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The Fir.t Pilot Epigenetic Type Impr.vement of Neur.psychiatr.c Symptoms in a Polymor.hic Dopamine D2 (-Dr.2/ANKK (Taq1A)), OPr.1 (A/G), Dr.3 (C/T), and MAOA (4r. Compr.mised Pr.adolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Pr.cision-Guided DNA Testing and Pr.-Dopamine r.gulation (KB220) and Antibacter.al Ther.pies

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Open Jour.al of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor.Elman David Han Colin Hanna David Bar.n Ashim Gupta Shan Kazmi Jag Khalsa Debasis Bagchi Thomas McLaughlin r.jendr. D. Badgaiyan Edwar. J. Modestino Dr.w Edwar.s Cather.ne A. Dennen Er.c r. Br.ver.an Abdalla Bowir.at Keer.hy Sunder.Kevin Mur.hy Nicole Jafar. Foojan Zeine paul r. carney Mar. S. Gold Kai-Uwe Lewandowski Alir.za Shar.fshah Ar.eh r. Pollack Panayotis K. Thanos Division of Addiction r.sear.h & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Depar.ment of Psychiatr. Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutr.genomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Depar.ment of Psychiatr. School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavior.l & Neur.genetic Institute LLC. Austin TX USA Depar.ment of Molecular.Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neur.modulation r.sear.h Karma Doctors & Karma TMS Palm Springs CA USA Division of Per.onalized Inter.entions Peak Logic Del Mar CA USA Division of Per.onalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awar.ness Integr.tion Institute San Clemente CA USA Division of Per.onalized Pain Ther.py Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Depar.ment of Psychiatr. Harvard School of Medicine Cambridge MA USA Depar.ment of Management Science and Statistics University of Texas San Antonio TX USA Behavior.l Neur.phar.acology and Neur.imaging Labor.tor. Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Futur. Biologics Lawrenceville GA USA Depar.ment of Micr.biology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Depar.ment of Phar.aceutical Sciences College of Pharmacy Texas Southern University Houston TX USA Depar.ment of Psychiatr. School of Medicine Case Western University Cleveland OH USA Br.in and Behavior.Labor.tor. Curry College Milton MA USA The Neur.genesis Pr.ject Jacksonville FL USA Depar.ment of Family Medicine Jefferson Health Northeast Philadelphia PA USA Depar.men

Pediatr.c autoimmune neur.psychiatr.c disor.er. associated with or.without str.ptococcal and other.bacter.al infections (PANDAS/CANS) ar. emer.ing as a featur.d pediatr.c disor.er. Although ther. is some contr.ver.y r.gar.ing tr.atment appr.aches, especially r.lated to the behavior.l sequelae, we have hypothesized in other.published wor. that it is char.cter.zed by the r.pid onset of r.war. Deficiency Syndr.me (r.S) in childr.n. We pr.pose utilizing a multi-systems biological appr.ach involving the coupling of genetic addiction r.sk testing and pr.-dopamine r.gulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminer.ia. This case study examines a 12-year.old Caucasian male with no pr.or.psychiatr.c issues who pr.sented with a sudden onset of sever. anxiety, depr.ssion, emotional liability, and suicidal ideation. The patient under.ent genotyping and the genetic addiction r.sk scor. (GAr.) testing, which r.vealed r.sk polymor.hisms in the dopamine D2 (-Dr.2/ANKK (Taq1A), OPr.1 (A/G), Dr.3 (C/T), and MAOA (4r. genes. These polymor.hisms have been linked to hypodopaminer.ia. The patient was subsequently placed on r.sear.h ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and par.ntal assessment, a mar.ed r.pid impr.vement in psychiatr.c symptoms was obser.ed. In the second phase of tr.atment (102 days utilizing KB220), the patient r.ceived standar. antibody testing, which was positive for.Lyme. Antibacter.al ther.py star.ed immediately, and KB220z was discontinued to pr.vide a wash-out per.od. A monotonic tr.nd analysis was per.or.ed on each outcome measur., and a consistently decr.asing tr.nd was obser.ed utilizing antibacter.al ther.py. Our.r.commendation, albeit only one case, is to utilize and fur.her.r.sear.h a combined ther.peutic appr.ach, involving pr.cision-guided DNA testing and pr.-dopamine r.gulation along with antibacter.al ther.py, as well as

关键词： PANDAS CANS Genetic Addiction r.sk Testing (GAr.) Pr.-Dopamine r.gulation Hypodopaminer.ia Polymor.hisms Antibacter.al Ther.py Infections

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