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Refinement of the Proposed Gamma-Ray Burst Time Delay Model

International Journal of Astronomy and Astrophysics 2024年第2期14卷 120-147页

作者： Godson Fortune Abbey Joseph Simfukwe Prospery Christopher Simpemba Saul paul Phiri Alok Srivastava Golden Gadzirayi Nyambuya Department of Physic School of Mathematics and Natural Sciences The Copperbelt University Kitwe Republic of Zambia Fundamental Theoretical and Research Group Department of Applied Physics Faculty of Applied Sciences National University of Science & Technology Bulawayo Republic of Zimbabwe

This paper is the second instalment in our study of the observed time delay in the arrival times of radio photons emanating from Gamma Ray Bursts (GRBs). The mundane assumption in contemporary physics as to the cause of these pondersome time delays is that they are a result of the photon being endowed with a non-zero mass. While we do not rule out the possibility of a non-zero mass for the photon, our working assumption is that the major cause of these time delays may very well be that these photons are travelling in a rarefied cosmic plasma in which the medium’s electrons interact with the electric component of the Photon, thus generating tiny currents that lead to dispersion, hence, a frequency-dependent speed of Light (FDSL). In the present instalment, we “improve” on the model presented in the first instalment by dropping the assumption that the resultant pairs of these radio photons leave the shock front simultaneously. The new assumption of a non-simultaneous— albeit systematic—emission of these photon pairs allows us to obtain a much more convincing and stronger correlation in the time delay. This new correlation allows us to build a unified model for the four GRBs in our sample using a relative distance correction mechanism. The new unified model allows us to obtain as our most significant result a value for the frequency equivalence of the interstellar medium (ISM)’s conductance ν* ~ 1.500 ± 0.009 Hzand also an independent distance measure to the GRBs where we obtain for our four GRB samples an average distance of: ~69.40 ± 0.10, 40.00 ± 0.00, 58.40 ± 0.40, and 86.00 ± 1.00 Mpc, for GRB 030329, 980425, 000418 and 021004 respectively.

关键词： Gamma-Ray Bursts (GRB) Photon Mass Plasma Time Delay Fireball Model

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当商业和政治碰撞企业领袖如何应对挑战

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商业周刊（中文版） 2024年第15期 11-12页

作者： paul Keegan 汪泽(译) 不详

在这个动荡的大选年,从移民到生育权等热门议题占据了媒体头条。商业领袖应该怎么做?在如今两极化的环境中选边站,有可能会得罪客户和其他相关方。保持沉默可能又会显得漠然、与时代脱节。要是采取中间立场,最终有可能谁也不满意。

关键词：商业领袖两极化生育权中间立场应对挑战保持沉默

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Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala paul Subrat Kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

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Clathrin light chains negatively regulate plant immunity by hijacking the autophagy pathway

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Plant Communications 2024年第8期5卷 172-188页

作者： Hu-Jiao Lan Jie Ran Wen-Xu Wang Lei Zhang Ni-Ni Wu Ya-Ting Zhao Min-Jun Huang Min Ni Fen Liu Ninghui Cheng paul A.Nakata Jianwei Pan Steven A.Whitham Barbara J.Baker Jian-Zhong Liu Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants Zhejiang Normal UniversityJinhua 321004China Institute of Plant Genetics and Developmental Biology College of Chemistry and Life SciencesZhejiang Normal UniversityJinhua 321004China College of Life Sciences Lanzhou UniversityLanzhou 730000China Department of Plant Pathology and Microbiology Iowa State UniversityAmesIA 50011USA Department of Plant and Microbial Biology University of CaliforniaBerkeleyBerkeleyCA 94720USA Plant Gene Expression Center U.S.Department of Agriculture-Agricultural Research ServiceAlbanyCA 94706USA Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332000China U.S.Department of Agriculture-Agricultural Research Service Children’s Nutrition Research CenterDepartment of PediatricsBaylor College of MedicineHoustonTX 77030USA

The crosstalk between clathrin-mediated endocytosis(CME)and the autophagy pathway has been reported in mammals;however,the interconnection of CME with autophagy has not been established in ***,we report that the Arabidopsis CLATHRIN LIGHT CHAIN(CLC)subunit 2 and 3 double mutant,clc2-1 clc3-1,phenocopies Arabidopsis AUTOPHAGY-RELATED GENE(ATG)mutants in both autoimmunity and nutrient ***,the autophagy pathway is significantly compromised in the clc2-1 clc3-1 ***,multiple assays demonstrate that CLC2 directly interacts with ATG8h/ATG8i in a domain-specific *** expected,both GFP-ATG8h/GFP-ATG8i and CLC2-GFP are subjected to autophagic degradation,and degradation of GFP-ATG8h is significantly reduced in the clc2-1 clc3-1 ***,simultaneous knockout of ATG8h and ATG8i by CRISPR-Cas9 results in enhanced resistance against Golovinomyces cichoracearum,supporting the functional relevance of the CLC2-ATG8h/8i *** conclusion,our results reveal a link between the function of CLCs and the autophagy pathway in Arabidopsis.

