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Diagnosis of CAh in a Sub Saharan Country: Visible Part of Iceberg

Open Journal of Pediatrics 2024年第2期14卷 227-233页

作者： Suzanne Sap ritha Mbono hélène Kamo Jocelyn Tony Charlotte Eposse Jeannette Epée Isabelle Mekone Adele Bodieu Gaelle Ntsoli paul Olivier Koki Mother and Child Center of the Chantal Biya Foundation University of Yaoundé I Yaoundé Cameroon Laquintinie hospital University of Douala Douala Cameroon Genral hospital of Garoua University of Garoua Garoua Cameroon human reproductive Center and research on Fertility of Yaoundé University of Yaoundé I Yaoundé Cameroon Yaounde General hospital University of Yaoundé I Yaoundé Cameroon Yaounde Central hospital Yaoundé Cameroon Laquintiinie hospital Douala Cameroon

Introduction :Congenital adrenal hyperplasia (CAh) is the most common cause of primary adrenal insufficiency. It is a rare monogenic recessive disorder. In African setting in absence of neonatal screening, the diagnosis is still late, based on a clinical approach. During this clinical enquiry, information from past history or pedigree of the patient is of a huge importance and may revealed surprises. Patients and Methods: In this observational study, we retrospectively included all patients with a diagnosis of CAh. The diagnosis of CAh was retained based on a high 17 hydroxyprogesterone level in addition to clinical and morphological findings. From patients’ files, we extracted data on family history of disease, pedigree, clinical findings and genetics when available of 39 patients from two endocrinopeadiatric centers. results: In 13 (30%) families, we found 20 reported deaths of infant less than 12 months. In these 13 families, half of the patients followed had 21 hydroxylase deficiencies and had 11 hydroxylase deficiencies. Unsurprisingly, we suspected adrenal insufficiency in these patients at verbal autopsy even in families with a patient with 11 hydroxylase deficiency. Other non DSD malformations or genetic disorders with apparently no link with CAh were reported in 3 families. The father of a patient reported to have hypospadias. Conclusion: Each diagnosis of CAh made in our context is visible part of an iceberg. Behind a diagnosis of CAh made in our setting, is a long course of care, a dramatic past history revealing access to appropriate care disparity. Neonatal screening should thus be considered as an emergency.

关键词： Congenital Adrenal hyperplasia

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Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding rpaul ross Catherine Stanton Jianxin Zhao Bo Yang Wei Chen State Key Laboratory of Food Science and resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint research Center for Probiotics&Gut health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food research Centre MooreparkFermoyCork T12 YT20Ireland National Engineering research Center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male C57BL/6J mice were divided into 4 groups(n=8 per group,Control,Model,FZJTZ26M3,FGSYC17L3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26M3 could alleviate NAFLD by regulating lipid ***,the results of 16S rrNA gene sequencing revealed a drop in the relative abundance of ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut microbiota

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Predictive Study of Trace Metal Pollution of Gold Panning Sites in Birimian Formations: Case of the Yaouré Furrow (Côte d’Ivoire)

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Open Journal of Applied Sciences 2024年第7期14卷 1691-1714页

作者： Tonga paul Tiemoko Gbele Ouattara Kouassi Ernest Ahoussi Laboratoire des Sciences Gographiques du Gnie Civil et des Gosciences Institut National Polytechnique Flix Houphout-Boigny (INP-HB) Yamoussoukro Cte dIvoire Laboratoiredes Sciences du Sol delEauetdes Gomatriaux Universit Flix Houphout-Boigny (UFHB) Abidjan-Cocody Cte dIvoire

