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Recent Advances in Metabolomics and Therapeutics for Cancer Cachexia

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Journal of Cancer Therapy 2023年第1期14卷 38-49页

作者： Charles paul lambert lambert Relentless R & D LLC USA

Cancer Cachexia afflicts 50 - 80 percent of cancer patients with roughly 20 percent of all cancer patients dying of cachexia. Metabolomics is the study of different metabolites, their location in the body, and the timing of their appearance and disappearance. As a result, this science of Metabolomics can be applied to solve the problem of Cancer Cachexia. In this review, I examine recent studies on metabolism that use Metabolomics as their instrument of discovery. Further, this review details potential therapeutic interventions at the cellular, animal, and human level that show promise for attenuating Cancer Cachexia.

关键词： Drug Discovery Stable Isotopes Muscle Wasting Oncology

Mineralogic Characterization and Petroleum Potential of Clays (Shales) of the N’Kappa Formation (Paléocene-Eocene) in the Douala Sedimentary Sub-basin (South-West Cameroon)

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International Journal of Geosciences 2012年第4期3卷 696-709页

作者： paul lambert Kenfack Pierre Ricard Njike Ngaha Georges Emmanuel Ekodeck Gabriel Ngueutchoua University of Dschang University of Yaounde

The aim of this research work was to report a facies analysis of the N’Kappa formation, identified the clay minerals present in those facies and evaluate their oil potential. For that to be done, Lithostratigraphic descriptions were performed on three natural outcrops chosen in three different localities of the northern border of Douala sedimentary basin. Ten shaly samples were then collected on those outcrops and submit to X ray diffraction and Rock-Eval pyrolysis. Lithologically, the N’Kappa formation is made up of dark to grey shales and fine to coarse sandtones. The mineralogic content of the shales is made up of Kaolinite, dickite, low quartz and vaterite. Those shaly facies present high amount of immature organic matter (average TOC content around 2%). The petroleum potential is fair to poor (average S2 for all the samples around 3.33 mg HC/g of rock) though some samples (M1 and M2) presenting a good petroleum potential up to 6.62 kg HC/t of rock and 6.44 kg HC/t of rock respectively. They have undergone a low degree of diagenesis (early to burying diagenesis). This is evidenced by the predominance of kaolinite and dickite, low quartz and vaterite which are minerals stable at low temperature.

关键词： Mineralogy Organic Matter Petroleum Potential N’Kappa Formation Douala Sub-Basin

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U900:一种符合成本效益的移动宽带选择

通信世界 2016年第28期 44-45页

作者： paul lambert Ovum

针对U900重整2G 900MHz频谱的主要挑战并非在于网络或终端,而是在于长期非智能手机用户如何使用G900服务以及G900服务如何用于M2M服务。U900也称为UMTS900。它是部署在900MHz频段的一种3G技术,通常用于2G或G900服务。它特别适用于发展... 详细信息

针对U900重整2G 900MHz频谱的主要挑战并非在于网络或终端,而是在于长期非智能手机用户如何使用G900服务以及G900服务如何用于M2M服务。U900也称为UMTS900。它是部署在900MHz频段的一种3G技术,通常用于2G或G900服务。它特别适用于发展中国家那些3G入网终端比例较高,但却只有G900服务可用的运营商。它支持没有广泛移动数据覆盖的新兴市场运营商,

关键词：移动宽带 U900 数据覆盖中国联通商用部署农村地区移动数据 ARPU 城市地区过渡式

OVUM:网络覆盖范围和智能终端将是5G增长关键

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通信世界 2016年第29期 41-42页

作者： paul lambert Ovum

运营商希望待准5G标准制定后推出5G,以了解该技术如何运作及其能力,但他们也考虑到了率先推出5G的潜在商业利益.各国运营商已纷纷推出5G商用计划表近日，欧洲运营商Telia宣布将于2018年首次在欧洲推出5G，Telia认为准5G标准将会在商用... 详细信息

运营商希望待准5G标准制定后推出5G,以了解该技术如何运作及其能力,但他们也考虑到了率先推出5G的潜在商业利益.各国运营商已纷纷推出5G商用计划表近日，欧洲运营商Telia宣布将于2018年首次在欧洲推出5G，Telia认为准5G标准将会在商用之前让其更好地了解标准。