关键词： autophagy clathrin light chain immunity clathrin-mediated endocytosis senescence cell death

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中共二十届三中全会为非洲发展带来重大机遇

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当代世界 2024年第8期 78-79页

作者： [南非]谭哲理南非哲理中非国际交流智库

2024年7月15—18日,中国共产党第二十届中央委员会第三次全体会议召开,审议通过了《中共中央关于进一步全面深化改革、推进中国式现代化的决定》(下称《决定》)。中共中央总书记习近平作了重要讲话。作为平等伙伴关系下的朋友和兄弟,非... 详细信息

2024年7月15—18日,中国共产党第二十届中央委员会第三次全体会议召开,审议通过了《中共中央关于进一步全面深化改革、推进中国式现代化的决定》(下称《决定》)。中共中央总书记习近平作了重要讲话。作为平等伙伴关系下的朋友和兄弟,非洲国家认识到,中共二十届三中全会及其决定不仅对中国意义重大,也为非中合作带来更多机遇。

关键词：中国式现代化中共中央总书记全面深化改革三中全会重大机遇《决定》中央委员会习近平

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Cervical Myelopathy: Diagnostic Aspects, Surgical Treatment and Evolution of Patients Operated upon in Yaounde

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Open Journal of Modern Neurosurgery 2024年第1期14卷 72-82页

作者： Bello Figuim Djoubairou Ben Ousmanou Oumarou Haman Nassourou Ndome Toto Orlande Amadou Tidjani Djientcheu Vincent de paul Yaounde Central Hospital Faculty of Medicine and Biomedical Sciences of the University of Yaounde 1 Yaounde Cameroon Yaounde Military Hospital Faculty of Medicine and Pharmaceutical Sciences of the University of Douala Douala Cameroon Douala General Hospital Faculty of Medicine and Pharmaceutical Sciences of the University of Douala Douala Cameroon Higher Institute of Health Sciences Université des Montagnes Bangangté Cameroon

Introduction: Although cervical myelopathy is the most common degenerative cervical spine pathology in adults, the indications and approaches of surgical treatment have not yet been clearly defined in the literature. Very few studies exist regarding these aspects in our setting, and they are mostly outdated. This study aimed to describe the diagnostic aspects, current surgical treatment with technical improvements, and progression in patients. Patients and Methods: We conducted a multicentre retrospective descriptive study over a 10-year period between January 2011 and January 2020 in three referral centres in Yaoundé. All patients who underwent surgery for cervical myelopathy were included. Results: Fifty-two patients were recruited. The rate of operated cervical myelopathies among all degenerative spinal pathologies was 14.05%. The M/F sex ratio was 3/1, and the average age was 52 ± 10 years. All included patients had gait problems, 90.38% demonstrated motor deficiency, and 67.30% experienced at least three levels of compression. Surgery was decided based on the Nurick grade;a posterior approach was applied to 86.54% of patients. Postoperative progression showed a neurological improvement of 82% with an average follow-up of 4 years. Conclusion: In this study, the patients who underwent surgery were relatively young, their clinical presentations were mostly advanced, and surgical management showed good results in well-selected cases.

关键词： Cervical Myelopathy Diagnosis Treatment Evolution Cameroon

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Sequential Analysis in the Identification of 3rd Order System Tract in the Abidjan Margin

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Open Journal of Applied Sciences 2024年第6期14卷 1474-1489页

作者： Blandine Akissi Egoran N’guessan Donald Ahoure Fori Yao paul Assalé Sylvain Mondé Loukou Victor N’da UFR Marine Sciences San Pedro University San Pedro Cte dIvoire UFR of Sciences and Technologies Alassane Ouattara Bouak Laboratory of Plant Biology and Earth Sciences Bouak Cte dIvoire UFR/STRM Flix Houphout Boigny de Cocody Abidjan Cte dIvoire PETROCI Consultant at the Center for Analysis and Research Department of Sequential Stratigraphy Abidjan Cte dIvoire

The use of sequential stratigraphy concept, based on well logs, sedimentology, and biostratigraphy, has shed light on the complex mechanisms controlling sedimentary accumulations. Consequently, identifying these mechanisms allows us to predict the hydrocarbon generation potential of source rocks. In the Ivorian offshore sedimentary basin, certain studies have contributed to understanding and characterizing the petroleum system. However, these previous works did not integrate biostratigraphic data to highlight sedimentary facies. This study, conducted on two wells in the Abidjan margin, is crucial as it helps us comprehend the geometry of fossil sediments in relation to sea level variations. It will also aid in reconstructing the basin-filling history and predicting the distribution of rocks capable of trapping oil, determining lowstand systems tracts (reservoir rocks), transgressive systems tracts, and highstand systems tracts (cap rocks). Lithological analysis revealed predominantly clayey sedimentation with sandy layers. Well log data facilitated the delineation of formation boundaries and highlighted reservoirs consisting of sands, sandstones, limestones, and occasionally intercalated shales. Integrating these analysis results with biostratigraphic interpretations based on foraminifera and palynomorphs revealed that the traversed formations were deposited in a transitional environment ranging from Coniacian to Maastrichtian ages. Applying sequential stratigraphy concept from well logging resolved dating issues encountered in microfossil-poor or microfossil-free zones. The results of the Coniacian-Maastrichtian age sequential subdivision were aligned with the chart.

