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Boosting hydrogen a.d chemica.s production through etha.ol electro-reforming on Pt-tra.sition meta. a.odes

Journa. of Energy Chemistry 2022年第7期31卷 394-406,I0011页

作者： a.berto rodríg.ez-gómez Ferna.do Dora.o paula Sánchez a.a.Ra.uel de la.Osa Chemica. Engineering Depa.tment Faculty of Chemical Sciences and TechnologyUniversity of Castilla-La Mancha

The a.m of this work is to boost the combined hydrogen a.d a.ded-va.ues compounds genera.ion(a.eta.dehyde, a.etic a.id a.d ethyl a.eta.e) through etha.ol electrochemica. reforming using bimeta.lic a.odes. In pa.ticula., the influence of the seconda.y meta. on the electrochemica. performa.ce a. well a. on the product distribution wa. studied. For tha. purpose, Pt X/C electroca.a.ysts(where X corresponds to Cu, Co, Ni a.d Ru) were synthesized by the modified polyol method a.d tested in both ha.f-cell a.d proton excha.ge membra.e(PEM) cell configura.ions. Cha.a.teriza.ion results showed tha. incorpora.ion of Ni a.d Co into the Pt ma.rix enha.ces the morphologica. properties of the ma.eria., providing sma.ler crysta.lite sizes, higher a.tive surfa.e a.ea. a.d hence, better dispersion when compa.ing to Ru a.d Cu-ba.ed electroca.a.ysts. Etha.ol oxida.ion rea.tion(EOR) wa. eva.ua.ed by cyclic, linea. volta.metry a.d chronopotentiometry a.sa.s. Pt Co/C a.d Pt Ni/C exhibited the highest electroca.a.ytic a.tivity a. high pola.iza.ion levels, which tra.sla.e into a. improvement of more tha. 30%(up to 1050 m a.cm^(-2)) in the hydrogen production a.d chemica. yields. On the other ha.d, Pt Ru/C results more a.va.ta.eous for a.lower potentia. interva.(g the a.etic a.id production despite sa.rificing etha.ol conversion. Pt Cu/C presented the lowest results in both electrochemica. performa.ce a.d product distribution. Such differences in the electrochemica. performa.ce ca. be ra.iona.ized in terms of the synergistic effect between both meta.s(pa.ticle size distribution, gra.e of dispersion a.d hydrophilic beha.ior), which demonstra.e tha. the incorpora.ion of a.different seconda.y meta. pla.s a. essentia. role in the EOR development.

关键词： Etha.ol electrochemica. reforming Bimeta.lic a.odic electroca.a.ysts PEM cell High current performa.ce Hydrogen Chemica.s production

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Cha.ges in microha.ita., but not a.lelopa.hy, a.fect pla.t esta.lishment a.ter a.a.ia.dea.ba.a.inva.ion

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Journa. of Pla.t Ecology 2017年第4期10卷 610-617页

作者： paula Lorenzo Jona.a. rodríg.ez Luís gonzález Susa.a.rodríg.ez-Echeverría Centre for Functiona. Ecology(CFE) Department of Life SciencesUniversity of CoimbraCalçada Martim de Freitas3000-456 CoimbraPortugal Fa.ulta.e de Bioloxía Departamento de Bioloxía Vexetal e Ciencia do SoloUniversidade de VigoAs Lagoas-Marcosende s/n36310PontevedraSpain

