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Amyloid-beta and tau protein beyond Alzheimer's disease

Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine T.O.Nguyen David I.Finkelstein Yuyi You paul.a.haynes Ghasem H.Salekdeh Stuart L.Graham Mehdi Mirzaei ProGene Technologies Pty Ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA School of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vision Sciences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia The Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVICAustralia School of Natural Sciences Macquarie UniversityMacquarie ParkNSWAustralia

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating ***,these two proteins are produced and expressed within the normal human ***,under pathological conditions,abnormal expression,posttranslational modifications,conformational changes,and truncation can make these proteins prone to aggregation,triggering specific disease-related *** studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as retinal neurodegenerative diseases like Glaucoma and age-related macular ***,these proteins have been linked to cardiovascular disease,cancer,traumatic brain injury,and diabetes,which are all leading causes of morbidity and *** this comprehensive review,we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration Tau traumatic brain injury

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A Numerical Study of Blowup in the Harmonic Map Heat Flow Using the MMPDE Moving Mesh Method

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Numerical Mathematics(Theory,Methods and Applications) 2013年第2期6卷 364-383页

作者： Ronald D.haynes Weizhang Huang paul A.Zegeling Department of Mathematics and Statistics Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada Department of Mathematics University of KansasLawrenceKS 66045USA Department of Mathematics Utrecht UniversityUtrechtThe Netherlands

The numerical solution of the harmonic heat map flow problems with blowup in finite or infinite time is considered using an adaptive moving mesh method.A properly chosen monitor function is derived so that the moving mesh method can be used to simulate blowup and produce accurate blowup profiles which agree with formal asymptotic ***,the moving mesh method has finite time blowup when the underlying continuous problem *** situations where the continuous problem has infinite time blowup,the moving mesh method exhibits finite time blowup with a blowup time tending to infinity as the number of mesh points *** inadequacy of a uniform mesh solution is clearly demonstrated.

关键词： Heat flow harmonic map blowup moving mesh method finite difference

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The Quest for Missing Proteins in Rice

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Molecular Plant 2019年第1期12卷 4-6页

作者： Mohsen Rahiminejad Mohammad Taheri Ledari Mehdi Mirzaei Zahra Ghorbanzadeh Kaveh.Kavousi Mohammad Reza Ghaffari paul.a.haynes Setsuko Komatsu Ghasem Hosseini Salekdeh Department of Systems Biology Agricultural Biotechnology Research Institute of Iran (ABRII)Agricultural Research Education and Extension Organization (AREO)KarajIran Department of Biotechnology University of TehranTehranIran Institute of Biochemistry and Biophysics (IBB) University of TehranTehran Iran Department of Molecular Sciences Macquarie UniversitySydneyAustralia Australian Proteome Analysis Facility Macquarie UniversitySydneyAustralia Faculty of Life and Environmental Sciences University of TsukubaTsukuba Japan

Rice (Oryza sativa)is the primary staple food source for more than half of the world's *** are active macromolecules and central to understanding biological molecular processes. Hence,it is necessary to study all protein forms of plant genes so that their biological functions and roles in regulating important traits such as yield,quality,and responses to environmental stresses can be determined.

关键词： Rice food

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Relative quantification of phosphoproteomic changes in grapevine (Vitis vinifera L.) leaves in response to abscisic acid

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Horticulture Research 2016年第1期3卷 173-181页

作者： Supakan Rattanakan Iniga George paul.a.haynes Grant R Cramer Department of Biochemistry and Molecular Biology University of NevadaRenoRenoNVUSA Department of Chemistry and Biomolecular Sciences Macquarie UniversityNorth RydeNew South WalesAustralia

In a previous transcriptomic analysis,abscisic acid(ABA)was found to affect the abundance of a number of transcripts in leaves of Cabernet Sauvignon grapevines with roots that had been exposed to 10μM ABA for 2 *** work has indicated that ABA affects protein abundance and protein phosphorylation as *** this study we investigated changes in protein abundance and phosphorylation of Cabernet Sauvignon grapevine *** abundance was assessed by both label-free and isobaric-label quantitive proteomic *** identified common proteins,but also additional proteins not found with the other ***,several thousand proteins were identified and several hundred were *** addition,hundreds of phosphoproteins were *** of proteins were found to be affected in the leaf after the roots had been exposed to ABA for 2 h,more than half of them were phosphorylated *** phosphosites were confirmed and several new ones were *** increased the abundance of some proteins,but the majority of the proteins had their protein abundance *** of these proteins were involved in growth and plant organ development,including proteins involved in protein synthesis,photosynthesis,sugar and amino-acid *** study provides new insights into how ABA regulates plant responses and acclimation to water deficits.

关键词： roots Vitis hundreds

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应用于压力容器和其他工业用途的高性能合金

应用于压力容器和其他工业用途的高性能合金

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第七届全国压力容器学术会议

作者：陈恭珉 paul Manning 汉斯合金(上海)有限公司美国哈氏合金国际公司

本文详细介绍了多个haynes公司发明的高性能合金,包括相关的ASME标准和工业应用。这些合金包括HastelloyG-35,HastelloyHYBRID-BCl,haynesHR-120,haynes230和HastelloyC-22HS。

关键词：哈氏合金 ASME

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