关键词： Sequence Stratigraphy Systems Tracts Senonian Côte d’Ivoire

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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

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Erratum to“The power of many brains:Catalyzing neuropsychiatric discovery through open neuroimaging data and large-scale collaboration”[Sci Bull 2024;69:1536-1555]

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Science Bulletin 2024年第17期69卷 2793-2793页

作者： Bin Lu Xiao Chen Francisco Xavier Castellanos paul MThompson Xi-Nian Zuo Yu-Feng Zang Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100101China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew York 10016USA Nathan Kline Institute for Psychiatric Research Orangeburg 10962USA Imaging Genetics Center Mark&Mary Stevens Institute for Neuroimaging&InformaticsKeck School of MedicineUniversity of Southern CaliforniaLos Angeles 90033USA Developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China National Basic Science Data Center Beijing 100190China Centre for Cognition and Brain Disorders The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310004China Institute of Psychological Science Hangzhou Normal UniversityHangzhou 310030China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairment Hangzhou 311121China International Big-Data Center for Depression Research Institute of PsychologyChinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China

The publisher regrets to note that reference citation errors have occurred in panels b,c,e-l in Fig 2 and the sentence“However,the literature reports both decreased and increased intra-network functional connections among patients with depression[115,116].”The publisher would like to apologise for any inconvenience *** neuroimaging findings in major depressive disorder.(a)Decreased intra-DMN FC is observed in recurrent MDD patients[35].(b)Eight-week antidepressant treatment reduce extensive large-scale functional networks[107].(c)Reduced global and local efficiency(Eglob/Eloc)are revealed in MDD patients[108].(d)Structural variations of the cortex and subcortical nuclei are found in ENIGMA-MDD studies[82].(e)Accelerated brain aging based on functional MRI is observed in MDD patients[114].(f)Accelerated brain aging based on structural MRI is observed in MDD patients[115].(g)Two subtypes of MDD can be identified through DMN FC[127].(h)A significant schizophrenia PRS by MDD interaction for rostral anterior cingulate cortex thickness is found in the UK Biobank dataset[215].(i)Stability of the four MDD subtypes based on FC[126].(j)The two subtypes of MDD exhibit distinct patterns of FC within and between SMS,DMN,and subcortical structures[130].(k)Performance of the functional connectivity-based classifiers across two multicenter datasets[135].(l)Salient brain regions that serve as important classification features for the graph convolutional network-based classifier[136].Brain-PAD:brain-predicted age difference;DAN:dorsal attention network;DMN:default mode network;FC:functional connectivity;FEDN:first-episode and drug-naïve;FPN:frontoparietal network;GCN:graph convolutional neural network;HC:healthy control;linear-SVM:linear support vector machine;MDD:major depressive disorder;mddrest:REST-meta-MDD dataset;NC:normal control;RACC:rostral anterior cingulate cortex;PRS:polygenic risk score;psymri:PsyMRI dataset;rbf-SVM:radial basis function support vector

关键词： cortex network scale

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保罗·奥特布里奇生不逢时的彩色摄影先驱

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旅游世界 2024年第7期 38-48页

作者：崔霁云 paul Outerbridge(图) 不详

保罗·奥特布里奇是彩色摄影史上的重要先驱,一生却被忽略和诋毁。他是20世纪20年代纽约最贵的摄影师,转向摄影之前,曾是一名设计师和插画家。1925年,他成为一名广告摄影师和平面设计师,移居巴黎后为法国版《时尚》杂志工作。大约在1930... 详细信息

保罗·奥特布里奇是彩色摄影史上的重要先驱,一生却被忽略和诋毁。他是20世纪20年代纽约最贵的摄影师,转向摄影之前,曾是一名设计师和插画家。1925年,他成为一名广告摄影师和平面设计师,移居巴黎后为法国版《时尚》杂志工作。大约在1930年,保罗开始尝试彩色摄影。在那个彩色摄影遭到鄙夷,被认为是不入艺术之流的黑白摄影时代,他大胆地运用彩色摄影进行实验。1940年代,因其对女性裸体照片的实验和探索,而被认为是进行色情摄影。因为情色摄影这顶帽子,他从纽约收入最高的商业摄影师的职业巅峰,重重摔落下来,从而搬到了加利福尼亚州,在那里开了一家小型的肖像工作室。

关键词：彩色摄影奥特平面设计师黑白摄影加利福尼亚州工作室情色

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