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Tracheal relaxation of five medicinal plants used in Mexico for the treatment of several diseases

Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 179-183页

作者： Amanda Snchez-Recillas paul mantecón-reyes Patricia Castillo-Espaa Rafael Villalobos-Molina Maximiliano Ibarra-Barajas Samuel Estrada-Soto Facultad de Farmacia Universidad Autonoma del Estado de MorelosAvenida Universidad 1001.Col.ChamilpaCuernavacaMorelos 62209México Centro de Investigación en Riotecnología Universidad Autónoma del Estado de Morelos.Avenida Universidad 1001Col.ChamilpaCuernavacaMorelos 62209México Unidad de Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantlaEstudo de Mexico 54090México

Objective:To assess the relaxant effect of several organic extracts obtained from Agastache mexicana(***),Cochlospermum vitifolium(***),Cordia morelosana(***),Lepechinia caulescens(***)and Talauma mexicana(71 mexicana)used in Mexican traditional medicine for the treatment of several ***:Extracts were obtained by maceration at room temperature using hexane,dicliloromethane and methanol for each plant *** organic extracts were evaluated ex vivo to determine their relaxant activity on the contractions induced by carbaehol(cholinergic receptor agonist,1μmol/L in isolated rat tracheal ***:A total of 15 extracts were evaluated(three for each species).All test samples showed significant relaxant effect,in a concentration-dependent manner,on the contractions induced by 1μmol/L carbachol,with exception of extracts from *** extracts were less potent than theophylline[phosphodiesterase inhibitor,EC_(50):(28.79±0.82)μg/mL]that was used as positive ***-response curves revealed that the extracts with more significant effects were dichloromethanic extracts of ***[E_(max):(103.03±3.32)%and EC_(50):(159.39±3.72)μg/mL)and ***[Emax:(106.58±2.42)%and EC_(50):(219.54±7.61)μg/mL].Finally,hexanic and dichloromethanic extracts from *** were fully effective but less potent than ***,and ***:Less polar extracts obtained from ***,71 mexicana and *** exhibited greater relaxant effect on tracheal rat rings,which allows us to suggest them as sources for the isolation of bioactive molecules with potential therapeutic value in the treatment of asthma.

关键词： Asthma Mexican medicinal plants Trachea Relaxant effect

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The Specimen Data Refinery:A Canonical Workflow Framework and FAIR Digital Object Approach to Speeding up Digital Mobilisation of natural History Collections

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Data Intelligence 2022年第2期4卷 320-341页

作者： Alex Hardisty paul Brack Carole Goble Laurence Livermore Ben Scott Quentin Groom Stuart Owen Stian Soiland-reyes School of Computer Science and Informatics Cardiff UniversityCardiff CF243AAUK The Department of Computer Science The University of ManchesterManchester M139PLUK The natural History Museum London SW75BDUK Meise Botanic Garden 1860 MeiseBelgium Informatics Institute Faculty of ScienceUniversity of Amsterdam1090 GH AmsterdamThe Netherlands

A key limiting factor in organising and using information from physical specimens curated in natural science collections is making that information computable,with institutional digitization tending to focus more on imaging the specimens themselves than on efficiently capturing computable data about *** data are traditionally manually transcribed today with high cost and low throughput,rendering such a task constrained for many collection-holding institutions at current funding *** show how computer vision,optical character recognition,handwriting recognition,named entity recognition and language translation technologies can be implemented into canonical workflow component libraries with findable,accessible,interoperable,and reusable(FAIR)*** libraries are being developed in a cloudbased workflow plaform-the Specimen Data Refinery'(SDR)-founded on Galaxy workflow engine,Common Workflow Language,Research Object Crates(RO-Crate)and WorkflowHub *** SDR can be applied to specimens'labels and other artefacts,offering the prospect of greatly accelerated and more accurate data capture in computable *** kinds of FAIR Digital Objects(FDO)are created by packaging outputs of SDR workflows and workflow components as digital objects with metadata,a persistent identifier,and a specific type *** first kind of FDO are computable Digital Specimen(DS)objects that can be consumed/produced by workflows,and other applications.A single DS is the input data structure submitted to a workflow that is modified by each workflow component in turn to produce a refined DS at the *** Specimen Data Refinery provides a library of such components that can be used individually,or in *** cofunction,each library component describes the fields it requires from the DS and the fields it will in turn populate or *** second kind of FDO,RO-Crates gather and archive the diverse set of digital and real-world resources,configurations,a

关键词： Digital Specimen Workflow FAIR Digital Object RO-Crate

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Making Canonical Workflow Building Blocks Interoperable across Workflow Languages

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Data Intelligence 2022年第2期4卷 342-357页

作者： Stian Soiland-reyes Genis Bayarri Pau Andrio Robin Long Douglas Lowe Ania niewielska Adam Hospital paul Groth Department of Computer Science The University of ManchesterManchester M139PLUK Informatics Institute University of AmsterdamAmsterdam 1098 XHThe Netherlands Institute for Research in Biomedicine(IRB Barcelona) The Barcelona Institute of Science and Technology(BIST)Barcelona O8028Spain The Spanish national Bioinformatics Institute(InB) Barcelona Supercomputing Center(BSC)Barcelona 08034Spain Data Science Institute Lancaster UniversityLancasterLancashire LA14YWUK Research IT IT ServicesThe University of ManchesterManchester M139PLUK European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeshire CB101SDUK

We introduce the concept of Canonical Workflow Building Blocks(CWBB),a methodology of describing and wrapping computational tools,in order for them to be utilised in a reproducible manner from multiple workflow languages and execution *** concept is implemented and demonstrated with the BioExcel Building Blocks library(BioBB),a collection of tool wrappers in the field of computational biomolecular *** across different workflow languages is showcased through a protein Molecular Dynamics setup transversal workflow,built using this library and run with 5 different Workflow Manager Systems(WfMS).We argue such practice is a necessary requirement for FAIR Computational Workflows and an element of Canonical Workflow Frameworks for Research(CWFR)in order to improve widespread adoption and reuse of computational methods across workflow language barriers.