The present study was carried out on small-scale gold mining sites in the Yaouré region of Côte d’Ivoire. This region is geologically representative of the Birimian formations (2.1 Ga) of West Africa. The aim is to determine the potentially toxic trace metals (TMEs) generated by these sites, with a view to preventing possible contamination and/or metal pollution of the waters that provide fish products for local populations. To this end, a sampling campaign was carried out, resulting in the collection of 20 mining waste samples analyzed by X-ray fluorescence spectrometry (XrF) and 10 by X-ray diffractometer (XrD). The XrF analysis detected 06 predominant TMEs: arsenic, chromium, copper, nickel, zinc and vanadium. Statistical analysis was carried out to determine the distributions and correlations between these ETMs. To assess contamination and/or pollution levels, the following indices were calculated on the basis of reference concentrations of upper continental crust MTEs: Enrichment Factor, Geo-accumulation Index, Concentration Factor, Degree of contamination and those related to ecological risks. The results of statistical analyses and indices have shown that arsenic and chromium are the most predominant and can be, depending on the chemical form, potentially more toxic. The results of the DrX analysis show the occurrence of several minerals carrying these two MTEs, especially that of a rare mineral, Stenhuggarite, an arsenic oxide linked to hydrothermal veins. The majority of gold mining operations in West Africa are located in the birimian zone, hence the need for environmental monitoring by the relevant authorities, to prevent potential ecological risks to water and possibly health risks via the food chain.

关键词： Small-Scale Mining Metallic Trace Elements Mining Discharges Contamination Pollution Contamination Pollution Index

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Impacts of human Activities and Season on Species Diversity and Abundance of Butterflies in Mpanga Kipengere Game reserve and Surrounding Farmlands, Tanzania

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Open Journal of Ecology 2024年第4期14卷 274-291页

作者： Privatus M. Kasisi Nsajigwa Mbije paul Lyimo Departiment of Ecosystem Science and Management College of Forest Wildlife and Tourism Sokoine University of Agriculture Morogoro Tanzania Departiment of Wildlife Management College of Forest Wildlife and Tourism Sokoine University of Agriculture Morogoro Tanzania

Maintaining natural habitats is crucial for the preservation of insects and other species that indicate environmental changes. however, the Mpanga/Kipengere Game reserve and its surrounding farmlands are facing disturbance due to human activities, which is putting many wildlife species, particularly larger mammals, at risk. To determine the impact of human activities on butterfly species diversity and abundance in the reserve and its surrounding areas, we conducted a study from November 2021 to October 2023. We collected butterfly data using transect walks and baited traps in two habitat types. Our study yielded 2799 butterfly Individuals ranging in 124 species divided into five families habitat, season, and anthropogenic factors are significant environmental variables influencing species diversity and abundance of butterflies. Therefore, it’s important to protect habitat and dry-season water for the conservation of invertebrates such as butterflies. Our study findings provide essential information for ecological monitoring and future assessment of the Mpanga/Kipengere Game reserve ecosystem health.

关键词： Mpanga Kipengere Game reserve Species Diversity habitat Butterflies Season human Activities

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Potential of Applying Artificial Intelligence to hot Metal Logistics Management

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China's refractories 2024年第3期33卷 37-41页

作者： Maria Gabriela Garcia CAMPOS paul van BEUrDEN Tata Steel IJmuiden 1970 CAThe Netherlands

The steel industry,known for its complexity and the need to reduce CO_(2)emissions,is adopting advanced digitalization tools to move towards a more sustainable,integrated,and agile operating *** twins with artificial intelligence-based optimization and scheduling models can improve decision-making in logistics,refractory maintenance,and energy *** incorporating advanced AI algorithms into this decision support system,the hot metal route scenarios can be evaluated,resulting in minimized hot metal temperature losses and increased scrap *** paper integrated digital twins with reinforcement learning algorithms to investigate the logistics of torpedoes and hot metal *** considered important input parameters such as the ladles and torpedoes'thermal state and location,refractory thickness,hot metal volume and temperature,and crane *** incorporating advanced AI algorithms into this decision support system,energy-efficient scenarios can be evaluated,increasing scrap utilization and resulting in a possible reduction of 15°C in hot metal temperature losses.