关键词：智能终端网络覆盖标准制定运营商商业利益商用欧洲

Hyperbaric oxygen therapy in malignant otitis externa:A systematic review of the literature

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第4期7卷 296-302页

作者： Young Jae Byun Jaimin Patel Shaun A.Nguyen paul R.lambert Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSCUSA University of Central Florida College of Medicine OrlandoFLUSA

Objective:To review the role of adjuvant hyperbaric oxygen therapy(HBOT)in the treatment of malignant otitis externa(MOE).Data sources:PubMed,Scopus,Web of Science,Science Direct,and Cochrane Library were searched for the following concepts:“hyperbaric oxygen”and“malignant or necrotizing otitis externa.”Methods:Studies were included if they contained(1)patients with reported evidence of MOE,(2)employment of adjuvant HBOT,(3)details on patients’medical condition,and(4)documented survival *** information included patient demographics,underlying medical conditions,infectious etiology,signs and symptoms,medical and surgical treatments,duration of medical treatment,mean follow up time,HBOT setting,number of HBOT sessions,complications,survival rate,and all-cause ***:A total of 16 studies comprising 58 patients(mean age 68.0 years)were *** was present in 94.7%of cases and Pseudomonas spp(64.3%)was the most common infectious *** nerve VII was involved in 55.2%of ***,the disease cure rate with adjuvant HBOT was 91.4%and all-cause mortality was 8.6%.Among those who had cranial nerve VII involvement,72.0%had return of function and 93.8%of them ***:HBOT may be an effective treatment option for refractory or advanced MOE but its efficacy remains unproven due to lack of strong scientific ***,its therapeutic value should not be underestimated given good results and few adverse events reported in this study.

关键词： Malignant otitis externa Necrotizing otitis externa Diabetes mellitus Hyperbaric oxygen Therapy Osteomyelitis

Preferences in stapes surgery among American otological society otologists

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 59-65页

作者： Yuan F.Liu Avigeet Gupta Shaun A.Nguyen paul R.lambert Timothy T.Jung Department of Otolaryngology-Head ond Neck Surgery Medical University of South CarolinaCharlestonSCUSA Department of Otolaryngology-Head and Neck Surgery Loma Linda University Medical CenterLomo LindaCAUSA

Objective:Stapes surgery is technically challenging,yet its methodology is not *** aim to elucidate preferences in stapes surgery among American Otological Society(AOS)otologists and determine if any common practice patterns *** design:Cross-sectional study via emailed ***:Surgery *** and methods:Members of the AOS were an emailed a survey to quantify variables including surgical volume,anesthetic preference,laser use,type of procedure,footplate sealing technique,antibiotic use,and trainee ***:Most otologists(71%)performed 2 to 5 stapes surgeries per month under general anesthesia(69%)with stapedotomy(71%)as the preferred ***(56%)used the rosette method of laser stapedotomy with manual pick debris removal for footplate *** the handheld potassium titanyl phosphate(KTP)laser(40%)or handheld carbon dioxide(CO2)laser(33%)was *** heat-activated memory hook(51%)was the preferred *** sealing method was variable,as was antibiotic use among *** participation was limited,as 42%of otologists allowed residents to place the prosthesis,and fewer allowed residents to crimp the prosthesis,and laser or drill the *** with higher surgical volume(≥6 surgeries per month)demonstrated the following statistically significant correlations:footplate fenestration with laser in a rosette pattern and pick for debris removal(rs=-0.365,P=0.014)and trainee participation with fellows only(rs=0.341,P=0.022).Conclusions:Trends in various surgical decisions showed a lack of consensus in all aspects of stapes surgery.

关键词： Footplate Resident training Surgical training Laser Stapes surgery Stapedotomy Surgical preference Otosclerosis Stapedectomy

Cochlear implantation in patients with Meniere’s disease:A systematic review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第4期7卷 303-311页

作者： Vincent M.Desiato Jaimin J.Patel Shaun A.Nguyen Ted A.Meyer paul R.lambert Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSCUSA

Background:Meniere’s disease(MD)is an idiopathic disorder of the inner ear,which manifests as cochleo-vestibular *** loss will progress to a profound levelin a subset of patients with MD,and vestibular interventions can independently cause loss of *** aim of this study was to systematically review the published literature describing the safety and efficacy of CI in patients with *** and methods:A systematic literature review was conducted in accordance PRISMA guidelines to identify articles that assessed at least one functional outcome in patients with MD who underwent *** information,disease history,MD symptoms,outcomes measures,and complications related to CI were extracted from included ***:In total,17 studies were included,and 182 patients with MD underwent *** weighted-mean age was 61.9 years(range 27-85).Study objective and methodology varied,and there was significant heterogeneity in CI outcome measures *** total,179(98.3%)of 182 patients reported objective improvements in at least one hearing metric after CI.A total of 69 patients(37.9%)reported vertigo or severe dizziness prior to CI,compared to 22 patients(15.4%)*** studies reported significant reductions in postoperative Tinnitus Handicap Inventory score(THI).Quality of life assessments varied between *** rates were low with only nine patients(4.9%)reporting a serious CI-related ***:This systematic review evaluated 17 studies describing the safety and efficacy of CI in patients with MD and encountered many challenges due to small sample sizes,and heterogeneity in study design and outcomes *** these limitations,this study of 182 patients is to the best of our knowledge the largest systematic review evaluating the safety and efficacy of CI in *** results of this study support the need for a standardized approach to evaluating outcomes of CI in patients with MD in future s

关键词： Cochlear implantation Meniere’s disease

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日本血吸虫McAb的初步研究

中国医学科学院学报 1983年第6期 346-347页

作者：严自助 Luc H Perin Elbe Ramiraz paul H lambert 中国医学科学院寄生虫病研究所世界卫生组织免疫研究与培训中心世界卫生组织免疫研究与培训中心世界卫生组织免疫研究与培训中心

用BALB/C小鼠骨髓瘤细胞X63-Ag8-653与感染日本血吸虫尾蚴20条后25～80天的同种小鼠脾细胞进行细胞杂交,获得了能产生特异性抗体的杂交瘤;杂交的成功率达到50％～100％。实验表明,童虫或成虫冰冻切片的间接荧光抗体试验是筛选杂交瘤分... 详细信息

用BALB/C小鼠骨髓瘤细胞X63-Ag8-653与感染日本血吸虫尾蚴20条后25～80天的同种小鼠脾细胞进行细胞杂交,获得了能产生特异性抗体的杂交瘤;杂交的成功率达到50％～100％。实验表明,童虫或成虫冰冻切片的间接荧光抗体试验是筛选杂交瘤分泌的特异抗体的简易而有效的方法。童虫的荧光反应类型不明显;但在成虫切片上,发现至少有3种不同

关键词：日本血吸虫 McAb 免疫荧光反应

The influence of obesity on operating room time and perioperative complications in cochlear implantation

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第4期3卷 231-234页

作者： Jonathan L.Hatch Isabel M.Boersma Forest W.Weir Michael J.Bauschard Meredith A.Holcomb paul R.lambert Ted A.Meyer Department of Otorhinolaryngology Head and Neck Surgery Medical University of South Carolina SC 29425 USA

Objective:The rising incidence of obesity in the United States is associated with increased healthcare expenditures and resource *** has been associated with prolonged operating times during surgical *** primary objective of this study is to compare body mass index (BMI) to length of surgery during cochlear ***:A retrospective case control study from a tertiary academic referral center was *** included were adults who underwent primary,single-sided cochlear implantation with documented BMI and operating room (OR) times from January 2009 to July *** following data were collected:BMI,total operating room time (TORT),surgical operating room time (SORT),ASA status,perioperative and postoperative complications,age,and ***:Two hundreds and thirty-four patients were included and stratified into obese (BMI ＞30)and non-obese (BMI ＜ 30) *** analysis was performed comparing TORT against the obesity category along with other *** sample t-test demonstrated that obesity increases TORT and SORT by 16.8 min (P ＝ 0.0002) and 9.3 min (P ＝ 0.03),respectively,compared to the non-obese *** linear regression analysis demonstrated no statistically significant impact of gender,or ASA status on total operating or surgical *** was associated with increased perioperative complications (odds ratio [OR],6.21;95％ CI,1.18-32.80;P ＝ 0.03) and postoperative complications (OR,3.97;95％ CI,1.29-12.26;P ＝ 0.02).Conclusions:Obesity leads to longer TORT and SORT during primary cochlear implant *** is also associated with increased perioperative and postoperative complications compared to non-obese *** data have implications with utilization of operating room resources.

关键词： Cochlear implant Body mass index Operating time Perioperative complications