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Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography

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Chinese Optics Letters 2017年第9期15卷 25-30页

作者： Roshan Dsouza Hrebesh Subhash Kai Neuhaus paul M.McNamara Josh Hogan Carol Wilson martin J.Leahy Tissue Optics and Microcirculation Imaging Group School of PhysicsNational University of IrelandGalway H91 CF50Ireland Compact Imaging Ireland Ltd. Galway H91 CF50Ireland Colgate-Palmolive Global Technology Centre Piscataway NJ 08855USA Compact Imaging Inc.Mountain View 94043USA Royal College of Surgeons(RCSI) DublinIreland

Multiple reference optical coherence tomography（MR-OCT） is a recently developed, low-cost and compact time-domain OCT solution for primary care and consumer level applications. A combination of a voice coil actuator and a partial mirror（PM） extends the scan range for imaging depths of approximately 1 mm in biological samples. Our previous research on MR-OCT is based only on intensity information obtained from the depth-resolved interference signal. In this Letter, we extract the phase information from the MR-OCT signal and, hence, provide an additional contrast modality. The phase sensitivity of the system is measured to be approximately 0.2 and 1.5 rad for the first and twelfth orders of reflection when using a mirror as the *** Letter describes first results of phase-sensitive data measured on a phantom obtained with MR-OCT. Data from a chick embryo chorioallantoic membrane（CAM） is used to demonstrate the feasibility of MR-OCT for in vivo phase-sensitive imaging.

关键词： Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography VCM Figure CAM

Expressive line drawings of human faces from range images

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Science in China(Series F) 2009年第2期52卷 295-307页

作者： HUANG YueZhu martin Ralph R. ROSIN paul L. MENG XiangXu YANG ChengLei Department of Computer Science and Technology Shandong University Jinan 250101 China School of Computer Science Cardiff University Cardiff United Kingdom

We propose a novel technique to extract features from a range image and use them to produce a 3D pen-and-ink style portrait similar to a traditional artistic drawing. Unlike most previous template-based, component-based or example-based face sketching methods, which work from a frontal photograph as input, our system uses a range image as input. Our method runs in real-time for models of moderate complexity, allowing the pose and drawing style to be modified interactively. Portrait drawing in our system makes use of occluding contours and suggestive contours as the most important shape cues. However, current 3D feature line detection methods require a smooth mesh and cannot be reliably applied directly to noisy range images. We thus present an improved silhouette line detection algorithm. Feature edges related to the significant parts of a face are extracted from the range image, connected, and smoothed, allowing us to construct chains of line paths which can then be rendered as desired. We also incorporate various portrait-drawing principles to provide several simple yet effective non- photorealistic portrait renderers such as a pen-and-ink shader, a hatch shader and a sketch shader. These are able to generate various life-like impressions in different styles from a user-chosen viewpoint. To obtain satisfactory results, we refine rendered output by smoothing changes in line thickness and opacity. We are careful to provide appropriate visual cues to enhance the viewer＇s comprehension of the human face. Our experimental results demonstrate the robustness and effectiveness of our approach, and further suggest that our approach can be extended to other 3D geometric objects.

关键词： portrait drawing non-photorealistic rendering line drawing suggestive contour occluding contour feature line stylization

甲醇浓度对Pt/C催化剂氧还原活性的影响(英文)

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催化学报 2013年第6期34卷 1105-1111页

作者：唐水花林文锋 paul A.CHRISTENSEN Geir martin HAARBERG 西南石油大学油气藏地质及开发工程国家重点实验室四川成都610500 纽卡斯尔大学化工和先进材料学院挪威科技大学材料科学与工程系

采用半池考察了Pt/C催化剂在含不同浓度甲醇的0.5mol/L硫酸中的氧还原活性(ORR).研究发现,当甲醇浓度为0.1mol/L时,Pt/C催化剂的ORR活性最高,在催化层上热压商品NafionNRE-212膜后也出现同样趋势.线性扫描伏安曲线显示,压膜前后的Pt/C... 详细信息

采用半池考察了Pt/C催化剂在含不同浓度甲醇的0.5mol/L硫酸中的氧还原活性(ORR).研究发现,当甲醇浓度为0.1mol/L时,Pt/C催化剂的ORR活性最高,在催化层上热压商品NafionNRE-212膜后也出现同样趋势.线性扫描伏安曲线显示,压膜前后的Pt/C催化剂的ORR活性在含0.1mol/L甲醇的0.5mol/L硫酸中几乎没有变化.电化学阻抗谱结果表明,在该溶液中,Nafion膜的电阻比在其它电解液中低,这可能是导致Pt/C催化剂ORR活性提高的主要原因.有必要关注Nafion膜的这一异常性质并通过特殊设计后用于电池堆,以提高燃料电池性能.