关键词： hot metal logistics energy efficiency artificial intelligence

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上海戏剧学院2020级音乐剧表演专业/舞美系毕业公演百老汇音乐剧《致埃文·汉森》剧照

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戏剧艺术 2024年第2期 I0005-I0006页

作者： Benj Pasek Justin paul Steven Levenson 不详

剧情梗概该剧讲述的是埃文·汉森,一位高中生,因为家庭的变故,常感到孤独,并患上了社交焦虑症。遵照心理医师的要求,他每天都要写一封致自己的信,以此来激励自己。可是他的一封信却被同班同学康纳·墨菲发现,让康纳误以为此信是埃文写... 详细信息

剧情梗概该剧讲述的是埃文·汉森,一位高中生,因为家庭的变故,常感到孤独,并患上了社交焦虑症。遵照心理医师的要求,他每天都要写一封致自己的信,以此来激励自己。可是他的一封信却被同班同学康纳·墨菲发现,让康纳误以为此信是埃文写给他的。不久传来康纳自杀身亡的消息,令所有人极度悲伤……此时康纳的父母也发现了埃文写的那封信,他们误以为自己的儿子和埃文是最亲密的好友,试图通过埃文去查清儿子的死因,为了安慰康納的家人,埃文决定将错就错。

关键词：上海戏剧学院自杀身亡心理医师同班同学康纳汉森一封信将错就错

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A simple and efficient CrISPr/Cas9 system permits ultra-multiplex genome editing in plants

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The Crop Journal 2024年第2期12卷 569-582页

作者： Suting Wu htin Kyaw Zhijun Tong Yirong Yang Zhiwei Wang Liying Zhang Lihua Deng Zhiguo Zhang Bingguang Xiao William paul Quick Tiegang Lu Guoying Xiao Guannan Qin Xue'an Cui Biotechnology research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Biological Breeding for Fujian and Taiwan Crops Ministry of Agriculture and Rural AffairsCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Agro-ecological Processes in Subtropical region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina School of Biosciences The University of SheffieldFirth CourtWestern BankSheffield S102TNUK Key Laboratory of Tobacco Biotechnological Breeding National Tobacco Genetic Engineering Research CenterYunnan Academy of Tobacco Agricultural SciencesKunming 650021YunnanChina

The development and maturation of the CrISPr/Cas genome editing system provides a valuable tool for plant functional genomics and genetic *** available genome-editing tools have a limited number of targets,restricting their application in genetic *** this study,we developed a novel CrISPr/Cas9 plant ultra-multiplex genome editing system consisting of two template vectors,eight donor vectors,four destination vectors,and one primer-design software *** combining the advantages of Golden Gate cloning to assemble multiple repetitive fragments and Gateway recombination to assemble large fragments and by changing the structure of the amplicons used to assemble sg rNA expression cassettes,the plant ultra-multiplex genome editing system can assemble a single binary vector targeting more than 40 genomic loci.A rice knockout vector containing 49 sg rNA expression cassettes was assembled and a high co-editing efficiency was *** plant ultra-multiplex genome editing system advances synthetic biology and plant genetic engineering.

关键词： CrISPr/Cas9 Multiplex genome editing Assembly system Plant

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Experimental Investigation of the Stability of the Performance Characteristics of a Photovoltaic Module in the Face of Environmental and Meteorological Factors

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Open Journal of Applied Sciences 2024年第2期14卷 589-608页

作者： Adingra paul Arsène Kouassi Siaka Touré Diakaridja Traoré Laboratoire des Sciences de la Matière de l’Environnement et de l’Energie Solaire (LASMES) Unité de Formation et de Recherche des Sciences des Structures de la Matière et Technologie (UFR-SSMT) Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire

The explosive technological improvement of photovoltaic systems as well as the necessity of populations to come to less expensive energy sources, that have led to an implosion at the level of solar panel manufacturers. This causes a large flow of these equipments to developing countries where the need is high, without any quality control. That conducted an experimental investigation on the performance characteristics of a 250 wp monocrystalline silicon photovoltaic module in other to check the verification and quality control. Most of these PV panels which often have missing informations are manufactured and tested in places that are inadequate for our environmental and meteorological conditions. Also, their influences on the stability of internal parameters were evaluated in order to optimize their performance. The results obtained at maximum illumination (1000 w/m2) confirmed those produced by the manufacturer. The analysis of these characteristics showed that the illumination and the temperature (meteorological factors) influenced at most the stability of the internal characteristics of the module in the sense that the maximum power increased very rapidly beyond 750 w/m2 but a degradation of performance was accentuated for a temperature of the solar cells exceeding 50°C. The degradation coefficients were evaluated at -0.0864 V/°C for the voltage and at -1.6248 w/°C for the power. The 10° inclination angle of the solar panel proved to be ideal for optimizing overall efficiency in practical situations.

