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Diagnostic accuracy and clinical utility of non-English versions of Edinburgh Post-Natal Depression Scale for screening post-natal depression in India:A meta-analysis

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World Journal of Psychiatry 2020年第4期10卷 71-80页

作者： paul swamidhas sudhakar russell Swetha Madhuri Chikkala Richa Earnest Shonima Aynipully Viswanathan Sushila russell Priya Mary Mammen Child and Adolescent Psychiatry Unit Department of PsychiatryChristian Medical CollegeVellore 632002India

BACKGROUND The prevalence of post-natal depression(PND)is high in India,as it is in many other low to middle income *** is an urgent need to identify PND and treat the mother as early as *** the many paper and pencil tests available to identify PND,the Edinburgh Postnatal Depression Scale(EPDS)is a widely used and validated measure in ***,the summary diagnostic accuracy and clinical utility data are not available for this *** To establish summary data for the global diagnostic accuracy parameter as well as the clinical utility of the non-English versions of the EPDS in *** Two researchers independently searched the PubMed,EMBASE,MEDKNOW and IndMED databases for published papers,governmental publications,conference proceedings and grey literature from *** studies that evaluated the diagnostic accuracy of EPDS in five Indian languages against DSM/ICD were included in the final *** other investigators extracted the Participants’details,Index measures,Comparative reference measures,and Outcomes of diagnostic accuracy data,and appraised the study quality using ***’s plots were used to evaluate publication *** used the area under the curve of the hierarchical summary area under the receiver operating characteristic curve,with the random effect model,to summarize the global diagnostic accuracy of *** the 2×2 table,we calculated positive and negative likelihood *** the likelihood ratios,the Fagan’s nomogram was built for evaluating clinical utility using the Bayesian *** calculated the 95%confidence interval(95%CI)whenever ***(version 15)with MIDAS and METANDI modules were *** There was no publication *** area under the curve for EPDS was 0.97(95%CI:0.95-0.98).The pre-test probability for the nomogram was 22%.For a positive likelihood ratio of 9,the positive post-test probability was 72%(95%CI:68%,76%)and for a negative LR of 0.08,the negativ

关键词： Clinical-utility Diagnostic-accuracy Edinburgh Postnatal Depression Scale Meta-analysis India Validation

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Pediatric Anesthesia Emergence Delirium Scale:A diagnostic metaanalysis

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World Journal of Clinical Pediatrics 2022年第2期11卷 196-205页

作者： paul swamidhas sudhakar russell Priya Mary Mammen Satya Raj Shankar Shonima Aynipully Viswanathan Grace Rebekah Sushila russell Richa Earnest Swetha Madhuri Chikkala Child and Adolescent Psychiatry Unit Christian Medical CollegeVellore 632002Tamil NaduIndia Department of Biostatistics Christian Medical CollegeVellore 632002Tamil NaduIndia

BACKGROUND Emergence delirium(EmD)is a troublesome motoric,emotional,and cognitive disturbance associated with *** is often misdiagnosed despite being present in a substantial proportion of children and adolescents during emergence from *** To evaluate the summary diagnostic accuracy of Pediatric Anesthesia Emergence Delirium Scale(PAEDS)for EmD among children and *** Two researchers electronically and hand searched the published literature from May 2004 to February 2021 that evaluated the diagnostic accuracy of PAEDS for EmD among children and adolescents,using appropriate *** independent researchers extracted the diagnostic parameters and appraised the study quality with ***,the diagnostic accuracy of the measures was calculated with the summary receiver operating characteristic curve(SROC),the summary sensitivity and specificity,and diagnostic odds ratio(DOR)for *** diagnostic cut-off points were evaluated for their diagnostic *** was analyzed by *** Nine diagnostic accuracy studies of EmD that conformed to our selection criteria and PRISMA guidelines were included in the final *** was no publication *** area under the SROC was 0.97(95%confidence interval[CI]:95%-98%).Summary sensitivity and specificity were 0.91(95%CI:0.81-0.96;I2=92.93%)and 0.94(95%CI:0.89-0.97;I2=87.44%),*** summary DOR was 148.33(95%CI:48.32-455.32).The effect size for the subgroup analysis of PAEDS cut-off scores of<10,≥10,and≥12 was 3.73,2.19,and 2.93,respectively;they were not statistically significantly *** setting of the study and reference standard were statistically significantly related to the sensitivity of PAEDS but not *** The PAEDS is an accurate diagnostic measure for the diagnosis of EmD among children and *** studies should document its clinical utility.

关键词： Anesthesia Children Emergence delirium Diagnostic accuracy Measure Meta-analysis

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Prevalence of intellectual disability in India:A meta-analysis

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World Journal of Clinical Pediatrics 2022年第2期11卷 206-214页

作者： paul swamidhas sudhakar russell Sahana Nagaraj Ashvini Vengadavaradan Sushila russell Priya Mary Mammen Satya Raj Shankar Shonima Aynipully Viswanathan Richa Earnest Swetha Madhuri Chikkala Grace Rebekah Child and Adolescent Psychiatry Unit Christian Medical CollegeVellore 632002Tamil NaduIndia Department of Psychiatry Christian Medical CollegeVellore 632002Tamil NaduIndia Department of Biostatistic Christian Medical CollegeVellore 632002Tamil NaduIndia