关键词： Scientific workflows Interoperable FAIR Computational tools Containers Software packaging FAIR digital object(FDO),BioExcel Building Blocks library(BioBB),Canonical Workflow Frameworks for Research(CWFR)

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Unique,Persistent,Resolvable:Identifiers as the Foundation of FAIR

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Data Intelligence 2020年第1期2卷 30-39,302页

作者： nick Juty Sarala M.Wimalaratne Stian Soiland-reyes John Kunze Carole A.Goble Tim Clark Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK California Digital Library OaklandCalifornia 94612-2901USA Data Science Institute University of VirginiaCharlottesvilleVA 22903-1738USA

The FAIR principles describe characteristics intended to support access to and reuse of digital artifacts in the scientific research ***,globally unique identifiers,resolvable on the Web,and associated with a set of additional descriptive metadata,are foundational to FAIR *** we describe some basic principles and exemplars for their design,use and orchestration with other system elements to achieve FAIRness for digital research objects.

关键词： Identifiers metadata findability FAIR data data infrastructures

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可爱的失败者

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疯狂英语（阅读版） 2004年第7期 50-52页

作者： Robert paul reyes 一一

进入“美国偶像”决赛圈的最后12名选手名单还没有公布,但是其中一名幸运的参赛者已经与唱片公司签了约,成立了歌迷会,拍了音乐录影带,成立数十个个人网站,还拥有在大大小小的电视台出镜的机会……要知道,该选手在第一轮比赛中就被淘汰... 详细信息

进入“美国偶像”决赛圈的最后12名选手名单还没有公布,但是其中一名幸运的参赛者已经与唱片公司签了约,成立了歌迷会,拍了音乐录影带,成立数十个个人网站,还拥有在大大小小的电视台出镜的机会……要知道,该选手在第一轮比赛中就被淘汰出局。

关键词：个人网站电视台奖学金获得者音乐唱片名单图书馆选拨人学意识

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法国烟雾血管病临床实践指南

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国际脑血管病杂志 2018年第5期26卷 321-330页

作者： D. Herve() M. Kossorotoff() D. Bresson() T. Blauwblomme() M. Carneiro() E. Touze() F. Proust() I. Desguerre() S. Alamowitch() J.-P. Bleton() A. Borsali() E. Brissaud F.Brunelle() L. Calviere() M. Chevignard() G. Geffroy-Greco() S. Faesch() M.-O. Habert() H.De Larocque() P. Meyer() S. reyes L. Thines() E. Tournier-Lasserve() H.Chabriat 郝方斌(译) 张勇(译) 韩聪(译) 段炼(译) From the Departement de neurologie centre de reference des maladies vasculaires rares du cerveau et de roeil (CERVCO) groupe hospitalier Saint- Louis-Lariboisiere-Femand-Widal 2 rue Ambroise-Pare 75010 Paris France Centre national de reference de I’AVC de l’enfant hopital universitaire Necker-Enfants malades AP-HP 149 rue de Sevres 75015 Paris France Service de neurochirurgie groupe hospitalier Saint-Louis-Lariboisiere-Fernand-Widal 2 rue Ambroise- Pare 75010 Paris France Service de neurochirurgie pediatrique hopital universitaire Necker-Enfants-Malades AP-HP 149 rue de Sevres 75015 Paris France neurologie pediatrique hopital Femme-Mere-Enfant hospices Civils-de-Lyon 59 boulevard Pinel 69677 Bron France Service de neurologie Normandie universite Unicaen Inserm U1237 CHU Caen-Normandie avenue de la Cotede-Nacre 14033 Caen France Service de neurochirttrgie CHRU de Rouen 1 rue Germont 76000 Rouen France Service de neuropediatrie hopital universitaire Necker-Enfants malades AP-HP 149 rue de Sevres 75015 Paris France Service de neurologie CHU Saint-Antoine AP-HP 184 rue du Faubourg-Saint-Antoine 75012 Paris France Cabinet de kinesitherapie 25 rue Manin 75019 Paris France Departement d’anesthesie-reanimation groupe hospitalier Saint-Louis-Lariboisiere-Fernand Widal 2 rue Ambroise-Pare 75010 Paris France Cabinet medical de neurologie 132 rue Lafayette 75010 Paris France Service de radiologie petiatrique hopital universitaire Necker- Enfants malades AP-HP 149 rue de Sevres 75015 Paris France Unite neurovasculaire hopital Pierre-Paul-Riquet place du Dr-Baylac 31000 Toulouse France Service de reeducation des pathologies neurologiques acquises de renfant hopitaux de Saint-Maurice 12 rue du Vald’Osne 94410 Saint-Maurice France Centre medical mairie de Port-Marly 78560 Le-Port-Marly France Cabinet medical pediatrique 46 rue Vital 75016 Paris France Service de medecine nucleaire groupe hospitalier Pitie-Salpetriere- Charle-Foix 47-83 bou

1序言1．1制定机构本指南在法国卫生部的组织下由法国脑部和眼部罕见血管疾病中心（reference center for rare vascular diseases of the brain and eye，CERVCO）与法国儿童卒中中心联合起草。

关键词：临床实践指南法国血管病 diseases 烟雾 brain 血管疾病卒中中心

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