a.ms The tree legume a.a.ia.dea.ba.a.Link is a. a.gressive a.stra.ia. inva.er tha. severely a.fects a.iotic a.d biotic compa.tments of eco-systems *** inva.ive species outcompetes na.ive pla.t communities through direct competition,cha.ges in microha.ita. a.d soil properties under the ca.opy a.d the relea.e of a.lelopa.hic ***,these effects a.e usua.ly studied sepa.a.ely a.d under controlled *** objective of this study wa. to eva.ua.e the combined effect of these modifica.ions exerted by *** on the esta.lishment of na.ive a.d inva.ive species in the *** a.full fa.toria. experiment wa. performed in order to test the com-bined effect of microha.ita.,soil type a.d a.lelopa.hy on the esta.lish-ment of the inva.ive *** a.d three na.ive species in the field(North-West Spa.n).We sowed seeds of na.ive or inva.ive species in pots with different soil type(soil collected under *** or Pinus pina.ter),a.lelopa.hy sta.us(soil trea.ed or untrea.ed with a.tiva.ed ca.-bon)a.d microha.ita.(under the ca.opy of *** or ***).The number a.d tota. bioma.s of esta.lished pla.ts were eva.ua.ed a.ter 8 *** a.iotic properties were determined in a.l *** Findings The esta.lishment of na.ive a.d inva.ive species wa. signifi-ca.tly a.fected by the microha.ita.,with a.higher number of seedlings under the na.ive forest(***).The esta.lishment of *** seedlings wa. a.so significa.tly promoted by its own soil.a.negligible effect of a.lelopa.hy wa. detected on the esta.lishment a.d growth of both inva.ive a.d na.ive *** conclude tha.(i)the ma.n fa.tor a.fecting seedling esta.lish-ment wa. microha.ita. ra.her tha. cha.ges in soil properties or a.lelopa.hy,(ii)soil modifica.ions by *** promote the esta.lishment of its own seedlings,contributing to the progress of inva.ion a.d(iii)a.lelochemica.s relea.ed by *** do not seem to pla. a.key role for the esta.lishment of na.ive

关键词： pla.t inva.ion microha.ita. soil cha.ges a.lelopa.hy pla.t esta.lishment

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Proteomics for discovery of ca.dida.e colorecta. ca.cer bioma.kers

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World Journa. of ga.troenterology 2014年第14期20卷 3804-3824页

作者： paula lva.ez-Cha.er Ola.la.Otero-Estévez Ma.ía.Páez de la.Ca.ena.Fra.cisco J rodríg.ez-Berroca. Vicenta.S Ma.tínez-Zorza.o Unida. de Proteómica Servicio de Determinación EstructuralProteómica y GenómicaCentro de Apoyo Científico y Tecnológico a la InvestigaciónUniversidad de VigoCampus As Lagoas-Marcosende área.de Bioquímica.y Biología.Molecula. Departamento de BioquímicaGenética e InmunologíaFacultad de BiologíaUniversidad de VigoCampus As Lagoas-Marcosende

Colorecta. ca.cer(CRC)is the second most common ca.se of ca.cer-rela.ed dea.hs in Europe a.d other Western countries,ma.nly due to the la.k of wellva.ida.ed clinica.ly useful bioma.kers with enough sensitivity a.d specificity to detect this disea.e a. ea.ly *** it is well known tha. the pa.hogenesis of CRC is a.progressive a.cumula.ion of muta.ions in multiple genes,much less is known a. the proteome ***,in the la.t yea.s ma.y proteomic studies ha.e been conducted to find new ca.dida.e protein bioma.kers for dia.nosis,prognosis a.d a. thera.eutic ta.gets for this ma.igna.cy,a. well a. to elucida.e the molecula. mecha.isms of colorecta. *** importa.t a.va.ta.e of the proteomic a.proa.hes is the ca.a.ity to look for multiple differentia.ly expressed proteins in a.single *** review provides a. overview of the recent reports describing the different proteomic tools used for the discovery of new protein ma.kers for CRC such a. two-dimensiona. electrophoresis methods,qua.tita.ive ma.s spectrometry-ba.ed techniques or protein ***,we will a.so focus on the diverse biologica. sa.ples used for CRC bioma.ker discovery such a. tissue,serum a.d fa.ces,besides cell lines a.d murine models,discussing their a.va.ta.es a.d disa.va.ta.es,a.d summa.ize the most frequently identified ca.dida.e CRC ma.kers.

关键词： Colorecta. ca.cer Serum Tissue Proteins Bioma.kers Proteomics Protein identifica.ion Ma.s spectrometry

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Sola.-a.sisted photoca.a.ytic wa.er splitting using defective UiO-66 solids from modula.ed synthesis

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Na.o Resea.ch 2024年第5期17卷 4134-4150页

作者： Celia.M.Rueda.Na.a.ro Ma.ía.Ca.rero-a.tonino paula Esca.illa.Va.entín Díez-Ca.a.es Dong Fa. Pedro a.ienza. Belén Ferrer Igna.io Va.á guilla.me Ma.rin Herme g.Ba.doví Sergio Na.a.ón Depa.ta.ento de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto de Ciencia.Molecula.(ICMOL) Universitat de ValènciaPaterna 46980Spain ICgM Univ.MontpellierCNRSENSCMMontpellier34095France Instituto de Tecnología.Química.UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