关键词：铂炭甲醇渗透氧还原燃料电池

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溃疡出血的药物治疗

药学研究 1994年第1期 26-26页

作者： Robert Dudnick.MD ,paul martin MD ,Lawrence S ,Firedman.MD. ,满昌强,马丽生,孙中华鲁枣庄市市中区人民医院鲁枣庄市卫生学校鲁枣庄市卫生学校

治疗溃疡病出血药物的机理是通过减少胃血流量或促进凝血来控制出血。在这方面,已研究了许多药物。1.抗纤维蛋白溶解剂tranexamic acid;已有二篇关于tranexamic acid控制消化性溃疡出血随机性试验的研究报告。在这两项研究中,高危病人... 详细信息

治疗溃疡病出血药物的机理是通过减少胃血流量或促进凝血来控制出血。在这方面,已研究了许多药物。1.抗纤维蛋白溶解剂tranexamic acid;已有二篇关于tranexamic acid控制消化性溃疡出血随机性试验的研究报告。在这两项研究中,高危病人均占少数。Barer等的研究表明,尽管tranexamic acid不能明显降低再出血率和外科手术率,却可降低病人的死亡率。第二项研究表明,接受治疗的患者需要进一步输血或急症外科手术的例数均明显减少,而对于降低再出血率却无显著意义.此外,3/69的病人并发血栓性静脉炎。令人费解的是,

关键词：溃疡出血药物再出血率外科手术溃疡病出血生长抑素生长激素释放抑制激素

The role of latanoprost in an inflammatory bowel disease flare

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Gastroenterology Report 2014年第3期2卷 232-234页

作者： Sonali paul martin Wand Geoffrey T.Emerick James M.Richter Department of Gastroenterology and Hepatology Tufts Medical CenterBostonMAUSA Department of Ophthalmology University of Connecticut School of Medicine and Consulting OphthalmologistsFarmingtonCTUSA Department of Gastroenterology Massachusetts General HospitalBostonMAUSA

Ulcerative colitis and Crohn’s disease(CD)are characterized by inflammation of the intestinal mucosa and symptoms of abdominal pain and *** studies have shown an association between elevated levels of prostaglandins and mucosal damage in inflammatory bowel *** report a 50-year-old woman with a history of CD and open-angle *** glaucoma was treated with latanoprost,a prostaglandin analog,which was associated with an exacerbation of her *** discontinuation of latanoprost,her CD symptoms disappeared *** case suggests that in a patient with CD,topical administration of latanoprost may result in sufficient systemic absorption and circulation to promote a relapse of *** finding has important implications,not only for patients with inflammatory bowel disease and glaucoma,but also for both ophthalmologists and gastroenterologists.

关键词： lantanoprost Crohn’s disease prostaglandin glaucoma

The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts

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Bone Research 2014年第2期2卷 110-120页

作者： Thomas S Lisse Kanagasabai Vadivel S paul Bajaj Rui Zhou Rene F Chun martin Hewison John S Adams Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center UCLA Los Angeles CA USA Department of Regenerative Biology and Medicine Mount Desert Island Biological Laboratory Bar Harbor ME USA

Heterogeneous nuclear ribonucleoprotein （hnRNP） C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D （1,25（OH）2D） by functioning as a vitamin D response element-binding protein （VDRE-BP）. hnRNPC acts a tetramer of hnRNPC1 （huC1） and hnRNPC2 （huC2）, and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25（OH）2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25（OH）2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ＂self-cleaving＂ 2A peptide to co-express huC1/C2 suppressed 1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25（OH）2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation.

关键词： gene The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts Figure EcoRI

Systematics of the avian family Alaudidae using multilocus and genomic data

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Avian Research 2023年第2期14卷 137-152页

