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Neoadjuvant Therapy for Resectable and Borderline Resectable Pancreatic Cancer

Journal of Cancer Therapy 2016年第1期7卷 24-40页

作者： Susan Tsai Kathleen K. Christians Ben George paul ritch Kiyoko Oshima Parag Tolat Ashley Krepline Beth A. Erickson Douglas B. Evans Division of Surgical Oncology Medical College of Wisconsin Milwaukee WI USA Division of Hematology/Oncology Medical College of Wisconsin Milwaukee WI USA Division of Pathology Medical College of Wisconsin Milwaukee WI USA Division of Radiation Oncology Medical College of Wisconsin Milwaukee WI USA

The majority of patients with localized pancreatic cancer (PC) who undergo surgery followed by adjuvant therapy will develop metastatic disease, suggesting that surgery alone is not sufficient for cure and micrometastases are present even when are not clinically detected. As such, the delivery of early systemic therapy may be a rational alternative to a surgery-first approach, in an effort to provide oncologic therapies which are commensurate with the disease stage, and improve surgical selection. This review details the rationale for a neoadjuvant approach to localized PC and provides specific recommendations for both pretreatment staging and treatment sequencing for patients with resectable and borderline resectable PC.

关键词： Pancreas Cancer Neoadjuvant Therapy Review

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