Meta.-orga.ic fra.eworks(MOFs)a.e a.tra.ting increa.ing interests a. photoca.a.ysts for sola.-driven hydrogen production from *** pa.er reports on a.compa.a.ive study of using either a.etic a.id(a.)or trifluoroa.etic a.id(TFa.a. the representa.ive UiO-66 orga.ic modula.ors for synthesizing visible light responsive UiO-66(Zr)-X(X:NH_(2) or NO_(2))photoca.a.ysts for wa.er *** results show tha. photoca.a.ytic hydrogen genera.ion from a.wa.er/metha.ol mixture ca. be improved by va.ying the na.ure a.d a.ount of the modula.or employed to prepa.e the different UiO-66(Zr)-X(X:NH_(2) or NO_(2))solid ***-66(Zr)-NH_(2) wa. the most a.tive photoca.a.yst,followed by UiO-66(Zr)-NO_(2),both prepa.ed with 12 equiva.ents of a. with respect to the orga.ic *** UiO-66(Zr)-NH_(2) solid wa. more a.tive tha. the pa.ent MOF in photoca.a.ytic overa.l wa.er splitting(OWS)(H_(2) a.d O_(2) production of 450 a.d 160μmol·g^(-1),respectively,in 5 h;a.pa.ent qua.tum yield(a.Y)a. 400 nm of 0.06%)in the a.sence of metha.ol a.d compa.es fa.oura.ly with a.a.ogous *** on the photoca.a.ytic a.tivity of the most a.tive solids of both series wa. obta.ned by mea.s of a.series of techniques,including ultra.iolet-visible(UV-vis)diffuse reflecta.ce,X-ra. photoelectron spectroscopy(XPS),la.er fla.h photolysis(LFP),electron spin resona.ce(ESR),photoluminescence a.d photoelectrochemica. mea.urements together with density functiona. theory(DFT)*** results showed tha. orga.ic a.id modula.ors ca. be used to enha.ce the photoca.a.ytic a.tivity of missing linker UiO-66 defective ma.eria.s in sola.-powered wa.er splitting.

关键词： heterogeneous photoca.a.ysis meta.-orga.ic fra.eworks(MOFs) UiO-66 ma.eria.s ca.boxylic a.id modula.ors wa.er splitting sola. light

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Doxycycline induces bone repa.r a.d cha.ges in Wnt signa.ling

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Interna.iona. Journa. of Ora. Science 2017年第3期9卷 158-166页

作者： kátia.do na.cimento gomes a.a.paula negreiros nunes a.ves paula góes pinheiro dutra.gla.ce socorro de ba.ros via.a fa.ulty of dentistry pharmacy and nursingfederal university of cearáFortalezaBrazil fa.ulty of medicine federal university of cearáFortaleza Brazil

Doxycycline （DOX） exhibits a.ti-infla.ma.ory a.d MMP inhibitory properties. The objectives of this study were to eva.ua.e the effects of DOX on a.veola. bone repa.r. Controls （CTL） a.d DOX-trea.ed （10 a.d 25 mg. kg- 1） mola.s were extra.ted, a.d ra.s were killed 7 or 14 da.s la.er. The ma.illa. were processed a.d subjected to histologica. a.d immunohistochemica. a.sa.s. Hema.oxylin-eosin sta.ning （7th da.） revea.ed infla.ma.ion in the CTL group tha. wa. pa.tly reversed a.ter DOX trea.ment. On the 14th da., the CTL group exhibited bone neoforma.ion, conjunctive tissue, re-epitheliza.ion a.d the a.sence of infla.ma.ory infiltra.e. DOX-trea.ed groups exhibited complete re-epitheliza.ion, tissue remodelling a.d a.most no infla.ma.ion. Picrosirius red sta.ning in the DOXlO group （7th a.d 14th da.s） revea.ed a. increa.ed percenta.e of type I a.d III colla.en fibres compa.ed with the CTL a.d DOX25 groups. The DOXlO a.d DOX25 groups exhibited increa.es in osteobla.ts on the 7th a.d 14th da.s. However, there were fewer osteocla.ts in the DOXlO a.d DOX25 groups on the 7th a.d 14th da.s. Wnt-lOb- immunopositive cells increa.ed by 130% a.d 150% on the 7th a.d 14th da.s, respectively, in DOX-trea.ed groups compa.ed with the CTL group. On the 7th da., Dickkopf （Dkk）-I immunosta.ning wa. decrea.ed by 63% a.d 46% in the DOXlO a.d DOX25 groups, respectively. On the 14th da., 69% a.d 42% decrea.es in immunopositive cells were observed in the DOXlO a.d DOX25 groups, respectively, compa.ed with the CTL group. By increa.ing osteobla.ts, decrea.ing osteocla.ts, a.tiva.ing Wnt lOb a.d neutra.ising Dkk, DOX is a.potentia. ca.dida.e for bone repa.r in periodonta. disea.es.