BACKGROUND Burden due to intellectual disability(ID) is only third to the depressive disorders and anxiety disorders in India. This national burden significantly contributes to the global burden of ID and hence one has to think globally and act locally to reduce this burden. At its best the collective prevalence of ID is in the form of narrative reviews. There is an urgent need to document the summary prevalence of ID to enhance further policymaking, national programs and resource *** To establish the summary prevalence of ID during the past 60 years in *** Two researchers independently and electronically searched Pub Med, Scopus, and the Cochrane library from January 1961 to December 2020 using appropriate search terms. Two other investigators extracted the study design, setting, participant characteristics, and measures used to identify ID. Two other researchers appraised the quality of the studies using the Joanna Briggs Institute critical appraisal format for Prevalence Studies. Funnel plot and Egger’s regression test were used to ascertain the publication and small study effect on the prevalence. To evaluate the summary prevalence of ID, we used the random effects model with arcsine square-root transformation. Heterogeneity of I^(2)≥ 50% was considered substantial and we determined the heterogeneity with meta-regression. The analyses were performed using STATA(version 16).RESULTS Nineteen studies were included in the meta-analysis. There was publication bias;the trim-and-fill method was used to further ascertain bias. Concerns with control of confounders and the reliable measure of outcome were noted in the critical appraisal. The summary prevalence of ID was 2% [(95%CI: 2%, 3%);I^(2)= 98%] and the adjusted summary prevalence was 1.4%. Meta-regression demonstrated that age of the participants was statistically significantly related to the prevalence;other factors did not influence the prevalence or *** The summary preva

关键词： India Intellectual disability Prevalence Children and adolescents Meta-analysis

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Elimination of Partial Overloading of Generators Under Unbalanced Operating Conditions of Power Systems

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CSEE Journal of Power and Energy Systems 2016年第1期2卷 81-87页

作者： sudhakar Reddy Sama Subrata paul Sunita Halder Nee Dey Department of Technical Education Andhra PradeshIndia Department of Electrical Engineering Jadavpur UniversityKolkataIndia

Unbalanced operating condition in a power system can cause partial overloading of the generators in the network,a condition where one or two of the three phases of the generator become overloaded even if the total 3-phase power output of the generator is within its specified *** overloading of generators beyond certain limits is undesirable and must be *** systems are often subjected to highly unbalanced operating *** of distributed generations(DGs),therefore,has rendered today’s distribution systems quite susceptible to this *** of this problem requires the issue to be addressed properly during analysis,operation and planning of such ***,operation and planning of power networks under unbalanced operating condition require 3-phase load flow *** existing methods of 3-phase load flow are not equipped to take into account any limit on the loadings of the individual phases of the *** the present work,a methodology based on NewtonRaphson(N-R)3-phase load flow with necessary modifications is *** proposed methodology is able to determine the safe loading limits of the generators,and,can be adopted for operation and planning of power networks under unbalanced operating conditions to overcome the above *** results on IEEE-37 bus feeder network are presented to demonstrate the effectiveness of the proposed method.

关键词： Newton Raphson 3-phase load flow partial overloading of generators unbalanced operating condition of power systems

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Nootropic Activity of <i>Caralluma fimbriata</i>Extract in Mice

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Food and Nutrition Sciences 2014年第2期5卷 147-152页

作者： Ramaswamy Rajendran Digambar Balkrishna Ambikar Rakesh Arun Khandare Vrushali Dattatraya Sannapuri Niraj sudhakar Vyawahare paul Clayton Department of Pharmacology AISSMS College of Pharmacy Pune India Green Chem Bangalore India Institute of Food Brain & Behaviour Oxford UK.

We investigated the effects of a standardized extract of Caralluma fimbriata Wall (CFE) on learning and memory in mice using various behavioural models. Unusually, CFE exerts both nootropic and anxiolytic effects.

关键词： Caralluma Ayurvedic Nootrope Anxiolytic Obesity Alzheimer’s

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Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models

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World Journal of Gastroenterology 2018年第12期24卷 1321-1331页

作者： Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States University of Puerto Rico Medical Sciences Campus San Juan 00921Puerto Rico Department of Medicine Faculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10400Thailand Division of Biomedical Statistics and Informatics Mayo ClinicRochesterMN 55905United States Division of Laboratory Medicine Department of Laboratory Medicine and PathologyMayo Clinic College of MedicineRochesterMN 55905United States Department of Radiology Mayo Clinic College of MedicineRochesterMN 55905United States Department of Transplantation Mayo Clinic FloridaJacksonvilleFL 32224United States Wako Life Sciences IncorporatedMountain ViewCA 94043United States

AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver *** BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD).

关键词： alpha-fetoprotein AFP-L3 des-gammacarboxyprothrombin BALAD BALAD-2 Hepatocellular carcinoma Liver transplant Recurrence Outcome

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Wheat Rht-B1 and Rht-D1, and maize D8 genes encode mutant gibberellin response modulators

Wheat Rht-B1 and Rht-D1, and maize D8 genes encode mutant gi...

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全国植物分子生物学与生物技术学术研讨会

作者： Jinrong Peng Donald Richards Nigel Hartley George Murphy Katrien Devos John Flintham James Beales Leslie Fish Anthony Worland Fatima Pelica D.sudhakar paul Christou John Snape Michael Gale Nicholas Harberd Institute of Molecular Agrobiology John Innes Centre Colney Lane John Innes Centre Colney Lane1Norwich NR4 7UH UK

Wheat Rht-B1 and Rht-D1 mutants and maize dwarf-8 (D8) mutants confer semi-dwarfism and display reduced response to the plant growth hormone gibbereellin (GA). Here we show that Rht-B1/Rht-D1 and d8 are orthologues of the Arabidopsis Gibberellin Insensitive (GAI) gene. These genes encode proteins that resemble nuclear transcription factors and contain an SH2-1ike domain, indicating that phosphotyrosine may

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