作者： Per Alstrom Zeinolabedin Mohammadi Erik D.Enbody martin Irestedt Derek Engelbrecht Pierre-Andre Crochet Alban Guillaumet Loïs Rancilhac B.Irene Tieleman Urban Olsson paul F.Donald martin Stervander Animal Ecology Department of Ecology and GeneticsEvolutionary Biology CentreUppsala UniversityNorbyvagen 18DSE-75236UppsalaSweden Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing100101China Department of Biology Faculty of SciencesGolestan UniversityGorganGolestanIran Department of Medical Biochemistry and Microbiology Uppsala University75123UppsalaSweden Department of Biomolecular Engineering University of CaliforniaSanta Cruz95060Santa CruzCAUSA Department of Bioinformatics and Genetics Swedish Museum of Natural HistoryP.O.Box 50007SE-10405StockholmSweden Department of Biodiversity University of LimpopoPrivate Bag X1106Sovenga0727South Africa CEFE CNRSUniv MontpellierEPHEIRDMontpellierFrance Department of Biological&Environmental Sciences Troy UniversityTroyAL36082USA Groningen Institute for Evolutionary Life Sciences University of GroningenNijenborgh 79747 AGGroningenthe Netherlands Department of Biological and Environmental Sciences University of GothenburgP.O.Box 463SE-40530GothenburgSweden Gothenburg Global Biodiversity Centre P.O.Box 461SE-40530GothenburgSweden BirdLife International The David Attenborough BuildingPembroke StCambridgeCB23QZUK Department of Zoology University of CambridgeDowning StreetCambridgeCB23EJUK Bird Group Natural History MuseumAkeman StreetTringHertfordshireHP236APUnited Kingdom

The family Alaudidae,larks,comprises 93-100 species(depending on taxonomy)that are widely distributed across Africa and Eurasia,with single species extending their ranges to North and northernmost South America and Australia.A decade-old molecular phylogeny,comprising~80%of the species,revealed multiple cases of parallel evolution and large variation in rates of morphological evolution,which had misled taxonomists into creating many non-monophyletic ***,we reconstruct the phylogeny of the larks,using a dataset covering one mitochondrial and 16 nuclear loci and comprising all except one of the currently recognised species as well as several recently proposed new species(in total 133 taxa;not all loci available for all species).We provide additional support using genome-wide markers to infer a genus-level phylogeny based on near-complete generic sampling(in total 51 samples of 44 taxa across 40 species).Our results confirm the previous findings of rampant morphological convergence and divergence,and reveal new cases of paraphyletic *** propose a new subfamily classification,and also that the genus Mirafra is divided into four genera to produce a more balanced generic classification of the *** study supports recently proposed species splits as well as some recent lumps,while also questioning some of the *** comprehensive phylogeny will form an important basis for future studies,such as comparative studies of lark natural history,ecology,evolution and conservation.

关键词： Phylogeny Phylogenomics Multispecies coalescent Lark Paraphyly Taxonomy Subfamily description

A force-compensated compliant MEMS-amplifier with electrostatic anti-springs

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Microsystems & Nanoengineering 2023年第3期9卷 235-244页

作者： Philip Schmitt martin Hoffmann Microsystems Technology Ruhr-Universität BochumUniversitätsstr.15044801 BochumGermany

In this paper,an electrostatic compliant mechanical amplifier intended for force-compensated displacement amplification in MEMS sensor applications is ***,mechanical transformers that enhance a small input displacement into a large output displacement generate large forces at the input of the *** microsystem proposed here allows for the reduction and compensation of the input stiffness of the amplifier and any mechanical components connected to it while providing a constant amplification ratio at the same *** amplifying mechanism features bidirectional electrostatic anti-springs enabling the control of the stiffness by applying a constant DC *** electrode design of the anti-springs and its influence on the force-displacement characteristic,the side instability and the maximal displacement are studied through analytical approaches and supported by FEA and by *** on the derived models,a compliant electromechanical amplifier is developed,featuring an amplification ratio of *** this amplifier the initial input stiffness of 422 N/m could be reduced to 6.8 N/m by applying a voltage of 100 *** an additional application,we show how the amplifier can be used as a mechanical force sensor with tuneable sensitivity,where the forces at the input are transformed into large output *** experiments,we show how the sensitivity can be adjusted and increased by a factor of 25 by applying a voltage at the anti-springs.

关键词： amplifier electrostatic spring

Esophageal tissue engineering:A new approach for esophageal replacement

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World Journal of Gastroenterology 2012年第47期18卷 6900-6907页

作者： Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari paul Sibbons martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi Surgery Unit Institute of Child Health and Great Ormond Street HospitalUniversity College LondonLondon WC1N 1EHUnited Kingdom Ear Institute University College LondonLondon WC1X 8EEUnited Kingdom Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineWinston-SalemNC 27157United States Northwick Park Institute for Medical Research London HA1 3UJUnited Kingdom Centre for Stem Cells and Regenerative Medicine University College LondonLondon WC1E 6BTUnited Kingdom

A number of congenital and acquired disorders require esophageal tissue *** surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other *** medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue *** review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the ***,Embase,the Cochrane Library,National Research Register and *** databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal *** lists of papers identified were also examined and experts in this field contacted for further *** full-text articles in English of all potentially relevant abstracts were *** engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to *** acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and *** has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain *** matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available *** in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a p

关键词： Esophagus Regenerative medicine Tissue engineering Scaffolds Transplantation