关键词： renewables Energies Instruments Internal Parameters of Photovoltaic Panel Monocrystalline Photovoltaic Panel Solar Energy Production Energy Intermittence

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Norian(Late Triassic) conodonts from the raohe area， heilongjiang， Northeastern China

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Journal of Earth Science 2024年

作者： Xianlang Wu paul B.Wignall Xulong Lai Yan Chen Jinling Yuan Guiyue Luo haishui Jiang State Key Laboratory of Biogeology and Environmental Geology， School of Earth Sciences， China University of Geosciences School of Earth and Environment， University of Leeds hubei Institute of Geosciences

The raohe area of heilongjiang Province， Northeast China belongs to the Nadanhada Terrane， which was in low latitudes of Panthalassa during the Triassic. The composition of the Late Triassic conodont fauna， derived from limestone lenses interpreted to be formed on seamounts， provides important new information on the pelagic biota in this ocean. New conodont samples collected from sections at Minzhu， Minnan and Chigangbei belong to three Norian conodont zones. In ascending order， they are: Mockina postera Zone， Mockina bidentata Zone and Parvigondolella andrusovi Zone. The Norian conodont fauna in the raohe area has distinct attributes: there are a lot of cosmopolitan species (e.g. Mockina postera， Mockina bidentata， Parvigondolella andrusovi) which enable good global correlation; endemic conodont species are also present， (e.g. Mockina sakurae， Mockina shamiseni， Norigondolella nadanhadaensis) indicating that Panthalassa Ocean conodont populations also contains unique taxa; and some conodonts belong to taxa with much shorter ranges in surrounding epeiric seas (e.g. Carnepigondolella pseudoechinata， Neocavitella cavitata and Epigondolella vialovi). The presence of the latter “relicts” indicates that the seamounts were persistently suitable habitats for many millions of years in the Late Triassic.

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Spatio-Temporal Change of Dispersal Areas of Greater Kudu (Tragelaphus strepsiceros) in Lake Bogoria Landscape, Kenya

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Open Journal of Ecology 2024年第3期14卷 183-198页

作者： Beatrice Chepkoech Cheserek George Morara Ogendi paul Mutua Makenzi Department of Environmental Science Egerton University Njoro Kenya

Decline in wildlife populations is manifest globally, regionally and locally. A wildlife decline of 68% has been reported in Kenya’s rangelands with Baringo County experiencing more than 85% wildlife loss in the last four decades. Greater Kudu (Tragelaphus strepsiceros) is endemic to Lake Bogoria landscape in Baringo County and constitutes a major tourist attraction for the region necessitating use of its photo on the County’s logo and thus a flagship species. Tourism plays a central role in Baringo County’s economy and is a major source of potential growth and employment creation. The study was carried out to assess spatio-temporal change of dispersal areas of Greater Kudu (GK) in Lake Bogoria landscape in the last four years for enhanced adaptive management and improved livelihoods. GK population distribution primary data collected in December 2022 and secondary data acquired from Lake Bogoria National Game reserve (LBNGr) for 2019 and 2020 were digitized using in a Geographic Information System (GIS). Measures of dispersion and point pattern analysis (PPA) were used to analyze dispersal of GK population using GIS. Spatio-temporal change of GK dispersal in LBNr was evident thus the null hypothesis was rejected. It is recommended that anthropogenic activities contributing to GK’s habitat degradation be curbed by providing alternative livelihood sources and promoting community adoption of sustainable technologies for improved livelihoods.

关键词： Spatio-Temporal Change Dispersal Greater Kudu (Tragelaphus Strepsiceros) Point Pattern Analysis (PPA) GIS

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