关键词： a.veola. bone loss bone disea.es bone repa.r doxycycline Dickkopf-1 immunohistochemistry Wnt-lOb

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Influence of in vitro ca.a.ita.ion time on structura. a.d functiona. huma. sperm pa.a.eters

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a.ia. Journa. of a.drology 2020年第5期22卷 447-453页

作者： paula Sa.z-Espinosa.Na.a.ia.Huerta.Reta.a. La.ra.Robles-gomez Ma.uel a.iles Jon a.zpurua.Irene Vela.co a.eja.dro Romero Ma.ia.Jose gomez-Torres Depa.tment of Biotechnology Faculty of ScienceUniversity of AlicanteAlicante 03080Spain FISa.I0-University Hospita. of Sa. Jua. de a.ica.te Service of Gynecology and ObstetricsSan Juan de Alicante 03550Spain Depa.tm ent of Cell Biology a.d Histology Faculty of MedicineUniversity of Murcia and IMIB-ArrixacaMurcia 30100Spain IVF Spa.n Reproductive MedicineAlicante 03540Spain University Hospita. of Sa. Jua. de a.ica.te Service of Gynecology and ObstetricsSan Juan de Alicante 03550Spain Huma. Fertility Ca.hedra University of AlicanteAlicante 03080Spain.

a.ca.ca.e of dra.a.ic physiologica. events is linked to the sperm a.rosome rea.tion a.d binding to the oocyte's zona.pellucida.during huma. sperm ***,structura. a.d functiona. sperm cha.ges during ca.a.ita.ion currently rema.n poorly ***,we performed a.multibioma.ker a.proa.h ba.ed on the utiliza.ion of sperm concentra.ion,motility,via.ility,morphology,a.rosome rea.tion,tyrosine phosphoryla.ion,DNa.fra.menta.ion,a.d lectin-binding sites to a.a.yze the impa.t ca.sed by swim-up selection times(unca.a.ita.ed,1 h ca.a.ita.ed,a.d 4 h ca.a.ita.ed)on sperm function a.d structure in normozoospermic *** found tha. a.4 h swim-up ca.a.ita.ion increa.ed sperm qua.ity,beca.se a.la.ge number of cells with norma. morphology a.d lower DNa.fra.menta.ion ra.es were ***,the long-term ca.a.ita.ion induced a.higher percenta.e of cells with tyrosine phosphoryla.ion of the principa. piece a. well a. a.redistribution of lectin-binding ***,the multiva.ia.e bioma.kers a.a.yzed showed a.less va.ia.le distribution on sperma.ozoa.recovered a.ter 4 h ca.a.ita.ion tha. tha. with the shorter ca.a.ita.ion *** findings stress the importa.ce of ca.a.ita.ion time a. a.releva.t fa.tor in sperm qua.ity with potentia. biologica. reproductive implica.ions both for ba.ic resea.ch a.d in a.sisted reproduction techniques.

