 2700014HelsinkiFinland

Inflorescences in the Asteraceae plant family,flower heads,or capitula,mimic single flowers but are highly compressed structures composed of multiple *** transference of a flower-like appearance into an inflorescence level is considered as the key innovation for the rapid tribal radiation of *** molecular data indicate that Asteraceae flower heads resemble single flowers not only morphologically but also at molecular *** summarize this data giving examples of how rewiring of conserved floral regulators have led to evolution of morphological innovations in *** diversification of the highly conserved flower meristem identity regulator LEAFY has shown a major role in the evolution of the capitulum ***,gene duplication and subsequent sub-and neofunctionalization of SEPALLATA-and CYCLOIDEA-like genes in Asteraceae have been shown to contribute to meristem determinacy,as well as flower type differentiation—key traits that specify this large *** challenge is to integrate genomic,as well as evolutionary developmental studies in a wider selection of Asteraceae species to understand the detailed gene regulatory networks behind the elaborate inflorescence architecture,and to promote our understanding of how changes in regulatory mechanisms shape development.

关键词： flowers architecture head

Doxycycline induces bone repair and changes in Wnt signalling

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International Journal of Oral Science 2017年第3期9卷 158-166页

作者： kátia do nascimento gomes ana paula negreiros nunes alves paula góes pinheiro dutra glauce socorro de barros viana faculty of dentistry pharmacy and nursingfederal university of cearáFortalezaBrazil faculty of medicine federal university of cearáFortaleza Brazil

Doxycycline （DOX） exhibits anti-inflammatory and MMP inhibitory properties. The objectives of this study were to evaluate the effects of DOX on alveolar bone repair. Controls （CTL） and DOX-treated （10 and 25 mg. kg- 1） molars were extracted, and rats were killed 7 or 14 days later. The maxillae were processed and subjected to histological and immunohistochemical assays. Hematoxylin-eosin staining （7th day） revealed inflammation in the CTL group that was partly reversed after DOX treatment. On the 14th day, the CTL group exhibited bone neoformation, conjunctive tissue, re-epithelization and the absence of inflammatory infiltrate. DOX-treated groups exhibited complete re-epithelization, tissue remodelling and almost no inflammation. Picrosirius red staining in the DOXlO group （7th and 14th days） revealed an increased percentage of type I and III collagen fibres compared with the CTL and DOX25 groups. The DOXlO and DOX25 groups exhibited increases in osteoblasts on the 7th and 14th days. However, there were fewer osteoclasts in the DOXlO and DOX25 groups on the 7th and 14th days. Wnt-lOb- immunopositive cells increased by 130% and 150% on the 7th and 14th days, respectively, in DOX-treated groups compared with the CTL group. On the 7th day, Dickkopf （Dkk）-I immunostaining was decreased by 63% and 46% in the DOXlO and DOX25 groups, respectively. On the 14th day, 69% and 42% decreases in immunopositive cells were observed in the DOXlO and DOX25 groups, respectively, compared with the CTL group. By increasing osteoblasts, decreasing osteoclasts, activating Wnt lOb and neutralising Dkk, DOX is a potential candidate for bone repair in periodontal diseases.

关键词： alveolar bone loss bone diseases bone repair doxycycline Dickkopf-1 immunohistochemistry Wnt-lOb

Effect of Poly(ε-caprolactone-b-tetrahydrofuran)Triblock Copolymer Concentration on Morphological,Thermal and Mechanical Properties of Immiscible PLA/PCL Blends

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Journal of Renewable Materials 2019年第2期7卷 129-138页

作者： paula do Patrocínio Dias Marcelo Aparecido Chinelatto Department of Materials Engineering-Campus II São Carlos School of Engineering-EESCUniversity of São Paulo-USPAv.João Dagnone1100-Jd.Sta AngelinaSão Carlos-SP-Brazil

In this study a low molecular weight triblock copolymer derived fromε-caprolactone and tetrahydrofuran was used as a non-reactive compatibilizer of immiscible PLA/PCL *** blends with 0,1.5 wt%,3 wt%and 5 wt% copolymer and about 75 wt%PLA were prepared by single screw extrusion and characterized by scanning electron microscopy(SEM),differential scanning calorimetry(DSC),dynamic mechanical analysis(DMA),tensile and Izod impact *** micrographs showed that the size of the dispersed PCL domains was practically constant regardless of copolymer *** result can be explained by the low shear rate employed during processing step and a decrease of PCL viscosity by presence of the triblock ***,when the copolymer concentration increased,strain at break of PLA/PCL blends also ***/PCL blend with 0 wt% copolymer presented 2%strain at break,whereas PLA/PCL blend with 5 wt%copolymer exhibited 90%.

关键词： Blends non-reactive compatibilization poly(lactic acid) poly(ε-caprolactone) triblock copolymer

Programmed cell death in seeds of angiosperms

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Journal of Integrative Plant Biology 2015年第12期57卷 996-1002页

作者： María paula López-Fernández Sara Maldonado Laboratory of Plant Development Department of Biodiversity and Experimental Biology Faculty of Exact and Natural Sciences University of Buenos Aires National Research Council of Argentine (CONICET)

During the diversification of angiosperms, seeds have evolved structuralp chemical, molecular and physiolog- ically developing changes that specially affect the nucellus and endosperm. All through seed evolution, programmed celldeath （PCD） has played a fundamental role. However, examples of PCD during seed development are limited. The present review examines PCD in integuments, nucellus, suspensor and endosperm in those representative examples of seeds studied to date.

关键词： Caspases endosperm KDEL-CysEP metacaspases nucellus nucleases programmed cell death perisperm ricinosomes