关键词： a.rosome rea.tion ca.a.ita.ion DNa.fra.menta.ion glycoca.yx lectin-binding sites membra.e integrity protein phosphoryla.ion sperm selection

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E2F tra.scription fa.tors a.d their complementa.y roles during DNa.da.a.e responses

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Molecula. Pla.t 2023年第9期16卷 1373-1375页

作者： paula Ca.a.i Centro de Estudios Fotosinteticos y Bioquimicos(CEFOBl) Universidad Nacional de RosarioSuipacha 5312000 RosarioArgentina

E2F tra.scription fa.tors(TF)comprise a.fa.ily of proteins tha. regula.e the expression of genes required for S-pha.e progression,a.ong *** genome encodes six E2F TFs(E2Fa.F),which a.e cla.sified a. typica.(E2Fa.C)a.d a.ypica.(E2FD–F)depending on their a.ility to intera.t with two DP intera.tion proteins(DPa.a.d DPb)(Sa.lowski a.d gutierrez,2022).While E2Fa.C need to heterodimerize with either DPa.or DPb to function,E2FD–F a.t independently of DP ***,the retinobla.toma.rela.ed1(RBR1)protein a.so binds a.d inhibits the typica. E2F/DP TF complexes when bound to the promoter of genes,repressing their expression in the a.sence of a.signa. to enter a.new cell *** genera.,E2Fa.a.d E2FB a.e considered tra.scriptiona. a.tiva.ors,while E2FC is genera.ly considered a.repressor of cell prolifera.ion(Sa.lowski a.d gutierrez,2022).In a.dition,it is well documented tha. E2FB a. lea.t,a.d proba.ly E2Fa.ca. a.so stimula.e the g2/M tra.sition.

关键词： da.a.e E2F complementa.y

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Pa.a.obiogeogra.hica. constra.nts on the distribution of fora.inifers a.d rugose cora.s in the Ca.boniferous Tindouf Ba.in,South Morocco

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Journa. of Pa.a.ogeogra.hy 2013年第1期2卷 1-18页

作者： Ia. D.Somerville Pedro Cóza. Isma.l Sa.d Da.iel Va.ha.d paula Medina.Va.ea.Sergio rodríg.ez UCD School of geologica. Sciences University College DublinBelfield Dpto.de geología.Sedimenta.ia. Ca.bio a.bienta. Instituto de Geociencias (CSICUCM)c/José Antonio Novais28040-Madrid Spain Dpto.de Pa.eontología Facultad de Ciencias Geológicas Universidad Complutense de Madridc/José Antonio Novais 228040-MadridSpain Université de Lille 1 UMR 8217 du CNRS:GéosystèmesBatiment SN 559655 Villeneuve d'Ascq France Dpto.de geología.Sedimenta.ia. Ca.bio a.bienta. Instituto de Geociencias (CSICUCM)c/José Antonio Novais28040-MadridSpain Dpto.de Pa.eontología Facultad de Ciencias GeológicasUniversidad Complutense de Madridc/José Antonio Novais 228040-MadridSpain

The northern fla.k of the Tindouf Syncline in southern Morocco exhibits a.continuous, well exposed Ca.boniferous succession with limestones of La.e a.bia. to Ea.ly Ba.hkiria. a.e conta.ning rich a.d diverse fora.inifera. a.d rugose cora. a.sembla.es. a.a.ysis of these a.sembla.es provides new da.a.on the rela.ively poorly known Sa.a.a. ba.ins. The pa.a.obiogeogra.hica. rela.ionship of the Tindouf Ba.in with other Pa.a.otethya. ba.ins is complex. a.though there is a.predomina.ce of cosmopolita. ta.a.for the Pa.a.otethys, it is recognized tha. there wa. a. influence of ba.ins from NW Europe, such a. the UK a.d Irela.d. Some ta.a.a.e recorded in both NW Europe a.d Tindouf without a.y cha.a.teristic contributions from intermedia.e ba.ins in northern Morocco. The neighbouring Bécha. Ba.in in a.geria.presents distinct a.sembla.es. The bulk of the da.a.a.a.yzed suggest tha. this sector of the western Pa.a.otethys ca. be subdivided into four pa.a.obiogeogra.hica. subprovinces: the a.la.tic Subprovince (UK, Irela.d, N Fra.ce a.d Belgium), the Mediterra.ea. Subprovince (Pyrenees, Monta.ne Noire, Betic Cordillera. Rif (N Morocco) a.d Ba.ea.ic Isla.ds), a.d the Sa.a.a. Subprovince (Bécha., Regga., a.net-Mouydir a.d Tindouf). In between, mobile belts of mixed fa.na. a.sembla.e cha.a.teristics a.e observed (e.g., SW Spa.n a.d Centra. Meseta. forming the West peri-gondwa.a. *** of the Tindouf Ba.in fa.na. shows tha., a. in other Sa.a.a. ba.ins, there is a.high diversity a.d a.unda.ce of fora.inifera. ta.a. with a.higher proportion of survivors a.d longer stra.igra.hic ra.ges; these fea.ures a.so a.e mirrored by rugose cora.s. This empha.izes the longevity of the ca.bona.e pla.form in a.tropica. setting, where periodic tra.sgressions introduced new a.sembla.es, a.d ocea.ic currents a.e interpreted a. one of the ma.n controlling fa.tors for the distribution of the ta.a.in these subprovinces. Moreover, not only were wa.er tempera.ures on the pla.form higher, but a.so

关键词： Ca.boniferous pa.a.obiogeogra.hy new subprovinces fora.inifers rugose cora.s Tindouf Ba.in North a.rica

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3D City Models a. a.Visua. Support Tool for the a.a.ysis of Buildings Seismic Vulnera.ility: The Ca.e of Lisbon

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Interna.iona. Journa. of Disa.ter Risk Science 2017年第3期8卷 308-325页

作者： paula Redweik paula Teves-Costa.Inês Vila.-Boa. Teresa.Sa.tos Instituto Dom Luiz Faculdade de CiênciasUniversidade de Lisboa ESRI Portuga. CICS.NOVa.Centro Interdisciplina. de Ciência. Socia.s Faculdade de Ciências Sociais e HumanasUniversidade Nova de Lisboa

3D city models a.socia.e a.da.a.a.e of a.city to a.rigorous geospa.ia. representa.ion tha. is close to the visible rea.ity by combining a.pea.a.ce, geometry, a.d sema.tics. a. such, these models ma. include tools tha. convey a.tribute a.a.ysis, not only a. the sta.istica. level but a.so in terms of visua. a.pea.a.ce of the objects, thus a.lowing the genera.ion of new knowledge a.out a.phenomenon or its effects. Lisbon is a.city with a.modera.e level of seismic risk, a.d ha. been hit in the pa.t by strong ea.thqua.es. Severa. seismic vulnera.ility studies of buildings ha.e been ca.ried out in Lisbon. These studies genera.e different scena.ios tha. consider the ma.nitude a.d source loca.ion of potentia. ea.thqua.es. The results of these studies were presented a. ma.s obta.ned from crossing informa.ion conta.ned in 2D la.ers a.d presented in a.gIS environment. In the present study a.seismic vulnera.ility a.sessment of Lisbon's buildings held in 2D is extended to the third dimension, which refines the resolution a.d the set of pa.a.eters a.d explores the ga.ns of spa.ia. a.a.ysis in 3D representa.ions. The numerous pa.a.eters tha. contribute to a.sess seismic vulnera.ility of buildings ma. be a.a.yzed individua.ly or simulta.eously a. well a. in multiple seismic scena.ios. a.though covering a.l residentia. buildings in Lisbon, the a.plica.ion of the 3Dcity model is demonstra.ed with more deta.l in three pilot a.ea..

关键词： 3D-gIS 3D models Building vulnera.ility Lisbon Seismic scena.ios

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Stria.um-specific mecha.isms regula.e neurona. cell cycle re-entry:the choice between life a.d dea.h

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Neura. Regenera.ion Resea.ch 2023年第3期18卷 523-524页

作者： paula Dietrich Ioa.nis Dra.a.sis Depa.tment of Physiology The University of TennesseeHealth Science CenterMemphisTNUSA

Mitochondria.dysfunction occurs in the a.ing bra.n a. well a. in severa. neurodegenera.ive disorders a.d predisposes neurona. cells to enha.ced sensitivity to *** pa.ticula.,defects in a.y of the mitochondria.respira.ory cha.n complexes lea. to impa.red a.enosine triphospha.e production resulting in disea.es tha. often a.fect the centra. nervous *** insta.ce,inna.e deficits in succina.e dehydrogena.e(SDH)mitochondria.respira.ory cha.n complex II a.tivity ca.sed by genetic muta.ions in SDH subunits lea. to ea.ly-onset neurodegenera.ion(Ja.n-gha. et a..,2013),while severa. a.ult-onset genetic neurodegenera.ive disorders a.e a.socia.ed with va.ia.le levels of complex II deficiency in the centra. nervous system(Túnez et a..,2010).a.so,chemica.ly induced complex II deficiency lea.s to neurodegenera.ion.

关键词： SDH impa.red cycle

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